REV1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REV1_MOUSE
• UniProt AC: Q920Q2
• Protein Name: DNA repair protein REV1
• Gene Name: Rev1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1249
• Subcellular Localization: Nucleus .
• Protein Description: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents..
• Protein Sequence: MRRGGWRKRTENDGWEKWGGYMAAKVQKLEEQFRTDAANQKDGTASAIFSGVAIYVNGYTDPSAEELRNLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKAGRLLSSAPYQLYTKPSAAQKSLNFNPVCKPEDPGPGPSNRAKQLNNRVNHIIKKIETESEVKANGLSSWNEDGVNDDFSFEDLEHTFPGRKQNGVMHPRDTAVIFNGHTHSSNGALKTQDCLVPVGNSVASRLSLDSTQEEKRAEKSNADFRDCTVQHLQHSTRSADALRSPHRTNSLSPSLHSNTKINGAHHSTVQGPSSTKSTSVLTLSKVAPSVPSKPSDCNFISDFYSRSRLHHISTWKCELTEFVNTLQRQSSGIFPGREKLKKVKTGRSSLVVTDTGTMSVLSSPRHQSCVMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGTAPLRPGANPQLEWQYYQNRALRGKAADIPDSSVWENQDSTQTNGIDSVLSKAEIASCSYEARQVGIKNGMFFGYAKQLCPNLQAVPYDFHACREVAQAMYETLASYTHSIEAVSCDEALIDVTDILAETKLSPEEFAAALRIEIKDKTKCAASVGIGSNILLARMATKKAKPDGQYHLQPDEVDDFIRGQLVTNLPGVGRSMESKLASLGIKTCGDLQCLTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRLEAAGMKGKRLTLKIMVRKPGAPIETAKFGGHGICDNIARTVTLDQATDSAKIIGKATLNMFHTMKLNISDMRGVGIQVNQLVPANSNLSTCSSRPSAQSSLFSGRPHSVRDLFQLQKAKKPTEEEHKEVFLAAVDLEVSSTSRACGLLSPLSAHLAASVSPDTNSGECSRKWNGLHSPVSGQSRLNLSIEVPSPSQIDQSVLEALPLDLREQIEQVCAAQQGEPRGKKKEPVNGCSSGVLPHPVGTVLLQIPEPQEPCNSDSKISVIALPAFSQVDPDVFAALPAELQKELKAAYDQRQRQGEDTTHQQPTSTSVPKNPLLQLKPPAMKDKRNKRKNLIGSPRKSPLKNKLLSSPAKTLPGAYGSPQKLMDGFLQHEGMASERPLEEVSASTPGAQDLSSLLPGQSSCFRPAAPNLAGAVEFSDVKTLLKEWITTISDPMEEDILQVVRYCTDLIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RGGWRKRTENDGWEK CCCCCCCCCCCCHHH	42.02	-
238	Phosphorylation	SSNGALKTQDCLVPV CCCCCCCCCCEEEEC	30.41	30635358
251	Phosphorylation	PVGNSVASRLSLDST ECCCHHHHHHCCCCH	31.44	21454597
291	Phosphorylation	RSADALRSPHRTNSL CCHHHHCCCCCCCCC	26.38	28066266
299	Phosphorylation	PHRTNSLSPSLHSNT CCCCCCCCCCCCCCC	16.56	27841257
645	Phosphorylation	FIRGQLVTNLPGVGR HHHCCCCCCCCCCCC	39.36	24719451
660	Phosphorylation	SMESKLASLGIKTCG HHHHHHHHCCCCCCH	37.25	24719451
783	Phosphorylation	DNIARTVTLDQATDS CCCEEEEEHHHHCHH	24.81	22871156
893	Phosphorylation	CGLLSPLSAHLAASV CCCCCHHHHHHHHHC	19.61	25293948
899	Phosphorylation	LSAHLAASVSPDTNS HHHHHHHHCCCCCCC	19.95	25293948
901	Phosphorylation	AHLAASVSPDTNSGE HHHHHHCCCCCCCCC	17.98	25293948
904	Phosphorylation	AASVSPDTNSGECSR HHHCCCCCCCCCCCC	34.37	25293948
906	Phosphorylation	SVSPDTNSGECSRKW HCCCCCCCCCCCCCC	37.75	25293948
910	Phosphorylation	DTNSGECSRKWNGLH CCCCCCCCCCCCCCC	32.37	25293948
918	Phosphorylation	RKWNGLHSPVSGQSR CCCCCCCCCCCCCCC	31.85	25338131
1082	Phosphorylation	KRKNLIGSPRKSPLK HCCCCCCCCCCCHHH	17.97	26824392
1086	Phosphorylation	LIGSPRKSPLKNKLL CCCCCCCCHHHCHHH	36.42	26824392
1094	Phosphorylation	PLKNKLLSSPAKTLP HHHCHHHCCCCCCCC	44.72	28066266
1095	Phosphorylation	LKNKLLSSPAKTLPG HHCHHHCCCCCCCCC	28.93	28066266
1104	Phosphorylation	AKTLPGAYGSPQKLM CCCCCCCCCCHHHHH	24.85	26643407
1106	Phosphorylation	TLPGAYGSPQKLMDG CCCCCCCCHHHHHHH	16.10	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REV1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REV1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REV1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCNA_MOUSE	Pcna	physical	22244149
PCNA_HUMAN	PCNA	physical	16982685
POLK_MOUSE	Polk	physical	14657033
POLI_MOUSE	Poli	physical	14657033
POLH_MOUSE	Polh	physical	14657033
UBC_MOUSE	Ubc	physical	16982685
RAD18_HUMAN	RAD18	physical	26795561

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.