POLK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POLK_MOUSE
• UniProt AC: Q9QUG2
• Protein Name: DNA polymerase kappa
• Gene Name: Polk
• Organism: Mus musculus (Mouse).
• Sequence Length: 852
• Subcellular Localization: Nucleus . Detected throughout the nucleus and at replication foci. Recruited to DNA damage sites in response to ultraviolet irradiation: N6-methyladenosine (m6A)-containing mRNAs accumulate in the vicinity of DNA damage sites and their presence is re
• Protein Description: DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. [PubMed: 12432099 Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity]
• Protein Sequence: MDNTKEKDNFKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDKFAMELERNRNLNNTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPEDKRRYFIKMGNYLKIDTPRQEANELTEYERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNPQIAQNSVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGERKSMSVERTFSEISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRTEVNVGSPHPLRLRLMGVRMSTFSSEDDRKHQQRSIIGFLQAGNQALSSTGDSLDKTDKTELAKPLEMSHKKSFFDKKRSERISNCQDTSRCKTAGQQALQILEPSQALKKLSESFETSENSNDCQTFICPVCFREQEGVSLEAFNEHVDECLDGPSTSENSKISCYSHASSADIGQKEDVHPSIPLCEKRGHENGEITLVDGVDLTGTEDRSLKAARMDTLENNRSKEECPDIPDKSCPISLENETISTLSRQDSVQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEGNSVKQPKESSRSTDRLQKASGRTKRPGTKTKSSTLKKTKPRDPRHTLDGFFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	VKEILAEYDPNFMAM HHHHHHHHCCCCCCC	30.97	24759943
195	Phosphorylation	DPNFMAMSLDEAYLN CCCCCCCCHHHHHHH	24.11	24759943
200	Phosphorylation	AMSLDEAYLNITQHL CCCHHHHHHHHHHHH	9.76	24759943
204	Phosphorylation	DEAYLNITQHLQERQ HHHHHHHHHHHHHCC	14.63	24759943
232	Phosphorylation	GNYLKIDTPRQEANE CCEEEECCCCHHHHH	24.68	23984901
739	Phosphorylation	PISLENETISTLSRQ CCCCCCCCHHHCCCC	31.63	23984901
741	Phosphorylation	SLENETISTLSRQDS CCCCCCHHHCCCCCC	30.62	23984901
742	Phosphorylation	LENETISTLSRQDSV CCCCCHHHCCCCCCC	25.54	23984901
744	Phosphorylation	NETISTLSRQDSVQP CCCHHHCCCCCCCCC	28.16	23984901
748	Phosphorylation	STLSRQDSVQPCTDE HHCCCCCCCCCCCCC	17.83	25266776
753	Phosphorylation	QDSVQPCTDEVVTGR CCCCCCCCCCCCCCC	41.71	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POLK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POLK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POLK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_MOUSE	Ubc	physical	18162470
REV1_MOUSE	Rev1	physical	14657033

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.