POLI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POLI_MOUSE
• UniProt AC: Q6R3M4
• Protein Name: DNA polymerase iota
• Gene Name: Poli
• Organism: Mus musculus (Mouse).
• Sequence Length: 717
• Subcellular Localization: Nucleus. Accumulates at replication forks after DNA damage..
• Protein Description: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity)..
• Protein Sequence: MEPLHAGAAGSSRAVCSQGPPTQISSSRVIVHVDLDCFYAQVEMISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRLQQLPSEEVPSVTVFGHVYNNQSVNLHNIMHRRLVVGSQIAAEMREAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFCNLKALSSAKKGPMDCYLTSLSTPAYTDKRAFKVKDTHTEDSHKEKEANWDCLPSRRIESTGTGESPLDATCFPKEKDTSDLPLQALPEGVDQEVFKQLPADIQEEILYGKSRENLKGKGSLSCPLHASRGVLSFFSTKQMQASRLSPRDTALPSKRVSAASPCEPGTSGLSPGSTSHPSCGKDCSYYIDSQLKDEQTSQGPTESQGCQFSSTNPAVSGFHSFPNLQTEQLFSTHRTVDSHKQTATASHQGLESHQGLESRELDSAEEKLPFPPDIDPQVFYELPEEVQKELMAEWERAGAARPSAHR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
373	Phosphorylation	HVIQKLGTGNHDSMP HHHHHHCCCCCCCCH	45.29	22871156
469	Phosphorylation	LPSRRIESTGTGESP CCCCCEEECCCCCCC	29.75	-
553	Phosphorylation	STKQMQASRLSPRDT CCCHHHHHCCCCCCC	19.50	23737553
556	Phosphorylation	QMQASRLSPRDTALP HHHHHCCCCCCCCCC	19.44	23737553
577	Phosphorylation	ASPCEPGTSGLSPGS CCCCCCCCCCCCCCC	30.27	26643407
578	Phosphorylation	SPCEPGTSGLSPGST CCCCCCCCCCCCCCC	43.59	26643407
581	Phosphorylation	EPGTSGLSPGSTSHP CCCCCCCCCCCCCCC	30.64	26643407
584	Phosphorylation	TSGLSPGSTSHPSCG CCCCCCCCCCCCCCC	30.07	26643407
585	Phosphorylation	SGLSPGSTSHPSCGK CCCCCCCCCCCCCCC	36.65	26643407
586	Phosphorylation	GLSPGSTSHPSCGKD CCCCCCCCCCCCCCC	34.79	26643407
589	Phosphorylation	PGSTSHPSCGKDCSY CCCCCCCCCCCCCCH	30.03	26643407
651	Ubiquitination	HRTVDSHKQTATASH CCCCHHCHHHCCHHH	53.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POLI_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POLI_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POLI_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCNA_HUMAN	PCNA	physical	16357261
UBC_MOUSE	Ubc	physical	20929865
REV1_MOUSE	Rev1	physical	14657033

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.