UniProt ID | POLH_MOUSE | |
---|---|---|
UniProt AC | Q9JJN0 | |
Protein Name | DNA polymerase eta | |
Gene Name | Polh | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 694 | |
Subcellular Localization |
Nucleus . Accumulates at replication forks after DNA damage. After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80% this recruitment may not be not restricted to cells active in DNA replication. |
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Protein Description | DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). [PubMed: 10871396 Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (By similarity Particularly important for the repair of UV-induced pyrimidine dimers] | |
Protein Sequence | MAPGQNRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSYFAVIERASIDEAYIDLTSAVQERLQKLQGQPISADLLPSTYIEGLPRGPTVEETVQKEAIRKQGLLQWLDSLQSDDPTSPDLRLTVGAMIVEEMRAAIESKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEVLGIEYMGDLTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLALELEERLTKDRNDNDRVATQLVVSIRFQGDRRLSSLRRCCALPRYDAHKMSQDAFAAIRNCNTSGIQTEWSPPLTMLFLCATKFSAAAPPACTDITAFLSSDSSCQPKVPIASSETRTQGSGPAVPTSKEAATSLASFFQKAAKKQRMKETSFVPLNTATEKLSSKPSLVFQSSQTTGSQSFFKQKSLLLQHTQLSNSAAPDPPQASPAAQPSCLPAECVDSGPDDGAVKPVSSKAVSTEMNVAGDSPNVLDSPAYNSQEVTQRATEDQVLCEKCDSLVPVWDMPEHTDYHFALELQKSFLQPCTSKPQAIPAVSPQGKRNPKSPSASSSKRLRPHGMQTLESFFKPLTH | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
322 | Acetylation | PKTIGCSKNFPGKTA CCCCCCCCCCCCCCC | 67.68 | 2374511 | |
378 | Phosphorylation | FQGDRRLSSLRRCCA ECCCHHHHHHHHHHH | 26.05 | 28725479 | |
379 | Phosphorylation | QGDRRLSSLRRCCAL CCCHHHHHHHHHHHC | 30.41 | 28725479 | |
478 | Phosphorylation | TSKEAATSLASFFQK CCHHHHHHHHHHHHH | 19.74 | 25338131 | |
597 | Phosphorylation | DSPNVLDSPAYNSQE CCCCCCCCCCCCCHH | 13.79 | 25338131 | |
651 | Ubiquitination | FLQPCTSKPQAIPAV HCCCCCCCCCCCCCC | 24.01 | - | |
659 | Phosphorylation | PQAIPAVSPQGKRNP CCCCCCCCCCCCCCC | 17.38 | 24453211 | |
668 | Phosphorylation | QGKRNPKSPSASSSK CCCCCCCCCCCCCCC | 25.91 | - | |
673 | Phosphorylation | PKSPSASSSKRLRPH CCCCCCCCCCCCCCC | 39.33 | 25266776 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of POLH_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of POLH_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of POLH_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
REV1_MOUSE | Rev1 | physical | 22244149 | |
PCNA_MOUSE | Pcna | physical | 22244149 | |
REV1_MOUSE | Rev1 | physical | 14657033 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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