POLH_MOUSE - dbPTM
POLH_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID POLH_MOUSE
UniProt AC Q9JJN0
Protein Name DNA polymerase eta
Gene Name Polh
Organism Mus musculus (Mouse).
Sequence Length 694
Subcellular Localization Nucleus . Accumulates at replication forks after DNA damage. After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%
this recruitment may not be not restricted to cells active in DNA replication.
Protein Description DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). [PubMed: 10871396 Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (By similarity Particularly important for the repair of UV-induced pyrimidine dimers]
Protein Sequence MAPGQNRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSYFAVIERASIDEAYIDLTSAVQERLQKLQGQPISADLLPSTYIEGLPRGPTVEETVQKEAIRKQGLLQWLDSLQSDDPTSPDLRLTVGAMIVEEMRAAIESKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIEVLGIEYMGDLTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLALELEERLTKDRNDNDRVATQLVVSIRFQGDRRLSSLRRCCALPRYDAHKMSQDAFAAIRNCNTSGIQTEWSPPLTMLFLCATKFSAAAPPACTDITAFLSSDSSCQPKVPIASSETRTQGSGPAVPTSKEAATSLASFFQKAAKKQRMKETSFVPLNTATEKLSSKPSLVFQSSQTTGSQSFFKQKSLLLQHTQLSNSAAPDPPQASPAAQPSCLPAECVDSGPDDGAVKPVSSKAVSTEMNVAGDSPNVLDSPAYNSQEVTQRATEDQVLCEKCDSLVPVWDMPEHTDYHFALELQKSFLQPCTSKPQAIPAVSPQGKRNPKSPSASSSKRLRPHGMQTLESFFKPLTH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
322AcetylationPKTIGCSKNFPGKTA
CCCCCCCCCCCCCCC
67.682374511
378PhosphorylationFQGDRRLSSLRRCCA
ECCCHHHHHHHHHHH
26.0528725479
379PhosphorylationQGDRRLSSLRRCCAL
CCCHHHHHHHHHHHC
30.4128725479
478PhosphorylationTSKEAATSLASFFQK
CCHHHHHHHHHHHHH
19.7425338131
597PhosphorylationDSPNVLDSPAYNSQE
CCCCCCCCCCCCCHH
13.7925338131
651UbiquitinationFLQPCTSKPQAIPAV
HCCCCCCCCCCCCCC
24.01-
659PhosphorylationPQAIPAVSPQGKRNP
CCCCCCCCCCCCCCC
17.3824453211
668PhosphorylationQGKRNPKSPSASSSK
CCCCCCCCCCCCCCC
25.91-
673PhosphorylationPKSPSASSSKRLRPH
CCCCCCCCCCCCCCC
39.3325266776

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of POLH_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of POLH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of POLH_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
REV1_MOUSERev1physical
22244149
PCNA_MOUSEPcnaphysical
22244149
REV1_MOUSERev1physical
14657033

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of POLH_MOUSE

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Related Literatures of Post-Translational Modification

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