OLIG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OLIG2_MOUSE
• UniProt AC: Q9EQW6
• Protein Name: Oligodendrocyte transcription factor 2
• Gene Name: Olig2
• Organism: Mus musculus (Mouse).
• Sequence Length: 323
• Subcellular Localization: Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
• Protein Description: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development..
• Protein Sequence: MDSDASLVSSRPSSPEPDDLFLPARSKGGSSSGFTGGTVSSSTPSDCPPELSSELRGAMGASGAHPGDKLGGGGFKSSSSSTSSSTSSAATSSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPTATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGTLPRLTSDAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	SDASLVSSRPSSPEP CCHHHCCCCCCCCCC	40.51	21382551
13	Phosphorylation	SLVSSRPSSPEPDDL HHCCCCCCCCCCCCC	58.37	21382551
14	Phosphorylation	LVSSRPSSPEPDDLF HCCCCCCCCCCCCCE	35.65	21382551
43	Phosphorylation	GGTVSSSTPSDCPPE CCCCCCCCCCCCCHH	28.85	21382551
78	Phosphorylation	GGGGFKSSSSSTSSS CCCCCCCCCCCCCCC	34.53	25777480
81	Phosphorylation	GFKSSSSSTSSSTSS CCCCCCCCCCCCCCC	33.97	25777480
82	Phosphorylation	FKSSSSSTSSSTSSA CCCCCCCCCCCCCCC	34.28	22871156
83	Phosphorylation	KSSSSSTSSSTSSAA CCCCCCCCCCCCCCC	25.00	22871156
84	Phosphorylation	SSSSSTSSSTSSAAT CCCCCCCCCCCCCCC	37.41	25777480
88	Phosphorylation	STSSSTSSAATSSTK CCCCCCCCCCCCCCH	23.24	22871156
91	Phosphorylation	SSTSSAATSSTKKDK CCCCCCCCCCCHHHH	23.95	25777480
147	Phosphorylation	GPSVRKLSKIATLLL CHHHHHHHHHHHHHH	25.67	21382552

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
13	S	Phosphorylation	Kinase	CK2B	P67870	PSP
13	S	Phosphorylation	Kinase	CK2B	P67871	PSP
14	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OLIG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OLIG2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OLIG2_MOUSE	Olig2	physical	15655114
NGN2_MOUSE	Neurog2	physical	15655114
TFE2_MOUSE	Tcf3	physical	15655114

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.