TFE2_MOUSE - dbPTM
TFE2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TFE2_MOUSE
UniProt AC P15806
Protein Name Transcription factor E2-alpha
Gene Name Tcf3
Organism Mus musculus (Mouse).
Sequence Length 651
Subcellular Localization Nucleus.
Protein Description Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region..
Protein Sequence MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKSRPASLGGTQFAGSGLEDRPSSGSWGSSDQNSSSFDPSRTYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELSLSSPGPLSPSGIKSSSQYYPSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPPSSGDSYSRDAAAYPSAKTPSSAYPSPFYVADGSLHPSAELWSTPSQVGFGPMLGDGSSPLPLAPGSSSVGSGTFGGLQQQDRMGYQLHGSEVNGSLPAVSSFSAAPGTYSGTSGHTPPVSGAAAESLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASDLHGLLPGHGALTTSFTGPMSLGGRHAGLVGGSHPEEGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSYSGLGRAGTTAGASEIKREEKEDEEIASVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationNGKSRPASLGGTQFA
CCCCCCCHHCCCCCC		30.1725338131
44PhosphorylationRPASLGGTQFAGSGL
CCCHHCCCCCCCCCC		20.79-
57PhosphorylationGLEDRPSSGSWGSSD
CCCCCCCCCCCCCCC		39.2629514104
116PhosphorylationYATFGRDTSVGTLSQ
HCCCCCCCCCCCHHH		24.7725777480
117PhosphorylationATFGRDTSVGTLSQA
CCCCCCCCCCCHHHC		23.8825777480
120PhosphorylationGRDTSVGTLSQAGFL
CCCCCCCCHHHCCCC		22.5325777480
122PhosphorylationDTSVGTLSQAGFLPG
CCCCCCHHHCCCCCC		20.1625777480
132PhosphorylationGFLPGELSLSSPGPL
CCCCCCEECCCCCCC		23.1526643407
134PhosphorylationLPGELSLSSPGPLSP
CCCCEECCCCCCCCC		30.9826745281
135PhosphorylationPGELSLSSPGPLSPS
CCCEECCCCCCCCCC		38.8921149613
140PhosphorylationLSSPGPLSPSGIKSS
CCCCCCCCCCCCCCC		21.8327087446
142PhosphorylationSPGPLSPSGIKSSSQ
CCCCCCCCCCCCCCC		50.1821149613
183PhosphorylationKVPPGLPSSVYPPSS
CCCCCCCCCCCCCCC		37.1622871156
190PhosphorylationSSVYPPSSGDSYSRD
CCCCCCCCCCCCCCC		53.0122871156
193PhosphorylationYPPSSGDSYSRDAAA
CCCCCCCCCCCCCHH		28.6522871156
273PhosphorylationQQQDRMGYQLHGSEV
CCCCCCCEEEECCCC		9.8825777480
278PhosphorylationMGYQLHGSEVNGSLP
CCEEEECCCCCCCCC		27.8525777480
283PhosphorylationHGSEVNGSLPAVSSF
ECCCCCCCCCCEEEE		26.4425777480
288PhosphorylationNGSLPAVSSFSAAPG
CCCCCCEEEEECCCC		27.9825777480
289PhosphorylationGSLPAVSSFSAAPGT
CCCCCEEEEECCCCC		19.3425777480
291PhosphorylationLPAVSSFSAAPGTYS
CCCEEEEECCCCCCC		26.0125777480
296PhosphorylationSFSAAPGTYSGTSGH
EEECCCCCCCCCCCC		17.2925777480
297PhosphorylationFSAAPGTYSGTSGHT
EECCCCCCCCCCCCC		15.8325777480
298PhosphorylationSAAPGTYSGTSGHTP
ECCCCCCCCCCCCCC		35.1225777480
300PhosphorylationAPGTYSGTSGHTPPV
CCCCCCCCCCCCCCC		26.1225777480
301PhosphorylationPGTYSGTSGHTPPVS
CCCCCCCCCCCCCCC		31.9125777480
304PhosphorylationYSGTSGHTPPVSGAA
CCCCCCCCCCCCHHH		32.5825777480
308PhosphorylationSGHTPPVSGAAAESL
CCCCCCCCHHHHHHH		28.6125777480
314PhosphorylationVSGAAAESLLGTRGT
CCHHHHHHHHCCCCC		24.9425777480
318PhosphorylationAAESLLGTRGTTASS
HHHHHHCCCCCCCCC		26.3725777480
325PhosphorylationTRGTTASSSGDALGK
CCCCCCCCHHHHHHH		35.5622802335
326PhosphorylationRGTTASSSGDALGKA
CCCCCCCHHHHHHHH		37.8922802335
336PhosphorylationALGKALASIYSPDHS
HHHHHHHHHCCCCCC		23.9426643407
338PhosphorylationGKALASIYSPDHSSN
HHHHHHHCCCCCCCC		16.2026643407
339PhosphorylationKALASIYSPDHSSNN
HHHHHHCCCCCCCCC		23.3726643407
343PhosphorylationSIYSPDHSSNNFSPS
HHCCCCCCCCCCCCC		41.9926643407
344PhosphorylationIYSPDHSSNNFSPSP
HCCCCCCCCCCCCCC		32.1626643407
348PhosphorylationDHSSNNFSPSPSTPV
CCCCCCCCCCCCCCC		26.9626643407
350PhosphorylationSSNNFSPSPSTPVGS
CCCCCCCCCCCCCCC		30.2226643407
352PhosphorylationNNFSPSPSTPVGSPQ
CCCCCCCCCCCCCCC		50.0826643407
353PhosphorylationNFSPSPSTPVGSPQG
CCCCCCCCCCCCCCC		25.9425266776
357PhosphorylationSPSTPVGSPQGLPGT
CCCCCCCCCCCCCCC		17.8125266776
364PhosphorylationSPQGLPGTSQWPRAG
CCCCCCCCCCCCCCC		18.7922802335
365PhosphorylationPQGLPGTSQWPRAGA
CCCCCCCCCCCCCCC		35.8422802335
369MethylationPGTSQWPRAGAPSAL
CCCCCCCCCCCCCCC		42.5724129315
374PhosphorylationWPRAGAPSALSPNYD
CCCCCCCCCCCCCCC		41.1127600695
377PhosphorylationAGAPSALSPNYDAGL
CCCCCCCCCCCCCCC		15.7126824392
380PhosphorylationPSALSPNYDAGLHGL
CCCCCCCCCCCCCCH		15.5626643407
388PhosphorylationDAGLHGLSKMEDRLD
CCCCCCHHHHHHHHH		34.2526643407
479PhosphorylationLSQRPPDSYSGLGRA
HHHCCCCCCCCCCCC		27.2924759943
480PhosphorylationSQRPPDSYSGLGRAG
HHCCCCCCCCCCCCC		17.7124759943
481PhosphorylationQRPPDSYSGLGRAGT
HCCCCCCCCCCCCCC		31.3424759943
488PhosphorylationSGLGRAGTTAGASEI
CCCCCCCCCCCHHHH		16.7024759943
489PhosphorylationGLGRAGTTAGASEIK
CCCCCCCCCCHHHHH		23.3724759943
493PhosphorylationAGTTAGASEIKREEK
CCCCCCHHHHHHHHH		38.6524759943
507PhosphorylationKEDEEIASVADAEED
HCHHHHHHHCCHHHH		24.4126824392
523 (in isoform 2)Phosphorylation-32.0326239621
525 (in isoform 2)Phosphorylation-43.9625266776
526PhosphorylationKVPRTRTSPDEDEDD
CCCCCCCCCCCCCCC		27.36-
526 (in isoform 2)Phosphorylation-27.3624704852
527 (in isoform 2)Phosphorylation-48.6926824392
528 (in isoform 2)Phosphorylation-75.6127742792
533 (in isoform 2)Phosphorylation-48.3226745281
567AcetylationRDINEAFKELGRMCQ
HHHHHHHHHHHHHHH		60.117713907
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
140SPhosphorylationKinaseMAPK14P47811
GPS
527SPhosphorylationKinaseAKT1P31749
PSP
527SPhosphorylationKinaseAKT1P31750
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TFE2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TFE2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TFE2_MOUSETcf3physical
20211142
ZN292_MOUSEZfp292physical
20211142
PDLI4_MOUSEPdlim4physical
20211142
TRIP4_MOUSETrip4physical
20211142
PAPOB_MOUSEPapolbphysical
20211142
RNF14_MOUSERnf14physical
20211142
ASCL3_MOUSEAscl3physical
20211142
SMCE1_MOUSESmarce1physical
20211142
ZDHC6_MOUSEZdhhc6physical
20211142
RFX4_MOUSERfx4physical
20211142
ERCC8_MOUSEErcc8physical
20211142
RAI14_MOUSERai14physical
20211142
CERS2_MOUSECers2physical
20211142
PBX4_MOUSEPbx4physical
20211142
FOXP1_MOUSEFoxp1physical
20211142
ZDH15_MOUSEZdhhc15physical
20211142
TLE6_MOUSETle6physical
20211142
NS1BP_MOUSEIvns1abpphysical
20211142
MED16_MOUSEMed16physical
20211142
SWAHC_MOUSESowahcphysical
20211142
JADE1_MOUSEJade1physical
20211142
CHIP_MOUSEStub1physical
15456869
BHE41_MOUSEBhlhe41physical
12657651
NUCL_MOUSENclphysical
22354994
RS3_MOUSERps3physical
22354994
RL27A_MOUSERpl27aphysical
22354994
RL4_MOUSERpl4physical
22354994
NPM_MOUSENpm1physical
22354994
RFC3_MOUSERfc3physical
22354994
RSSA_MOUSERpsaphysical
22354994
1433S_MOUSESfnphysical
22354994
1433T_MOUSEYwhaqphysical
22354994
EIF3G_MOUSEEif3gphysical
22354994
IF4A1_MOUSEEif4a1physical
22354994
IF4A2_MOUSEEif4a2physical
22354994
EF1B_MOUSEEef1b2physical
22354994
DNMT1_MOUSEDnmt1physical
22354994
NONO_MOUSENonophysical
22354994
H4_MOUSEHist1h4hphysical
22354994
H2A2B_MOUSEHist2h2abphysical
22354994
H2A3_MOUSEHist3h2aphysical
22354994
RBBP4_MOUSERbbp4physical
22354994
RBBP7_MOUSERbbp7physical
22354994
PSD11_MOUSEPsmd11physical
22354994
PSD13_MOUSEPsmd13physical
22354994
PSMD2_MOUSEPsmd2physical
22354994
PSME3_MOUSEPsme3physical
22354994
UBE2N_MOUSEUbe2nphysical
22354994
UBC9_MOUSEUbe2iphysical
22354994
UBB_MOUSEUbbphysical
22354994
PRP8_MOUSEPrpf8physical
22354994
PRP31_MOUSEPrpf31physical
22354994
SRSF1_MOUSESrsf1physical
22354994
SF3B3_MOUSESf3b3physical
22354994
LSM2_MOUSELsm2physical
22354994
ID3_MOUSEId3physical
22354994
STIP1_MOUSEStip1physical
22354994
PCNA_MOUSEPcnaphysical
22354994
SMCA4_MOUSESmarca4physical
22354994
RL7A_MOUSERpl7aphysical
22354994
PDCD6_MOUSEPdcd6physical
22354994
PAK2_MOUSEPak2physical
22354994
CHD4_MOUSEChd4physical
22354994
SKP1_MOUSESkp1aphysical
22354994
CND1_MOUSENcapd2physical
22354994
PARK7_MOUSEPark7physical
22354994
TCP4_MOUSESub1physical
22354994
ASCL3_MOUSEAscl3physical
11784080
ASCL3_HUMANASCL3physical
11784080
TFE2_MOUSETcf3physical
15351717
ITF2_MOUSETcf4physical
15351717
HTF4_MOUSETcf12physical
15351717
ASCL1_MOUSEAscl1physical
12200424
UBC9_MOUSEUbe2iphysical
12200424
ID2_MOUSEId2physical
12200424
RGPA1_MOUSERalgapa1physical
12200424
NGN2_MOUSENeurog2physical
8948587
ASCL1_MOUSEAscl1physical
8948587
TFE2_MOUSETcf3physical
17339447
TCF15_MOUSETcf15physical
23395635
TWST1_MOUSETwist1physical
23395635
NDF1_MOUSENeurod1physical
23395635
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TFE2_MOUSE

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Related Literatures of Post-Translational Modification

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