TLE6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLE6_MOUSE
• UniProt AC: Q9WVB3
• Protein Name: Transducin-like enhancer protein 6
• Gene Name: Tle6
• Organism: Mus musculus (Mouse).
• Sequence Length: 581
• Subcellular Localization: Cytoplasm. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions.
• Protein Description: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions..
• Protein Sequence: MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
139	Phosphorylation	PTRRRFLSESDELQD CCHHHHCCCCCCCCC	32.13	-
187	Phosphorylation	EHGGEDSSQESKDSG HHCCCCCCHHHCCCC	50.73	-
209	Phosphorylation	PQPRHRNSLSDSADP CCCCCCCCCCCCCCC	29.25	26824392
211	Phosphorylation	PRHRNSLSDSADPFL CCCCCCCCCCCCCCC	29.37	26824392
213	Phosphorylation	HRNSLSDSADPFLIK CCCCCCCCCCCCCCC	31.06	28066266
223	Phosphorylation	PFLIKSPSALLDYYQ CCCCCCHHHHHHHHH	38.34	25338131
519	Phosphorylation	TILGLKFSPNGKWWA EEEEEEECCCCCEEE	18.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLE6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLE6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLE6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN473_MOUSE	Zfp473	physical	20211142
EP300_MOUSE	Ep300	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.