ZN473_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN473_MOUSE
• UniProt AC: Q8BI67
• Protein Name: Zinc finger protein 473 homolog
• Gene Name: Znf473
• Organism: Mus musculus (Mouse).
• Sequence Length: 892
• Subcellular Localization: Nucleus. Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA (By similarity)..
• Protein Description: Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (By similarity)..
• Protein Sequence: MERKEDDLKGGCWNQPAVAEEFETLKDLAMDFTVEDWKDLESEWDQRDLFWDVTLNHYQDMFSFTDTSQPSLTSQPDVREELEATSTEVPETKSSPLQSGFVEEDFSQIMEIFSNGQLNFEACIGEDWLNSFLGDPESLPRPDISDKESPADHQSPESKSGLSPGPPLCTREDAVMSASPEKTLTPVILKESRSDLSQEDSVQGHEKPYKCSECGESFSQSHHLIQHWVLHTSGEPPIWREQQRGLSQGAHFPMCPGTPASYESYTCQECGKRFSQNVYLQWHQKIHTGEKLCKTQSDSNLEGLSRSPSVEPGKQRLSKDTDSAKPSTIHGQDQEKPPTGESRDQENLHESQPGDRPSVLHPKPLRHQKTPTNAKCFRCKKCGETFSGAFHLAKHQRAHAQRLYKCASCPAVFNLSKHCFQHRKSHFPSAACECQGCRKSFNWRSSLIKHQAIHKGEKPYKCDECGKAFNHSSTLKIHQRIHSGQKPHKCSECGKAFCRRTDLTEHQRVHSGFRPHQCPVCARTFNRPSHLVRHRLRHAEERHFGCAKCKETFIYKEQLERHNKIHTIEGLYECKQCGEHFICRSTLNCHLSIHIRENTSEKVVGQNSQHTEKCFKNTKCRKAPNHSRYLGQHEKIHAQVTSGECDPCGETYDQSVQPICHQSICAGVKPSECAEPEKCTRNTSASEHHPSQREPSFKCDIYNRAFKQRAHLSKHQLIHITEKPFKCNECDRAFKQSNYLIQHQKTHTAEKHFECSECGKTFHQRSCLSKHQKIHSGEKPFKCGDCGKAFISGAQLIRHQRIHTGEKPYVCQECGKTFSQSSCLTLHLRIHTGEKPYTCGTCGKAFAQRANQRKHERIHTGEKPYACGLCGKAFGLRTHLQQHQRIHTKAKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
183	Phosphorylation	MSASPEKTLTPVILK CCCCCCCCCCCEEEH	33.91	21454597
185	Phosphorylation	ASPEKTLTPVILKES CCCCCCCCCEEEHHC	22.27	21454597
192	Phosphorylation	TPVILKESRSDLSQE CCEEEHHCCCCCCCC	35.18	21454597
307	Phosphorylation	NLEGLSRSPSVEPGK CCCCCCCCCCCCCCC	20.39	30482847
309	Phosphorylation	EGLSRSPSVEPGKQR CCCCCCCCCCCCCCC	40.12	30482847
776	Phosphorylation	SKHQKIHSGEKPFKC HHCCHHHCCCCCCCC	52.71	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN473_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN473_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN473_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN473_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.