ITF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITF2_MOUSE
• UniProt AC: Q60722
• Protein Name: Transcription factor 4
• Gene Name: Tcf4
• Organism: Mus musculus (Mouse).
• Sequence Length: 670
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Isoform 2 inhibits MYOD1 activation of the cardiac alpha-actin promoter. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. May have a regulatory function in developmental processes as well as during neuronal plasticity..
• Protein Sequence: MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGTGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNARRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPAASTFPSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIMGPSHNGAMGSLGSGYGTSLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDAANHMGQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	LGTDKELSDLLDFSA HCCCHHHHHHHCHHH	27.57	21183079
23	Phosphorylation	LSDLLDFSAMFSPPV HHHHHCHHHHCCCCC	20.63	21183079
28 (in isoform 2)	Phosphorylation	-	23.26	28066266
30 (in isoform 2)	Phosphorylation	-	8.92	28066266
31	Phosphorylation	AMFSPPVSSGKNGPT HHCCCCCCCCCCCCC	38.86	21183079
31 (in isoform 2)	Phosphorylation	-	38.86	28066266
34 (in isoform 2)	Phosphorylation	-	61.76	28066266
38 (in isoform 2)	Phosphorylation	-	37.46	28066266
41 (in isoform 2)	Phosphorylation	-	17.15	28066266
43 (in isoform 2)	Phosphorylation	-	17.83	28066266
44 (in isoform 2)	Phosphorylation	-	18.01	28066266
54	Phosphorylation	GSNVEDRSSSGSWGT CCCCCCCCCCCCCCC	40.97	28066266
55	Phosphorylation	SNVEDRSSSGSWGTG CCCCCCCCCCCCCCC	39.34	28066266
56	Phosphorylation	NVEDRSSSGSWGTGG CCCCCCCCCCCCCCC	37.79	28066266
58	Phosphorylation	EDRSSSGSWGTGGHP CCCCCCCCCCCCCCC	25.04	28066266
61	Phosphorylation	SSSGSWGTGGHPSPS CCCCCCCCCCCCCCC	33.46	29472430
66	Phosphorylation	WGTGGHPSPSRNYGD CCCCCCCCCCCCCCC	29.81	23684622
68	Phosphorylation	TGGHPSPSRNYGDGT CCCCCCCCCCCCCCC	37.18	24899341
71	Phosphorylation	HPSPSRNYGDGTPYD CCCCCCCCCCCCCCC	18.58	-
87	Phosphorylation	MTSRDLGSHDNLSPP CCHHCCCCCCCCCCC	34.66	25168779
92	Phosphorylation	LGSHDNLSPPFVNSR CCCCCCCCCCCCCHH	36.46	25521595
98	Phosphorylation	LSPPFVNSRIQSKTE CCCCCCCHHHCCCCC	26.01	25777480
124	Phosphorylation	VQGCHQQSLLGGDMD CCCHHHCHHCCCCCC	20.99	23984901
137	Phosphorylation	MDMGNPGTLSPTKPG CCCCCCCCCCCCCCC	25.89	23984901
139	Phosphorylation	MGNPGTLSPTKPGSQ CCCCCCCCCCCCCCC	30.29	24759943
141	Phosphorylation	NPGTLSPTKPGSQYY CCCCCCCCCCCCCCE	46.63	23984901
145	Phosphorylation	LSPTKPGSQYYQYSS CCCCCCCCCCEECCC	24.44	23984901
147	Phosphorylation	PTKPGSQYYQYSSNN CCCCCCCCEECCCCC	8.34	23984901
148	Phosphorylation	TKPGSQYYQYSSNNA CCCCCCCEECCCCCC	8.04	23984901
150	Phosphorylation	PGSQYYQYSSNNARR CCCCCEECCCCCCCC	9.65	24759943
151	Phosphorylation	GSQYYQYSSNNARRR CCCCEECCCCCCCCC	15.86	24759943
184	Phosphorylation	PGLPSSVYAPSASTA CCCCCCEECCCCCCC	18.10	26643407
187	Phosphorylation	PSSVYAPSASTADYN CCCEECCCCCCCCCC	27.04	26643407
189	Phosphorylation	SVYAPSASTADYNRD CEECCCCCCCCCCCC	28.59	26643407
190	Phosphorylation	VYAPSASTADYNRDS EECCCCCCCCCCCCC	24.22	26643407
193	Phosphorylation	PSASTADYNRDSPGY CCCCCCCCCCCCCCC	15.05	26643407
197	Phosphorylation	TADYNRDSPGYPSSK CCCCCCCCCCCCCCC	19.58	26643407
200	Phosphorylation	YNRDSPGYPSSKPAA CCCCCCCCCCCCCCH	11.88	26643407
202	Phosphorylation	RDSPGYPSSKPAAST CCCCCCCCCCCCHHC	42.37	26643407
203	Phosphorylation	DSPGYPSSKPAASTF CCCCCCCCCCCHHCC	37.85	26643407
294	Phosphorylation	TNHYSTSSCTPPANG CCCCCCCCCCCCCCC	23.30	29899451
296	Phosphorylation	HYSTSSCTPPANGTD CCCCCCCCCCCCCCC	33.97	29514104
316	Phosphorylation	RGTGAAGSSQTGDAL CCCCCCCCCHHHHHH	17.97	28066266
317	Phosphorylation	GTGAAGSSQTGDALG CCCCCCCCHHHHHHH	30.73	28066266
319	Phosphorylation	GAAGSSQTGDALGKA CCCCCCHHHHHHHHH	38.69	28066266
332	Phosphorylation	KALASIYSPDHTNNS HHHHHHCCCCCCCCC	23.37	25338131
336	Phosphorylation	SIYSPDHTNNSFSSN HHCCCCCCCCCCCCC	43.40	25338131
339	Phosphorylation	SPDHTNNSFSSNPST CCCCCCCCCCCCCCC	28.68	26643407
341	Phosphorylation	DHTNNSFSSNPSTPV CCCCCCCCCCCCCCC	29.09	26643407
342	Phosphorylation	HTNNSFSSNPSTPVG CCCCCCCCCCCCCCC	51.23	26643407
345	Phosphorylation	NSFSSNPSTPVGSPP CCCCCCCCCCCCCCC	49.98	26643407
346	Phosphorylation	SFSSNPSTPVGSPPS CCCCCCCCCCCCCCC	24.21	26643407
350	Phosphorylation	NPSTPVGSPPSLSAG CCCCCCCCCCCCCCC	33.59	26643407
353	Phosphorylation	TPVGSPPSLSAGTAV CCCCCCCCCCCCCEE	38.04	26643407
355	Phosphorylation	VGSPPSLSAGTAVWS CCCCCCCCCCCEEEE	29.05	26643407
358	Phosphorylation	PPSLSAGTAVWSRNG CCCCCCCCEEEECCC	20.11	26643407
362	Phosphorylation	SAGTAVWSRNGGQAS CCCCEEEECCCCCCC	14.85	26643407
369	Phosphorylation	SRNGGQASSSPNYEG ECCCCCCCCCCCCCC	24.38	30372032
370	Phosphorylation	RNGGQASSSPNYEGP CCCCCCCCCCCCCCC	53.48	29899451
371	Phosphorylation	NGGQASSSPNYEGPL CCCCCCCCCCCCCCH	18.05	27742792
374	Phosphorylation	QASSSPNYEGPLHSL CCCCCCCCCCCHHHH	26.16	23984901
380	Phosphorylation	NYEGPLHSLQSRIED CCCCCHHHHHHHHHH	35.47	26160508
383	Phosphorylation	GPLHSLQSRIEDRLE CCHHHHHHHHHHHHH	40.28	26160508
463	Phosphorylation	DGVALRGSHSLLPNQ CCEEECCCCCCCCCC	11.94	26160508
465	Phosphorylation	VALRGSHSLLPNQVP EEECCCCCCCCCCCC	33.04	26160508
480	Phosphorylation	VPQLPVQSATSPDLN CCCCCCCCCCCCCCC	33.47	24925903
482	Phosphorylation	QLPVQSATSPDLNPP CCCCCCCCCCCCCCC	46.14	24925903
483	Phosphorylation	LPVQSATSPDLNPPQ CCCCCCCCCCCCCCC	19.01	24925903
493	Phosphorylation	LNPPQDPYRGMPPGL CCCCCCCCCCCCCCC	28.26	23984901
504	Phosphorylation	PPGLQGQSVSSGSSE CCCCCCCCCCCCCCC	30.69	25619855
506	Phosphorylation	GLQGQSVSSGSSEIK CCCCCCCCCCCCCCC	33.94	25619855
507	Phosphorylation	LQGQSVSSGSSEIKS CCCCCCCCCCCCCCC	40.30	25619855
509	Phosphorylation	GQSVSSGSSEIKSDD CCCCCCCCCCCCCCC	27.09	25619855
510	Phosphorylation	QSVSSGSSEIKSDDE CCCCCCCCCCCCCCC	47.03	25619855
514	Phosphorylation	SGSSEIKSDDEGDEN CCCCCCCCCCCCCCC	56.83	25521595
525	Phosphorylation	GDENLQDTKSSEDKK CCCCCCCCCCCCCCC	21.62	25619855
544 (in isoform 3)	Phosphorylation	-	29.68	29899451
545 (in isoform 3)	Phosphorylation	-	28.53	25521595
546	Phosphorylation	DIKSITRSRSSNNDD HHHHHHHHCCCCCCC	28.06	29899451
548	Phosphorylation	KSITRSRSSNNDDED HHHHHHCCCCCCCCC	38.37	29899451
549	Phosphorylation	SITRSRSSNNDDEDL HHHHHCCCCCCCCCC	38.24	25521595
557	Phosphorylation	NNDDEDLTPEQKAER CCCCCCCCHHHHHHH	36.78	29899451
588	Acetylation	RDINEAFKELGRMVQ HHHHHHHHHHHHHHH	60.11	7714051

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITF2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASCL3_MOUSE	Ascl3	physical	11784080
ASCL3_HUMAN	ASCL3	physical	11784080
TFE2_MOUSE	Tcf3	physical	15351717
ITF2_MOUSE	Tcf4	physical	15351717
HTF4_MOUSE	Tcf12	physical	15351717
MYF5_MOUSE	Myf5	physical	14762206

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.