HTF4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HTF4_MOUSE
• UniProt AC: Q61286
• Protein Name: Transcription factor 12
• Gene Name: Tcf12
• Organism: Mus musculus (Mouse).
• Sequence Length: 706
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3')..
• Protein Sequence: MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLYSRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDSVALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSSSNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNASIGNLNSNYGGSSLVTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPENFRGGVQNQSGSVVPTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAASAEPPNTLPGAHPGLSESTNPMGHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	LSDLLDFSAMFSPPV HHHHHCHHHHCCCCC	20.63	27600695
28	Phosphorylation	LDFSAMFSPPVNSGK HCHHHHCCCCCCCCC	18.40	27600695
47	Phosphorylation	TLGSSQFSGSGMDER CCCCCCCCCCCCCCC	25.14	25338131
57	Phosphorylation	GMDERGGTTSWGTSG CCCCCCCCCCCCCCC	22.08	25619855
58	Phosphorylation	MDERGGTTSWGTSGQ CCCCCCCCCCCCCCC	26.25	25619855
59	Phosphorylation	DERGGTTSWGTSGQP CCCCCCCCCCCCCCC	24.28	25619855
62	Phosphorylation	GGTTSWGTSGQPSPS CCCCCCCCCCCCCCC	24.35	25619855
63	Phosphorylation	GTTSWGTSGQPSPSY CCCCCCCCCCCCCCC	31.34	28066266
67	Phosphorylation	WGTSGQPSPSYDSSR CCCCCCCCCCCCCCC	20.70	25521595
69	Phosphorylation	TSGQPSPSYDSSRGF CCCCCCCCCCCCCCC	46.00	28066266
70	Phosphorylation	SGQPSPSYDSSRGFT CCCCCCCCCCCCCCC	24.19	25619855
77	Phosphorylation	YDSSRGFTDSPHYSD CCCCCCCCCCCCCHH	38.09	27600695
79	Phosphorylation	SSRGFTDSPHYSDHL CCCCCCCCCCCHHCC	15.54	27742792
82	Phosphorylation	GFTDSPHYSDHLNDS CCCCCCCCHHCCCCC	21.12	26643407
83	Phosphorylation	FTDSPHYSDHLNDSR CCCCCCCHHCCCCCC	18.60	27742792
89	Phosphorylation	YSDHLNDSRLGTHEG CHHCCCCCCCCCCCC	28.47	28066266
93	Phosphorylation	LNDSRLGTHEGLSPT CCCCCCCCCCCCCCC	22.73	25266776
98	Phosphorylation	LGTHEGLSPTPFMNS CCCCCCCCCCCCCCC	37.27	25521595
100	Phosphorylation	THEGLSPTPFMNSNL CCCCCCCCCCCCCCC	26.28	26643407
116	Phosphorylation	GKTSERGSFSLYSRD CCCCCCCCEEEEECC	20.20	28066266
121	Phosphorylation	RGSFSLYSRDSGLSG CCCEEEEECCCCCCH	34.60	27600695
124	Phosphorylation	FSLYSRDSGLSGCQS EEEEECCCCCCHHHH	40.29	22817900
142	Phosphorylation	RQDLGLGSPAQLSSS HHHCCCCCHHHHHCC	23.31	27600695
147	Phosphorylation	LGSPAQLSSSGKPGT CCCHHHHHCCCCCCC	15.46	28066266
148	Phosphorylation	GSPAQLSSSGKPGTP CCHHHHHCCCCCCCC	52.26	28066266
149	Phosphorylation	SPAQLSSSGKPGTPY CHHHHHCCCCCCCCC	47.67	28066266
198	Phosphorylation	PSSVYAPSPNSDDFN CCCCCCCCCCCCCCC	28.65	22817900
264	Phosphorylation	TSHMSQSSSYGSLHS CCCCCCCCCCCCCCC	21.68	-
276	Phosphorylation	LHSHDRLSYPPHSVS CCCCCCCCCCCCCCC	36.17	26160508
277	Phosphorylation	HSHDRLSYPPHSVSP CCCCCCCCCCCCCCC	25.94	26160508
281	Phosphorylation	RLSYPPHSVSPTDIN CCCCCCCCCCCCCCC	30.02	26160508
283	Phosphorylation	SYPPHSVSPTDINTS CCCCCCCCCCCCCCC	25.71	26160508
285	Phosphorylation	PPHSVSPTDINTSLP CCCCCCCCCCCCCCC	41.84	26160508
289	Phosphorylation	VSPTDINTSLPPMSS CCCCCCCCCCCCCCC	31.79	26160508
290	Phosphorylation	SPTDINTSLPPMSSF CCCCCCCCCCCCCCC	34.10	26160508
295	Phosphorylation	NTSLPPMSSFHRGST CCCCCCCCCCCCCCC	35.31	25777480
296	Phosphorylation	TSLPPMSSFHRGSTS CCCCCCCCCCCCCCC	20.86	25777480
301	Phosphorylation	MSSFHRGSTSSSPYV CCCCCCCCCCCCCCE	25.69	21082442
302	Phosphorylation	SSFHRGSTSSSPYVA CCCCCCCCCCCCCEE	35.14	27600695
303	Phosphorylation	SFHRGSTSSSPYVAA CCCCCCCCCCCCEEC	30.43	21183079
304	Phosphorylation	FHRGSTSSSPYVAAS CCCCCCCCCCCEECC	35.11	21082442
305	Phosphorylation	HRGSTSSSPYVAASH CCCCCCCCCCEECCC	21.73	19060867
307	Phosphorylation	GSTSSSPYVAASHTP CCCCCCCCEECCCCC	12.50	26643407
311	Phosphorylation	SSPYVAASHTPPING CCCCEECCCCCCCCC	20.39	23527152
313	Phosphorylation	PYVAASHTPPINGSD CCEECCCCCCCCCCC	28.41	27180971
319	Phosphorylation	HTPPINGSDSILGTR CCCCCCCCCCCCCCC	24.56	26643407
332	Phosphorylation	TRGNAAGSSQTGDAL CCCCCCCCCHHHHHH	17.97	28285833
333	Phosphorylation	RGNAAGSSQTGDALG CCCCCCCCHHHHHHH	30.73	27149854
345	Phosphorylation	ALGKALASIYSPDHT HHHHHHHHHCCCCCC	23.94	26643407
347	Phosphorylation	GKALASIYSPDHTSS HHHHHHHCCCCCCCC	16.20	26643407
348	Phosphorylation	KALASIYSPDHTSSS HHHHHHCCCCCCCCC	23.37	26643407
352	Phosphorylation	SIYSPDHTSSSFPSN HHCCCCCCCCCCCCC	37.37	26643407
353	Phosphorylation	IYSPDHTSSSFPSNP HCCCCCCCCCCCCCC	22.14	26643407
354	Phosphorylation	YSPDHTSSSFPSNPS CCCCCCCCCCCCCCC	36.83	26643407
355	Phosphorylation	SPDHTSSSFPSNPST CCCCCCCCCCCCCCC	40.73	26643407
358	Phosphorylation	HTSSSFPSNPSTPVG CCCCCCCCCCCCCCC	60.40	30482847
361	Phosphorylation	SSFPSNPSTPVGSPS CCCCCCCCCCCCCCC	49.98	25338131
362	Phosphorylation	SFPSNPSTPVGSPSP CCCCCCCCCCCCCCC	24.21	25338131
366	Phosphorylation	NPSTPVGSPSPLTGT CCCCCCCCCCCCCCC	23.57	26643407
368	Phosphorylation	STPVGSPSPLTGTSQ CCCCCCCCCCCCCCC	33.95	26643407
371	Phosphorylation	VGSPSPLTGTSQWPR CCCCCCCCCCCCCCC	41.62	26643407
373	Phosphorylation	SPSPLTGTSQWPRAG CCCCCCCCCCCCCCC	16.71	26643407
374	Phosphorylation	PSPLTGTSQWPRAGG CCCCCCCCCCCCCCC	31.43	26643407
385	Phosphorylation	RAGGQAPSSPSYENS CCCCCCCCCCCHHHH	58.87	25619855
385 (in isoform 2)	Phosphorylation	-	58.87	22942356
386 (in isoform 2)	Phosphorylation	-	19.46	26824392
386	Phosphorylation	AGGQAPSSPSYENSL CCCCCCCCCCHHHHH	19.46	26824392
388	Phosphorylation	GQAPSSPSYENSLHS CCCCCCCCHHHHHHH	47.21	25619855
388 (in isoform 2)	Phosphorylation	-	47.21	22942356
389	Phosphorylation	QAPSSPSYENSLHSL CCCCCCCHHHHHHHH	23.63	25619855
389 (in isoform 2)	Phosphorylation	-	23.63	25266776
392	Phosphorylation	SSPSYENSLHSLKNR CCCCHHHHHHHHHHH	18.60	25619855
392 (in isoform 2)	Phosphorylation	-	18.60	29233185
395	Phosphorylation	SYENSLHSLKNRVEQ CHHHHHHHHHHHHHH	46.46	25619855
395 (in isoform 2)	Phosphorylation	-	46.46	25367039
398 (in isoform 2)	Phosphorylation	-	59.53	25777480
543	Acetylation	SVVPTEIKTENKEKD CCCCCEEECCCHHHC	43.48	-
558	Phosphorylation	ENLHEPPSSDDMKSD CCCCCCCCCHHCCCC	58.05	27717184
559	Phosphorylation	NLHEPPSSDDMKSDD CCCCCCCCHHCCCCC	43.32	27717184
564	Phosphorylation	PSSDDMKSDDESSQK CCCHHCCCCCHHHHH	43.59	26643407
568	Phosphorylation	DMKSDDESSQKDIKV HCCCCCHHHHHCEEE	45.09	26643407
569	Phosphorylation	MKSDDESSQKDIKVS CCCCCHHHHHCEEEE	38.92	26643407
576	Phosphorylation	SQKDIKVSSRGRTSS HHHCEEEECCCCCCC	14.87	29550500
577	Phosphorylation	QKDIKVSSRGRTSST HHCEEEECCCCCCCC	41.56	29550500
581	Phosphorylation	KVSSRGRTSSTNEDE EEECCCCCCCCCCCC	29.83	27087446
582	Phosphorylation	VSSRGRTSSTNEDED EECCCCCCCCCCCCC	33.53	25521595
583	Phosphorylation	SSRGRTSSTNEDEDL ECCCCCCCCCCCCCC	34.34	27087446
584	Phosphorylation	SRGRTSSTNEDEDLN CCCCCCCCCCCCCCC	42.25	27087446
622	Acetylation	RDINEAFKELGRMCQ HHHHHHHHHHHHHHH	60.11	7714061

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HTF4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HTF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HTF4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EP300_MOUSE	Ep300	physical	15189737
CHD4_MOUSE	Chd4	physical	15189737
ASCL3_MOUSE	Ascl3	physical	11784080
ASCL3_HUMAN	ASCL3	physical	11784080
TFE2_MOUSE	Tcf3	physical	15351717
ITF2_MOUSE	Tcf4	physical	15351717
HTF4_MOUSE	Tcf12	physical	15351717

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.