dbPTM

CHD4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHD4_MOUSE
UniProt AC	Q6PDQ2
Protein Name	Chromodomain-helicase-DNA-binding protein 4
Gene Name	Chd4
Organism	Mus musculus (Mouse).
Sequence Length	1915
Subcellular Localization	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associates with centrosomes in interphase..
Protein Description	Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones..
Protein Sequence	MASGLGSPSPCSAGSEEEDMDALLNNSLPPPHPENEEDPDEDLSEAETPKLKKKKKPKKPRDPKIPKSKRQKKELGDSSGEGPEFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDEDDDSKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIAVSKMMMVLGAKWREFSTNNPFKGSSGASVAAAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKPKPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKKLRTAKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDPEEEDDHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIWKWGQPPSPTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRILNHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELMRGEEGRPGKKLKKVKLRKLERPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLLLQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGMNEYLSSFKVAQYVVREEEMGEEEEVEREIIKQEESVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDGSQEDRDWQDDQSDNQSDYSVASEEGDEDFDERSEAPRRPSRKGLRNDKDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRYGMPPQDAFTTQWLVRDLRGKSEKEFKAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLIRKKVQEFEHVNGRWSMPELAEVEENKKMSQPGSPSPKTPTPSTPGDTQPNTPAPVPPAEDGIKIEENSLKEEESTEGEKEVKSTAPEATVECAQPPAPAPATAPATATAPEDDKAPAEPPEGEEKVEKAEVKERTEEPMETEAKGTTEVEKVEEKSAVDLTPIVVEDKEEKKEEEEKKDVMLQNGETPKDLSDEKQKKNSKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWHRRHDYWLLAGIINHGYARWQDIQNDPRYAILNEPFKGEMNRGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNMSEDPSHPSMALNTRFAEVECLAESHQHLSKESMAGNKPANAVLHKVLKQLEELLSDMKADVTRLPATIARIPPVAVRLQMSERNILSRLANRAPEPPPQQVAQQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MASGLGSPSPCSAG -CCCCCCCCCCCCCC	27.52	25338131
12	Phosphorylation	LGSPSPCSAGSEEED CCCCCCCCCCCCHHH	38.76	25338131
15	Phosphorylation	PSPCSAGSEEEDMDA CCCCCCCCCHHHHHH	41.36	25338131
44	Phosphorylation	EDPDEDLSEAETPKL CCCCCCCHHCCCHHH	47.27	19367708
48	Phosphorylation	EDLSEAETPKLKKKK CCCHHCCCHHHCCCC	32.54	25338131
78	Phosphorylation	QKKELGDSSGEGPEF HHHHHCCCCCCCCHH	38.14	21183079
79	Phosphorylation	KKELGDSSGEGPEFV HHHHCCCCCCCCHHC	45.67	29899451
96	Phosphorylation	EEEVALRSDSEGSDY HHHHHHCCCCCCCCC	46.46	21082442
98	Phosphorylation	EVALRSDSEGSDYTP HHHHCCCCCCCCCCC	45.14	27087446
101	Phosphorylation	LRSDSEGSDYTPGKK HCCCCCCCCCCCCCH	24.32	27087446
103	Phosphorylation	SDSEGSDYTPGKKKK CCCCCCCCCCCCHHC	19.28	27087446
104	Phosphorylation	DSEGSDYTPGKKKKK CCCCCCCCCCCHHCC	30.47	21743459
138	Phosphorylation	EEDEDDDSKEPKSSA HCCCCCCCCCCCHHH	46.01	27841257
167	Phosphorylation	FSEEDYRTLTNYKAF CCHHHHHHHHCHHHH	31.53	18779572
169	Phosphorylation	EEDYRTLTNYKAFSQ HHHHHHHHCHHHHHH	35.57	18779572
214	Phosphorylation	TNNPFKGSSGASVAA CCCCCCCCHHHHHHH	26.62	25367039
215	Phosphorylation	NNPFKGSSGASVAAA CCCCCCCHHHHHHHH	47.23	25367039
218	Phosphorylation	FKGSSGASVAAAAAA CCCCHHHHHHHHHHH	18.80	25367039
232	Phosphorylation	AAVAVVESMVTATEV HHHHHHHHHHHCCCC	13.62	25367039
235	Phosphorylation	AVVESMVTATEVAPP HHHHHHHHCCCCCCC	21.15	25367039
237	Phosphorylation	VESMVTATEVAPPPP HHHHHHCCCCCCCCC	22.94	25367039
270	Phosphorylation	ARRKPKGSPRVPDAK CCCCCCCCCCCCCCC	18.69	25266776
296	Phosphorylation	IKLGGFGSKRKRSSS EECCCCCCCCCCCCC	27.33	24704852
297	Acetylation	KLGGFGSKRKRSSSE ECCCCCCCCCCCCCC	63.42	130025
301	Phosphorylation	FGSKRKRSSSEDDDL CCCCCCCCCCCCCCC	41.05	21082442
302	Phosphorylation	GSKRKRSSSEDDDLD CCCCCCCCCCCCCCC	41.60	21082442
303	Phosphorylation	SKRKRSSSEDDDLDV CCCCCCCCCCCCCCC	46.41	27087446
312	Phosphorylation	DDDLDVESDFDDASI CCCCCCCCCCCCCCC	43.35	25521595
318	Phosphorylation	ESDFDDASINSYSVS CCCCCCCCCEEEECC	29.33	21149613
321	Phosphorylation	FDDASINSYSVSDGS CCCCCCEEEECCCCC	19.67	21149613
322	Phosphorylation	DDASINSYSVSDGST CCCCCEEEECCCCCC	14.49	21149613
323	Phosphorylation	DASINSYSVSDGSTS CCCCEEEECCCCCCC	18.24	21149613
325	Phosphorylation	SINSYSVSDGSTSRS CCEEEECCCCCCCCC	30.25	21149613
328	Phosphorylation	SYSVSDGSTSRSSRS EEECCCCCCCCCHHH	28.35	21149613
329	Phosphorylation	YSVSDGSTSRSSRSR EECCCCCCCCCHHHH	33.42	21149613
330	Phosphorylation	SVSDGSTSRSSRSRK ECCCCCCCCCHHHHH	31.68	21149613
332	Phosphorylation	SDGSTSRSSRSRKKL CCCCCCCCHHHHHHH	29.85	20531401
333	Phosphorylation	DGSTSRSSRSRKKLR CCCCCCCHHHHHHHH	32.91	19854140
335	Phosphorylation	STSRSSRSRKKLRTA CCCCCHHHHHHHHHH	50.85	20531401
353	Phosphorylation	KKGEEEVTAVDGYET CCCCCCCEEECCCCC	25.01	30635358
358	Phosphorylation	EVTAVDGYETDHQDY CCEEECCCCCCCHHH	15.93	30635358
360	Phosphorylation	TAVDGYETDHQDYCE EEECCCCCCCHHHHH	30.23	23649490
365	Phosphorylation	YETDHQDYCEVCQQG CCCCCHHHHHHHHCC	5.50	30635358
396	Acetylation	CLDPDMEKAPEGKWS EECCCHHHCCCCCCC	63.70	22826441
421	Phosphorylation	WEAKEDNSEGEEILE EEEECCCCCHHHHHH	60.34	24925903
497	Acetylation	ALKGKVQKILIWKWG HHCCCEEEEEEEECC	42.33	22826441
508	Phosphorylation	WKWGQPPSPTPVPRP EECCCCCCCCCCCCC	48.35	26824392
510	Phosphorylation	WGQPPSPTPVPRPPD CCCCCCCCCCCCCCC	41.05	23684622
522	Phosphorylation	PPDADPNTPSPKPLE CCCCCCCCCCCCCCC	30.45	23375375
524	Phosphorylation	DADPNTPSPKPLEGR CCCCCCCCCCCCCCC	43.44	28542873
624	Phosphorylation	IHRILNHSVDKKGHV HHHHHCCCCCCCCCE	30.82	25338131
627	Acetylation	ILNHSVDKKGHVHYL HHCCCCCCCCCEEEE	59.50	23806337
689	Acetylation	LKKVKLRKLERPPET CCCCEEECCCCCCCC	66.20	23806337
696	Phosphorylation	KLERPPETPTVDPTV CCCCCCCCCCCCCCC	29.99	25159016
698	Phosphorylation	ERPPETPTVDPTVKY CCCCCCCCCCCCCCC	44.98	25159016
733	Phosphorylation	GLNWLRFSWAQGTDT CCCCEEEEECCCCCC	18.31	-
738	Phosphorylation	RFSWAQGTDTILADE EEEECCCCCCEEECC	20.21	-
754	Phosphorylation	GLGKTVQTAVFLYSL CCCHHHHHHHHHHHH	22.06	22802335
759	Phosphorylation	VQTAVFLYSLYKEGH HHHHHHHHHHHHCCC	5.79	22802335
760	Phosphorylation	QTAVFLYSLYKEGHS HHHHHHHHHHHCCCC	27.63	22802335
762	Phosphorylation	AVFLYSLYKEGHSKG HHHHHHHHHCCCCCC	10.89	22802335
815	Phosphorylation	IIRENEFSFEDNAIR EEECCCCCCCHHCCC	22.88	-
826	Acetylation	NAIRGGKKASRMKKE HCCCCCHHHHHCCHH	55.67	19851005
972	Phosphorylation	LIVRVELSPMQKKYY EEEEEEECHHHHHHH	12.57	-
978	Phosphorylation	LSPMQKKYYKYILTR ECHHHHHHHHHHHHC	16.54	-
984	Phosphorylation	KYYKYILTRNFEALN HHHHHHHHCCHHHHH	17.63	-
1009	Acetylation	LNVVMDLKKCCNHPY HHHHHHHHHHCCCCC	39.23	70803
1044	Acetylation	ALIRASGKLLLLQKM HHHHHHHHHHHHHHH	33.20	22826441
1050	Acetylation	GKLLLLQKMLKNLKE HHHHHHHHHHHCHHH	46.28	22826441
1050	Ubiquitination	GKLLLLQKMLKNLKE HHHHHHHHHHHCHHH	46.28	-
1066	Phosphorylation	GHRVLIFSQMTKMLD CEEEEEEHHHHHHHH	16.43	-
1085	Ubiquitination	FLEHEGYKYERIDGG HHHHCCCCEEEECCC	52.04	-
1202	Phosphorylation	GLGSKTGSMSKQELD CCCCCCCCCCHHHHH	25.72	25266776
1204	Phosphorylation	GSKTGSMSKQELDDI CCCCCCCCHHHHHHH	32.65	27600695
1225	Phosphorylation	ELFKDEATDGGGDNK HHHCCCCCCCCCCCC	32.88	26525534
1238	Phosphorylation	NKEGEDSSVIHYDDK CCCCCCCCCEEECHH	37.10	27600695
1301	Phosphorylation	EIIKQEESVDPDYWE HHHHCHHCCCHHHHH	30.94	25521595
1342	Phosphorylation	QVNYNDGSQEDRDWQ HCCCCCCCCCCCCCC	33.01	25521595
1353	Phosphorylation	RDWQDDQSDNQSDYS CCCCCCCCCCCCCCC	45.59	25195567
1357	Phosphorylation	DDQSDNQSDYSVASE CCCCCCCCCCCHHCC	44.78	25338131
1360	Phosphorylation	SDNQSDYSVASEEGD CCCCCCCCHHCCCCC	19.05	25338131
1363	Phosphorylation	QSDYSVASEEGDEDF CCCCCHHCCCCCCCH	33.74	25195567
1389	Acetylation	RKGLRNDKDKPLPPL CCCCCCCCCCCCCHH	71.80	23806337
1524	Phosphorylation	VEENKKMSQPGSPSP HHHHHCCCCCCCCCC	41.94	27087446
1528	Phosphorylation	KKMSQPGSPSPKTPT HCCCCCCCCCCCCCC	28.96	27087446
1530	Phosphorylation	MSQPGSPSPKTPTPS CCCCCCCCCCCCCCC	40.50	25521595
1533	Phosphorylation	PGSPSPKTPTPSTPG CCCCCCCCCCCCCCC	35.46	25521595
1535	Phosphorylation	SPSPKTPTPSTPGDT CCCCCCCCCCCCCCC	34.79	25521595
1537	Phosphorylation	SPKTPTPSTPGDTQP CCCCCCCCCCCCCCC	50.11	23684622
1538	Phosphorylation	PKTPTPSTPGDTQPN CCCCCCCCCCCCCCC	32.28	27087446
1542	Phosphorylation	TPSTPGDTQPNTPAP CCCCCCCCCCCCCCC	52.41	25521595
1546	Phosphorylation	PGDTQPNTPAPVPPA CCCCCCCCCCCCCCH	27.75	27087446
1563	Phosphorylation	GIKIEENSLKEEEST CCCCCCCCCCHHCCC	44.06	25521595
1565	Ubiquitination	KIEENSLKEEESTEG CCCCCCCCHHCCCCC	64.00	-
1569	Phosphorylation	NSLKEEESTEGEKEV CCCCHHCCCCCCHHH	34.73	25619855
1570	Phosphorylation	SLKEEESTEGEKEVK CCCHHCCCCCCHHHH	51.82	25619855
1646	Acetylation	KGTTEVEKVEEKSAV CCCCCCEECHHHCCC	61.19	-
1651	Phosphorylation	VEKVEEKSAVDLTPI CEECHHHCCCCCCCE	36.48	28066266
1656	Phosphorylation	EKSAVDLTPIVVEDK HHCCCCCCCEECCCH	13.40	27180971
1682	Phosphorylation	VMLQNGETPKDLSDE HHCCCCCCCCCCCHH	36.72	25266776
1687	Phosphorylation	GETPKDLSDEKQKKN CCCCCCCCHHHHHHH	54.58	26745281
1834	Phosphorylation	EVECLAESHQHLSKE HHHHHHHHHHHHCHH	23.88	-
1858	Acetylation	AVLHKVLKQLEELLS HHHHHHHHHHHHHHH	56.69	22826441
1868	Ubiquitination	EELLSDMKADVTRLP HHHHHHHHCCHHHCC	46.56	-
1891	Phosphorylation	VAVRLQMSERNILSR HHHHHHCCHHHHHHH	22.05	-
1897	Phosphorylation	MSERNILSRLANRAP CCHHHHHHHHHHCCC	22.81	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CHD4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHD4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHD4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RORG_MOUSE	Rorc	physical	15144897
HTF4_MOUSE	Tcf12	physical	15189737
EP300_MOUSE	Ep300	physical	15189737

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CHD4_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1301, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1533; THR-1538 ANDTHR-1542, AND MASS SPECTROMETRY.	17242355 [Abstract]