RORG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RORG_MOUSE
• UniProt AC: P51450
• Protein Name: Nuclear receptor ROR-gamma
• Gene Name: Rorc
• Organism: Mus musculus (Mouse).
• Sequence Length: 516
• Subcellular Localization: Nucleus .
• Protein Description: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. [PubMed: 17666523]
• Protein Sequence: MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	Acetylation	VKFGRMSKKQRDSLH HHHCCCCHHHHHHHH	43.51	7743837
134	Phosphorylation	QQEQVAKTPPAGSRG HHHHHHCCCCCCCCC	25.43	23140645
161	Phosphorylation	GQLPLGASPDLPEAS CCCCCCCCCCCCHHH	19.69	26026062
197	Phosphorylation	KTEVQGASCHLEYSP CCEECCCEEEEEECC	14.64	27600695
203	Phosphorylation	ASCHLEYSPERGKAE CEEEEEECCCCCCCC	15.77	19060867
299	Phosphorylation	RQRTNLFSREEVTSY HHHHCCCCHHHHHHH	41.78	28059163
397	Phosphorylation	GCSELISSIFDFSHF CCHHHHHHHHCHHHH	21.93	-
505	Phosphorylation	PLYKELFSTDVESPE HHHHHHHCCCCCCCC	36.00	-
510	Phosphorylation	LFSTDVESPEGLSK- HHCCCCCCCCCCCC-	28.27	27600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Itch	Q8C863	PMID:27322655

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RORG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RORG_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD4_MOUSE	Chd4	physical	15144897
ITCH_MOUSE	Itch	physical	27322655

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.