dbPTM

UBC9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBC9_MOUSE
UniProt AC	P63280
Protein Name	SUMO-conjugating enzyme UBC9
Gene Name	Ube2i
Organism	Mus musculus (Mouse).
Sequence Length	158
Subcellular Localization	Nucleus. Cytoplasm. Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body.
Protein Description	Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386'..
Protein Sequence	MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGIALSRL ------CCCHHHHHH	38.62	-
2	Phosphorylation	------MSGIALSRL ------CCCHHHHHH	38.62	29514104
18	Ubiquitination	QERKAWRKDHPFGFV HHHHHHHCCCCCEEE	50.08	22790023
48	Sumoylation	WECAIPGKKGTPWEG EEEECCCCCCCCCCC	42.55	28289178
49	Ubiquitination	ECAIPGKKGTPWEGG EEECCCCCCCCCCCC	74.14	27667366
59	Acetylation	PWEGGLFKLRMLFKD CCCCCEEEEEECCCC	39.98	22826441
65	Acetylation	FKLRMLFKDDYPSSP EEEEECCCCCCCCCC	45.81	23236377
68	Phosphorylation	RMLFKDDYPSSPPKC EECCCCCCCCCCCCC	18.36	28285833
71	Phosphorylation	FKDDYPSSPPKCKFE CCCCCCCCCCCCCCC	40.49	27841257
101	Sumoylation	LSILEEDKDWRPAIT EHHHHCCCCCCCCHH	63.57	28289178
158	Phosphorylation	QAKKFAPS------- HHHHHCCC-------	49.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
71	S	Phosphorylation	-
Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
71	S	Sumoylation	-
Phosphorylation at Ser-71 significantly enhances SUMOylation activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBC9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNR6_MOUSE	Fas	physical	9257699
GTR4_HUMAN	SLC2A4	physical	10655495
GTR1_HUMAN	SLC2A1	physical	10655495
HIPK2_HUMAN	HIPK2	physical	10535925
GMEB1_HUMAN	GMEB1	physical	11812797
GMEB2_HUMAN	GMEB2	physical	11812797
GCR_RAT	Nr3c1	physical	11812797
RBP2_HUMAN	RANBP2	physical	11792325
SP100_HUMAN	SP100	physical	11792325
SOX2_MOUSE	Sox2	physical	17097055
PO5F1_MOUSE	Pou5f1	physical	17097055
MDM2_MOUSE	Mdm2	physical	21183956
UIMC1_MOUSE	Uimc1	physical	17698038
IRF1_MOUSE	Irf1	physical	18955028
TNR6_HUMAN	FAS	physical	10068040
ESPB1_HUMAN	ELSPBP1	physical	9409784
TFE2_HUMAN	TCF3	physical	9409784
SUMO1_HUMAN	SUMO1	physical	20543865
GATA1_MOUSE	Gata1	physical	15173587
SUMO1_HUMAN	SUMO1	physical	17491593
C8AP2_MOUSE	Casp8ap2	physical	23673342
PIAS3_MOUSE	Pias3	physical	12387893
MTHFS_MOUSE	Mthfs	physical	22303332
SUMO3_MOUSE	Sumo3	physical	20077568
SUMO1_MOUSE	Sumo1	physical	20077568
RAGP1_MOUSE	Rangap1	physical	15094046
RAGP1_MOUSE	Rangap1	physical	11792325
HIF1A_MOUSE	Hif1a	physical	17981124
RCC1_HUMAN	RCC1	physical	26496610
GLE1_HUMAN	GLE1	physical	26496610
IMB1_HUMAN	KPNB1	physical	26496610
NUP88_HUMAN	NUP88	physical	26496610
NUP98_HUMAN	NUP98	physical	26496610
RAN_HUMAN	RAN	physical	26496610
RBP2_HUMAN	RANBP2	physical	26496610
RAGP1_HUMAN	RANGAP1	physical	26496610
SEC13_HUMAN	SEC13	physical	26496610
SUMO2_HUMAN	SUMO2	physical	26496610
SUMO1_HUMAN	SUMO1	physical	26496610
NU214_HUMAN	NUP214	physical	26496610
AF10_HUMAN	MLLT10	physical	26496610
AAAS_HUMAN	AAAS	physical	26496610
RAE1L_HUMAN	RAE1	physical	26496610
NU155_HUMAN	NUP155	physical	26496610
NUP93_HUMAN	NUP93	physical	26496610
NU153_HUMAN	NUP153	physical	26496610
SAE2_HUMAN	UBA2	physical	26496610
SAE1_HUMAN	SAE1	physical	26496610
NXF1_HUMAN	NXF1	physical	26496610
NUP50_HUMAN	NUP50	physical	26496610
NUPL2_HUMAN	NUPL2	physical	26496610
PRS23_HUMAN	PRSS23	physical	26496610
NU205_HUMAN	NUP205	physical	26496610
NU160_HUMAN	NUP160	physical	26496610
NEMP1_HUMAN	TMEM194A	physical	26496610
NU188_HUMAN	NUP188	physical	26496610
SENP1_HUMAN	SENP1	physical	26496610
NUSAP_HUMAN	NUSAP1	physical	26496610
TM214_HUMAN	TMEM214	physical	26496610
NSMA3_HUMAN	SMPD4	physical	26496610
NDC1_HUMAN	NDC1	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
NU133_HUMAN	NUP133	physical	26496610
NU107_HUMAN	NUP107	physical	26496610
SENP2_HUMAN	SENP2	physical	26496610
NUP37_HUMAN	NUP37	physical	26496610
NUP85_HUMAN	NUP85	physical	26496610
SEH1_HUMAN	SEH1L	physical	26496610
USMG5_HUMAN	USMG5	physical	26496610
TM209_HUMAN	TMEM209	physical	26496610
NUP53_HUMAN	NUP35	physical	26496610
NUP43_HUMAN	NUP43	physical	26496610
RGPD8_HUMAN	RGPD8	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBC9_MOUSE

Related Literatures of Post-Translational Modification

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