| UniProt ID | NEMP1_HUMAN | |
|---|---|---|
| UniProt AC | O14524 | |
| Protein Name | Nuclear envelope integral membrane protein 1 | |
| Gene Name | NEMP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 444 | |
| Subcellular Localization |
Nucleus inner membrane Multi-pass membrane protein Nucleoplasmic side . Nucleus envelope . Colocalizes with lamins and RAN-GTP at the nuclear envelope. |
|
| Protein Description | ||
| Protein Sequence | MAGGMKVAVSPAVGPGPWGSGVGGGGTVRLLLILSGCLVYGTAETDVNVVMLQESQVCEKRASQQFCYTNVLIPKWHDIWTRIQIRVNSSRLVRVTQVENEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEIIEKDTKYSVIVIRRFDPKLFLVFLLGLMLFFCGDLLSRSQIFYYSTGMTVGIVASLLIIIFILSKFMPKKSPIYVILVGGWSFSLYLIQLVFKNLQEIWRCYWQYLLSYVLTVGFMSFAVCYKYGPLENERSINLLTWTLQLMGLCFMYSGIQIPHIALAIIIIALCTKNLEHPIQWLYITCRKVCKGAEKPVPPRLLTEEEYRIQGEVETRKALEELREFCNSPDCSAWKTVSRIQSPKRFADFVEGSSHLTPNEVSVHEQEYGLGSIIAQDEIYEEASSEEEDSYSRCPAITQNNFLT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 75 | Ubiquitination | YTNVLIPKWHDIWTR CCCEEECCHHHHHHH | - | ||
| 96 | Phosphorylation | SSRLVRVTQVENEEK CCCEEEEEEEECHHH | - | ||
| 103 | Ubiquitination | TQVENEEKLKELEQF EEEECHHHHHHHHHH | 22817900 | ||
| 103 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 103 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 105 | Ubiquitination | VENEEKLKELEQFSI EECHHHHHHHHHHHH | 22817900 | ||
| 111 | Ubiquitination | LKELEQFSIWNFFSS HHHHHHHHHHHHHHH | 22817900 | ||
| 113 | Ubiquitination | ELEQFSIWNFFSSFL HHHHHHHHHHHHHHH | 22817900 | ||
| 118 | Phosphorylation | SIWNFFSSFLKEKLN HHHHHHHHHHHHHHC | 24719451 | ||
| 123 | Ubiquitination | FSSFLKEKLNDTYVN HHHHHHHHHCCCEEE | 29967540 | ||
| 125 | N-linked_Glycosylation | SFLKEKLNDTYVNVG HHHHHHHCCCEEEEE | UniProtKB CARBOHYD | ||
| 127 | Phosphorylation | LKEKLNDTYVNVGLY HHHHHCCCEEEEEEE | 25262027 | ||
| 128 | Phosphorylation | KEKLNDTYVNVGLYS HHHHCCCEEEEEEEE | 25262027 | ||
| 134 | Phosphorylation | TYVNVGLYSTKTCLK CEEEEEEEECCCEEE | 24719451 | ||
| 135 | Phosphorylation | YVNVGLYSTKTCLKV EEEEEEEECCCEEEE | 22210691 | ||
| 136 | Phosphorylation | VNVGLYSTKTCLKVE EEEEEEECCCEEEEE | 22210691 | ||
| 137 | Ubiquitination | NVGLYSTKTCLKVEI EEEEEECCCEEEEEE | 21963094 | ||
| 141 | Ubiquitination | YSTKTCLKVEIIEKD EECCCEEEEEEEECC | 22817900 | ||
| 145 | Ubiquitination | TCLKVEIIEKDTKYS CEEEEEEEECCCCEE | 21963094 | ||
| 149 | Ubiquitination | VEIIEKDTKYSVIVI EEEEECCCCEEEEEE | 22817900 | ||
| 151 | Ubiquitination | IIEKDTKYSVIVIRR EEECCCCEEEEEEEC | 22817900 | ||
| 153 | Ubiquitination | EKDTKYSVIVIRRFD ECCCCEEEEEEECCC | 22817900 | ||
| 185 | Ubiquitination | DLLSRSQIFYYSTGM HHHHCHHHHHHHHCC | 21963094 | ||
| 189 | Ubiquitination | RSQIFYYSTGMTVGI CHHHHHHHHCCHHHH | 22817900 | ||
| 258 | Ubiquitination | LSYVLTVGFMSFAVC HHHHHHHHHHHHHHH | 29967540 | ||
| 262 | Ubiquitination | LTVGFMSFAVCYKYG HHHHHHHHHHHHHHC | 29967540 | ||
| 284 | Ubiquitination | INLLTWTLQLMGLCF HHHHHHHHHHHHHHH | 29967540 | ||
| 302 | Ubiquitination | GIQIPHIALAIIIIA CCCHHHHHHHHHHHH | 29967540 | ||
| 331 | Ubiquitination | ITCRKVCKGAEKPVP HHHHHHHCCCCCCCC | 29967540 | ||
| 335 | Ubiquitination | KVCKGAEKPVPPRLL HHHCCCCCCCCCCCC | 29967540 | ||
| 343 | Phosphorylation | PVPPRLLTEEEYRIQ CCCCCCCCHHHHHHH | - | ||
| 357 | Ubiquitination | QGEVETRKALEELRE HCHHHHHHHHHHHHH | 29967540 | ||
| 368 | Phosphorylation | ELREFCNSPDCSAWK HHHHHHCCCCCCHHH | 25159151 | ||
| 372 | Phosphorylation | FCNSPDCSAWKTVSR HHCCCCCCHHHHHHC | 25850435 | ||
| 375 | Ubiquitination | SPDCSAWKTVSRIQS CCCCCHHHHHHCCCC | 29967540 | ||
| 376 | Phosphorylation | PDCSAWKTVSRIQSP CCCCHHHHHHCCCCC | 23090842 | ||
| 378 | Phosphorylation | CSAWKTVSRIQSPKR CCHHHHHHCCCCCHH | 22199227 | ||
| 382 | Phosphorylation | KTVSRIQSPKRFADF HHHHCCCCCHHHHHH | 22199227 | ||
| 424 | Phosphorylation | DEIYEEASSEEEDSY HHHHHHHCCCCCCCC | 25137130 | ||
| 425 | Phosphorylation | EIYEEASSEEEDSYS HHHHHHCCCCCCCCC | 25137130 | ||
| 444 | Phosphorylation | ITQNNFLT------- HHCCCCCC------- | 25159151 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NEMP1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NEMP1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NEMP1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RGPD2_HUMAN | RGPD2 | physical | 28514442 | |
| RGPD8_HUMAN | RGPD8 | physical | 28514442 | |
| ADCY9_HUMAN | ADCY9 | physical | 28514442 | |
| RGPD5_HUMAN | RGPD5 | physical | 28514442 | |
| DLGP5_HUMAN | DLGAP5 | physical | 28514442 | |
| RBP2_HUMAN | RANBP2 | physical | 28514442 | |
| ACD11_HUMAN | ACAD11 | physical | 28514442 | |
| GLRB_HUMAN | GLRB | physical | 28514442 | |
| RAGP1_HUMAN | RANGAP1 | physical | 28514442 | |
| PI42A_HUMAN | PIP4K2A | physical | 28514442 | |
| PI42B_HUMAN | PIP4K2B | physical | 28514442 | |
| UBC9_HUMAN | UBE2I | physical | 28514442 | |
| MAP2_HUMAN | METAP2 | physical | 28514442 | |
| NOP58_HUMAN | NOP58 | physical | 28514442 | |
| SDA1_HUMAN | SDAD1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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