dbPTM

UBC9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBC9_HUMAN
UniProt AC	P63279
Protein Name	SUMO-conjugating enzyme UBC9
Gene Name	UBE2I
Organism	Homo sapiens (Human).
Sequence Length	158
Subcellular Localization	Nucleus. Cytoplasm. Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity)..
Protein Description	Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'..
Protein Sequence	MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGIALSRL ------CCCHHHHHH	38.62	23403867
2	Acetylation	------MSGIALSRL ------CCCHHHHHH	38.62	20058876
7	Phosphorylation	-MSGIALSRLAQERK -CCCHHHHHHHHHHH	19.07	24719451
14	Sumoylation	SRLAQERKAWRKDHP HHHHHHHHHHHCCCC	52.10	-
14	Sumoylation	SRLAQERKAWRKDHP HHHHHHHHHHHCCCC	52.10	-
18	Ubiquitination	QERKAWRKDHPFGFV HHHHHHHCCCCCEEE	50.08	18781797
18	2-Hydroxyisobutyrylation	QERKAWRKDHPFGFV HHHHHHHCCCCCEEE	50.08	-
18	Sumoylation	QERKAWRKDHPFGFV HHHHHHHCCCCCEEE	50.08	28112733
30	Acetylation	GFVAVPTKNPDGTMN EEEEEECCCCCCCEE	61.48	25953088
35	Phosphorylation	PTKNPDGTMNLMNWE ECCCCCCCEEEEEEE	15.40	21406692
43	Glutathionylation	MNLMNWECAIPGKKG EEEEEEEEECCCCCC	2.92	22555962
48	Sumoylation	WECAIPGKKGTPWEG EEEECCCCCCCCCCC	42.55	-
48	Acetylation	WECAIPGKKGTPWEG EEEECCCCCCCCCCC	42.55	25953088
48	Sumoylation	WECAIPGKKGTPWEG EEEECCCCCCCCCCC	42.55	-
49	Sumoylation	ECAIPGKKGTPWEGG EEECCCCCCCCCCCC	74.14	25114211
49	Ubiquitination	ECAIPGKKGTPWEGG EEECCCCCCCCCCCC	74.14	21906983
49	Sumoylation	ECAIPGKKGTPWEGG EEECCCCCCCCCCCC	74.14	-
59	Ubiquitination	PWEGGLFKLRMLFKD CCCCCEEEEEECCCC	39.98	21890473
59	2-Hydroxyisobutyrylation	PWEGGLFKLRMLFKD CCCCCEEEEEECCCC	39.98	-
59	Acetylation	PWEGGLFKLRMLFKD CCCCCEEEEEECCCC	39.98	25953088
65	Sumoylation	FKLRMLFKDDYPSSP EEEEECCCCCCCCCC	45.81	19608861
65	Acetylation	FKLRMLFKDDYPSSP EEEEECCCCCCCCCC	45.81	19608861
65	Ubiquitination	FKLRMLFKDDYPSSP EEEEECCCCCCCCCC	45.81	21890473
68	Phosphorylation	RMLFKDDYPSSPPKC EECCCCCCCCCCCCC	18.36	29978859
70	Phosphorylation	LFKDDYPSSPPKCKF CCCCCCCCCCCCCCC	49.61	21712546
71	Phosphorylation	FKDDYPSSPPKCKFE CCCCCCCCCCCCCCC	40.49	23401153
74	Ubiquitination	DYPSSPPKCKFEPPL CCCCCCCCCCCCCCC	54.14	-
101	Sumoylation	LSILEEDKDWRPAIT EHHHHCCCCCCCCHH	63.57	28112733
146	Acetylation	QNRVEYEKRVRAQAK CCCHHHHHHHHHHHH	56.12	26051181
146	Sumoylation	QNRVEYEKRVRAQAK CCCHHHHHHHHHHHH	56.12	-
146	Sumoylation	QNRVEYEKRVRAQAK CCCHHHHHHHHHHHH	56.12	-
153	Sumoylation	KRVRAQAKKFAPS-- HHHHHHHHHHCCC--	36.02	-
153	Sumoylation	KRVRAQAKKFAPS-- HHHHHHHHHHCCC--	36.02	-
154	Sumoylation	RVRAQAKKFAPS--- HHHHHHHHHCCC---	50.18	-
158	Phosphorylation	QAKKFAPS------- HHHHHCCC-------	49.80	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
71	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
71	S	Phosphorylation	22509284
Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
71	S	Sumoylation	22509284
Phosphorylation at Ser-71 significantly enhances SUMOylation activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBC9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD3_HUMAN	CHD3	physical	14609633
MISSL_HUMAN	MAPK1IP1L	physical	16189514
CR025_HUMAN	C18orf25	physical	16189514
NUDC3_HUMAN	NUDCD3	physical	16189514
IKZF1_HUMAN	IKZF1	physical	16189514
RIPK2_HUMAN	RIPK2	physical	16189514
PDLI7_HUMAN	PDLIM7	physical	16189514
ZN646_HUMAN	ZNF646	physical	16189514
IKZF3_HUMAN	IKZF3	physical	16189514
CHM4B_HUMAN	CHMP4B	physical	16189514
HGS_HUMAN	HGS	physical	16189514
FSBP_HUMAN	RAD54B	physical	16189514
RA54B_HUMAN	RAD54B	physical	16189514
ZBED1_HUMAN	ZBED1	physical	16189514
TRI29_HUMAN	TRIM29	physical	16189514
ZN451_HUMAN	ZNF451	physical	16189514
PIAS2_HUMAN	PIAS2	physical	16189514
RAGP1_HUMAN	RANGAP1	physical	17353931
SAE1_HUMAN	SAE1	physical	17353931
RBP2_HUMAN	RANBP2	physical	17353931
SUMO1_HUMAN	SUMO1	physical	17353931
SUMO3_HUMAN	SUMO3	physical	17353931
SAE2_HUMAN	UBA2	physical	17353931
DNM3A_HUMAN	DNMT3A	physical	14752048
PIAS1_HUMAN	PIAS1	physical	14609633
PIAS2_HUMAN	PIAS2	physical	14609633
HIPK2_HUMAN	HIPK2	physical	14609633
TYDP2_HUMAN	TDP2	physical	14609633
RAGP1_HUMAN	RANGAP1	physical	12924945
PPM1J_HUMAN	PPM1J	physical	12633878
P73_HUMAN	TP73	physical	10961991
P53_HUMAN	TP53	physical	10961991
SUMO1_HUMAN	SUMO1	physical	10961991
U119A_HUMAN	UNC119	physical	16169070
IPO13_HUMAN	IPO13	physical	11447110
DNM3B_HUMAN	DNMT3B	physical	11735126
DACH1_HUMAN	DACH1	physical	11025202
PIAS1_HUMAN	PIAS1	physical	12356736
DAXX_HUMAN	DAXX	physical	11112409
TRI55_HUMAN	TRIM55	physical	11927605
TRI54_HUMAN	TRIM54	physical	11927605
TRI63_HUMAN	TRIM63	physical	11927605
TNR1A_HUMAN	TNFRSF1A	physical	9563508
M3K1_HUMAN	MAP3K1	physical	9563508
ANDR_HUMAN	AR	physical	10383460
TFE2_HUMAN	TCF3	physical	10497239
FHIT_HUMAN	FHIT	physical	11085938
RAGP1_HUMAN	RANGAP1	physical	18691969
HDAC4_HUMAN	HDAC4	physical	18691969
UBE2K_HUMAN	UBE2K	physical	18691969
SP100_HUMAN	SP100	physical	18691969
PML_HUMAN	PML	physical	18691969
TDG_HUMAN	TDG	physical	18691969
DAXX_HUMAN	DAXX	physical	18691969
ETS1_HUMAN	ETS1	physical	9333025
WT1_HUMAN	WT1	physical	8798754
UBC9_HUMAN	UBE2I	physical	8610150
SALL1_HUMAN	SALL1	physical	12200128
IKKA_HUMAN	CHUK	physical	11853669
P53_HUMAN	TP53	physical	11853669
RAGP1_MOUSE	Rangap1	physical	11853669
TOP1_HUMAN	TOP1	physical	10759568
GCM1_HUMAN	GCM1	physical	17646165
SUZ12_HUMAN	SUZ12	physical	18628979
RNF10_HUMAN	RNF10	physical	19549727
RN111_HUMAN	RNF111	physical	19549727
RAD18_HUMAN	RAD18	physical	19549727
RNF4_HUMAN	RNF4	physical	19549727
CBLC_HUMAN	CBLC	physical	19549727
DTX3L_HUMAN	DTX3L	physical	19549727
DZIP3_HUMAN	DZIP3	physical	19549727
R144B_HUMAN	RNF144B	physical	19549727
LNX2_HUMAN	LNX2	physical	19549727
MARH5_HUMAN	MARCH5	physical	19549727
MGRN1_HUMAN	MGRN1	physical	19549727
MKRN3_HUMAN	MKRN3	physical	19549727
RC3H2_HUMAN	RC3H2	physical	19549727
TRI72_HUMAN	TRIM72	physical	19549727
RN128_HUMAN	RNF128	physical	19549727
TRI23_HUMAN	TRIM23	physical	19549727
TRI41_HUMAN	TRIM41	physical	19549727
BMI1_HUMAN	BMI1	physical	19549727
PEX10_HUMAN	PEX10	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
RN133_HUMAN	RNF133	physical	19549727
RN185_HUMAN	RNF185	physical	19549727
BRCA1_HUMAN	BRCA1	physical	20016594
GOGB1_HUMAN	GOLGB1	physical	20936779
EXOS9_HUMAN	EXOSC9	physical	20936779
RBP2_HUMAN	RANBP2	physical	20936779
RNF4_HUMAN	RNF4	physical	20936779
SP100_HUMAN	SP100	physical	20936779
UBC9_HUMAN	UBE2I	physical	20936779
ZMYM2_HUMAN	ZMYM2	physical	20936779
PIAS1_HUMAN	PIAS1	physical	20936779
PIAS2_HUMAN	PIAS2	physical	20936779
SETB1_HUMAN	SETDB1	physical	20936779
C8AP2_HUMAN	CASP8AP2	physical	20936779
HIPK3_HUMAN	HIPK3	physical	20936779
PIAS3_HUMAN	PIAS3	physical	20936779
SETX_HUMAN	SETX	physical	20936779
CYTSA_HUMAN	SPECC1L	physical	20936779
ZN451_HUMAN	ZNF451	physical	20936779
HIPK2_HUMAN	HIPK2	physical	20936779
RN111_HUMAN	RNF111	physical	20936779
MCAF1_HUMAN	ATF7IP	physical	20936779
ZN106_HUMAN	ZNF106	physical	20936779
HIPK1_HUMAN	HIPK1	physical	20936779
MITF_HUMAN	MITF	physical	16029420
HDAC7_HUMAN	HDAC7	physical	18625722
HDAC4_HUMAN	HDAC4	physical	16166628
RUVB1_HUMAN	RUVBL1	physical	18087039
PIAS2_HUMAN	PIAS2	physical	11867732
MDM2_HUMAN	MDM2	physical	11384992
HIC1_HUMAN	HIC1	physical	17283066
ETV6_HUMAN	ETV6	physical	10377438
NCOR2_HUMAN	NCOR2	physical	20555024
PIAS1_HUMAN	PIAS1	physical	19965618
EGR2_HUMAN	EGR2	physical	21836637
BIRC3_HUMAN	BIRC3	physical	21113135
BIRC7_HUMAN	BIRC7	physical	21113135
XIAP_HUMAN	XIAP	physical	21113135
SUMO1_HUMAN	SUMO1	physical	21174150
PELI1_HUMAN	PELI1	physical	21120624
HRSL4_HUMAN	RARRES3	physical	21203974
RAGP1_HUMAN	RANGAP1	physical	14578449
PPARA_HUMAN	PPARA	physical	19955185
HIPK2_HUMAN	HIPK2	physical	15896780
ANXA1_HUMAN	ANXA1	physical	20359522
T22D3_HUMAN	TSC22D3	physical	20671745
KMT5A_HUMAN	SETD8	physical	21829513
CSEN_HUMAN	KCNIP3	physical	21070824
UBC9_HUMAN	UBE2I	physical	21139563
UBE2K_HUMAN	UBE2K	physical	21139563
RAGP1_HUMAN	RANGAP1	physical	21139563
KAT5_HUMAN	KAT5	physical	17704809
SKI_HUMAN	SKI	physical	22411991
CDC37_HUMAN	CDC37	physical	17709345
MED7_HUMAN	MED7	physical	17709345
CSK2B_HUMAN	CSNK2B	physical	17709345
DRG1_HUMAN	DRG1	physical	17709345
EDF1_HUMAN	EDF1	physical	17709345
FOS_HUMAN	FOS	physical	17709345
HMGN2_HUMAN	HMGN2	physical	17709345
HSF2B_HUMAN	HSF2BP	physical	17709345
PRS6A_HUMAN	PSMC3	physical	17709345
KS6A6_HUMAN	RPS6KA6	physical	17709345
TAF10_HUMAN	TAF10	physical	17709345
RPA12_HUMAN	ZNRD1	physical	17709345
P53_HUMAN	TP53	physical	17709345
SUMO1_HUMAN	SUMO1	physical	17491593
SUMO2_HUMAN	SUMO2	physical	17491593
FOXL2_HUMAN	FOXL2	physical	19744555
SOX4_HUMAN	SOX4	physical	16631117
ZEB2_HUMAN	ZEB2	physical	16061479
STAT1_HUMAN	STAT1	physical	14517261
PLAL1_HUMAN	PLAGL1	physical	17336575
GRIP1_HUMAN	GRIP1	physical	17336575
DYN1_RAT	Dnm1	physical	15123615
RAGP1_HUMAN	RANGAP1	physical	9497385
MEF2A_HUMAN	MEF2A	physical	19684601
HSF1_HUMAN	HSF1	physical	19684601
P53_HUMAN	TP53	physical	19684601
HSF2_HUMAN	HSF2	physical	18211895
PCGF2_HUMAN	PCGF2	physical	18211895
CDK1_HUMAN	CDK1	physical	22407595
P53_HUMAN	TP53	physical	15327968
ATX7_HUMAN	ATXN7	physical	19843541
SRSF1_HUMAN	SRSF1	physical	20805487
SP100_HUMAN	SP100	physical	20805487
UBP25_HUMAN	USP25	physical	18538659
BRCA1_HUMAN	BRCA1	physical	19287951
TIF1B_HUMAN	TRIM28	physical	21940674
NFAC1_HUMAN	NFATC1	physical	19218564
HNRPK_HUMAN	HNRNPK	physical	22825850
ZBT16_HUMAN	ZBTB16	physical	14527952
SRF_HUMAN	SRF	physical	12788062
PML_HUMAN	PML	physical	22155184
CDN2A_HUMAN	CDKN2A	physical	15876874
ARF_HUMAN	CDKN2A	physical	15876874
BCAM_HUMAN	BCAM	physical	17087659
PARP1_HUMAN	PARP1	physical	9197546
P63_HUMAN	TP63	physical	15539951
UBC9_HUMAN	UBE2I	physical	8668125
CBF3A_YEAST	CBF2	physical	8668125
CBF3B_YEAST	CEP3	physical	8668125
UBC9_SCHPO	hus5	physical	8668125
UBC9_HUMAN	UBE2I	physical	8940097
TNR6_HUMAN	FAS	physical	8940097
P53_HUMAN	TP53	physical	22214662
MYB_HUMAN	MYB	physical	22910413
FUS_HUMAN	FUS	physical	19946338
PA2G4_HUMAN	PA2G4	physical	19946338
HNRPD_HUMAN	HNRNPD	physical	12674497
SUMO1_HUMAN	SUMO1	physical	9353268
CASP2_HUMAN	CASP2	physical	15882978
RAGP1_HUMAN	RANGAP1	physical	18706886
LMNA_HUMAN	LMNA	physical	16248985
TRPS1_HUMAN	TRPS1	physical	17391059
PCGF2_HUMAN	PCGF2	physical	19727227
EGF_HUMAN	EGF	physical	19727227
SUMO1_HUMAN	SUMO1	physical	14673145
XPO1_HUMAN	XPO1	physical	22939629
UBP8_HUMAN	USP8	physical	22939629
XPO7_HUMAN	XPO7	physical	22939629
ELK1_HUMAN	ELK1	physical	17036045
NR5A2_HUMAN	NR5A2	physical	17036045
RAGP1_HUMAN	RANGAP1	physical	17036045
CHFR_HUMAN	CHFR	physical	23131550
TRAF6_HUMAN	TRAF6	physical	23264041
HSPB1_HUMAN	HSPB1	physical	23155000
HSPB2_HUMAN	HSPB2	physical	23155000
RB_HUMAN	RB1	physical	15806172
HDAC4_HUMAN	HDAC4	physical	23417673
UBC9_HUMAN	UBE2I	physical	21988832
ZHX1_HUMAN	ZHX1	physical	21988832
PML_HUMAN	PML	physical	12641448
TAF5_HUMAN	TAF5	physical	15637059
TAF12_HUMAN	TAF12	physical	15637059
TBP_HUMAN	TBP	physical	15637059
TAF1_HUMAN	TAF1	physical	15637059
ELK1_HUMAN	ELK1	physical	12887893
P63_HUMAN	TP63	physical	15611636
DSRAD_HUMAN	ADAR	physical	16120648
MAFB_MOUSE	Mafb	physical	17548468
HDAC1_HUMAN	HDAC1	physical	24068740
TRAF3_HUMAN	TRAF3	physical	24260396
CARM1_HUMAN	CARM1	physical	23455924
NSD3_HUMAN	WHSC1L1	physical	23455924
FOXM1_HUMAN	FOXM1	physical	24362530
CBS_HUMAN	CBS	physical	17087506
CFTR_HUMAN	CFTR	physical	23155000
SUMO1_HUMAN	SUMO1	physical	24352468
RBBP5_HUMAN	RBBP5	physical	24930734
COR2A_HUMAN	CORO2A	physical	24930734
UBC9_HUMAN	UBE2I	physical	20061386
TAB2_HUMAN	TAB2	physical	24096733
ZHX1_HUMAN	ZHX1	physical	23686912
P53_HUMAN	TP53	physical	23202365
PTEN_HUMAN	PTEN	physical	22713753
RAGP1_HUMAN	RANGAP1	physical	18538659
SP100_HUMAN	SP100	physical	18538659
PARP1_HUMAN	PARP1	physical	23871147
CBP_HUMAN	CREBBP	physical	23395904
DAXX_HUMAN	DAXX	physical	23395904
ELK1_HUMAN	ELK1	physical	23395904
RAGP1_HUMAN	RANGAP1	physical	23395904
PRGC1_HUMAN	PPARGC1A	physical	19625249
CEBPD_HUMAN	CEBPD	physical	16397300
XBP1_HUMAN	XBP1	physical	23470653
SUMO1_HUMAN	SUMO1	physical	25416956
PIAS2_HUMAN	PIAS2	physical	25416956
ZBED1_HUMAN	ZBED1	physical	25416956
BRE1B_HUMAN	RNF40	physical	25416956
IKZF1_HUMAN	IKZF1	physical	25416956
TRI38_HUMAN	TRIM38	physical	25416956
RFPL3_HUMAN	RFPL3	physical	25416956
PUF60_HUMAN	PUF60	physical	25416956
SETBP_HUMAN	SETBP1	physical	25416956
UBXN1_HUMAN	UBXN1	physical	25416956
RN111_HUMAN	RNF111	physical	25416956
ZBT26_HUMAN	ZBTB26	physical	25416956
KLH12_HUMAN	KLHL12	physical	25416956
BEND5_HUMAN	BEND5	physical	25416956
ZCHC7_HUMAN	ZCCHC7	physical	25416956
HNRLL_HUMAN	HNRNPLL	physical	25416956
MISSL_HUMAN	MAPK1IP1L	physical	25416956
EDAD_HUMAN	EDARADD	physical	25416956
KCTD1_HUMAN	KCTD1	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
HMGA1_HUMAN	HMGA1	physical	22207709
PIAS2_HUMAN	PIAS2	physical	25409927
RAGP1_HUMAN	RANGAP1	physical	16820290
ZN451_HUMAN	ZNF451	physical	18656483
TOP2B_HUMAN	TOP2B	physical	10862613
TOP2A_HUMAN	TOP2A	physical	10862613
RL8_HUMAN	RPL8	physical	19596686
RL7_HUMAN	RPL7	physical	19596686
RS3A_HUMAN	RPS3A	physical	19596686
NONO_HUMAN	NONO	physical	19596686
NOP56_HUMAN	NOP56	physical	19596686
DDX5_HUMAN	DDX5	physical	19596686
LMNA_HUMAN	LMNA	physical	19596686
RBM14_HUMAN	RBM14	physical	19596686
HNRPM_HUMAN	HNRNPM	physical	19596686
SFPQ_HUMAN	SFPQ	physical	19596686
DDX21_HUMAN	DDX21	physical	19596686
SND1_HUMAN	SND1	physical	19596686
MATR3_HUMAN	MATR3	physical	19596686
NOP2_HUMAN	NOP2	physical	19596686
NAT10_HUMAN	NAT10	physical	19596686
NOL6_HUMAN	NOL6	physical	19596686
HNRPU_HUMAN	HNRNPU	physical	19596686
PARP1_HUMAN	PARP1	physical	19596686
MBB1A_HUMAN	MYBBP1A	physical	19596686
TOP2A_HUMAN	TOP2A	physical	19596686
U520_HUMAN	SNRNP200	physical	19596686
IQGA1_HUMAN	IQGAP1	physical	19596686
PRP8_HUMAN	PRPF8	physical	19596686
MYH9_HUMAN	MYH9	physical	19596686
PRKDC_HUMAN	PRKDC	physical	19596686
SAE2_HUMAN	UBA2	physical	21518904
NOX5_HUMAN	NOX5	physical	21527745
SUMO1_HUMAN	SUMO1	physical	23871147
IKBA_HUMAN	NFKBIA	physical	9734360
PML_HUMAN	PML	physical	9885291
P53_HUMAN	TP53	physical	10562557
BOREA_HUMAN	CDCA8	physical	18946085
JUN_HUMAN	JUN	physical	10788439
P53_HUMAN	TP53	physical	10788439
SUMO2_HUMAN	SUMO2	physical	11451954
SUMO3_HUMAN	SUMO3	physical	11451954
HDAC4_HUMAN	HDAC4	physical	11451954
SUMO1_HUMAN	SUMO1	physical	17956732
RWDD3_HUMAN	RWDD3	physical	17956732
SH3K1_HUMAN	SH3KBP1	physical	22203040
CD2AP_HUMAN	CD2AP	physical	22203040
RAGP1_HUMAN	RANGAP1	physical	20501649
THA_HUMAN	THRA	physical	22930759
THB_HUMAN	THRB	physical	22930759
P53_HUMAN	TP53	physical	16442531
SOX6_HUMAN	SOX6	physical	16442531
SNUT1_HUMAN	SART1	physical	15175327
AURKA_HUMAN	AURKA	physical	21554500
AURKB_HUMAN	AURKB	physical	21554500
ST65G_HUMAN	SUPT7L	physical	15561718
ETV1_HUMAN	ETV1	physical	15561718
TOP2B_HUMAN	TOP2B	physical	15561718
XRCC5_HUMAN	XRCC5	physical	15561718
CHD4_HUMAN	CHD4	physical	15561718
C8AP2_HUMAN	CASP8AP2	physical	15561718
ZNF24_HUMAN	ZNF24	physical	15561718
SATB1_HUMAN	SATB1	physical	15561718
PML_HUMAN	PML	physical	15561718
TSH2_HUMAN	TSHZ2	physical	15561718
GTF2I_HUMAN	GTF2I	physical	15561718
CAMP2_HUMAN	CAMSAP2	physical	15561718
TSNAX_HUMAN	TSNAX	physical	15561718
A4_HUMAN	APP	physical	15561718
PARP1_HUMAN	PARP1	physical	15561718
MEF2C_HUMAN	MEF2C	physical	15561718
CTNA1_HUMAN	CTNNA1	physical	15561718
RBM25_HUMAN	RBM25	physical	15561718
HNRPM_HUMAN	HNRNPM	physical	15561718
SYMPK_HUMAN	SYMPK	physical	15561718
KAT6B_HUMAN	KAT6B	physical	15561718
SEM6A_HUMAN	SEMA6A	physical	15561718
ADDG_HUMAN	ADD3	physical	15561718
SSRP1_HUMAN	SSRP1	physical	15561718
FANCM_HUMAN	FANCM	physical	15561718
KAT2A_HUMAN	KAT2A	physical	15561718
COG1_HUMAN	COG1	physical	15561718
STMN2_HUMAN	STMN2	physical	15561718
DDX24_HUMAN	DDX24	physical	15561718
CADH4_HUMAN	CDH4	physical	15561718
WNK1_HUMAN	WNK1	physical	15561718
TCRG1_HUMAN	TCERG1	physical	15561718
KDM1A_HUMAN	KDM1A	physical	15561718
HIRA_HUMAN	HIRA	physical	15561718
CALU_HUMAN	CALU	physical	15561718
XRCC1_HUMAN	XRCC1	physical	15561718
P53_HUMAN	TP53	physical	17060459
TDG_HUMAN	TDG	physical	17060459
FOS_HUMAN	FOS	physical	16055710
EVI1_HUMAN	MECOM	physical	23770046
ITF2_HUMAN	TCF4	physical	23772552
TRPS1_HUMAN	TRPS1	physical	23772552
P53_HUMAN	TP53	physical	23772552
ATF3_HUMAN	ATF3	physical	22991139
MP2K1_HUMAN	MAP2K1	physical	21336309
TIF1B_HUMAN	TRIM28	physical	18082607
ZBT7A_HUMAN	ZBTB7A	physical	17595526
DAXX_HUMAN	DAXX	physical	21474068
TRAF6_HUMAN	TRAF6	physical	18093978
RAGP1_HUMAN	RANGAP1	physical	16194093
UBE2K_HUMAN	UBE2K	physical	15723079
KCNA5_HUMAN	KCNA5	physical	17261810
SP100_HUMAN	SP100	physical	17491593
HDAC4_HUMAN	HDAC4	physical	17491593
AR13B_HUMAN	ARL13B	physical	23128241
ARL13_CAEEL	arl-13	physical	23128241
DAXX_HUMAN	DAXX	physical	17081986
FOS_HUMAN	FOS	physical	16236267
P53_HUMAN	TP53	physical	16122737
PML_HUMAN	PML	physical	17081986
SUMO2_HUMAN	SUMO2	physical	17938407
SUMO1_HUMAN	SUMO1	physical	17938407
HIF1A_HUMAN	HIF1A	physical	17938407
ZBTB1_HUMAN	ZBTB1	physical	20797634
NOP58_HUMAN	NOP58	physical	20797634
ANDR_HUMAN	AR	physical	19692572
STF1_HUMAN	NR5A1	physical	19692572
NR5A2_HUMAN	NR5A2	physical	19692572
SOX9_HUMAN	SOX9	physical	19692572
PIAS1_HUMAN	PIAS1	physical	19692572
GCR_HUMAN	NR3C1	physical	19692572
PPARG_HUMAN	PPARG	physical	19692572
RXRA_HUMAN	RXRA	physical	19692572
SUMO2_HUMAN	SUMO2	physical	24969970
HNF4A_HUMAN	HNF4A	physical	22505616
NR1I2_HUMAN	NR1I2	physical	20719936
RAGP1_HUMAN	RANGAP1	physical	20719936
ESR1_HUMAN	ESR1	physical	15961505
POL_HV1H2	gag-pol	physical	21454548
RAGP1_HUMAN	RANGAP1	physical	21098080
UBE2K_HUMAN	UBE2K	physical	21098080
RAGP1_MOUSE	Rangap1	physical	12821332
BC11A_HUMAN	BCL11A	physical	18681895
PPARG_HUMAN	PPARG	physical	26192107
CDN2A_HUMAN	CDKN2A	physical	25691462
ARF_HUMAN	CDKN2A	physical	25691462
ARFG2_HUMAN	ARFGAP2	physical	26344197
ROA1_HUMAN	HNRNPA1	physical	26344197
SAE1_HUMAN	SAE1	physical	26344197
SUMO1_HUMAN	SUMO1	physical	26344197
SUMO2_HUMAN	SUMO2	physical	26344197
SUMO3_HUMAN	SUMO3	physical	26344197
SAE2_HUMAN	UBA2	physical	26344197
UB2D2_HUMAN	UBE2D2	physical	26344197
UB2E1_HUMAN	UBE2E1	physical	26344197
UBE2K_HUMAN	UBE2K	physical	26344197
UBP8_HUMAN	USP8	physical	26344197
MX1_HUMAN	MX1	physical	25447205
TF7L2_HUMAN	TCF7L2	physical	23395904
KLF5_HUMAN	KLF5	physical	18500350
EP300_HUMAN	EP300	physical	12718889
RHXF2_HUMAN	RHOXF2	physical	21516116
NMI_HUMAN	NMI	physical	21516116
PCH2_HUMAN	TRIP13	physical	21516116
RCC1_HUMAN	RCC1	physical	26496610
FMR1_HUMAN	FMR1	physical	26496610
IMB1_HUMAN	KPNB1	physical	26496610
NUP98_HUMAN	NUP98	physical	26496610
RAN_HUMAN	RAN	physical	26496610
RBP2_HUMAN	RANBP2	physical	26496610
RAGP1_HUMAN	RANGAP1	physical	26496610
SUMO2_HUMAN	SUMO2	physical	26496610
SUMO1_HUMAN	SUMO1	physical	26496610
NU214_HUMAN	NUP214	physical	26496610
AAAS_HUMAN	AAAS	physical	26496610
NU155_HUMAN	NUP155	physical	26496610
NUP93_HUMAN	NUP93	physical	26496610
SAE2_HUMAN	UBA2	physical	26496610
SAE1_HUMAN	SAE1	physical	26496610
NXF1_HUMAN	NXF1	physical	26496610
KIF1B_HUMAN	KIF1B	physical	26496610
NU205_HUMAN	NUP205	physical	26496610
PO210_HUMAN	NUP210	physical	26496610
DTL_HUMAN	DTL	physical	26496610
NDC1_HUMAN	NDC1	physical	26496610
NU107_HUMAN	NUP107	physical	26496610
ISY1_HUMAN	ISY1	physical	26496610
PHAR4_HUMAN	PHACTR4	physical	26496610
NUP85_HUMAN	NUP85	physical	26496610
SEH1_HUMAN	SEH1L	physical	26496610
TM209_HUMAN	TMEM209	physical	26496610
NUP53_HUMAN	NUP35	physical	26496610
CDN1B_HUMAN	CDKN1B	physical	26450989
CFTR_HUMAN	CFTR	physical	26627832
TERF2_HUMAN	TERF2	physical	26450775
METK2_HUMAN	MAT2A	physical	26416353
TDG_HUMAN	TDG	physical	24753249
RAGP1_MOUSE	Rangap1	physical	24753249
SMUF2_HUMAN	SMURF2	physical	26679521
SLX4_HUMAN	SLX4	physical	25533188
NACC1_HUMAN	NACC1	physical	25891951
TBL1R_HUMAN	TBL1XR1	physical	26369384
TBL1X_HUMAN	TBL1X	physical	26369384
CDN2A_HUMAN	CDKN2A	physical	26578773
ARF_HUMAN	CDKN2A	physical	26578773
PSME3_HUMAN	PSME3	physical	21445096
EXO1_HUMAN	EXO1	physical	26083678
WWP2_HUMAN	WWP2	physical	27852060
PCGF2_HUMAN	PCGF2	physical	27030546
PML_HUMAN	PML	physical	27030546
LATS1_HUMAN	LATS1	physical	27847303
SAE2_HUMAN	UBA2	physical	28514442
RAGP1_HUMAN	RANGAP1	physical	28514442
SUMO2_HUMAN	SUMO2	physical	28514442
SAE1_HUMAN	SAE1	physical	28514442
SUMO3_HUMAN	SUMO3	physical	28514442
RBP2_HUMAN	RANBP2	physical	28514442
RAN_HUMAN	RAN	physical	28514442
RCC1_HUMAN	RCC1	physical	28514442
CACL1_HUMAN	CACUL1	physical	27889610
NR1H3_HUMAN	NR1H3	physical	27485016
GDIR1_HUMAN	ARHGDIA	physical	26719334
FUBP2_HUMAN	KHSRP	physical	29020972

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBC9_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-65, AND MASS SPECTROMETRY.	19608861 [Abstract]
Ubiquitylation
Reference	PubMed
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-18, AND MASSSPECTROMETRY.	18781797 [Abstract]

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