SEM6A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM6A_HUMAN
• UniProt AC: Q9H2E6
• Protein Name: Semaphorin-6A
• Gene Name: SEMA6A
• Organism: Homo sapiens (Human).
• Sequence Length: 1030
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity)..
• Protein Sequence: MRSEALLLYFTLLHFAGAGFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERYGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSTAQEGYESRGGMLDWKHLLDSPDSTDPLGAVSSHNHQDKKGVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGITVYCVCDHRRKDVAVVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPGNTAKMLIKADQHHLDLTALPTPESTPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGASLSQTGLSKRLEMHHSSSYGVDYKRSYPTNSLTRSHQATTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDACT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	PISISHGNYTKQYPV CEEEECCCEECEECE	35.56	32589945
49	N-linked_Glycosylation	VGHKPGRNTTQRHRL ECCCCCCCCCCCCCC	54.09	UniProtKB CARBOHYD
65	N-linked_Glycosylation	IQMIMIMNGTLYIAA EEEEEEECCEEEEEE	29.40	32589945
67	Phosphorylation	MIMIMNGTLYIAARD EEEEECCEEEEEECC	16.04	28122231
69	Phosphorylation	MIMNGTLYIAARDHI EEECCEEEEEECCCE	6.58	28122231
77	Phosphorylation	IAARDHIYTVDIDTS EEECCCEEEEECCCC	9.40	27732954
78	Phosphorylation	AARDHIYTVDIDTSH EECCCEEEEECCCCC	15.88	27732954
83	Phosphorylation	IYTVDIDTSHTEEIY EEEEECCCCCCCEEE	23.81	27732954
84	Phosphorylation	YTVDIDTSHTEEIYC EEEECCCCCCCEEEE	25.35	27732954
86	Phosphorylation	VDIDTSHTEEIYCSK EECCCCCCCEEEEEC	34.77	27732954
90	Phosphorylation	TSHTEEIYCSKKLTW CCCCCEEEEECCCCC	8.24	27732954
92	Phosphorylation	HTEEIYCSKKLTWKS CCCEEEEECCCCCCC	18.82	27732954
106	Phosphorylation	SRQADVDTCRMKGKH CCCCCHHHHHHCCCC	11.23	28152594
151	Phosphorylation	CRNYKMDTLEPFGDE HHCCCCCCCCCCCCC	29.53	-
183	Phosphorylation	LFADGKLYSATVTDF EECCCCEEEEEHHHH	10.35	27762562
198	Phosphorylation	LAIDAVIYRSLGESP HHHHHHHHHHCCCCC	6.37	27762562
204	Phosphorylation	IYRSLGESPTLRTVK HHHHCCCCCCCEEEC	22.76	-
231	Phosphorylation	QAVDYGDYIYFFFRE EECCCCCCEEEEEEE	7.99	30576142
233	Phosphorylation	VDYGDYIYFFFREIA CCCCCCEEEEEEEHH	6.52	30576142
243	Phosphorylation	FREIAVEYNTMGKVV EEEHHHHCCCCCCCC	14.88	30576142
265	Phosphorylation	CKNDMGGSQRVLEKQ HHCCCCCCHHHHHHH	14.75	25159151
275	Phosphorylation	VLEKQWTSFLKARLN HHHHHHHHHHHHHHC	26.14	24719451
282	N-linked_Glycosylation	SFLKARLNCSVPGDS HHHHHHHCCCCCCCC	15.51	UniProtKB CARBOHYD
352	Phosphorylation	EQKSPDSTWTPVPDE CCCCCCCCCCCCCCC	40.51	27762562
354	Phosphorylation	KSPDSTWTPVPDERV CCCCCCCCCCCCCCC	17.94	27762562
434	N-linked_Glycosylation	TAAGPYQNHTVVFLG CCCCCCCCCEEEEEC	27.27	32589945
461	N-linked_Glycosylation	IGNSGFLNDSLFLEE HCCCCCCCCCCEEEE	34.27	UniProtKB CARBOHYD
523	Ubiquitination	ERYGKCKKTCIASRD HHCCCCCCEEECCCC	59.09	-
637	Phosphorylation	KKGVIRESYLKGHDQ CCCCCCHHHHCCCCC	26.39	24719451
692	Phosphorylation	QRKEKELTHSRRGSM ECHHHHCCCCCCCCH	20.92	24719451
694	Phosphorylation	KEKELTHSRRGSMSS HHHHCCCCCCCCHHH	20.59	24173317
698	Phosphorylation	LTHSRRGSMSSVTKL CCCCCCCCHHHHHHH	17.43	21406692
700	Phosphorylation	HSRRGSMSSVTKLSG CCCCCCHHHHHHHHH	24.29	21406692
701	Phosphorylation	SRRGSMSSVTKLSGL CCCCCHHHHHHHHHH	25.76	21406692
703	Phosphorylation	RGSMSSVTKLSGLFG CCCHHHHHHHHHHCC	28.37	21406692
706	Phosphorylation	MSSVTKLSGLFGDTQ HHHHHHHHHHCCCCC	34.70	21406692
711 (in isoform 2)	Phosphorylation	-	33.95	21406692
712	Phosphorylation	LSGLFGDTQSKDPKP HHHHCCCCCCCCCCC	34.81	21406692
714	Phosphorylation	GLFGDTQSKDPKPEA HHCCCCCCCCCCCCC	40.91	21406692
715	Phosphorylation	LFGDTQSKDPKPEAI HCCCCCCCCCCCCCE	69.13	-
715 (in isoform 2)	Phosphorylation	-	69.13	21406692
717 (in isoform 2)	Phosphorylation	-	58.81	21406692
718	Phosphorylation	DTQSKDPKPEAILTP CCCCCCCCCCCEECC	66.67	-
718 (in isoform 2)	Phosphorylation	-	66.67	21406692
723	Phosphorylation	DPKPEAILTPLMHNG CCCCCCEECCCEECC	5.34	-
723 (in isoform 2)	Phosphorylation	-	5.34	21406692
753	Phosphorylation	DQHHLDLTALPTPES HHCCCCCCCCCCCCC	26.30	21406692
757	Phosphorylation	LDLTALPTPESTPTL CCCCCCCCCCCCCCH	40.30	30266825
760	Phosphorylation	TALPTPESTPTLQQK CCCCCCCCCCCHHHH	40.67	30266825
761	Phosphorylation	ALPTPESTPTLQQKR CCCCCCCCCCHHHHC	20.73	30266825
763	Phosphorylation	PTPESTPTLQQKRKP CCCCCCCCHHHHCCC	36.97	30266825
774 (in isoform 2)	Phosphorylation	-	26.39	21406692
774	Phosphorylation	KRKPSRGSREWERNQ HCCCCCCCHHHHHHH	26.39	-
777 (in isoform 2)	Phosphorylation	-	14.56	21406692
801	Phosphorylation	MGSPVIPTDLPLRAS CCCCCCCCCCCCCCC	38.76	28348404
808	Phosphorylation	TDLPLRASPSHIPSV CCCCCCCCCCCCCEE	22.09	29116813
810	Phosphorylation	LPLRASPSHIPSVVV CCCCCCCCCCCEEEE	31.39	29116813
814	Phosphorylation	ASPSHIPSVVVLPIT CCCCCCCEEEEEECC	27.26	27732954
829	Phosphorylation	QQGYQHEYVDQPKMS CCCCCCCCCCCCCHH	13.75	-
852	Phosphorylation	DQAATLEYKTIKEHL HHHHHHHHHHHHHHH	19.28	-
869	Phosphorylation	KSPNHGVNLVENLDS CCCCCCCCHHHCHHH	42.85	-
876	Phosphorylation	NLVENLDSLPPKVPQ CHHHCHHHCCCCCCC	46.04	27251275
887	Phosphorylation	KVPQREASLGPPGAS CCCCCHHHCCCCCCC	29.16	22210691
893	Phosphorylation	ASLGPPGASLSQTGL HHCCCCCCCHHHCCH	17.05	-
898	Phosphorylation	PGASLSQTGLSKRLE CCCCHHHCCHHHHHH	36.39	22210691
901	Phosphorylation	SLSQTGLSKRLEMHH CHHHCCHHHHHHHHC	19.64	28555341
904	Phosphorylation	QTGLSKRLEMHHSSS HCCHHHHHHHHCCCC	8.66	-
912	Phosphorylation	EMHHSSSYGVDYKRS HHHCCCCCCCCCCCC	24.10	25884760
916	Phosphorylation	SSSYGVDYKRSYPTN CCCCCCCCCCCCCCC	13.09	25884760
922	Phosphorylation	DYKRSYPTNSLTRSH CCCCCCCCCCCCHHH	29.25	25884760
924	Phosphorylation	KRSYPTNSLTRSHQA CCCCCCCCCCHHHCC	33.33	23403867
929	Phosphorylation	TNSLTRSHQATTLKR CCCCCHHHCCCCCCC	20.29	-
933	Phosphorylation	TRSHQATTLKRNNTN CHHHCCCCCCCCCCC	33.04	-
939	Phosphorylation	TTLKRNNTNSSNSSH CCCCCCCCCCCCCCC	39.77	28857561
941	Phosphorylation	LKRNNTNSSNSSHLS CCCCCCCCCCCCCCC	28.94	-
952	Phosphorylation	SHLSRNQSFGRGDNP CCCCCCCCCCCCCCC	32.97	10993894
956	Phosphorylation	RNQSFGRGDNPPPAP CCCCCCCCCCCCCCC	39.15	-
968	Phosphorylation	PAPQRVDSIQVHSSQ CCCCCCCEEEEECCC	16.44	28857561
969 (in isoform 2)	Phosphorylation	-	4.25	21406692
969	Phosphorylation	APQRVDSIQVHSSQP CCCCCCEEEEECCCC	4.25	-
973	Phosphorylation	VDSIQVHSSQPSGQA CCEEEEECCCCCCCE	31.63	21406692
974	Phosphorylation	DSIQVHSSQPSGQAV CEEEEECCCCCCCEE	31.09	21406692
977	Phosphorylation	QVHSSQPSGQAVTVS EEECCCCCCCEEEEE	35.58	21406692
982	Phosphorylation	QPSGQAVTVSRQPSL CCCCCEEEEECCCCC	18.77	21406692
984	Phosphorylation	SGQAVTVSRQPSLNA CCCEEEEECCCCCHH	18.81	21406692
988	Phosphorylation	VTVSRQPSLNAYNSL EEEECCCCCHHHHCC	26.39	21406692
990 (in isoform 2)	Phosphorylation	-	44.72	21406692
992	Phosphorylation	RQPSLNAYNSLTRSG CCCCCHHHHCCCCCC	12.29	25884760
994	Phosphorylation	PSLNAYNSLTRSGLK CCCHHHHCCCCCCCC	20.59	23312004
996	Phosphorylation	LNAYNSLTRSGLKRT CHHHHCCCCCCCCCC	23.70	-
998	Phosphorylation	AYNSLTRSGLKRTPS HHHCCCCCCCCCCCC	43.15	-
1005	Phosphorylation	SGLKRTPSLKPDVPP CCCCCCCCCCCCCCC	48.70	29116813
1005 (in isoform 2)	Phosphorylation	-	48.70	21406692
1007	Acetylation	LKRTPSLKPDVPPKP CCCCCCCCCCCCCCC	43.43	7677947
1009	Phosphorylation	RTPSLKPDVPPKPSF CCCCCCCCCCCCCCC	65.06	-
1011	Phosphorylation	PSLKPDVPPKPSFAP CCCCCCCCCCCCCCC	38.28	-
1024	Acetylation	APLSTSMKPNDACT- CCCCCCCCCCCCCC-	40.20	7677957

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM6A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM6A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM6A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EVL_HUMAN	EVL	physical	10993894
SRBS2_HUMAN	SORBS2	physical	12421765
ITSN2_HUMAN	ITSN2	physical	12421765
SRBS1_HUMAN	SORBS1	physical	12421765
SH3R1_HUMAN	SH3RF1	physical	12421765

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.