PPM1J_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPM1J_HUMAN
• UniProt AC: Q5JR12
• Protein Name: Protein phosphatase 1J
• Gene Name: PPM1J
• Organism: Homo sapiens (Human).
• Sequence Length: 505
• Protein Sequence: MLNRVRSAVAHLVSSGGAPPPRPKSPDLPNAASAPPAAAPEAPRSPPAKAGSGSATPAKAVEARASFSRPTFLQLSPGGLRRADDHAGRAVQSPPDTGRRLPWSTGYAEVINAGKSRHNEDQACCEVVYVEGRRSVTGVPREPSRGQGLCFYYWGLFDGHAGGGAAEMASRLLHRHIREQLKDLVEILQDPSPPPLCLPTTPGTPDSSDPSHLLGPQSCWSSQKEVSHESLVVGAVENAFQLMDEQMARERRGHQVEGGCCALVVIYLLGKVYVANAGDSRAIIVRNGEIIPMSREFTPETERQRLQLLGFLKPELLGSEFTHLEFPRRVLPKELGQRMLYRDQNMTGWAYKKIELEDLRFPLVCGEGKKARVMATIGVTRGLGDHSLKVCSSTLPIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTTDCEVAATVDRVLSAYEPNDHSRYTALAQALVLGARGTPRDRGWRLPNNKLGSGDDISVFVIPLGGPGSYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLNRVRSAVAHLVS -CHHHHHHHHHHHHH	25.00	26437602
25	Phosphorylation	APPPRPKSPDLPNAA CCCCCCCCCCCCCCC	26.74	30266825
33	Phosphorylation	PDLPNAASAPPAAAP CCCCCCCCCCCCCCC	38.61	29255136
45	Phosphorylation	AAPEAPRSPPAKAGS CCCCCCCCCCCCCCC	33.89	25849741
54	Phosphorylation	PAKAGSGSATPAKAV CCCCCCCCCCHHHHH	30.57	-
56	Phosphorylation	KAGSGSATPAKAVEA CCCCCCCCHHHHHHH	26.02	-
66	Phosphorylation	KAVEARASFSRPTFL HHHHHHHHCCCCCEE	20.43	30266825
68	Phosphorylation	VEARASFSRPTFLQL HHHHHHCCCCCEEEC	34.55	30266825
71	Phosphorylation	RASFSRPTFLQLSPG HHHCCCCCEEECCCC	35.55	30266825
76	Phosphorylation	RPTFLQLSPGGLRRA CCCEEECCCCCCCCC	14.45	30266825
135	Phosphorylation	VYVEGRRSVTGVPRE EEEECCCEEECCCCC	23.75	27134283
200	Phosphorylation	PPPLCLPTTPGTPDS CCCCCCCCCCCCCCC	32.45	28348404
201	Phosphorylation	PPLCLPTTPGTPDSS CCCCCCCCCCCCCCC	20.13	28348404
204	Phosphorylation	CLPTTPGTPDSSDPS CCCCCCCCCCCCCHH	25.73	27251275
273	Phosphorylation	IYLLGKVYVANAGDS HHHHCCEEEECCCCC	9.42	21406692
280	Phosphorylation	YVANAGDSRAIIVRN EEECCCCCCEEEEEC	23.77	21406692
313	Ubiquitination	LQLLGFLKPELLGSE HHHHHCCCHHHCCCC	33.90	-
352	Acetylation	NMTGWAYKKIELEDL CCCCCEEEEEEHHHC	39.26	7427325
353	Acetylation	MTGWAYKKIELEDLR CCCCEEEEEEHHHCC	28.83	7427335
458	Phosphorylation	EPNDHSRYTALAQAL CCCCHHHHHHHHHHH	10.20	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPM1J_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPM1J_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPM1J_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARP3_HUMAN	ACTR3	physical	27880917
BAX_HUMAN	BAX	physical	27880917
DPYL3_HUMAN	DPYSL3	physical	27880917
NUFP2_HUMAN	NUFIP2	physical	27880917
PPM1H_HUMAN	PPM1H	physical	27880917
PPM1M_HUMAN	PPM1M	physical	27880917
SLTM_HUMAN	SLTM	physical	27880917
TCPH_HUMAN	CCT7	physical	27880917
TCPB_HUMAN	CCT2	physical	27880917
TCPE_HUMAN	CCT5	physical	27880917
TCPG_HUMAN	CCT3	physical	27880917
TCPA_HUMAN	TCP1	physical	27880917
TCPD_HUMAN	CCT4	physical	27880917

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, AND MASSSPECTROMETRY.
PubMed: 18669648