| UniProt ID | PPM1H_HUMAN | |
|---|---|---|
| UniProt AC | Q9ULR3 | |
| Protein Name | Protein phosphatase 1H | |
| Gene Name | PPM1H | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 514 | |
| Subcellular Localization | Nucleus . Cytoplasm . | |
| Protein Description | Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.. | |
| Protein Sequence | MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDILKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MLTRVKSAVANFMG -CCHHHHHHHHHHHC | 25.72 | 28857561 | |
| 95 | Ubiquitination | KSTHNEDQASCEVLT CCCCCCCCCCCEEEE | 29.06 | 24816145 | |
| 104 | Ubiquitination | SCEVLTVKKKAGAVT CCEEEEEEECCCCCC | 43.23 | 29967540 | |
| 111 | Phosphorylation | KKKAGAVTSTPNRNS EECCCCCCCCCCCCC | 26.75 | 28152594 | |
| 112 | Phosphorylation | KKAGAVTSTPNRNSS ECCCCCCCCCCCCCC | 34.96 | 28102081 | |
| 113 | Phosphorylation | KAGAVTSTPNRNSSK CCCCCCCCCCCCCCC | 18.41 | 23401153 | |
| 118 | Phosphorylation | TSTPNRNSSKRRSSL CCCCCCCCCCCCCCC | 33.72 | 25159151 | |
| 119 | Phosphorylation | STPNRNSSKRRSSLP CCCCCCCCCCCCCCC | 33.46 | 25262027 | |
| 123 | Phosphorylation | RNSSKRRSSLPNGEG CCCCCCCCCCCCCCC | 40.01 | 23401153 | |
| 124 | Phosphorylation | NSSKRRSSLPNGEGL CCCCCCCCCCCCCCE | 46.14 | 29255136 | |
| 199 | Phosphorylation | LGEEPENTPANSRTL CCCCCCCCCCCCHHH | 23.32 | 26074081 | |
| 203 | Phosphorylation | PENTPANSRTLTRAA CCCCCCCCHHHHHHH | 28.84 | 26074081 | |
| 205 | Phosphorylation | NTPANSRTLTRAASL CCCCCCHHHHHHHHH | 32.10 | 26074081 | |
| 207 | Phosphorylation | PANSRTLTRAASLRG CCCCHHHHHHHHHCC | 20.04 | 26074081 | |
| 211 | Phosphorylation | RTLTRAASLRGGVGA HHHHHHHHHCCCCCC | 20.02 | 23401153 | |
| 213 | Methylation | LTRAASLRGGVGAPG HHHHHHHCCCCCCCC | 37.01 | 16186173 | |
| 221 | Phosphorylation | GGVGAPGSPSTPPTR CCCCCCCCCCCCCCC | 18.02 | 23401153 | |
| 223 | Phosphorylation | VGAPGSPSTPPTRFF CCCCCCCCCCCCCCC | 56.07 | 29255136 | |
| 224 | Phosphorylation | GAPGSPSTPPTRFFT CCCCCCCCCCCCCCC | 36.35 | 29255136 | |
| 227 | Phosphorylation | GSPSTPPTRFFTEKK CCCCCCCCCCCCCCC | 41.11 | 29255136 | |
| 289 | Phosphorylation | YVANAGDSRAIIIRN HHCCCCCCCEEEEEC | 23.77 | - | |
| 308 | Ubiquitination | PMSSEFTPETERQRL CCCCCCCCHHHHHHH | 52.40 | 24816145 | |
| 342 | Acetylation | FPRRVQRKELGKKML CCHHHHHHHHHHHHH | 39.95 | 22361687 | |
| 346 | Ubiquitination | VQRKELGKKMLYRDF HHHHHHHHHHHHHHH | 47.86 | 24816145 | |
| 346 | Acetylation | VQRKELGKKMLYRDF HHHHHHHHHHHHHHH | 47.86 | 22361243 | |
| 369 | Ubiquitination | TIEDEDLKFPLIYGE ECCCCCCCCCEEECC | 58.20 | 29967540 | |
| 419 | Phosphorylation | SAPEVRIYDLSKYDH CCCEEEEEEHHHCCC | 10.56 | 18669648 | |
| 422 | Phosphorylation | EVRIYDLSKYDHGSD EEEEEEHHHCCCCCC | 26.69 | 22586611 | |
| 476 | Sulfoxidation | LAAQDLVMRARGVLK HHHHHHHHHHHHHHH | 3.45 | 21406390 | |
| 490 | Phosphorylation | KDRGWRISNDRLGSG HHCCEEECCCCCCCC | 24.89 | 24719451 | |
| 496 | Phosphorylation | ISNDRLGSGDDISVY ECCCCCCCCCCEEEE | 43.57 | 28348404 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PPM1H_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPM1H_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPM1H_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASSSPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-211; SER-221;THR-224; TYR-419 AND SER-422, AND MASS SPECTROMETRY. | |
