ZBT21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT21_HUMAN
• UniProt AC: Q9ULJ3
• Protein Name: Zinc finger and BTB domain-containing protein 21
• Gene Name: ZBTB21
• Organism: Homo sapiens (Human).
• Sequence Length: 1066
• Subcellular Localization: Nucleus . Colocalizes with ZBTB14 in nucleus in HEK293 cells.
• Protein Description: Acts as a transcription repressor..
• Protein Sequence: MEGLLHYINPAHAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTNKENESQTVFQLDFCEPDAFDNVLNYIYSSSLFVEKSSLAAVQELGYSLGISFLTNIVSKTPQAPFPTCPNRKKVFVEDDENSSQKRSVIVCQSRNEAQGKTVSQNQPDVSHTSRPSPSIAVKANTNKPHVPKPIEPLHNLSLTEKSWPKDSSVVYAKSLEHSGSLDDPNRISLVKRNAVLPSKPLQDREAMDDKPGVSGQLPKGKALELALKRPRPPVLSVCSSSETPYLLKETNKGNGQGEDRNLLYYSKLGLVIPSSGSGSGNQSIDRSGPLVKSLLRRSLSMDSQVPVYSPSIDLKSSQGSSSVSSDAPGNVLCALSQKSSLKDCSEKTALDDRPQVLQPHRLRSFSASQSTDREGASPVTEVRIKTEPSSPLSDPSDIIRVTVGDAATTAAASSSSVTRDLSLKTEDDQKDMSRLPAKRRFQADRRLPFKKLKVNEHGSPVSEDNFEEGSSPTLLDADFPDSDLNKDEFGELEGTRPNKKFKCKHCLKIFRSTAGLHRHVNMYHNPEKPYACDICHKRFHTNFKVWTHCQTQHGIVKNPSPASSSHAVLDEKFQRKLIDIVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKRNLRSRAKGAYICTYCGKAYRFLSQFKQHIKMHPGEKPLGVNKVAKPKEHAPLASPVENKEVYQCRLCNAKLSSLLEQGSHERLCRNAAVCPYCSLRFFSPELKQEHESKCEYKKLTCLECMRTFKSSFSIWRHQVEVHNQNNMAPTENFSLPVLDHNGDVTGSSRPQSQPEPNKVNHIVTTKDDNVFSDSSEQVNFDSEDSSCLPEDLSLSKQLKIQVKEEPVEEAEEEAPEASTAPKEAGPSKEASLWPCEKCGKMFTVHKQLERHQELLCSVKPFICHVCNKAFRTNFRLWSHFQSHMSQASEESAHKESEVCPVPTNSPSPPPLPPPPPLPKIQPLEPDSPTGLSENPTPATEKLFVPQESDTLFYHAPPLSAITFKRQFMCKLCHRTFKTAFSLWSHEQTHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Sumoylation	LLIVGDQKFRAHKNV EEEECCHHHHHCCCH		-
40	Sumoylation	LLIVGDQKFRAHKNV EEEECCHHHHHCCCH		25114211
121	Phosphorylation	LTNIVSKTPQAPFPT HHHHHCCCCCCCCCC		28555341
143	Phosphorylation	FVEDDENSSQKRSVI EEECCCCCCCEEEEE		25159151
144	Phosphorylation	VEDDENSSQKRSVIV EECCCCCCCEEEEEE		25159151
148	Phosphorylation	ENSSQKRSVIVCQSR CCCCCEEEEEEECCC		28188228
161	Acetylation	SRNEAQGKTVSQNQP CCCHHCCCCCCCCCC		26051181
162	Phosphorylation	RNEAQGKTVSQNQPD CCHHCCCCCCCCCCC		26074081
164	Phosphorylation	EAQGKTVSQNQPDVS HHCCCCCCCCCCCCC		26074081
171	Phosphorylation	SQNQPDVSHTSRPSP CCCCCCCCCCCCCCC		26074081
173	Phosphorylation	NQPDVSHTSRPSPSI CCCCCCCCCCCCCCE		25159151
174	Phosphorylation	QPDVSHTSRPSPSIA CCCCCCCCCCCCCEE		25159151
177	Phosphorylation	VSHTSRPSPSIAVKA CCCCCCCCCCEEEEC		30576142
179	Phosphorylation	HTSRPSPSIAVKANT CCCCCCCCEEEECCC		25159151
202	Phosphorylation	IEPLHNLSLTEKSWP CCCCCCCCCCCCCCC		25159151
204	Phosphorylation	PLHNLSLTEKSWPKD CCCCCCCCCCCCCCC		25627689
219	Phosphorylation	SSVVYAKSLEHSGSL CCEEEEEECCCCCCC		25159151
223	Phosphorylation	YAKSLEHSGSLDDPN EEEECCCCCCCCCCC		29978859
225	Phosphorylation	KSLEHSGSLDDPNRI EECCCCCCCCCCCCE		25159151
233	Phosphorylation	LDDPNRISLVKRNAV CCCCCCEEEEECCCC		25159151
243	Phosphorylation	KRNAVLPSKPLQDRE ECCCCCCCCCCCCHH		24719451
244	Acetylation	RNAVLPSKPLQDREA CCCCCCCCCCCCHHH		25953088
255	Sumoylation	DREAMDDKPGVSGQL CHHHHCCCCCCCCCC		28112733
266	Sumoylation	SGQLPKGKALELALK CCCCCCCHHHHHHHC		28112733
273	Acetylation	KALELALKRPRPPVL HHHHHHHCCCCCCEE		25953088
273	Sumoylation	KALELALKRPRPPVL HHHHHHHCCCCCCEE		28112733
281	Phosphorylation	RPRPPVLSVCSSSET CCCCCEEEEECCCCC		27251275
284	Phosphorylation	PPVLSVCSSSETPYL CCEEEEECCCCCCCE		29449344
285	Phosphorylation	PVLSVCSSSETPYLL CEEEEECCCCCCCEE		29449344
286	Phosphorylation	VLSVCSSSETPYLLK EEEEECCCCCCCEEE		29449344
288	Phosphorylation	SVCSSSETPYLLKET EEECCCCCCCEEECC		29449344
309	Phosphorylation	GEDRNLLYYSKLGLV CCCCCEEEEEEEEEE		-
312	Sumoylation	RNLLYYSKLGLVIPS CCEEEEEEEEEEECC		28112733
319	Phosphorylation	KLGLVIPSSGSGSGN EEEEEECCCCCCCCC		28348404
320	Phosphorylation	LGLVIPSSGSGSGNQ EEEEECCCCCCCCCC		25159151
322	Phosphorylation	LVIPSSGSGSGNQSI EEECCCCCCCCCCCC		25159151
324	Phosphorylation	IPSSGSGSGNQSIDR ECCCCCCCCCCCCCC		25627689
328	Phosphorylation	GSGSGNQSIDRSGPL CCCCCCCCCCCCCHH		25159151
332	Phosphorylation	GNQSIDRSGPLVKSL CCCCCCCCCHHHHHH		24719451
337	Sumoylation	DRSGPLVKSLLRRSL CCCCHHHHHHHHHHC		28112733
338	Phosphorylation	RSGPLVKSLLRRSLS CCCHHHHHHHHHHCC		27174698
343	Phosphorylation	VKSLLRRSLSMDSQV HHHHHHHHCCCCCCC		23927012
345	Phosphorylation	SLLRRSLSMDSQVPV HHHHHHCCCCCCCCE		25159151
348	Phosphorylation	RRSLSMDSQVPVYSP HHHCCCCCCCCEECC		30266825
353	Phosphorylation	MDSQVPVYSPSIDLK CCCCCCEECCCEECC		23927012
354	Phosphorylation	DSQVPVYSPSIDLKS CCCCCEECCCEECCC		23927012
356	Phosphorylation	QVPVYSPSIDLKSSQ CCCEECCCEECCCCC		23927012
361	Phosphorylation	SPSIDLKSSQGSSSV CCCEECCCCCCCCCC		17525332
362	Phosphorylation	PSIDLKSSQGSSSVS CCEECCCCCCCCCCC		17525332
365	Phosphorylation	DLKSSQGSSSVSSDA ECCCCCCCCCCCCCC		21130716
367	Phosphorylation	KSSQGSSSVSSDAPG CCCCCCCCCCCCCCC		28555341
369	Phosphorylation	SQGSSSVSSDAPGNV CCCCCCCCCCCCCCE		-
370	Phosphorylation	QGSSSVSSDAPGNVL CCCCCCCCCCCCCEE		-
381	Phosphorylation	GNVLCALSQKSSLKD CCEEEHHHCCCCCCC		17525332
383	Sumoylation	VLCALSQKSSLKDCS EEEHHHCCCCCCCCC		28112733
398	Methylation	EKTALDDRPQVLQPH CCCCCCCCCCCCCHH		115920441
409	Phosphorylation	LQPHRLRSFSASQST CCHHHHHCCCCCCCC		30266825
411	Phosphorylation	PHRLRSFSASQSTDR HHHHHCCCCCCCCCC		29255136
413	Phosphorylation	RLRSFSASQSTDREG HHHCCCCCCCCCCCC		17525332
415	Phosphorylation	RSFSASQSTDREGAS HCCCCCCCCCCCCCC		30278072
416	Phosphorylation	SFSASQSTDREGASP CCCCCCCCCCCCCCC		30278072
422	Phosphorylation	STDREGASPVTEVRI CCCCCCCCCCEEEEE		29255136
425	Phosphorylation	REGASPVTEVRIKTE CCCCCCCEEEEEECC		30278072
430	Sumoylation	PVTEVRIKTEPSSPL CCEEEEEECCCCCCC		-
430	Sumoylation	PVTEVRIKTEPSSPL CCEEEEEECCCCCCC		28112733
431	Phosphorylation	VTEVRIKTEPSSPLS CEEEEEECCCCCCCC		29255136
434	Phosphorylation	VRIKTEPSSPLSDPS EEEECCCCCCCCCHH		29255136
435	Phosphorylation	RIKTEPSSPLSDPSD EEECCCCCCCCCHHH		29255136
438	Phosphorylation	TEPSSPLSDPSDIIR CCCCCCCCCHHHCEE		29255136
441	Phosphorylation	SSPLSDPSDIIRVTV CCCCCCHHHCEEEEC		23927012
447	O-linked_Glycosylation	PSDIIRVTVGDAATT HHHCEEEECCHHHHH		30379171
453	Phosphorylation	VTVGDAATTAAASSS EECCHHHHHHHHCCC		27273156
454	Phosphorylation	TVGDAATTAAASSSS ECCHHHHHHHHCCCC		27273156
459	Phosphorylation	ATTAAASSSSVTRDL HHHHHHCCCCCCCCC		25627689
460	Phosphorylation	TTAAASSSSVTRDLS HHHHHCCCCCCCCCC		25627689
461	Phosphorylation	TAAASSSSVTRDLSL HHHHCCCCCCCCCCC		25627689
467	Phosphorylation	SSVTRDLSLKTEDDQ CCCCCCCCCCCCCCH		-
469	Sumoylation	VTRDLSLKTEDDQKD CCCCCCCCCCCCHHH		-
469	Sumoylation	VTRDLSLKTEDDQKD CCCCCCCCCCCCHHH		28112733
475	Sumoylation	LKTEDDQKDMSRLPA CCCCCCHHHHHCCCH		28112733
478	Phosphorylation	EDDQKDMSRLPAKRR CCCHHHHHCCCHHHH		23911959
495	Acetylation	ADRRLPFKKLKVNEH CCCCCCCCCCCCCCC		24469731
504	Phosphorylation	LKVNEHGSPVSEDNF CCCCCCCCCCCCCCC		25159151
504 (in isoform 2)	Phosphorylation	-		25921289
507	Phosphorylation	NEHGSPVSEDNFEEG CCCCCCCCCCCCCCC		30576142
507 (in isoform 2)	Phosphorylation	-		25921289
515	Phosphorylation	EDNFEEGSSPTLLDA CCCCCCCCCCCEECC		30576142
516	Phosphorylation	DNFEEGSSPTLLDAD CCCCCCCCCCEECCC		30576142
516 (in isoform 2)	Phosphorylation	-		24247654
518	Phosphorylation	FEEGSSPTLLDADFP CCCCCCCCEECCCCC		30576142
527	Phosphorylation	LDADFPDSDLNKDEF ECCCCCCCCCCHHHC		26074081
538 (in isoform 2)	Phosphorylation	-		25159151
602	Ubiquitination	QTQHGIVKNPSPASS CCCCCEECCCCCCCC		-
605	Phosphorylation	HGIVKNPSPASSSHA CCEECCCCCCCCCCH		29255136
608	Phosphorylation	VKNPSPASSSHAVLD ECCCCCCCCCCHHHC		24732914
609	Phosphorylation	KNPSPASSSHAVLDE CCCCCCCCCCHHHCH		24732914
610	Phosphorylation	NPSPASSSHAVLDEK CCCCCCCCCHHHCHH		24732914
617	Sumoylation	SHAVLDEKFQRKLID CCHHHCHHHHHHHHH		-
617	Sumoylation	SHAVLDEKFQRKLID CCHHHCHHHHHHHHH		28112733
617	Ubiquitination	SHAVLDEKFQRKLID CCHHHCHHHHHHHHH		-
643	Ubiquitination	IIKLRRGKPGFQGQS HHHHHCCCCCCCCCC		-
643	Acetylation	IIKLRRGKPGFQGQS HHHHHCCCCCCCCCC		26051181
643	Sumoylation	IIKLRRGKPGFQGQS HHHHHCCCCCCCCCC		28112733
659	Sumoylation	SQAQQVIKRNLRSRA HHHHHHHHHHHHHHC		28112733
702	Sumoylation	EKPLGVNKVAKPKEH CCCCCCCCCCCCCCC		28112733
714	Phosphorylation	KEHAPLASPVENKEV CCCCCCCCCCCCCCH		29255136
722	Phosphorylation	PVENKEVYQCRLCNA CCCCCCHHHHHHCCH		28111955
730	Acetylation	QCRLCNAKLSSLLEQ HHHHCCHHHHHHHHC		25953088
739	Phosphorylation	SSLLEQGSHERLCRN HHHHHCCCHHHHHCH		25159151
754	Phosphorylation	AAVCPYCSLRFFSPE HCCCCHHHHHHCCHH		28555341
759	Phosphorylation	YCSLRFFSPELKQEH HHHHHHCCHHHHHHH		22617229
763	Sumoylation	RFFSPELKQEHESKC HHCCHHHHHHHHHHC		28112733
770	S-palmitoylation	KQEHESKCEYKKLTC HHHHHHHCCHHHCHH		29575903
776	Phosphorylation	KCEYKKLTCLECMRT HCCHHHCHHHHHHHH		29759185
777	S-palmitoylation	CEYKKLTCLECMRTF CCHHHCHHHHHHHHH		29575903
780	S-palmitoylation	KKLTCLECMRTFKSS HHCHHHHHHHHHHHH		29575903
783	Phosphorylation	TCLECMRTFKSSFSI HHHHHHHHHHHHHHH		29759185
785	Sumoylation	LECMRTFKSSFSIWR HHHHHHHHHHHHHEE		28112733
789	Phosphorylation	RTFKSSFSIWRHQVE HHHHHHHHHEEEEEE		24719451
848	Phosphorylation	TKDDNVFSDSSEQVN ECCCCCCCCCCCCCC		24144214
850	Phosphorylation	DDNVFSDSSEQVNFD CCCCCCCCCCCCCCC		24144214
851	Phosphorylation	DNVFSDSSEQVNFDS CCCCCCCCCCCCCCC		24144214
858	Phosphorylation	SEQVNFDSEDSSCLP CCCCCCCCCCCCCCC		20068231
861	Phosphorylation	VNFDSEDSSCLPEDL CCCCCCCCCCCCCCC		20068231
862	Phosphorylation	NFDSEDSSCLPEDLS CCCCCCCCCCCCCCC		24144214
869	Phosphorylation	SCLPEDLSLSKQLKI CCCCCCCCCCHHHCE		20068231
871	Phosphorylation	LPEDLSLSKQLKIQV CCCCCCCCHHHCEEE		20068231
875	Sumoylation	LSLSKQLKIQVKEEP CCCCHHHCEEEECCC		28112733
879	Sumoylation	KQLKIQVKEEPVEEA HHHCEEEECCCHHHH		-
879	Sumoylation	KQLKIQVKEEPVEEA HHHCEEEECCCHHHH		25114211
879	Acetylation	KQLKIQVKEEPVEEA HHHCEEEECCCHHHH		26051181
935	Sumoylation	QELLCSVKPFICHVC HHHHHHCHHHHHHHC		28112733
972	Phosphorylation	EESAHKESEVCPVPT HHHHHCCCCCCCCCC		23927012
979	Phosphorylation	SEVCPVPTNSPSPPP CCCCCCCCCCCCCCC		29255136
981	Phosphorylation	VCPVPTNSPSPPPLP CCCCCCCCCCCCCCC		29255136
983	Phosphorylation	PVPTNSPSPPPLPPP CCCCCCCCCCCCCCC		29255136
1003	Phosphorylation	IQPLEPDSPTGLSEN CCCCCCCCCCCCCCC		29255136
1005	Phosphorylation	PLEPDSPTGLSENPT CCCCCCCCCCCCCCC		29255136
1008	Phosphorylation	PDSPTGLSENPTPAT CCCCCCCCCCCCCCC		28176443
1012	Phosphorylation	TGLSENPTPATEKLF CCCCCCCCCCCCCCC		23403867
1015	Phosphorylation	SENPTPATEKLFVPQ CCCCCCCCCCCCCCC		23403867
1029	Phosphorylation	QESDTLFYHAPPLSA CCCCCEEECCCCCCH		27642862
1038	Phosphorylation	APPLSAITFKRQFMC CCCCCHHHHHHHHHH		-
1040	Acetylation	PLSAITFKRQFMCKL CCCHHHHHHHHHHHH		30593687

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT21_HUMAN	ZBTB21	physical	15629158
KI13B_HUMAN	KIF13B	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
CING_HUMAN	CGN	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
NADK_HUMAN	NADK	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
RGPS2_HUMAN	RALGPS2	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
RPTOR_HUMAN	RPTOR	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435
MELK_HUMAN	MELK	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
HDAC7_HUMAN	HDAC7	physical	27173435
MFR1L_HUMAN	MTFR1L	physical	27173435
KIF1B_HUMAN	KIF1B	physical	27173435
AFAD_HUMAN	MLLT4	physical	27173435
HDAC5_HUMAN	HDAC5	physical	27173435
TBCD1_HUMAN	TBC1D1	physical	27173435
PANK2_HUMAN	PANK2	physical	27173435
REEP3_HUMAN	REEP3	physical	27173435
CRTC3_HUMAN	CRTC3	physical	27173435
CRTC2_HUMAN	CRTC2	physical	27173435
DCP1A_HUMAN	DCP1A	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.