dbPTM

NADK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NADK_HUMAN
UniProt AC	O95544
Protein Name	NAD kinase
Gene Name	NADK
Organism	Homo sapiens (Human).
Sequence Length	446
Subcellular Localization
Protein Description
Protein Sequence	MEMEQEKMTMNKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGKKTAVHNGLGENGSQAAGLDMDVGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSDWFESLAQCLHWNVRKKQAHFEEEEEEEEEG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	EMEQEKMTMNKELSP CHHHHHHHCCCCCCH	28.76	30576142
15	Phosphorylation	MTMNKELSPDAAAYC HHCCCCCCHHHHHHH	23.09	30576142
31	Phosphorylation	SACHGDETWSYNHPI HHHCCCCCCCCCCCC	25.17	30576142
44	Phosphorylation	PIRGRAKSRSLSASP CCCCCCCCCCCCCCC	26.56	25159151
45	Methylation	IRGRAKSRSLSASPA CCCCCCCCCCCCCCC	40.69	115484421
46	Phosphorylation	RGRAKSRSLSASPAL CCCCCCCCCCCCCCC	33.49	22167270
48	Phosphorylation	RAKSRSLSASPALGS CCCCCCCCCCCCCCC	28.13	22167270
50	Phosphorylation	KSRSLSASPALGSTK CCCCCCCCCCCCCCH	13.82	22167270
55	Phosphorylation	SASPALGSTKEFRRT CCCCCCCCCHHHHHH	36.84	22167270
56	Phosphorylation	ASPALGSTKEFRRTR CCCCCCCCHHHHHHH	32.56	23403867
57	Ubiquitination	SPALGSTKEFRRTRS CCCCCCCHHHHHHHH	57.46	21890473
57	Ubiquitination	SPALGSTKEFRRTRS CCCCCCCHHHHHHHH	57.46	21890473
57	Ubiquitination	SPALGSTKEFRRTRS CCCCCCCHHHHHHHH	57.46	2189047
62	Phosphorylation	STKEFRRTRSLHGPC CCHHHHHHHHCCCCC	21.98	23401153
64	Phosphorylation	KEFRRTRSLHGPCPV HHHHHHHHCCCCCCC	24.89	23927012
72	Phosphorylation	LHGPCPVTTFGPKAC CCCCCCCCCCCCCEE	11.10	30266825
73	Phosphorylation	HGPCPVTTFGPKACV CCCCCCCCCCCCEEE	27.16	23403867
102	Ubiquitination	SQRLTWNKSPKSVLV HHCCCCCCCCCCEEE	60.75	-
103	Phosphorylation	QRLTWNKSPKSVLVI HCCCCCCCCCCEEEE	34.05	-
140	Ubiquitination	NMIVYVEKKVLEDPA CCEEEEEEHHHCCCC	37.83	-
141	Ubiquitination	MIVYVEKKVLEDPAI CEEEEEEHHHCCCCC	38.25	-
158	Acetylation	DESFGAVKKKFCTFR CCCCCHHHHHCCCCC	50.11	19820839
158	Ubiquitination	DESFGAVKKKFCTFR CCCCCHHHHHCCCCC	50.11	-
168	Phosphorylation	FCTFREDYDDISNQI CCCCCCCHHHHHHCC	15.68	-
191 (in isoform 2)	Phosphorylation	-	17.64	21406692
199 (in isoform 2)	Phosphorylation	-	19.91	21406692
203 (in isoform 2)	Phosphorylation	-	6.74	21406692
231 (in isoform 2)	Phosphorylation	-	16.37	-
264	Phosphorylation	NGLGENGSQAAGLDM CCCCCCCCCCCCCCC	28.38	29214152
280	Phosphorylation	VGKQAMQYQVLNEVV HHHHHHHHHHHHEEE	6.36	24043423
354	Phosphorylation	PICPHSLSFRPIVVP CCCCCCCCCCCEEEE	23.40	24719451
369	Sulfoxidation	AGVELKIMLSPEARN CCEEEEEEECHHHHC	2.64	21406390
381	Phosphorylation	ARNTAWVSFDGRKRQ HHCEEEEEECCCCCE	13.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NADK_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NADK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NADK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	16189514
NUD18_HUMAN	NUDT18	physical	16189514
EF1G_HUMAN	EEF1G	physical	16169070
KI13B_HUMAN	KIF13B	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
CING_HUMAN	CGN	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NADK_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46 AND SER-48, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46; SER-48; SER-50 ANDSER-64, AND MASS SPECTROMETRY.	18669648 [Abstract]