TESK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TESK2_HUMAN
• UniProt AC: Q96S53
• Protein Name: Dual specificity testis-specific protein kinase 2
• Gene Name: TESK2
• Organism: Homo sapiens (Human).
• Sequence Length: 571
• Subcellular Localization: Nucleus .
• Protein Description: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis..
• Protein Sequence: MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFTCEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRRTIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPSKSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSDGPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASEEMEVEERPAGSTPATFSTSGIGLQTQGKQDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MDRSKRNSIAGFPPR CCHHHHHCCCCCCCC	20.18	22210691
41	Phosphorylation	QVGRVWPSSYRALIS HCCCCCCHHHHHHHH	25.04	22210691
42	Phosphorylation	VGRVWPSSYRALISA CCCCCCHHHHHHHHH	17.98	22210691
43	Phosphorylation	GRVWPSSYRALISAF CCCCCHHHHHHHHHH	12.30	22210691
90	Phosphorylation	VMALKMNTLSSNRAN EEEEEHHHCCCCHHH	25.23	28634120
128 (in isoform 2)	Phosphorylation	-	25.44	22210691
135 (in isoform 2)	Phosphorylation	-	21.35	22210691
180	Ubiquitination	FHRDLTSKNCLIKRD CCCCCCCCCCEEEEC	46.58	-
219	Phosphorylation	EKLAVVGSPFWMAPE CEEEEECCCCCCCHH	12.81	21082442
241	Phosphorylation	NEKADVFSYGIILCE CCCCCHHHHHHHHHH	23.46	24114839
242	Phosphorylation	EKADVFSYGIILCEI CCCCHHHHHHHHHHH	10.81	24114839
314	Phosphorylation	KTLEEILSRLQEEEQ HHHHHHHHHHHHHHH	36.28	24719451
326	Ubiquitination	EEQERDRKLQPTARG HHHHHHHCCCHHHHH	56.62	-
345	Phosphorylation	APGVKRLSSLDDKIP CCCCCCCCCCCCCCC	32.65	30108239
346	Phosphorylation	PGVKRLSSLDDKIPH CCCCCCCCCCCCCCC	40.17	20363803
367	Phosphorylation	RTIWLSRSQSDIFSR CEEEEECCHHHHHCC	30.57	23401153
369	Phosphorylation	IWLSRSQSDIFSRKP EEEECCHHHHHCCCC	33.64	30266825
373	Phosphorylation	RSQSDIFSRKPPRTV CCHHHHHCCCCCCEE	39.46	30266825
379	Phosphorylation	FSRKPPRTVSVLDPY HCCCCCCEEEEECCC	23.94	24114839
381	Phosphorylation	RKPPRTVSVLDPYYR CCCCCEEEEECCCCC	19.15	28348404
412	Ubiquitination	RQDLMGGKIKFFDLP HHHHHCCEEEEEECC	36.67	-
420	Phosphorylation	IKFFDLPSKSVISLV EEEEECCCCCEEEEE	44.88	24719451
456	Phosphorylation	PPIRRWRSLPGSPEF CCCHHHHCCCCCHHH	31.77	28102081
460	Phosphorylation	RWRSLPGSPEFLHQE HHHCCCCCHHHHCCC	21.22	28102081
477	Phosphorylation	PFVGREESLSDGPPP CCCCCCHHHCCCCCC	28.55	28060719
479	Phosphorylation	VGREESLSDGPPPRL CCCCHHHCCCCCCCH	50.21	28060719
487	Phosphorylation	DGPPPRLSSLKYRVK CCCCCCHHHCCEEHH	34.60	24719451
488	Phosphorylation	GPPPRLSSLKYRVKE CCCCCHHHCCEEHHC	33.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TESK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TESK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
367	Phosphorylation	372 (5)	R ⇒ C	rs17853159	Immature fraction of reticulocytes Mean platelet volume High light scatter reticulocyte percentage of red cells	27863252
369	Phosphorylation	372 (3)	R ⇒ C	rs17853159	Immature fraction of reticulocytes Mean platelet volume High light scatter reticulocyte percentage of red cells	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433B_HUMAN	YWHAB	physical	11555644
MAGI1_HUMAN	MAGI1	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
CING_HUMAN	CGN	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435
HDAC7_HUMAN	HDAC7	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.