F110B_HUMAN - dbPTM
F110B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID F110B_HUMAN
UniProt AC Q8TC76
Protein Name Protein FAM110B
Gene Name FAM110B
Organism Homo sapiens (Human).
Sequence Length 370
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Protein Description May be involved in tumor progression..
Protein Sequence MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFGNHAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRSEATDLHRHSFAESLKVYPTQGRRSPQEGGSHVGRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKIAAIASMKSPEADPVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationGSMVKPVSPAGTFTS
CCCCCCCCCCCCCCC		19.9822067460
36PhosphorylationILNKGPDYFRRQAEP
HHHCCCCHHHHCCCC		11.34-
49PhosphorylationEPNPKRLSAVERLEA
CCCHHHCHHHHHHHH		34.0128857561
95PhosphorylationAAKRALGSPTLKVFG
HHHHHHCCCEEEECC		18.6325849741
97PhosphorylationKRALGSPTLKVFGNH
HHHHCCCEEEECCCC		40.6926699800
127PhosphorylationILKNIINSSEGSSSG
HHHHHHHCCCCCCCC		21.2522210691
128PhosphorylationLKNIINSSEGSSSGS
HHHHHHCCCCCCCCC		41.3022210691
131PhosphorylationIINSSEGSSSGSGHK
HHHCCCCCCCCCCCC		19.7828348404
132PhosphorylationINSSEGSSSGSGHKH
HHCCCCCCCCCCCCC		49.9628348404
135PhosphorylationSEGSSSGSGHKHSSR
CCCCCCCCCCCCCCC		39.4122210691
149PhosphorylationRNWPPHRSEATDLHR
CCCCCCHHHCHHHHH		28.6626699800
152PhosphorylationPPHRSEATDLHRHSF
CCCHHHCHHHHHHHH		34.7322210691
158PhosphorylationATDLHRHSFAESLKV
CHHHHHHHHHHHCCE		26.5526699800
162PhosphorylationHRHSFAESLKVYPTQ
HHHHHHHHCCEECCC		30.0227732954
173PhosphorylationYPTQGRRSPQEGGSH
ECCCCCCCCCCCCCH		29.5828348404
189PhosphorylationGRRLLEQSAESFLHV
HHHHHHHHHHHHHCC		25.3223312004
192PhosphorylationLLEQSAESFLHVSHS
HHHHHHHHHHCCCCC		32.5926699800
197PhosphorylationAESFLHVSHSSSDIR
HHHHHCCCCCCHHCE		13.6026699800
199PhosphorylationSFLHVSHSSSDIRKV
HHHCCCCCCHHCEEC		24.8326699800
200PhosphorylationFLHVSHSSSDIRKVT
HHCCCCCCHHCEECC		26.9726699800
201PhosphorylationLHVSHSSSDIRKVTS
HCCCCCCHHCEECCC		39.8226699800
218PhosphorylationPLKAIPCSSSAPPLP
CCEEEECCCCCCCCC		23.2128348404
219PhosphorylationLKAIPCSSSAPPLPP
CEEEECCCCCCCCCC		36.9228348404
220PhosphorylationKAIPCSSSAPPLPPK
EEEECCCCCCCCCCC		28.6228348404
227AcetylationSAPPLPPKPKIAAIA
CCCCCCCCCCEEEEE		57.937708445
229AcetylationPPLPPKPKIAAIASM
CCCCCCCCEEEEECC		51.627708455
235PhosphorylationPKIAAIASMKSPEAD
CCEEEEECCCCCCCC		22.1920068231
238PhosphorylationAAIASMKSPEADPVE
EEEECCCCCCCCCCC		21.2320068231
255PhosphorylationCGVSRRPSLQRSKSD
CCCCCCHHHHCCCCC		35.0129496963
259PhosphorylationRRPSLQRSKSDLSDR
CCHHHHCCCCCCHHC		24.4527422710
260AcetylationRPSLQRSKSDLSDRY
CHHHHCCCCCCHHCC		50.6118586795
261PhosphorylationPSLQRSKSDLSDRYF
HHHHCCCCCCHHCCE		45.0622617229
264PhosphorylationQRSKSDLSDRYFRVD
HCCCCCCHHCCEECC		25.6520363803
267PhosphorylationKSDLSDRYFRVDADV
CCCCHHCCEECCHHH		10.7520363803
301PhosphorylationENFARANSDIISLNF
HHHHHHCCCEEEEEC		29.2419664994
305PhosphorylationRANSDIISLNFRSAS
HHCCCEEEEECCCHH		20.0026074081
310PhosphorylationIISLNFRSASMISSD
EEEEECCCHHHCCCC		22.13-
312PhosphorylationSLNFRSASMISSDCE
EEECCCHHHCCCCCC		20.21-
357PhosphorylationRIIKWLYSIKQARES
HHHHHHHHHHHHHHH		22.5724719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of F110B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of F110B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of F110B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAGI1_HUMANMAGI1physical
27173435
SYDE1_HUMANSYDE1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of F110B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND MASSSPECTROMETRY.

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