dbPTM

CING_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CING_HUMAN
UniProt AC	Q9P2M7
Protein Name	Cingulin
Gene Name	CGN
Organism	Homo sapiens (Human).
Sequence Length	1197
Subcellular Localization	Cell junction, tight junction. Localizes to the apical junction complex composed of tight and adherens junctions..
Protein Description	Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier..
Protein Sequence	MAEPRGPVDHGVQIRFITEPVSGAEMGTLRRGGRRPAKDARASTYGVAVRVQGIAGQPFVVLNSGEKGGDSFGVQIKGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSHSQASLAGPGPVDPSNRSNSMLELAPKVASPGSTIDTAPLSSVDSLINKFDSQLGGQARGRTGRRTRMLPPEQRKRSKSLDSRLPRDTFEERERQSTNHWTSSTKYDNHVGTSKQPAQSQNLSPLSGFSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTESNLQTSSC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Methylation	---MAEPRGPVDHGV ---CCCCCCCCCCCC	54.26	-
18	Phosphorylation	GVQIRFITEPVSGAE CCEEEEEECCCCCCC	31.37	23312004
22	Phosphorylation	RFITEPVSGAEMGTL EEEECCCCCCCCCCC	42.89	23312004
26	Sulfoxidation	EPVSGAEMGTLRRGG CCCCCCCCCCCCCCC	5.01	21406390
28	Phosphorylation	VSGAEMGTLRRGGRR CCCCCCCCCCCCCCC	18.78	25850435
34	Phosphorylation	GTLRRGGRRPAKDAR CCCCCCCCCCCCCCH	44.21	-
43	Phosphorylation	PAKDARASTYGVAVR CCCCCHHHHCCEEEE	19.33	26657352
44	Phosphorylation	AKDARASTYGVAVRV CCCCHHHHCCEEEEE	24.26	26552605
45	Phosphorylation	KDARASTYGVAVRVQ CCCHHHHCCEEEEEE	13.70	26552605
49	Phosphorylation	ASTYGVAVRVQGIAG HHHCCEEEEEECCCC	5.98	27251275
71	Phosphorylation	SGEKGGDSFGVQIKG CCCCCCCCCCEEEEC	27.46	19413330
77	Phosphorylation	DSFGVQIKGANDQGA CCCCEEEECCCCCCC	34.57	19413330
85	Phosphorylation	GANDQGASGALSSDL CCCCCCCCCCCCCCC	31.27	21945579
89	Phosphorylation	QGASGALSSDLELPE CCCCCCCCCCCCCCC	22.67	21945579
90	Phosphorylation	GASGALSSDLELPEN CCCCCCCCCCCCCCC	47.25	21945579
96	Phosphorylation	SSDLELPENPYSQVK CCCCCCCCCCCHHCC	81.24	24719451
99	Phosphorylation	LELPENPYSQVKGFP CCCCCCCCHHCCCCC	24.26	21945579
100	Phosphorylation	ELPENPYSQVKGFPA CCCCCCCHHCCCCCC	29.74	21945579
105	Phosphorylation	PYSQVKGFPAPSQSS CCHHCCCCCCCCCCC	3.75	19605366
106	Phosphorylation	YSQVKGFPAPSQSST CHHCCCCCCCCCCCC	52.51	27251275
109	Phosphorylation	VKGFPAPSQSSTSDE CCCCCCCCCCCCCCC	44.81	28450419
111	Phosphorylation	GFPAPSQSSTSDEEP CCCCCCCCCCCCCCC	39.66	28450419
112	Phosphorylation	FPAPSQSSTSDEEPG CCCCCCCCCCCCCCC	25.05	26657352
113	Phosphorylation	PAPSQSSTSDEEPGA CCCCCCCCCCCCCCC	45.50	26657352
114	Phosphorylation	APSQSSTSDEEPGAY CCCCCCCCCCCCCCC	45.00	22617229
115	Phosphorylation	PSQSSTSDEEPGAYW CCCCCCCCCCCCCCC	65.45	27251275
118	Phosphorylation	SSTSDEEPGAYWNGK CCCCCCCCCCCCCCC	30.57	27251275
119	Phosphorylation	STSDEEPGAYWNGKL CCCCCCCCCCCCCCC	34.28	33259812
120	Phosphorylation	TSDEEPGAYWNGKLL CCCCCCCCCCCCCCC	19.51	24719451
121	Phosphorylation	SDEEPGAYWNGKLLR CCCCCCCCCCCCCCC	12.81	26074081
127	Phosphorylation	AYWNGKLLRSHSQAS CCCCCCCCCCCCCHH	6.34	-
129	Phosphorylation	WNGKLLRSHSQASLA CCCCCCCCCCCHHHC	27.71	30266825
131	Phosphorylation	GKLLRSHSQASLAGP CCCCCCCCCHHHCCC	28.78	30175587
134	Phosphorylation	LRSHSQASLAGPGPV CCCCCCHHHCCCCCC	15.89	22617229
135	Phosphorylation	RSHSQASLAGPGPVD CCCCCHHHCCCCCCC	7.77	20166139
137	Phosphorylation	HSQASLAGPGPVDPS CCCHHHCCCCCCCCC	32.75	19664995
140	Phosphorylation	ASLAGPGPVDPSNRS HHHCCCCCCCCCCCC	30.39	19664995
144	Phosphorylation	GPGPVDPSNRSNSML CCCCCCCCCCCCCHH	40.17	25867546
147	Phosphorylation	PVDPSNRSNSMLELA CCCCCCCCCCHHHHC	37.19	30183078
149	Phosphorylation	DPSNRSNSMLELAPK CCCCCCCCHHHHCCC	26.45	22617229
150	Phosphorylation	PSNRSNSMLELAPKV CCCCCCCHHHHCCCC	3.84	20068231
150	Sulfoxidation	PSNRSNSMLELAPKV CCCCCCCHHHHCCCC	3.84	21406390
153	Phosphorylation	RSNSMLELAPKVASP CCCCHHHHCCCCCCC	9.71	32142685
155	Phosphorylation	NSMLELAPKVASPGS CCHHHHCCCCCCCCC	44.25	24719451
159	Phosphorylation	ELAPKVASPGSTIDT HHCCCCCCCCCCCCC	32.55	28176443
162	Phosphorylation	PKVASPGSTIDTAPL CCCCCCCCCCCCCCC	26.10	30278072
163	Phosphorylation	KVASPGSTIDTAPLS CCCCCCCCCCCCCCC	28.87	30278072
165	Phosphorylation	ASPGSTIDTAPLSSV CCCCCCCCCCCCCHH	36.58	19664995
166	Phosphorylation	SPGSTIDTAPLSSVD CCCCCCCCCCCCHHH	26.73	30278072
168	Phosphorylation	GSTIDTAPLSSVDSL CCCCCCCCCCHHHHH	34.56	24719451
169	Phosphorylation	STIDTAPLSSVDSLI CCCCCCCCCHHHHHH	5.74	32142685
170	Phosphorylation	TIDTAPLSSVDSLIN CCCCCCCCHHHHHHH	27.53	28464451
171	Phosphorylation	IDTAPLSSVDSLINK CCCCCCCHHHHHHHH	37.31	28464451
172	Phosphorylation	DTAPLSSVDSLINKF CCCCCCHHHHHHHHH	5.35	27251275
174	Phosphorylation	APLSSVDSLINKFDS CCCCHHHHHHHHHHH	29.06	24732914
180	Phosphorylation	DSLINKFDSQLGGQA HHHHHHHHHHHCCCC	36.76	27251275
181	Phosphorylation	SLINKFDSQLGGQAR HHHHHHHHHHCCCCC	30.36	23403867
188	Methylation	SQLGGQARGRTGRRT HHHCCCCCCCCCCCC	27.52	-
190	Methylation	LGGQARGRTGRRTRM HCCCCCCCCCCCCCC	28.58	-
194	Methylation	ARGRTGRRTRMLPPE CCCCCCCCCCCCCHH	28.20	-
196	Methylation	GRTGRRTRMLPPEQR CCCCCCCCCCCHHHH	23.87	-
206	Phosphorylation	PPEQRKRSKSLDSRL CHHHHHCCCCHHHCC	29.63	28176443
208	Phosphorylation	EQRKRSKSLDSRLPR HHHHCCCCHHHCCCC	38.36	28355574
211	Phosphorylation	KRSKSLDSRLPRDTF HCCCCHHHCCCCCCH	40.80	21406692
212	Phosphorylation	RSKSLDSRLPRDTFE CCCCHHHCCCCCCHH	48.67	24719451
214	Phosphorylation	KSLDSRLPRDTFEER CCHHHCCCCCCHHHH	30.87	24719451
217	Phosphorylation	DSRLPRDTFEERERQ HHCCCCCCHHHHHHH	33.94	23312004
223	Phosphorylation	DTFEERERQSTNHWT CCHHHHHHHHCCCCC	41.81	-
230	Phosphorylation	RQSTNHWTSSTKYDN HHHCCCCCCCCCCCC	12.78	27251275
231	Phosphorylation	QSTNHWTSSTKYDNH HHCCCCCCCCCCCCC	30.71	28348404
232	Phosphorylation	STNHWTSSTKYDNHV HCCCCCCCCCCCCCC	22.88	28348404
233	Phosphorylation	TNHWTSSTKYDNHVG CCCCCCCCCCCCCCC	33.13	27251275
235	Phosphorylation	HWTSSTKYDNHVGTS CCCCCCCCCCCCCCC	23.28	-
238	Phosphorylation	SSTKYDNHVGTSKQP CCCCCCCCCCCCCCC	19.24	27251275
248	Phosphorylation	TSKQPAQSQNLSPLS CCCCCCCCCCCCCCC	24.12	30278072
252	Phosphorylation	PAQSQNLSPLSGFSR CCCCCCCCCCCCCCC	31.20	30266825
255	Phosphorylation	SQNLSPLSGFSRSRQ CCCCCCCCCCCCCHH	40.97	30266825
258	Phosphorylation	LSPLSGFSRSRQTQD CCCCCCCCCCHHCHH	32.64	30266825
260	Phosphorylation	PLSGFSRSRQTQDWV CCCCCCCCHHCHHHH	27.78	26074081
263	Phosphorylation	GFSRSRQTQDWVLQS CCCCCHHCHHHHHHC	27.64	26074081
270	Phosphorylation	TQDWVLQSFEEPRRS CHHHHHHCCCCCHHC	30.39	30266825
276	Phosphorylation	QSFEEPRRSAQDPTM HCCCCCHHCCCCCCC	47.24	24719451
277	Phosphorylation	SFEEPRRSAQDPTML CCCCCHHCCCCCCCH	31.40	23312004
282	Phosphorylation	RRSAQDPTMLQFKST HHCCCCCCCHHCCCC	38.51	23898821
283	Phosphorylation	RSAQDPTMLQFKSTP HCCCCCCCHHCCCCH	3.17	27251275
288	Phosphorylation	PTMLQFKSTPDLLRD CCCHHCCCCHHHHHH	46.60	30266825
289	Phosphorylation	TMLQFKSTPDLLRDQ CCHHCCCCHHHHHHC	22.78	25849741
293	Ubiquitination	FKSTPDLLRDQQEAA CCCCHHHHHHCHHHC	8.06	32015554
294	Phosphorylation	KSTPDLLRDQQEAAP CCCHHHHHHCHHHCC	47.17	24719451
311	Phosphorylation	SVDHMKATIYGILRE CHHHHHHHHHHHHHC	14.82	28152594
313	Phosphorylation	DHMKATIYGILREGS HHHHHHHHHHHHCCC	8.18	28152594
320	Phosphorylation	YGILREGSSESETSV HHHHHCCCCCCCHHH	26.61	23911959
321	Phosphorylation	GILREGSSESETSVR HHHHCCCCCCCHHHH	56.87	29802988
323	Phosphorylation	LREGSSESETSVRRK HHCCCCCCCHHHHHH	48.39	29802988
325	Phosphorylation	EGSSESETSVRRKVS CCCCCCCHHHHHHHH	41.63	23312004
326	Phosphorylation	GSSESETSVRRKVSL CCCCCCHHHHHHHHH	15.02	23312004
327	Phosphorylation	SSESETSVRRKVSLV CCCCCHHHHHHHHHH	10.03	-
332	Phosphorylation	TSVRRKVSLVLEKMQ HHHHHHHHHHHHHCC	18.78	28355574
338	Phosphorylation	VSLVLEKMQPLVMVS HHHHHHHCCCEEEEE	3.47	19664995
345	Phosphorylation	MQPLVMVSSGSTKAV CCCEEEEECCCCCCC	15.75	20068231
346	Phosphorylation	QPLVMVSSGSTKAVA CCEEEEECCCCCCCC	25.92	20068231
348	Phosphorylation	LVMVSSGSTKAVAGQ EEEEECCCCCCCCCC	28.78	20068231
349	Phosphorylation	VMVSSGSTKAVAGQG EEEECCCCCCCCCCH	26.92	20068231
354	Phosphorylation	GSTKAVAGQGELTRK CCCCCCCCCHHHHHH	29.44	24719451
356	Ubiquitination	TKAVAGQGELTRKVE CCCCCCCHHHHHHHH	30.85	32015554
367	Ubiquitination	RKVEELQRKLDEEVK HHHHHHHHHHHHHHH	54.88	-
382	Phosphorylation	KRQKLEPSQVGLERQ HHHCCCHHHHHHHHH	28.29	-
394	Phosphorylation	ERQLEEKTEECSRLQ HHHHHHHHHHHHHHH	40.05	26074081
398	Phosphorylation	EEKTEECSRLQELLE HHHHHHHHHHHHHHH	39.03	26074081
422	Ubiquitination	NKELQNMKRLLDQGE HHHHHHHHHHHHHHH	47.66	32015554
428	Ubiquitination	MKRLLDQGEDLRHGL HHHHHHHHHHHHHHH	30.01	24816145
451	Ubiquitination	NKLKHVQGPEPAKEV HHHHHCCCCCCHHHH	27.70	32015554
461	Ubiquitination	PAKEVLLKDLLETRE CHHHHHHHHHHHHHH	42.01	21890473
461 (in isoform 2)	Ubiquitination	-	42.01	21890473
462	Ubiquitination	AKEVLLKDLLETREL HHHHHHHHHHHHHHH	57.36	22817900
467	Ubiquitination	LKDLLETRELLEEVL HHHHHHHHHHHHHHH	24.16	21890473
467 (in isoform 1)	Ubiquitination	-	24.16	21890473
483	Ubiquitination	GKQRVEEQLRLRERE HHHHHHHHHHHHHHH	20.55	32015554
505	Ubiquitination	LKEEVASRDQEVEHV HHHHHHCCHHHHHHH	39.64	32015554
526	Phosphorylation	DTEQLRRSMQDATQD HHHHHHHHHHHHHHH	17.86	29978859
527	Sulfoxidation	TEQLRRSMQDATQDH HHHHHHHHHHHHHHH	3.86	21406390
531	Phosphorylation	RRSMQDATQDHAVLE HHHHHHHHHHHHHHH	42.70	29978859
532	Phosphorylation	RSMQDATQDHAVLEA HHHHHHHHHHHHHHH	42.06	27251275
573	Acetylation	QSMFQKNKEDLRATK HHHHHHCHHHHHHHH	60.69	19608861
579	Acetylation	NKEDLRATKQELLQL CHHHHHHHHHHHHHH	27.16	19608861
580	Ubiquitination	KEDLRATKQELLQLR HHHHHHHHHHHHHHH	40.57	21890473
580 (in isoform 2)	Ubiquitination	-	40.57	21890473
586	Ubiquitination	TKQELLQLRMEKEEM HHHHHHHHHHCHHHH	5.93	21890473
586 (in isoform 1)	Ubiquitination	-	5.93	21890473
642	Ubiquitination	LKELQAERQSQEVAG HHHHHHHHHHHHHHH	44.45	32015554
658	Ubiquitination	HRDRELEKQLAVLRV HCCHHHHHHHHHHHH	64.34	21890473
658 (in isoform 2)	Ubiquitination	-	64.34	21890473
664	Ubiquitination	EKQLAVLRVEADRGR HHHHHHHHHHHHCCH	20.03	21890473
664 (in isoform 1)	Ubiquitination	-	20.03	21890473
688	Ubiquitination	QKTLQQLRQDCEEAS HHHHHHHHHHHHHHH	26.42	32015554
706	Phosphorylation	MVAEAEATVLGQRRA HHHHHHHHHHHHHHH	14.04	21406692
712	Phosphorylation	ATVLGQRRAAVETTL HHHHHHHHHHHHHHH	21.00	-
717	Phosphorylation	QRRAAVETTLRETQE HHHHHHHHHHHHHHH	25.24	29142712
747	Ubiquitination	LKETRGLVDGGEAVE HHHHCCCCCHHHHHH	7.76	24816145
778	Phosphorylation	LEEALNASQEEEGSL HHHHHHHCHHHHHHH	36.73	20068231
784	Phosphorylation	ASQEEEGSLAAAKRA HCHHHHHHHHHHHHH	20.36	20068231
790	Phosphorylation	GSLAAAKRALEARLE HHHHHHHHHHHHHHH	39.41	20068231
866	Ubiquitination	SKQALQQLQAQLEDY HHHHHHHHHHHHHHH	2.69	32015554
925	Phosphorylation	ASQAERDTARLDKEL HHHHHHHHHHHCHHH	21.65	20068231
931	Phosphorylation	DTARLDKELLAQRLQ HHHHHCHHHHHHHHH	49.00	20068231
953	Ubiquitination	NKKRSQDDRARQLKG HHHCCHHHHHHHHHH	38.20	32015554
965	Ubiquitination	LKGLEEKVSRLETEL HHHHHHHHHHHHHHH	4.56	32015554
970	Phosphorylation	EKVSRLETELDEEKN HHHHHHHHHHHHHHC	46.57	25367160
970	Ubiquitination	EKVSRLETELDEEKN HHHHHHHHHHHHHHC	46.57	24816145
976	Phosphorylation	ETELDEEKNTVELLT HHHHHHHHCHHHHHH	56.74	-
985	Methylation	TVELLTDRVNRGRDQ HHHHHHHHHHHCHHH	23.52	-
991	Methylation	DRVNRGRDQVDQLRT HHHHHCHHHHHHHHH	56.53	-
1016	Phosphorylation	DLECDKISLERQNKD HHHHCHHCHHHCCCC	29.89	23898821
1022	Phosphorylation	ISLERQNKDLKTRLA HCHHHCCCCHHHHHH	56.98	24719451
1026	Phosphorylation	RQNKDLKTRLASSEG HCCCCHHHHHHCCCC	37.91	28674151
1030	Phosphorylation	DLKTRLASSEGFQKP CHHHHHHCCCCCCCC	33.25	28674151
1031	Phosphorylation	LKTRLASSEGFQKPS HHHHHHCCCCCCCCC	35.81	28674151
1031	Ubiquitination	LKTRLASSEGFQKPS HHHHHHCCCCCCCCC	35.81	24816145
1038	Phosphorylation	SEGFQKPSASLSQLE CCCCCCCCCCHHHHH	37.21	28674151
1040	Phosphorylation	GFQKPSASLSQLESQ CCCCCCCCHHHHHHH	32.65	28674151
1042	Phosphorylation	QKPSASLSQLESQNQ CCCCCCHHHHHHHHH	30.17	28348404
1044	Phosphorylation	PSASLSQLESQNQLL CCCCHHHHHHHHHHH	6.50	27251275
1080	Phosphorylation	ERKVKELSIQIEDER HHHHHHHHEEEHHHH	17.34	25072903
1098	Phosphorylation	NDQKDQLSLRVKALK CCCHHHHHHHHHHHH	14.43	24719451
1145	Phosphorylation	QLQARIKSLEKDSWR HHHHHHHHHHHHHHH	39.11	24719451
1150	Phosphorylation	IKSLEKDSWRKASRS HHHHHHHHHHHHHHH	39.59	23882029
1151	Phosphorylation	KSLEKDSWRKASRSA HHHHHHHHHHHHHHH	18.87	24719451
1155	Phosphorylation	KDSWRKASRSAAESA HHHHHHHHHHHHHHH	29.78	23882029
1156	Phosphorylation	DSWRKASRSAAESAL HHHHHHHHHHHHHHH	34.86	24719451
1157	Phosphorylation	SWRKASRSAAESALK HHHHHHHHHHHHHHH	29.36	18669648
1161	Phosphorylation	ASRSAAESALKNEGL HHHHHHHHHHHHCCC	33.89	18669648
1163	Phosphorylation	RSAAESALKNEGLSS HHHHHHHHHHCCCCC	9.48	18669648
1167	Phosphorylation	ESALKNEGLSSDEEF HHHHHHCCCCCHHHC	40.01	18669648
1169	Phosphorylation	ALKNEGLSSDEEFDS HHHHCCCCCHHHCCC	46.75	23898821
1170	Phosphorylation	LKNEGLSSDEEFDSV HHHCCCCCHHHCCCC	54.83	26657352
1175	Phosphorylation	LSSDEEFDSVYDPSS CCCHHHCCCCCCHHH	40.24	27251275
1176	Phosphorylation	SSDEEFDSVYDPSSI CCHHHCCCCCCHHHH	28.09	18669648
1178	Phosphorylation	DEEFDSVYDPSSIAS HHHCCCCCCHHHHHH	26.53	18669648
1181	Phosphorylation	FDSVYDPSSIASLLT CCCCCCHHHHHHHHH	31.32	24275569
1182	Phosphorylation	DSVYDPSSIASLLTE CCCCCHHHHHHHHHH	27.80	18669648
1184	Phosphorylation	VYDPSSIASLLTESN CCCHHHHHHHHHHCC	8.96	18669648
1185	Phosphorylation	YDPSSIASLLTESNL CCHHHHHHHHHHCCC	23.42	24275569
1187	Phosphorylation	PSSIASLLTESNLQT HHHHHHHHHHCCCCC	4.65	-
1191	Phosphorylation	ASLLTESNLQTSSC- HHHHHHCCCCCCCC-	29.90	-
1194	Phosphorylation	LTESNLQTSSC---- HHHCCCCCCCC----	26.27	28102081
1195	Phosphorylation	TESNLQTSSC----- HHCCCCCCCC-----	19.42	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
131	S	Phosphorylation	Kinase	PRKAA1	Q13131	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CING_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CING_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZO1_MOUSE	Tjp1	physical	12023291
ZO2_HUMAN	TJP2	physical	11042084
ZO1_HUMAN	TJP1	physical	11042084
1433Z_HUMAN	YWHAZ	physical	28514442
ZO1_HUMAN	TJP1	physical	28514442
1433E_HUMAN	YWHAE	physical	28514442
1433B_HUMAN	YWHAB	physical	28514442
1433G_HUMAN	YWHAG	physical	28514442
NEB1_HUMAN	PPP1R9A	physical	28514442
1433F_HUMAN	YWHAH	physical	28514442
1433T_HUMAN	YWHAQ	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
SYDE1_HUMAN	SYDE1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CING_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-573, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-121; SER-134; SER-149AND SER-159, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-114; SER-159 ANDSER-332, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-134, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND MASSSPECTROMETRY.	18220336 [Abstract]
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