dbPTM

ZO1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZO1_MOUSE
UniProt AC	P39447
Protein Name	Tight junction protein ZO-1
Gene Name	Tjp1
Organism	Mus musculus (Mouse).
Sequence Length	1745
Subcellular Localization	Cell membrane Peripheral membrane protein Cytoplasmic side . Cell junction, tight junction . Cell junction, gap junction . Cytoplasm, myofibril, sarcomere, I band . Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact
Protein Description	Tjp1, TjpP2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting Cdc42bpb to the leading edge of migrating cells (By similarity). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (By similarity). With Tjp2 and TJjp3, participates to the junctional retention and stability of the transcription factor Dbpa, but is not involved in its shuttling to the nucleus (By similarity)..
Protein Sequence	MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSHPDPEPVSDNEDDSYDEEVHDPRAGRGALANRRSEKSWARDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSQSRSPDQRSEPSDHSTQSPQQPSNGSLRSREEERMSKPGAISTPVKHVDDHPPKAVEEVTVEKNEKQTPTLPEPKPVYAQVGQPDVDLPVSPSDGALPNSAHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDHRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQAIHRIDSPGLKPASQQKAEASSPVPYLSPETTPASSASAVNHNVSVTNVSLEEPAPAPPTSHASQPGCLGAPSAEAAHVVLRGEGPPLPPHADPAKVYRKEPYSEEMMRQNHILKQPALGHPGQRPDKEPNLAYEPQLPYIEKQASRDLEQPSYRYEVSSYTDQFSRNYDHRLRFEDRIPTYEDQWSYYDDKQPYQPRPFENQHPRDLDSRQHPEEASERGYFQRFEEPAPLSYDSRTRYEQLPRTSTLRHEEQPAPAYEVHNRYRPEAQPYSSTGPKSSEPKQYFDQYPRSYEQVPPPGFTSKTGHYEPLHGAAVVPPLIPSSQQKPEVLPSATKPQPPPPTLTEEEEDPAMKPQSVLTRVKMFENKRSASLENKKDVNDTASFKPPEVASKPPGASLAGPKPVPQSQFSEHDKTLYRLPEPQKPQVKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFESKPSAHLPAGHHSEPAKPVHSQSQPNFSSYSSKGKPETDAVDRSFSEKRYDPAQATPPPPPLPSQYSQPAPPLSSSSLHIHSKGAQGEGNSVSLDFQNSYMSKPDPPPSQSKPATFRPPTREDPPQTFYPQKSFPDKAPVNGAEQTQKTITPVYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETVHKPELSSKTPTSPKTLMKAHSSTQPPEFDSGVETFSVHTDKPKYQMNNISTMPKAVPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGIEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSARAAAAK ------CCHHHHHHH	37.45	23375375
117	Phosphorylation	KKVQIPVSHPDPEPV CCEECCCCCCCCCCC	24.77	25619855
125	Phosphorylation	HPDPEPVSDNEDDSY CCCCCCCCCCCCCCC	45.49	27087446
131	Phosphorylation	VSDNEDDSYDEEVHD CCCCCCCCCCCCCCC	46.97	25521595
132	Phosphorylation	SDNEDDSYDEEVHDP CCCCCCCCCCCCCCC	34.08	25521595
151	Phosphorylation	GALANRRSEKSWARD CHHHCCCCCCHHHHC	46.25	26824392
154	Phosphorylation	ANRRSEKSWARDRSA HCCCCCCHHHHCHHH	23.16	27681418
160	Phosphorylation	KSWARDRSASRERSL CHHHHCHHHHHCCCC	34.58	25521595
162	Phosphorylation	WARDRSASRERSLSP HHHCHHHHHCCCCCC	35.60	23737553
166	Phosphorylation	RSASRERSLSPRSDR HHHHHCCCCCCHHHC	28.57	25521595
168	Phosphorylation	ASRERSLSPRSDRRS HHHCCCCCCHHHCCC	21.36	25521595
171	Phosphorylation	ERSLSPRSDRRSVAS CCCCCCHHHCCCHHH	38.56	28973931
175	Phosphorylation	SPRSDRRSVASSQPA CCHHHCCCHHHCCCC	23.95	25521595
178	Phosphorylation	SDRRSVASSQPAKPT HHCCCHHHCCCCCCC	27.61	26824392
179	Phosphorylation	DRRSVASSQPAKPTK HCCCHHHCCCCCCCE	30.37	27087446
183	Ubiquitination	VASSQPAKPTKVTLV HHHCCCCCCCEEEEE	60.96	22790023
185	Phosphorylation	SSQPAKPTKVTLVKS HCCCCCCCEEEEEEC	37.12	21743459
194	Ubiquitination	VTLVKSRKNEEYGLR EEEEECCCCCCHHHH	75.66	22790023
198	Phosphorylation	KSRKNEEYGLRLASH ECCCCCCHHHHHHEE	18.45	29514104
212	Phosphorylation	HIFVKEISQDSLAAR EEEEEECCCCCHHHC	29.09	27180971
215	Phosphorylation	VKEISQDSLAARDGN EEECCCCCHHHCCCC	16.57	26643407
241	Phosphorylation	GTVTENMSLTDAKTL CEEECCCCCHHHHHH	39.43	19060867
243	Phosphorylation	VTENMSLTDAKTLIE EECCCCCHHHHHHHH	26.97	21082442
267	Phosphorylation	VQRDERATLLNVPDL EEHHHCCEECCCCCC	37.69	23737553
275	Phosphorylation	LLNVPDLSDSIHSAN ECCCCCCHHHHHHCC	36.37	27742792
277	Phosphorylation	NVPDLSDSIHSANAS CCCCCHHHHHHCCHH	20.87	27087446
280	Phosphorylation	DLSDSIHSANASERD CCHHHHHHCCHHHCC	22.88	27087446
284	Phosphorylation	SIHSANASERDDISE HHHHCCHHHCCCHHH	32.73	27742792
290	Phosphorylation	ASERDDISEIQSLAS HHHCCCHHHHHHHHH	35.32	25619855
294	Phosphorylation	DDISEIQSLASDHSG CCHHHHHHHHHCCCC	31.40	25619855
297	Phosphorylation	SEIQSLASDHSGRSH HHHHHHHHCCCCCCC	40.94	25521595
300	Phosphorylation	QSLASDHSGRSHDRP HHHHHCCCCCCCCCC	40.67	25521595
303	Phosphorylation	ASDHSGRSHDRPPRR HHCCCCCCCCCCCCC	33.01	21743459
311	Phosphorylation	HDRPPRRSQSRSPDQ CCCCCCCCCCCCCCC	33.51	27087446
313	Phosphorylation	RPPRRSQSRSPDQRS CCCCCCCCCCCCCCC	35.65	26824392
315	Phosphorylation	PRRSQSRSPDQRSEP CCCCCCCCCCCCCCC	37.77	27087446
320	Phosphorylation	SRSPDQRSEPSDHST CCCCCCCCCCCCCCC	48.50	20139300
323	Phosphorylation	PDQRSEPSDHSTQSP CCCCCCCCCCCCCCC	43.85	20139300
326	Phosphorylation	RSEPSDHSTQSPQQP CCCCCCCCCCCCCCC	32.88	20139300
327	Phosphorylation	SEPSDHSTQSPQQPS CCCCCCCCCCCCCCC	29.64	27087446
329	Phosphorylation	PSDHSTQSPQQPSNG CCCCCCCCCCCCCCC	25.43	20139300
334	Phosphorylation	TQSPQQPSNGSLRSR CCCCCCCCCCCCCHH	49.86	26160508
337	Phosphorylation	PQQPSNGSLRSREEE CCCCCCCCCCHHHHH	25.51	20139300
347	Phosphorylation	SREEERMSKPGAIST HHHHHHHCCCCCCCC	41.75	25338131
348	Ubiquitination	REEERMSKPGAISTP HHHHHHCCCCCCCCC	37.82	22790023
353	Phosphorylation	MSKPGAISTPVKHVD HCCCCCCCCCCCCCC	26.56	21149613
354	Phosphorylation	SKPGAISTPVKHVDD CCCCCCCCCCCCCCC	26.45	26824392
374	Ubiquitination	VEEVTVEKNEKQTPT EEEEEEECCCCCCCC	67.10	22790023
379	Phosphorylation	VEKNEKQTPTLPEPK EECCCCCCCCCCCCC	29.34	29233185
381	Phosphorylation	KNEKQTPTLPEPKPV CCCCCCCCCCCCCCC	59.33	26824392
389	Phosphorylation	LPEPKPVYAQVGQPD CCCCCCCEEECCCCC	10.39	29514104
402	Phosphorylation	PDVDLPVSPSDGALP CCCCCCCCCCCCCCC	19.42	26824392
404	Phosphorylation	VDLPVSPSDGALPNS CCCCCCCCCCCCCCC	40.96	26643407
411	Phosphorylation	SDGALPNSAHEDGIL CCCCCCCCCCCCCCC	29.12	21082442
421	Phosphorylation	EDGILRPSMKLVKFR CCCCCCCCEEEEEEC	23.32	26643407
432	Phosphorylation	VKFRKGDSVGLRLAG EEECCCCCEEEEECC	27.10	29899451
553	Ubiquitination	VDTLYNGKLGSWLAI EEEECCCCCCCEEEE	46.14	22790023
588	Phosphorylation	EQLASVQYTLPKTAG HHHHCCEEECCCCCC	14.21	18846507
589	Phosphorylation	QLASVQYTLPKTAGG HHHCCEEECCCCCCC	21.35	22942356
617	Phosphorylation	SKRNLRKSREDLSAQ HHHHHHHCHHHHHCC	34.17	27087446
622	Phosphorylation	RKSREDLSAQPVQTK HHCHHHHHCCCCCCC	36.86	27087446
628	Phosphorylation	LSAQPVQTKFPAYER HHCCCCCCCCCCHHH	34.58	22982522
681	Phosphorylation	SEPRDAGTDHRSSGI CCCCCCCCCCCCCCE	30.28	29514104
685	Phosphorylation	DAGTDHRSSGIIRLH CCCCCCCCCCEEEEE	29.51	30352176
686	Phosphorylation	AGTDHRSSGIIRLHT CCCCCCCCCEEEEEH	33.69	26824392
809	Phosphorylation	EGKADGATSDDLDLH ECCCCCCCCCCCCCC	37.91	25521595
810	Phosphorylation	GKADGATSDDLDLHD CCCCCCCCCCCCCCC	28.70	25521595
821	Phosphorylation	DLHDDRLSYLSAPGS CCCCCHHHHEECCCC	25.56	27087446
822	Phosphorylation	LHDDRLSYLSAPGSE CCCCHHHHEECCCCC	14.85	27180971
824	Phosphorylation	DDRLSYLSAPGSEYS CCHHHHEECCCCCCE	24.96	27087446
828	Phosphorylation	SYLSAPGSEYSMYST HHEECCCCCCEEEEC	32.10	25521595
830	Phosphorylation	LSAPGSEYSMYSTDS EECCCCCCEEEECCC	10.63	23737553
831	Phosphorylation	SAPGSEYSMYSTDSR ECCCCCCEEEECCCC	13.75	23737553
833	Phosphorylation	PGSEYSMYSTDSRHT CCCCCEEEECCCCCC	11.50	25293948
834	Phosphorylation	GSEYSMYSTDSRHTS CCCCEEEECCCCCCC	19.66	23737553
835	Phosphorylation	SEYSMYSTDSRHTSD CCCEEEECCCCCCCC	22.10	25521595
837	Phosphorylation	YSMYSTDSRHTSDYE CEEEECCCCCCCCCC	26.50	27180971
840	Phosphorylation	YSTDSRHTSDYEDTD EECCCCCCCCCCCCC	23.37	19060867
841	Phosphorylation	STDSRHTSDYEDTDT ECCCCCCCCCCCCCC	31.88	19060867
843	Phosphorylation	DSRHTSDYEDTDTEG CCCCCCCCCCCCCCC	18.57	19060867
846	Phosphorylation	HTSDYEDTDTEGGAY CCCCCCCCCCCCCCC	32.64	19060867
848	Phosphorylation	SDYEDTDTEGGAYTD CCCCCCCCCCCCCCH	38.33	19060867
853	Phosphorylation	TDTEGGAYTDQELDE CCCCCCCCCHHHHHH	17.71	23984901
854	Phosphorylation	DTEGGAYTDQELDET CCCCCCCCHHHHHHH	30.58	27087446
861	Phosphorylation	TDQELDETLNDEVGT CHHHHHHHHCCCCCC	30.44	21149613
868	Phosphorylation	TLNDEVGTPPESAIT HHCCCCCCCCHHHCC	40.63	27180971
872	Phosphorylation	EVGTPPESAITRSSE CCCCCCHHHCCCCCC	30.64	23984901
875	Phosphorylation	TPPESAITRSSEPVR CCCHHHCCCCCCCCC	24.98	23984901
877	Phosphorylation	PESAITRSSEPVRED CHHHCCCCCCCCCCC	30.33	25777480
878	Phosphorylation	ESAITRSSEPVREDS HHHCCCCCCCCCCCC	42.50	25777480
885	Phosphorylation	SEPVREDSSGMHHEN CCCCCCCCCCCCCCC	24.84	25777480
886	Phosphorylation	EPVREDSSGMHHENQ CCCCCCCCCCCCCCC	53.08	21183079
894	Phosphorylation	GMHHENQTYPPYSPQ CCCCCCCCCCCCCCC	49.96	25777480
895	Phosphorylation	MHHENQTYPPYSPQA CCCCCCCCCCCCCCC	7.76	26643407
898	Phosphorylation	ENQTYPPYSPQAQPQ CCCCCCCCCCCCCCC	28.60	25777480
899	Phosphorylation	NQTYPPYSPQAQPQA CCCCCCCCCCCCCCC	19.13	28507225
912	Phosphorylation	QAIHRIDSPGLKPAS CCCHHCCCCCCCHHH	20.63	25521595
919	Phosphorylation	SPGLKPASQQKAEAS CCCCCHHHHHHHHHC	41.49	25777480
1005	Ubiquitination	DPAKVYRKEPYSEEM CHHHHHCCCCCCHHH	45.41	22790023
1008	Phosphorylation	KVYRKEPYSEEMMRQ HHHCCCCCCHHHHHH	29.79	25619855
1009	Phosphorylation	VYRKEPYSEEMMRQN HHCCCCCCHHHHHHC	37.48	25619855
1039	Phosphorylation	DKEPNLAYEPQLPYI CCCCCCCCCCCCCHH	31.16	29514104
1051	Phosphorylation	PYIEKQASRDLEQPS CHHHHHHCCCCCCCC	24.67	25521595
1058	Phosphorylation	SRDLEQPSYRYEVSS CCCCCCCCEEEEEEC	23.18	22499769
1059	Phosphorylation	RDLEQPSYRYEVSSY CCCCCCCEEEEEECC	24.73	22499769
1061	Phosphorylation	LEQPSYRYEVSSYTD CCCCCEEEEEECCCH	16.67	22499769
1064	Phosphorylation	PSYRYEVSSYTDQFS CCEEEEEECCCHHHC	12.99	22499769
1065	Phosphorylation	SYRYEVSSYTDQFSR CEEEEEECCCHHHCC	36.91	22499769
1066	Phosphorylation	YRYEVSSYTDQFSRN EEEEEECCCHHHCCC	13.56	22499769
1067	Phosphorylation	RYEVSSYTDQFSRNY EEEEECCCHHHCCCC	25.85	22499769
1071	Phosphorylation	SSYTDQFSRNYDHRL ECCCHHHCCCCCCCC	17.62	22499769
1086	Phosphorylation	RFEDRIPTYEDQWSY CHHHCCCCCCCCCCC	36.85	27180971
1087	Phosphorylation	FEDRIPTYEDQWSYY HHHCCCCCCCCCCCC	16.50	26643407
1092	Phosphorylation	PTYEDQWSYYDDKQP CCCCCCCCCCCCCCC	14.26	25521595
1093	Phosphorylation	TYEDQWSYYDDKQPY CCCCCCCCCCCCCCC	14.14	23984901
1094	Phosphorylation	YEDQWSYYDDKQPYQ CCCCCCCCCCCCCCC	16.49	23984901
1097	Ubiquitination	QWSYYDDKQPYQPRP CCCCCCCCCCCCCCC	50.72	22790023
1100	Phosphorylation	YYDDKQPYQPRPFEN CCCCCCCCCCCCCCC	28.76	29514104
1123	Phosphorylation	RQHPEEASERGYFQR CCCHHHHHHCCCCCC	30.98	23140645
1127	Phosphorylation	EEASERGYFQRFEEP HHHHHCCCCCCCCCC	11.62	29514104
1138	Phosphorylation	FEEPAPLSYDSRTRY CCCCCCCCCCCCCCH	26.32	19060867
1139	Phosphorylation	EEPAPLSYDSRTRYE CCCCCCCCCCCCCHH	26.14	17947660
1141	Phosphorylation	PAPLSYDSRTRYEQL CCCCCCCCCCCHHHC	27.58	23984901
1143	Phosphorylation	PLSYDSRTRYEQLPR CCCCCCCCCHHHCCC	41.37	22499769
1145	Phosphorylation	SYDSRTRYEQLPRTS CCCCCCCHHHCCCCC	13.86	22499769
1151	Phosphorylation	RYEQLPRTSTLRHEE CHHHCCCCCCCCCCC	24.91	29899451
1152	Phosphorylation	YEQLPRTSTLRHEEQ HHHCCCCCCCCCCCC	27.07	18846507
1153	Phosphorylation	EQLPRTSTLRHEEQP HHCCCCCCCCCCCCC	27.48	19060867
1164	Phosphorylation	EEQPAPAYEVHNRYR CCCCCCCCCCCCCCC	19.88	18515860
1177	Phosphorylation	YRPEAQPYSSTGPKS CCCCCCCCCCCCCCC	11.81	22499769
1178	Phosphorylation	RPEAQPYSSTGPKSS CCCCCCCCCCCCCCC	28.27	22499769
1179	Phosphorylation	PEAQPYSSTGPKSSE CCCCCCCCCCCCCCC	31.38	29514104
1184	Phosphorylation	YSSTGPKSSEPKQYF CCCCCCCCCCCHHHH	42.96	29514104
1185	Phosphorylation	SSTGPKSSEPKQYFD CCCCCCCCCCHHHHH	65.13	-
1188	Ubiquitination	GPKSSEPKQYFDQYP CCCCCCCHHHHHHCC	54.28	22790023
1190	Phosphorylation	KSSEPKQYFDQYPRS CCCCCHHHHHHCCCC	18.43	29514104
1198	Phosphorylation	FDQYPRSYEQVPPPG HHHCCCCHHCCCCCC	16.20	29514104
1250	Phosphorylation	QPPPPTLTEEEEDPA CCCCCCCCCCCCCCC	43.77	-
1273	Acetylation	RVKMFENKRSASLEN HHHHHCCCCCCCCCC	40.30	7713965
1275	Phosphorylation	KMFENKRSASLENKK HHHCCCCCCCCCCCC	24.66	29899451
1277	Phosphorylation	FENKRSASLENKKDV HCCCCCCCCCCCCCC	37.15	27087446
1313	Phosphorylation	GPKPVPQSQFSEHDK CCCCCCHHHCCCCCC	27.42	29472430
1316	Phosphorylation	PVPQSQFSEHDKTLY CCCHHHCCCCCCCCC	26.78	30352176
1323	Phosphorylation	SEHDKTLYRLPEPQK CCCCCCCCCCCCCCC	18.48	-
1345	Phosphorylation	DIVRSNHYDPEEDEE HHHHCCCCCHHHCHH	37.13	18563927
1353	Phosphorylation	DPEEDEEYYRKQLSY CHHHCHHHHHHHHHH	13.41	17947660
1354	Phosphorylation	PEEDEEYYRKQLSYF HHHCHHHHHHHHHHH	18.02	29514104
1356	Ubiquitination	EDEEYYRKQLSYFDR HCHHHHHHHHHHHCH	39.20	22790023
1360	Phosphorylation	YYRKQLSYFDRRSFE HHHHHHHHHCHHHCC	20.35	29514104
1365	Phosphorylation	LSYFDRRSFESKPSA HHHHCHHHCCCCCCC	33.97	29514104
1368	Phosphorylation	FDRRSFESKPSAHLP HCHHHCCCCCCCCCC	48.10	21183079
1371	Phosphorylation	RSFESKPSAHLPAGH HHCCCCCCCCCCCCC	31.86	22817900
1380	Phosphorylation	HLPAGHHSEPAKPVH CCCCCCCCCCCCCCC	39.33	21183079
1388	Phosphorylation	EPAKPVHSQSQPNFS CCCCCCCCCCCCCCC	31.59	22817900
1390	Phosphorylation	AKPVHSQSQPNFSSY CCCCCCCCCCCCCCC	51.09	29472430
1395	Phosphorylation	SQSQPNFSSYSSKGK CCCCCCCCCCCCCCC	34.70	-
1398	Phosphorylation	QPNFSSYSSKGKPET CCCCCCCCCCCCCCC	27.76	23375375
1399	Phosphorylation	PNFSSYSSKGKPETD CCCCCCCCCCCCCCC	36.88	23375375
1405	Phosphorylation	SSKGKPETDAVDRSF CCCCCCCCCCCCCCC	37.47	25777480
1411	Phosphorylation	ETDAVDRSFSEKRYD CCCCCCCCCCHHCCC	28.76	29895711
1413	Phosphorylation	DAVDRSFSEKRYDPA CCCCCCCCHHCCCHH	43.38	25777480
1417	Phosphorylation	RSFSEKRYDPAQATP CCCCHHCCCHHHCCC	37.03	26643407
1423	Phosphorylation	RYDPAQATPPPPPLP CCCHHHCCCCCCCCC	25.01	27742792
1444	Phosphorylation	APPLSSSSLHIHSKG CCCCCCCCEEEECCC	26.39	-
1500	Phosphorylation	QTFYPQKSFPDKAPV CCCCCCCCCCCCCCC	36.44	29514104
1516	Phosphorylation	GAEQTQKTITPVYNR CHHHCCCCCCCCCCC	21.92	26643407
1518	Phosphorylation	EQTQKTITPVYNRFT HHCCCCCCCCCCCCC	16.37	26643407
1521	Phosphorylation	QKTITPVYNRFTPKP CCCCCCCCCCCCCCC	11.21	25263469
1529	Phosphorylation	NRFTPKPYTSSARPF CCCCCCCCCCCCCCC	25.94	29514104
1542	Phosphorylation	PFERKFESPKFNHNL CCCCCCCCCCCCCCC	36.20	19060867
1561	Phosphorylation	TVHKPELSSKTPTSP CCCCCCCCCCCCCCH	28.29	21743459
1562	Phosphorylation	VHKPELSSKTPTSPK CCCCCCCCCCCCCHH	53.85	21743459
1564	Phosphorylation	KPELSSKTPTSPKTL CCCCCCCCCCCHHHH	33.47	21743459
1566	Phosphorylation	ELSSKTPTSPKTLMK CCCCCCCCCHHHHHH	63.99	23737553
1567	Phosphorylation	LSSKTPTSPKTLMKA CCCCCCCCHHHHHHH	26.13	23737553
1576	Phosphorylation	KTLMKAHSSTQPPEF HHHHHHCCCCCCCCC	39.68	26824392
1577	Phosphorylation	TLMKAHSSTQPPEFD HHHHHCCCCCCCCCC	22.61	29514104
1578	Phosphorylation	LMKAHSSTQPPEFDS HHHHCCCCCCCCCCC	48.38	27742792
1585	Phosphorylation	TQPPEFDSGVETFSV CCCCCCCCCCEEEEE	50.49	30352176
1589	Phosphorylation	EFDSGVETFSVHTDK CCCCCCEEEEECCCC	20.85	27717184
1599	Phosphorylation	VHTDKPKYQMNNIST ECCCCCCEECCCCCC	22.86	29514104
1606	Phosphorylation	YQMNNISTMPKAVPV EECCCCCCCCCEEEC	33.42	22006019
1614	Phosphorylation	MPKAVPVSPSAVEED CCCEEECCHHHCCCC	13.68	25521595
1616	Phosphorylation	KAVPVSPSAVEEDED CEEECCHHHCCCCCC	37.12	27742792
1628	Phosphorylation	DEDEDGHTVVATARG CCCCCCCEEEEEEEE	23.39	25619855
1632	Phosphorylation	DGHTVVATARGIFNS CCCEEEEEEEEEEEC	12.79	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
168	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZO1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZO1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ACTN4_MOUSE	Actn4	physical	16944923

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZO1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-175; SER-178;SER-179; SER-300; SER-617 AND SER-912, AND MASS SPECTROMETRY.	19367708 [Abstract]
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-912, AND MASSSPECTROMETRY.	18630941 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175; SER-284; SER-297;SER-300 AND SER-617, AND MASS SPECTROMETRY.	17242355 [Abstract]
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1164, AND MASSSPECTROMETRY.	19131326 [Abstract]
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