ACTN4_MOUSE - dbPTM
ACTN4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACTN4_MOUSE
UniProt AC P57780
Protein Name Alpha-actinin-4 {ECO:0000305}
Gene Name Actn4 {ECO:0000312|MGI:MGI:1890773}
Organism Mus musculus (Mouse).
Sequence Length 912
Subcellular Localization Nucleus . Cytoplasm . Cell junction . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers.
Protein Description F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. [PubMed: 18332111 May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (By similarity]
Protein Sequence MVDYHAANQAYQYGPNSGGGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKQRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPSLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MVDYHAANQAY
----CCCCCCCCCCC		5.0724224561
32PhosphorylationGGGSMGDYMAQEDDW
CCCCHHHHHCCCCCC		6.6622996825
51UbiquitinationLLDPAWEKQQRKTFT
CCCHHHHHHHHHHHH		40.82-
55UbiquitinationAWEKQQRKTFTAWCN
HHHHHHHHHHHHHHH		43.59-
55MalonylationAWEKQQRKTFTAWCN
HHHHHHHHHHHHHHH		43.5926320211
58PhosphorylationKQQRKTFTAWCNSHL
HHHHHHHHHHHHHHH		25.2028542873
63PhosphorylationTFTAWCNSHLRKAGT
HHHHHHHHHHHHHCC		22.2928542873
70PhosphorylationSHLRKAGTQIENIDE
HHHHHHCCCCCCCCH		31.1029514104
115AcetylationHKINNVNKALDFIAS
EECCCHHHHHHHHHH		46.1523954790
122PhosphorylationKALDFIASKGVKLVS
HHHHHHHHCCCEEEE		25.7328542873
126UbiquitinationFIASKGVKLVSIGAE
HHHHCCCEEEEECCH		52.4122790023
160PhosphorylationRFAIQDISVEETSAK
HHHHHCCCCCCCCHH		31.5926824392
164PhosphorylationQDISVEETSAKEGLL
HCCCCCCCCHHHCCH		22.0727742792
165PhosphorylationDISVEETSAKEGLLL
CCCCCCCCHHHCCHH		40.3927742792
182MalonylationQRKTAPYKNVNVQNF
CCCCCCCCCCCCCEE		54.0526320211
192PhosphorylationNVQNFHISWKDGLAF
CCCEEEEECCCCHHH		21.3623375375
213PhosphorylationHRPELIEYDKLRKDD
CCHHHHCHHHCCCCC		16.0426824392
215AcetylationPELIEYDKLRKDDPV
HHHHCHHHCCCCCCC		49.6522826441
215UbiquitinationPELIEYDKLRKDDPV
HHHHCHHHCCCCCCC		49.6522790023
218AcetylationIEYDKLRKDDPVTNL
HCHHHCCCCCCCCCC		76.5423236377
218UbiquitinationIEYDKLRKDDPVTNL
HCHHHCCCCCCCCCC		76.5422790023
234UbiquitinationNAFEVAEKYLDIPKM
HHHHHHHHHCCCCCC		41.1822790023
235PhosphorylationAFEVAEKYLDIPKML
HHHHHHHHCCCCCCC		10.9162053
250PhosphorylationDAEDIVNTARPDEKA
CHHHHHHCCCCCHHH		17.1026824392
256UbiquitinationNTARPDEKAIMTYVS
HCCCCCHHHHHHHHH		51.06-
261PhosphorylationDEKAIMTYVSSFYHA
CHHHHHHHHHHHHHH		4.8723984901
263PhosphorylationKAIMTYVSSFYHAFS
HHHHHHHHHHHHHHH		12.3322499769
264PhosphorylationAIMTYVSSFYHAFSG
HHHHHHHHHHHHHHC		21.5622499769
266PhosphorylationMTYVSSFYHAFSGAQ
HHHHHHHHHHHHCHH		8.3226824392
270PhosphorylationSSFYHAFSGAQKAET
HHHHHHHHCHHHHHH		33.7222499769
274AcetylationHAFSGAQKAETAANR
HHHHCHHHHHHHHHH		47.8922826441
304PhosphorylationEDYERLASDLLEWIR
HHHHHHHHHHHHHHH		33.1273666003
324MalonylationLEDRVPQKTIQEMQQ
HHHCCCHHHHHHHHH		41.3426320211
324AcetylationLEDRVPQKTIQEMQQ
HHHCCCHHHHHHHHH		41.3423236377
332UbiquitinationTIQEMQQKLEDFRDY
HHHHHHHHHHHHHHH		36.6322790023
347UbiquitinationRRVHKPPKVQEKCQL
HHHCCCCCHHHCEEE		66.14-
351UbiquitinationKPPKVQEKCQLEINF
CCCCHHHCEEEEEEC		15.3622790023
352S-nitrosylationPPKVQEKCQLEINFN
CCCHHHCEEEEEECC		5.7020925432
352S-nitrosocysteinePPKVQEKCQLEINFN
CCCHHHCEEEEEECC		5.70-
360PhosphorylationQLEINFNTLQTKLRL
EEEEECCHHHHHHHH		18.9928464351
363PhosphorylationINFNTLQTKLRLSNR
EECCHHHHHHHHHCC		34.8528464351
368PhosphorylationLQTKLRLSNRPAFMP
HHHHHHHHCCCCCCC		25.1025266776
376PhosphorylationNRPAFMPSEGRMVSD
CCCCCCCCCCCCCCC		40.6828638064
382PhosphorylationPSEGRMVSDINNGWQ
CCCCCCCCCCCCCHH		24.3527087446
418AcetylationRLDHLAEKFRQKASI
HHHHHHHHHHHHHHH		39.9922826441
418UbiquitinationRLDHLAEKFRQKASI
HHHHHHHHHHHHHHH		39.9922790023
422UbiquitinationLAEKFRQKASIHEAW
HHHHHHHHHHHHHHC		39.5822790023
424PhosphorylationEKFRQKASIHEAWTD
HHHHHHHHHHHHCCC		31.3625521595
430PhosphorylationASIHEAWTDGKEAML
HHHHHHCCCHHHHHH		41.7523684622
433UbiquitinationHEAWTDGKEAMLKQR
HHHCCCHHHHHHHHC		45.1422790023
438MalonylationDGKEAMLKQRDYETA
CHHHHHHHHCCHHHC		30.1526320211
442PhosphorylationAMLKQRDYETATLSD
HHHHHCCHHHCCHHH		19.8522871156
446PhosphorylationQRDYETATLSDIKAL
HCCHHHCCHHHHHHH		33.9329514104
451UbiquitinationTATLSDIKALIRKHE
HCCHHHHHHHHHHHH		41.9722790023
462PhosphorylationRKHEAFESDLAAHQD
HHHHHHHHHHHHCHH		31.3227742792
508PhosphorylationDQWDNLGSLTHSRRE
HCCHHHHHHHHHHHH		33.0122817900
510PhosphorylationWDNLGSLTHSRREAL
CHHHHHHHHHHHHHH		21.3625168779
512PhosphorylationNLGSLTHSRREALEK
HHHHHHHHHHHHHHH		28.0025168779
522AcetylationEALEKTEKQLETIDQ
HHHHHHHHHHHHHHH		66.4723954790
593MalonylationEAILAIHKEAQRIAE
HHHHHHHHHHHHHHH		48.9426320211
593AcetylationEAILAIHKEAQRIAE
HHHHHHHHHHHHHHH		48.94-
605UbiquitinationIAESNHIKLSGSNPY
HHHHCCCCCCCCCCC		29.11-
605AcetylationIAESNHIKLSGSNPY
HHHHCCCCCCCCCCC		29.1123236377
605MalonylationIAESNHIKLSGSNPY
HHHHCCCCCCCCCCC		29.1126320211
607PhosphorylationESNHIKLSGSNPYTT
HHCCCCCCCCCCCCC		34.8629472430
609PhosphorylationNHIKLSGSNPYTTVT
CCCCCCCCCCCCCCC		31.1225195567
612PhosphorylationKLSGSNPYTTVTPQI
CCCCCCCCCCCCHHH		21.2029472430
613PhosphorylationLSGSNPYTTVTPQII
CCCCCCCCCCCHHHH		18.9529472430
614PhosphorylationSGSNPYTTVTPQIIN
CCCCCCCCCCHHHHH		19.2829472430
623AcetylationTPQIINSKWEKVQQL
CHHHHHHCHHHHHHH		55.6823236377
626AcetylationIINSKWEKVQQLVPK
HHHHCHHHHHHHCCC		44.2023806337
626MalonylationIINSKWEKVQQLVPK
HHHHCHHHHHHHCCC		44.2026320211
626SuccinylationIINSKWEKVQQLVPK
HHHHCHHHHHHHCCC		44.2023806337
633MalonylationKVQQLVPKRDHALLE
HHHHHCCCCHHHHHH		64.0826320211
633UbiquitinationKVQQLVPKRDHALLE
HHHHHCCCCHHHHHH		64.08-
657PhosphorylationHLRRQFASQANMVGP
HHHHHHHHHHHCCHH		30.9827180971
692AcetylationEDQLSHLKQYERSIV
HHHHHHHHHHHHHHC		45.4723954790
697PhosphorylationHLKQYERSIVDYKPS
HHHHHHHHHCCCCCC		18.28-
702AcetylationERSIVDYKPSLDLLE
HHHHCCCCCCHHHHH		24.5423954790
728PhosphorylationFDNKHTNYTMEHIRV
HCCCCCCCCHHHHHH		14.4928464351
761UbiquitinationQILTRDAKGISQEQM
HHHCCCCCCCCHHHH		62.1522790023
780AcetylationASFNHFDKDHGGALG
HHCCCCCCCCCCCCC		51.1623806337
794S-nitrosocysteineGPEEFKACLISLGYD
CHHHHHHHHHHCCCC		3.41-
794GlutathionylationGPEEFKACLISLGYD
CHHHHHHHHHHCCCC		3.4124333276
794S-nitrosylationGPEEFKACLISLGYD
CHHHHHHHHHHCCCC		3.4120925432
845PhosphorylationRETTDTDTADQVIAS
CCCCCCCCHHHHHHH		33.9426525534
860AcetylationFKVLAGDKNFITAEE
HHHHHCCCCEECHHH		53.4923806337
901PhosphorylationPGALDYKSFSTALYG
CCCCCCCHHHHHHCC		20.4229895711
903PhosphorylationALDYKSFSTALYGES
CCCCCHHHHHHCCCC		21.6229472430
904PhosphorylationLDYKSFSTALYGESD
CCCCHHHHHHCCCCC		20.7629472430
907PhosphorylationKSFSTALYGESDL--
CHHHHHHCCCCCC--		19.1829472430
910PhosphorylationSTALYGESDL-----
HHHHCCCCCC-----		39.5925521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACTN4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACTN4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACTN4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ACTN4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACTN4_MOUSE

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Related Literatures of Post-Translational Modification

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