dbPTM

1433T_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	1433T_HUMAN
UniProt AC	P27348
Protein Name	14-3-3 protein theta
Gene Name	YWHAQ
Organism	Homo sapiens (Human).
Sequence Length	245
Subcellular Localization	Cytoplasm. In neurons, axonally transported to the nerve terminals.
Protein Description	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1..
Protein Sequence	MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEKTELIQ -------CCHHHHHH	12.29	25944712
3	Acetylation	-----MEKTELIQKA -----CCHHHHHHHH	46.10	19608861
3	Ubiquitination	-----MEKTELIQKA -----CCHHHHHHHH	46.10	23000965
4	Phosphorylation	----MEKTELIQKAK ----CCHHHHHHHHH	23.79	26270265
9	Acetylation	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	23236377
9	Ubiquitination	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	23000965
9	Malonylation	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	26320211
9	Neddylation	EKTELIQKAKLAEQA CHHHHHHHHHHHHHH	40.26	32015554
11	Acetylation	TELIQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	25953088
11	Ubiquitination	TELIQKAKLAEQAER HHHHHHHHHHHHHHH	56.09	23000965
19	Phosphorylation	LAEQAERYDDMATCM HHHHHHHHHHHHHHH	14.06	29396449
24	Phosphorylation	ERYDDMATCMKAVTE HHHHHHHHHHHHHHH	13.39	29396449
25	S-nitrosylation	RYDDMATCMKAVTEQ HHHHHHHHHHHHHHH	1.59	2212679
25	Glutathionylation	RYDDMATCMKAVTEQ HHHHHHHHHHHHHHH	1.59	22555962
25	S-nitrosocysteine	RYDDMATCMKAVTEQ HHHHHHHHHHHHHHH	1.59	-
27	Ubiquitination	DDMATCMKAVTEQGA HHHHHHHHHHHHHHH	41.68	21906983
27	Acetylation	DDMATCMKAVTEQGA HHHHHHHHHHHHHHH	41.68	25953088
30	Phosphorylation	ATCMKAVTEQGAELS HHHHHHHHHHHHHCC	27.70	21601212
37	Phosphorylation	TEQGAELSNEERNLL HHHHHHCCHHHHHHH	33.43	20873877
45	Phosphorylation	NEERNLLSVAYKNVV HHHHHHHHHHHHCHH	14.10	19664994
48	Phosphorylation	RNLLSVAYKNVVGGR HHHHHHHHHCHHCCC	10.84	22617229
49	Sumoylation	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	28112733
49	Succinylation	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	23954790
49	Acetylation	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	19608861
49	Ubiquitination	NLLSVAYKNVVGGRR HHHHHHHHCHHCCCH	33.26	23000965
57	Phosphorylation	NVVGGRRSAWRVISS CHHCCCHHHHHHHHH	30.72	20068231
63	Phosphorylation	RSAWRVISSIEQKTD HHHHHHHHHHHHCCC	23.54	27273156
64	Phosphorylation	SAWRVISSIEQKTDT HHHHHHHHHHHCCCC	21.01	23911959
68	Acetylation	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	19608861
68	Ubiquitination	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	23000965
68	Malonylation	VISSIEQKTDTSDKK HHHHHHHCCCCCHHH	35.26	26320211
74	Ubiquitination	QKTDTSDKKLQLIKD HCCCCCHHHHHHHHH	55.97	23000965
75	Ubiquitination	KTDTSDKKLQLIKDY CCCCCHHHHHHHHHH	46.59	23000965
80	Succinylation	DKKLQLIKDYREKVE HHHHHHHHHHHHHHH	58.25	23954790
80	Acetylation	DKKLQLIKDYREKVE HHHHHHHHHHHHHHH	58.25	25953088
80	Ubiquitination	DKKLQLIKDYREKVE HHHHHHHHHHHHHHH	58.25	23000965
82	Nitration	KLQLIKDYREKVESE HHHHHHHHHHHHHHH	18.70	-
82	Phosphorylation	KLQLIKDYREKVESE HHHHHHHHHHHHHHH	18.70	21406692
85	Succinylation	LIKDYREKVESELRS HHHHHHHHHHHHHHH	42.16	23954790
85	Ubiquitination	LIKDYREKVESELRS HHHHHHHHHHHHHHH	42.16	23000965
85	Acetylation	LIKDYREKVESELRS HHHHHHHHHHHHHHH	42.16	23749302
88	Phosphorylation	DYREKVESELRSICT HHHHHHHHHHHHHHH	44.94	24719451
92	Phosphorylation	KVESELRSICTTVLE HHHHHHHHHHHHHHH	34.34	20068231
94	S-nitrosocysteine	ESELRSICTTVLELL HHHHHHHHHHHHHHH	2.48	-
94	S-nitrosylation	ESELRSICTTVLELL HHHHHHHHHHHHHHH	2.48	19483679
95	Phosphorylation	SELRSICTTVLELLD HHHHHHHHHHHHHHH	20.47	20068231
96	Phosphorylation	ELRSICTTVLELLDK HHHHHHHHHHHHHHH	20.77	28348404
103	Ubiquitination	TVLELLDKYLIANAT HHHHHHHHHHHHCCC	41.76	21906983
104	Phosphorylation	VLELLDKYLIANATN HHHHHHHHHHHCCCC	11.74	20068231
104	Nitration	VLELLDKYLIANATN HHHHHHHHHHHCCCC	11.74	-
110	Phosphorylation	KYLIANATNPESKVF HHHHHCCCCCCCCEE	51.63	20068231
114	Phosphorylation	ANATNPESKVFYLKM HCCCCCCCCEEEEEE	35.06	20068231
115	Succinylation	NATNPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	23954790
115	Acetylation	NATNPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	19608861
115	Ubiquitination	NATNPESKVFYLKMK CCCCCCCCEEEEEEC	34.40	23000965
120	Acetylation	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	25825284
120	Ubiquitination	ESKVFYLKMKGDYFR CCCEEEEEECCCHHH	27.47	23000965
122	Ubiquitination	KVFYLKMKGDYFRYL CEEEEEECCCHHHHH	47.22	23000965
122	Acetylation	KVFYLKMKGDYFRYL CEEEEEECCCHHHHH	47.22	26822725
125	Phosphorylation	YLKMKGDYFRYLAEV EEEECCCHHHHHHHH	9.91	21253578
128	Phosphorylation	MKGDYFRYLAEVACG ECCCHHHHHHHHHCC	10.60	24927040
134	Glutathionylation	RYLAEVACGDDRKQT HHHHHHHCCCCCCCC	8.09	22555962
134	S-nitrosylation	RYLAEVACGDDRKQT HHHHHHHCCCCCCCC	8.09	20140087
134	S-nitrosocysteine	RYLAEVACGDDRKQT HHHHHHHCCCCCCCC	8.09	-
139	Acetylation	VACGDDRKQTIDNSQ HHCCCCCCCCCCCCC	59.80	11921019
139	Ubiquitination	VACGDDRKQTIDNSQ HHCCCCCCCCCCCCC	59.80	22053931
139	Malonylation	VACGDDRKQTIDNSQ HHCCCCCCCCCCCCC	59.80	26320211
141	Phosphorylation	CGDDRKQTIDNSQGA CCCCCCCCCCCCCCH	33.08	22186773
145	Phosphorylation	RKQTIDNSQGAYQEA CCCCCCCCCCHHHHH	26.66	28152594
149	Phosphorylation	IDNSQGAYQEAFDIS CCCCCCHHHHHHHCC	17.45	28152594
156	O-linked_Glycosylation	YQEAFDISKKEMQPT HHHHHHCCHHHCCCC	39.25	30379171
156	Phosphorylation	YQEAFDISKKEMQPT HHHHHHCCHHHCCCC	39.25	22186783
157	Acetylation	QEAFDISKKEMQPTH HHHHHCCHHHCCCCC	53.76	23236377
157	Ubiquitination	QEAFDISKKEMQPTH HHHHHCCHHHCCCCC	53.76	23000965
158	Acetylation	EAFDISKKEMQPTHP HHHHCCHHHCCCCCC	52.18	18525141
158	Ubiquitination	EAFDISKKEMQPTHP HHHHCCHHHCCCCCC	52.18	23000965
160	Sulfoxidation	FDISKKEMQPTHPIR HHCCHHHCCCCCCCC	8.75	28183972
193	Ubiquitination	ELACTLAKTAFDEAI HHHHHHHHHHHHHHH	43.42	-
205	Phosphorylation	EAIAELDTLNEDSYK HHHHHHHCCCCCCCC	44.07	27732954
210	Phosphorylation	LDTLNEDSYKDSTLI HHCCCCCCCCCHHHH	28.09	28102081
211	Phosphorylation	DTLNEDSYKDSTLIM HCCCCCCCCCHHHHH	31.01	119397
212	Methylation	TLNEDSYKDSTLIMQ CCCCCCCCCHHHHHH	49.51	-
212	Ubiquitination	TLNEDSYKDSTLIMQ CCCCCCCCCHHHHHH	49.51	16196087
214	Phosphorylation	NEDSYKDSTLIMQLL CCCCCCCHHHHHHHH	22.44	22617229
215	Phosphorylation	EDSYKDSTLIMQLLR CCCCCCHHHHHHHHH	30.36	19664994
218	Sulfoxidation	YKDSTLIMQLLRDNL CCCHHHHHHHHHCCC	2.30	21406390
226	Phosphorylation	QLLRDNLTLWTSDSA HHHHCCCEEEECCCC	26.89	23927012
229	Phosphorylation	RDNLTLWTSDSAGEE HCCCEEEECCCCCCC	26.26	30266825
230	Phosphorylation	DNLTLWTSDSAGEEC CCCEEEECCCCCCCC	20.27	25463755
232	Phosphorylation	LTLWTSDSAGEECDA CEEEECCCCCCCCCH	37.63	20201521

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
232	S	Phosphorylation	Kinase	BCR	P11274	PSP
232	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
232	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
232	S	Phosphorylation	Kinase	CK1-FAMILY	-	GPS
232	S	Phosphorylation	Kinase	CK1_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
232	S	Phosphorylation		9360956
Ser-232 is probably phosphorylated by CK1.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 1433T_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRTC2_HUMAN	CRTC2	physical	15454081
KINH_HUMAN	KIF5B	physical	17353931
PI4KB_HUMAN	PI4KB	physical	17353931
SMAG2_HUMAN	SAMD4B	physical	17353931
KIF5C_HUMAN	KIF5C	physical	17353931
MPRIP_HUMAN	MPRIP	physical	17353931
KLC4_HUMAN	KLC4	physical	17353931
BRAF_HUMAN	BRAF	physical	17353931
PNKP_HUMAN	PNKP	physical	17353931
E41L3_HUMAN	EPB41L3	physical	17353931
ZO2_HUMAN	TJP2	physical	17353931
CALL5_HUMAN	CALML5	physical	17353931
PAK4_HUMAN	PAK4	physical	17353931
UNC79_HUMAN	UNC79	physical	17353931
CBWD2_HUMAN	CBWD2	physical	17353931
RAI14_HUMAN	RAI14	physical	17353931
MARK2_HUMAN	MARK2	physical	17353931
SPIR1_HUMAN	SPIRE1	physical	17353931
RAF1_HUMAN	RAF1	physical	17353931
EDC3_HUMAN	EDC3	physical	17353931
EMAL3_HUMAN	EML3	physical	17353931
IRS2_HUMAN	IRS2	physical	17353931
K0930_HUMAN	KIAA0930	physical	17353931
GRP3_HUMAN	RASGRP3	physical	17353931
AFAD_HUMAN	MLLT4	physical	17353931
RABE1_HUMAN	RABEP1	physical	17353931
UBP8_HUMAN	USP8	physical	17353931
LC7L2_HUMAN	LUC7L2	physical	17353931
TSC2_HUMAN	TSC2	physical	17353931
KIF23_HUMAN	KIF23	physical	17353931
SRSF3_HUMAN	SRSF3	physical	17353931
DDX6_HUMAN	DDX6	physical	17353931
MARK3_HUMAN	MARK3	physical	17353931
FA83G_HUMAN	FAM83G	physical	17353931
KMT5B_HUMAN	SUV420H1	physical	17353931
MYCPP_HUMAN	DENND4A	physical	17353931
PAK6_HUMAN	PAK6	physical	17353931
SRSF1_HUMAN	SRSF1	physical	17353931
SRS10_HUMAN	SRSF10	physical	17353931
E41L2_HUMAN	EPB41L2	physical	17353931
CRTC2_HUMAN	CRTC2	physical	17353931
LIPB1_HUMAN	PPFIBP1	physical	17353931
RL21_HUMAN	RPL21	physical	17353931
SH3B4_HUMAN	SH3BP4	physical	17353931
SRSF6_HUMAN	SRSF6	physical	17353931
LARP1_HUMAN	LARP1	physical	17353931
KLC2_HUMAN	KLC2	physical	17353931
PANK2_HUMAN	PANK2	physical	17353931
PLM_HUMAN	FXYD1	physical	14597563
F262_HUMAN	PFKFB2	physical	12853467
CCAR1_HUMAN	CCAR1	physical	12816952
NRIP1_HUMAN	NRIP1	physical	11266503
NRIP1_HUMAN	NRIP1	genetic	11266503
ANDR_HUMAN	AR	physical	11266503
ESR1_HUMAN	ESR1	physical	11266503
ESR2_HUMAN	ESR2	physical	11266503
THA_HUMAN	THRA	physical	11266503
MED1_HUMAN	MED1	physical	11266503
NCOA3_HUMAN	NCOA3	physical	11266503
NCOA1_HUMAN	NCOA1	physical	11266503
REM1_HUMAN	REM1	physical	10441394
CBL_HUMAN	CBL	physical	11024037
RAF1_HUMAN	RAF1	physical	10757792
MEF2D_HUMAN	MEF2D	physical	11433030
BAX_HUMAN	BAX	physical	12426317
YAP1_HUMAN	YAP1	physical	12535517
KPCD1_HUMAN	PRKD1	physical	10831594
DAPK1_HUMAN	DAPK1	physical	12911633
KPCD1_HUMAN	PRKD1	physical	10092600
MPIP2_HUMAN	CDC25B	physical	10713667
TERT_HUMAN	TERT	physical	10835362
CBL_HUMAN	CBL	physical	8663231
RAF1_HUMAN	RAF1	physical	8663231
UCP3_HUMAN	UCP3	physical	10785390
E2F1_HUMAN	E2F1	physical	15494392
ING1_HUMAN	ING1	physical	16581770
H32_HUMAN	HIST2H3C	physical	18059471
SAMN1_HUMAN	SAMSN1	physical	20478393
CAF1A_HUMAN	CHAF1A	physical	21209461
H10_HUMAN	H1F0	physical	20618440
H13_HUMAN	HIST1H1D	physical	20618440
H1T_HUMAN	HIST1H1T	physical	20618440
H2AX_HUMAN	H2AFX	physical	20618440
H2B1D_HUMAN	HIST1H2BD	physical	20618440
H2B1C_HUMAN	HIST1H2BD	physical	20618440
NPM_HUMAN	NPM1	physical	20618440
TF2LY_HUMAN	TGIF2LY	physical	20618440
HNRPC_HUMAN	HNRNPC	physical	20618440
ROA2_HUMAN	HNRNPA2B1	physical	20618440
RALY_HUMAN	RALY	physical	20618440
RS3_HUMAN	RPS3	physical	20618440
SC65_HUMAN	P3H4	physical	20618440
CAC1S_HUMAN	CACNA1S	physical	20618440
ATPA_HUMAN	ATP5A1	physical	20618440
UBP42_HUMAN	USP42	physical	20618440
H12_HUMAN	HIST1H1C	physical	20618440
ML12B_HUMAN	MYL12B	physical	20618440
TITIN_HUMAN	TTN	physical	20618440
CP250_HUMAN	CEP250	physical	20618440
TSC2_HUMAN	TSC2	physical	20618440
MYLK2_HUMAN	MYLK2	physical	20618440
1433Z_HUMAN	YWHAZ	physical	20618440
1433E_HUMAN	YWHAE	physical	20618440
1433G_HUMAN	YWHAG	physical	20618440
1433F_HUMAN	YWHAH	physical	20618440
BANK1_HUMAN	BANK1	physical	20618440
VIME_HUMAN	VIM	physical	20618440
LMNA_HUMAN	LMNA	physical	20618440
ACTN2_HUMAN	ACTN2	physical	20618440
DESM_HUMAN	DES	physical	20618440
VASP_HUMAN	VASP	physical	20618440
MYH2_HUMAN	MYH2	physical	20618440
MYH7_HUMAN	MYH7	physical	20618440
MYH9_HUMAN	MYH9	physical	20618440
MYH11_HUMAN	MYH11	physical	20618440
MYH13_HUMAN	MYH13	physical	20618440
MYL3_HUMAN	MYL3	physical	20618440
ACTA_HUMAN	ACTA2	physical	20618440
ACTG_HUMAN	ACTG1	physical	20618440
ACTB_HUMAN	ACTB	physical	20618440
TBB2A_HUMAN	TUBB2A	physical	20618440
AN18A_HUMAN	ANKRD18A	physical	20618440
K2C8_HUMAN	KRT8	physical	20618440
K1C17_HUMAN	KRT17	physical	20618440
K1C18_HUMAN	KRT18	physical	20618440
TPM1_HUMAN	TPM1	physical	20618440
EF1A1_HUMAN	EEF1A1	physical	20618440
ATPB_HUMAN	ATP5B	physical	20618440
CPSM_HUMAN	CPS1	physical	20618440
HMCS2_HUMAN	HMGCS2	physical	20618440
STPAP_HUMAN	TUT1	physical	20618440
1433S_HUMAN	SFN	physical	20618440
1433B_HUMAN	YWHAB	physical	20618440
PRKDC_HUMAN	PRKDC	physical	20618440
WNK4_HUMAN	WNK4	physical	20618440
TBA1C_HUMAN	TUBA1C	physical	20618440
HSPB1_HUMAN	HSPB1	physical	20618440
HSP7C_HUMAN	HSPA8	physical	15324660
KINH_HUMAN	KIF5B	physical	15324660
K2C1_HUMAN	KRT1	physical	15324660
K1C9_HUMAN	KRT9	physical	15324660
MGN_HUMAN	MAGOH	physical	15324660
PI4KB_HUMAN	PI4KB	physical	15324660
SRSF3_HUMAN	SRSF3	physical	15324660
UBP8_HUMAN	USP8	physical	15324660
IF4A3_HUMAN	EIF4A3	physical	15324660
TBA3C_HUMAN	TUBA3C	physical	15324660
MPRIP_HUMAN	MPRIP	physical	15324660
LARP1_HUMAN	LARP1	physical	15324660
RAI14_HUMAN	RAI14	physical	15324660
SMAG2_HUMAN	SAMD4B	physical	15324660
ADCK2_HUMAN	ADCK2	physical	15324660
EXO1_HUMAN	EXO1	physical	22222486
HDAC4_HUMAN	HDAC4	physical	22649097
HDAC5_HUMAN	HDAC5	physical	22649097
ABL1_HUMAN	ABL1	physical	22649097
TPOR_HUMAN	MPL	physical	22649097
PDE3B_HUMAN	PDE3B	physical	22649097
HDAC4_HUMAN	HDAC4	physical	22466704
BAD_HUMAN	BAD	physical	11697890
RAF1_HUMAN	RAF1	physical	11697890
CBL_HUMAN	CBL	physical	11697890
MDM2_HUMAN	MDM2	physical	20086099
PSA3_HUMAN	PSMA3	physical	20086099
CDN1A_HUMAN	CDKN1A	physical	20086099
CBL_HUMAN	CBL	physical	9092538
ZHX2_HUMAN	ZHX2	physical	9092538
KPCT_HUMAN	PRKCQ	physical	8816492
RPTOR_HUMAN	RPTOR	physical	18439900
PKP2_HUMAN	PKP2	physical	12941695
DAB2P_HUMAN	DAB2IP	physical	17389591
M3K5_HUMAN	MAP3K5	physical	17389591
FSHR_HUMAN	FSHR	physical	15196694
M3K1_HUMAN	MAP3K1	physical	21152872
PDPK1_HUMAN	PDPK1	physical	19010391
LCK_HUMAN	LCK	physical	19010391
SIK2_HUMAN	SIK2	physical	22462548
LRRK2_HUMAN	LRRK2	physical	20642453
MARK3_HUMAN	MARK3	physical	20642453
SYUA_HUMAN	SNCA	physical	15280438
BAD_HUMAN	BAD	physical	15280438
UBP8_HUMAN	USP8	physical	23333852
TRI32_HUMAN	TRIM32	physical	23444366
SMUF1_HUMAN	SMURF1	physical	23444366
ZNRF2_HUMAN	ZNRF2	physical	23444366
NED4L_HUMAN	NEDD4L	physical	23444366
BRE1A_HUMAN	RNF20	physical	23444366
MYCB2_HUMAN	MYCBP2	physical	23444366
HECD1_HUMAN	HECTD1	physical	23444366
KKCC1_HUMAN	CAMKK1	physical	23444366
PDE3A_HUMAN	PDE3A	physical	23444366
TY3H_HUMAN	TH	physical	23444366
TPD54_HUMAN	TPD52L2	physical	23444366
MFF_HUMAN	MFF	physical	23444366
TPD52_HUMAN	TPD52	physical	23444366
WDR20_HUMAN	WDR20	physical	23444366
TPD53_HUMAN	TPD52L1	physical	23444366
GGYF1_HUMAN	GIGYF1	physical	23444366
E41L3_HUMAN	EPB41L3	physical	23444366
RAE1L_HUMAN	RAE1	physical	23444366
CDK18_HUMAN	CDK18	physical	23444366
MYCBP_HUMAN	MYCBP	physical	23444366
RMD3_HUMAN	RMDN3	physical	23444366
WNK1_HUMAN	WNK1	physical	23444366
RENT1_HUMAN	UPF1	physical	23444366
WASF2_HUMAN	WASF2	physical	23444366
PKHA7_HUMAN	PLEKHA7	physical	23444366
TFEB_HUMAN	TFEB	physical	23444366
SI1L3_HUMAN	SIPA1L3	physical	23444366
RHG23_HUMAN	ARHGAP23	physical	23444366
SPEG_HUMAN	SPEG	physical	23444366
AFAD_HUMAN	MLLT4	physical	23444366
CE170_HUMAN	CEP170	physical	23444366
TBCD4_HUMAN	TBC1D4	physical	23444366
CRTC2_HUMAN	CRTC2	physical	23444366
HDAC4_HUMAN	HDAC4	physical	23444366
AKTS1_HUMAN	AKT1S1	physical	23444366
MPIP2_HUMAN	CDC25B	physical	15629715
MPIP3_HUMAN	CDC25C	physical	15629715
TNFA_HUMAN	TNF	physical	15014438
ABL1_HUMAN	ABL1	physical	16888623
RAF1_HUMAN	RAF1	physical	16093354
CDN1B_MOUSE	Cdkn1b	physical	17470459
CD11B_HUMAN	CDK11B	physical	15883043
CLH1_HUMAN	CLTC	physical	15161933
MYCB2_HUMAN	MYCBP2	physical	15161933
RT27_HUMAN	MRPS27	physical	15161933
ZC3HD_HUMAN	ZC3H13	physical	15161933
FL2D_HUMAN	WTAP	physical	15161933
VIR_HUMAN	KIAA1429	physical	15161933
LMO7_HUMAN	LMO7	physical	15161933
TIF1B_HUMAN	TRIM28	physical	15161933
NFAC1_HUMAN	NFATC1	physical	15161933
XPO2_HUMAN	CSE1L	physical	15161933
TCPA_HUMAN	TCP1	physical	15161933
TPIS_HUMAN	TPI1	physical	15161933
PDXK_HUMAN	PDXK	physical	15161933
ENOA_HUMAN	ENO1	physical	15161933
SAHH_HUMAN	AHCY	physical	15161933
KPYM_HUMAN	PKM	physical	15161933
ATPA_HUMAN	ATP5A1	physical	15161933
PANK1_HUMAN	PANK1	physical	15161933
SPRE_HUMAN	SPR	physical	15161933
LDHA_HUMAN	LDHA	physical	15161933
KCRM_HUMAN	CKM	physical	15161933
G3P_HUMAN	GAPDH	physical	15161933
PGK1_HUMAN	PGK1	physical	15161933
ECHA_HUMAN	HADHA	physical	15161933
S27A2_HUMAN	SLC27A2	physical	15161933
ACSL4_HUMAN	ACSL4	physical	15161933
FAS_HUMAN	FASN	physical	15161933
PFKAL_HUMAN	PFKL	physical	15161933
COF1_HUMAN	CFL1	physical	15161933
PROF1_HUMAN	PFN1	physical	15161933
TLN1_HUMAN	TLN1	physical	15161933
HAKAI_HUMAN	CBLL1	physical	15161933
SPTB1_HUMAN	SPTB	physical	15161933
SPTA1_HUMAN	SPTA1	physical	15161933
FSCN1_HUMAN	FSCN1	physical	15161933
ANXA1_HUMAN	ANXA1	physical	15161933
ANXA2_HUMAN	ANXA2	physical	15161933
LMNB1_HUMAN	LMNB1	physical	15161933
LMNA_HUMAN	LMNA	physical	15161933
VIME_HUMAN	VIM	physical	15161933
TBB5_HUMAN	TUBB	physical	15161933
TBA1A_HUMAN	TUBA1A	physical	15161933
DYHC1_HUMAN	DYNC1H1	physical	15161933
KIF23_HUMAN	KIF23	physical	15161933
GCN1_HUMAN	GCN1L1	physical	15161933
PABP4_HUMAN	PABPC4	physical	15161933
PABP2_HUMAN	PABPN1	physical	15161933
SYAM_HUMAN	AARS2	physical	15161933
SYLM_HUMAN	LARS2	physical	15161933
SYIM_HUMAN	IARS2	physical	15161933
SYVC_HUMAN	VARS	physical	15161933
RL10A_HUMAN	RPL10A	physical	15161933
RL7_HUMAN	RPL7	physical	15161933
RLA2_HUMAN	RPLP2	physical	15161933
RL15_HUMAN	RPL15	physical	15161933
RL19_HUMAN	RPL19	physical	15161933
RLA0_HUMAN	RPLP0	physical	15161933
RS3_HUMAN	RPS3	physical	15161933
DCPS_HUMAN	DCPS	physical	15161933
RNAS2_HUMAN	RNASE2	physical	15161933
DHX9_HUMAN	DHX9	physical	15161933
DDX3X_HUMAN	DDX3X	physical	15161933
DDX1_HUMAN	DDX1	physical	15161933
HNRPK_HUMAN	HNRNPK	physical	15161933
ROA1_HUMAN	HNRNPA1	physical	15161933
HNRPC_HUMAN	HNRNPC	physical	15161933
HNRH1_HUMAN	HNRNPH1	physical	15161933
HNRPF_HUMAN	HNRNPF	physical	15161933
RUVB2_HUMAN	RUVBL2	physical	15161933
DNMT1_HUMAN	DNMT1	physical	15161933
HAT1_HUMAN	HAT1	physical	15161933
SSBP_HUMAN	SSBP1	physical	15161933
HDAC7_HUMAN	HDAC7	physical	15161933
HDAC4_HUMAN	HDAC4	physical	15161933
NDK7_HUMAN	NME7	physical	15161933
NADK_HUMAN	NADK	physical	15161933
PYRG1_HUMAN	CTPS1	physical	15161933
WWC2_HUMAN	WWC2	physical	15161933
BAP31_HUMAN	BCAP31	physical	15161933
PDCD6_HUMAN	PDCD6	physical	15161933
HUS1_HUMAN	HUS1	physical	15161933
CE170_HUMAN	CEP170	physical	15161933
PRDX1_HUMAN	PRDX1	physical	15161933
UBP8_HUMAN	USP8	physical	15161933
WWP1_HUMAN	WWP1	physical	15161933
CSN4_HUMAN	COPS4	physical	15161933
PSME3_HUMAN	PSME3	physical	15161933
NPM_HUMAN	NPM1	physical	15161933
NUCL_HUMAN	NCL	physical	15161933
NOLC1_HUMAN	NOLC1	physical	15161933
APC_HUMAN	APC	physical	15161933
YAP1_HUMAN	YAP1	physical	15161933
PTN3_HUMAN	PTPN3	physical	15161933
LIMA1_HUMAN	LIMA1	physical	15161933
AKTS1_HUMAN	AKT1S1	physical	15161933
PDE3A_HUMAN	PDE3A	physical	15161933
IRS2_HUMAN	IRS2	physical	15161933
TSC2_HUMAN	TSC2	physical	15161933
PHLB2_HUMAN	PHLDB2	physical	15161933
LIPB1_HUMAN	PPFIBP1	physical	15161933
ARHGG_HUMAN	ARHGEF16	physical	15161933
IQGA1_HUMAN	IQGAP1	physical	15161933
RHG10_HUMAN	ARHGAP10	physical	15161933
MPRIP_HUMAN	MPRIP	physical	15161933
PAK4_HUMAN	PAK4	physical	15161933
PRKDC_HUMAN	PRKDC	physical	15161933
RUXE_HUMAN	SNRPE	physical	15161933
MARK3_HUMAN	MARK3	physical	15161933
MARK2_HUMAN	MARK2	physical	15161933
MTOR_HUMAN	MTOR	physical	15161933
P3C2B_HUMAN	PIK3C2B	physical	15161933
CDK17_HUMAN	CDK17	physical	15161933
CDK18_HUMAN	CDK18	physical	15161933
WEE1_HUMAN	WEE1	physical	15161933
WDR61_HUMAN	WDR61	physical	15161933
RFC1_HUMAN	RFC1	physical	15161933
ASPP2_HUMAN	TP53BP2	physical	15161933
NDE1_HUMAN	NDE1	physical	15161933
PCM1_HUMAN	PCM1	physical	15161933
MCM3_HUMAN	MCM3	physical	15161933
NUMA1_HUMAN	NUMA1	physical	15161933
MPIP1_HUMAN	CDC25A	physical	15161933
AL7A1_HUMAN	ALDH7A1	physical	22863883
CAN1_HUMAN	CAPN1	physical	22863883
MAT2B_HUMAN	MAT2B	physical	22863883
6PGD_HUMAN	PGD	physical	22863883
SPSY_HUMAN	SMS	physical	22863883
TXND5_HUMAN	TXNDC5	physical	22863883
UBFD1_HUMAN	UBFD1	physical	22863883
VINC_HUMAN	VCL	physical	22863883
1433B_HUMAN	YWHAB	physical	22863883
1433G_HUMAN	YWHAG	physical	22863883
1433F_HUMAN	YWHAH	physical	22863883
SGK1_HUMAN	SGK1	physical	15650334
TAU_HUMAN	MAPT	physical	15650334
PK3C3_HUMAN	PIK3C3	physical	7479742
RAF1_HUMAN	RAF1	physical	7479742
P85B_HUMAN	PIK3R2	physical	7479742
DTL_HUMAN	DTL	physical	25154416
TRI42_HUMAN	TRIM42	physical	25416956
FOXO3_HUMAN	FOXO3	physical	11896584
ROA1_HUMAN	HNRNPA1	physical	25324306
MCFD2_HUMAN	MCFD2	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
SMD1_HUMAN	SNRPD1	physical	26344197
TTP_HUMAN	ZFP36	physical	21078877

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 1433T_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1; LYS-3; LYS-49; LYS-68 ANDLYS-115, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND MASSSPECTROMETRY.	18691976 [Abstract]
"14-3-3 is phosphorylated by casein kinase I on residue 233.Phosphorylation at this site in vivo regulates Raf/14-3-3interaction."; Dubois T., Rommel C., Howell S., Steinhussen U., Soneji Y.,Morrice N., Moelling K., Aitken A.; J. Biol. Chem. 272:28882-28888(1997). Cited for: PHOSPHORYLATION AT SER-232, AND MASS SPECTROMETRY.	9360956 [Abstract]

show