RHG10_HUMAN - dbPTM
RHG10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHG10_HUMAN
UniProt AC A1A4S6
Protein Name Rho GTPase-activating protein 10
Gene Name ARHGAP10
Organism Homo sapiens (Human).
Sequence Length 786
Subcellular Localization Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Association to cell membrane is dependent on PH domain..
Protein Description GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity)..
Protein Sequence MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51AcetylationKNLIAATKSLSVAQR
HHHHHHHHCCHHHHH		44.687823923
121UbiquitinationKPLEKFRKEQLGAVK
HHHHHHHHHHHCCCH		53.60-
133AcetylationAVKEEKKKFDKETEK
CCHHHHHCCCHHHHH		70.627226389
136AcetylationEEKKKFDKETEKNYS
HHHHCCCHHHHHHHH		70.447226399
140UbiquitinationKFDKETEKNYSLIDK
CCCHHHHHHHHHHHH		69.47-
147AcetylationKNYSLIDKHLNLSAK
HHHHHHHHHHCCCCC		42.897226409
147UbiquitinationKNYSLIDKHLNLSAK
HHHHHHHHHHCCCCC		42.89-
154UbiquitinationKHLNLSAKKKDSHLQ
HHHCCCCCCCCCCHH		57.91-
156AcetylationLNLSAKKKDSHLQEA
HCCCCCCCCCCHHHH		64.857226419
224PhosphorylationLAKDFNHYKMELQIN
HHHHCCCCEEEEEEE		17.0927174698
252UbiquitinationEVEELMNKIRQNPKD
HHHHHHHHHHHCCCC		25.8721906983
309PhosphorylationMIPFEHRSGGKLGDG
CCCEECCCCCCCCCC		54.5324708550
312UbiquitinationFEHRSGGKLGDGEVF
EECCCCCCCCCCEEE		53.472190698
322UbiquitinationDGEVFFLKECTKRHT
CCEEEEECCHHHHCC		45.66-
370UbiquitinationWLEALGGKEALSHSF
HHHHCCHHHHHHCCC		37.71-
374PhosphorylationLGGKEALSHSFNTAI
CCHHHHHHCCCCEEE		24.9225627689
376PhosphorylationGKEALSHSFNTAIIP
HHHHHHCCCCEEEEE		19.4726657352
379PhosphorylationALSHSFNTAIIPRPE
HHHCCCCEEEEECCC		19.7527080861
530PhosphorylationHSKQNLMTVANLGVV
CCHHHHCHHHHCCEE		21.4523663014
541PhosphorylationLGVVFGPTLMRPQEE
CCEEECCCCCCCCHH		33.3022210691
576PhosphorylationNHEKIFRTPPDTTFP
CCHHHCCCCCCCCCC		28.5523403867
580PhosphorylationIFRTPPDTTFPEPTC
HCCCCCCCCCCCCCC		35.7930266825
581PhosphorylationFRTPPDTTFPEPTCL
CCCCCCCCCCCCCCC		44.5730266825
586PhosphorylationDTTFPEPTCLSASPP
CCCCCCCCCCCCCCC		25.1530266825
589PhosphorylationFPEPTCLSASPPNAP
CCCCCCCCCCCCCCC		28.9330266825
591PhosphorylationEPTCLSASPPNAPPR
CCCCCCCCCCCCCCC		37.2030266825
600PhosphorylationPNAPPRQSKRQGQRT
CCCCCCCCCCCCCCC		30.9629514088
614PhosphorylationTKRPVAVYNLCLELE
CCCCCEEEEEEEEEC		7.8427642862
633PhosphorylationPYPSKEDTPTSSLDS
CCCCCCCCCCCCCCC		29.5629514088
635PhosphorylationPSKEDTPTSSLDSLS
CCCCCCCCCCCCCCC		32.8029514088
636PhosphorylationSKEDTPTSSLDSLSS
CCCCCCCCCCCCCCC		30.0629514088
637PhosphorylationKEDTPTSSLDSLSSP
CCCCCCCCCCCCCCC		38.3821955146
640PhosphorylationTPTSSLDSLSSPSPV
CCCCCCCCCCCCCCC		35.1321955146
642PhosphorylationTSSLDSLSSPSPVTT
CCCCCCCCCCCCCCC		44.1226657352
643PhosphorylationSSLDSLSSPSPVTTA
CCCCCCCCCCCCCCC		34.3925159151
645PhosphorylationLDSLSSPSPVTTAVP
CCCCCCCCCCCCCCC		33.6726657352
648PhosphorylationLSSPSPVTTAVPGPP
CCCCCCCCCCCCCCC		16.6621955146
649PhosphorylationSSPSPVTTAVPGPPG
CCCCCCCCCCCCCCC		26.3726074081
668PhosphorylationHLLADGGSFGDWAST
CEECCCCCCCCHHHC		31.4227251275
692PhosphorylationVQWLNPQSPTTTSSN
CHHCCCCCCCCCCCC		26.0228348404
694PhosphorylationWLNPQSPTTTSSNSA
HCCCCCCCCCCCCCC		48.2128348404
695PhosphorylationLNPQSPTTTSSNSAV
CCCCCCCCCCCCCCC		28.2328348404
696PhosphorylationNPQSPTTTSSNSAVT
CCCCCCCCCCCCCCC		32.4128348404
697PhosphorylationPQSPTTTSSNSAVTP
CCCCCCCCCCCCCCC		25.9830576142
698PhosphorylationQSPTTTSSNSAVTPL
CCCCCCCCCCCCCCC		32.4828348404
700PhosphorylationPTTTSSNSAVTPLSP
CCCCCCCCCCCCCCC		26.5128348404
703PhosphorylationTSSNSAVTPLSPGSS
CCCCCCCCCCCCCCC		20.4428348404
706PhosphorylationNSAVTPLSPGSSPFP
CCCCCCCCCCCCCCC		28.5528348404
710PhosphorylationTPLSPGSSPFPFSPP
CCCCCCCCCCCCCCC		36.1530576142
719PhosphorylationFPFSPPATVADKPPE
CCCCCCCCCCCCCCH		23.2330576142
782PhosphorylationRGLIPQNYVKLL---
CCCCCHHHEECC---		8.1721945579
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHG10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHG10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHG10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHOA_HUMANRHOAphysical
11432776
CDC42_HUMANCDC42physical
11432776
ARF6_HUMANARF6physical
16527809
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHG10_HUMAN

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Related Literatures of Post-Translational Modification

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