dbPTM

CDC42_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDC42_HUMAN
UniProt AC	P60953
Protein Name	Cell division control protein 42 homolog
Gene Name	CDC42
Organism	Homo sapiens (Human).
Sequence Length	191
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Midbody . Localizes to spindle during prometaphase cells. Moves to the central spindle as cells
Protein Description	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups..
Protein Sequence	MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MQTIKCVVVGDG ---CCEEEEEEECCC	25.10	-
6	S-palmitoylation	--MQTIKCVVVGDGA --CCEEEEEEECCCC	2.19	29575903
30	Phosphorylation	YTTNKFPSEYVPTVF EECCCCCHHHCCCEE	44.70	-
32	O-AMP-tyrosine	TNKFPSEYVPTVFDN CCCCCHHHCCCEECC	18.96	-
32	Phosphorylation	TNKFPSEYVPTVFDN CCCCCHHHCCCEECC	18.96	-
32	O-linked_Glycosylation	TNKFPSEYVPTVFDN CCCCCHHHCCCEECC	18.96	24141704
32	AMPylation	TNKFPSEYVPTVFDN CCCCCHHHCCCEECC	18.96	19362538
35	O-AMP-threonine	FPSEYVPTVFDNYAV CCHHHCCCEECCEEE	24.62	-
35	Phosphorylation	FPSEYVPTVFDNYAV CCHHHCCCEECCEEE	24.62	-
35	O-linked_Glycosylation	FPSEYVPTVFDNYAV CCHHHCCCEECCEEE	24.62	7775453
35	AMPylation	FPSEYVPTVFDNYAV CCHHHCCCEECCEEE	24.62	19039103
64	Phosphorylation	DTAGQEDYDRLRPLS CCCCCCCHHHCCCCC	11.38	20736484
71	Phosphorylation	YDRLRPLSYPQTDVF HHHCCCCCCCCCCEE	37.13	18669648
107 (in isoform 1)	Ubiquitination	-	74.38	21890473
107 (in isoform 2)	Ubiquitination	-	74.38	21890473
107	Ubiquitination	EITHHCPKTPFLLVG CHHCCCCCCCEEEEE	74.38	-
128	Acetylation	DDPSTIEKLAKNKQK CCHHHHHHHHHCCCC	50.31	26051181
128 (in isoform 1)	Ubiquitination	-	50.31	21890473
128	Ubiquitination	DDPSTIEKLAKNKQK CCHHHHHHHHHCCCC	50.31	-
128 (in isoform 2)	Ubiquitination	-	50.31	21890473
133 (in isoform 1)	Ubiquitination	-	60.02	21890473
133 (in isoform 2)	Ubiquitination	-	60.02	21890473
133	Ubiquitination	IEKLAKNKQKPITPE HHHHHHCCCCCCCHH	60.02	-
135	Acetylation	KLAKNKQKPITPETA HHHHCCCCCCCHHHH	39.74	19608861
135 (in isoform 2)	Ubiquitination	-	39.74	21890473
135	Ubiquitination	KLAKNKQKPITPETA HHHHCCCCCCCHHHH	39.74	-
135 (in isoform 1)	Ubiquitination	-	39.74	21890473
138	Phosphorylation	KNKQKPITPETAEKL HCCCCCCCHHHHHHH	24.49	28060719
141	Phosphorylation	QKPITPETAEKLARD CCCCCHHHHHHHHHH	41.12	28985074
144 (in isoform 2)	Ubiquitination	-	45.01	21890473
144	Acetylation	ITPETAEKLARDLKA CCHHHHHHHHHHHHH	45.01	23749302
144 (in isoform 1)	Ubiquitination	-	45.01	21890473
144	Ubiquitination	ITPETAEKLARDLKA CCHHHHHHHHHHHHH	45.01	-
153 (in isoform 2)	Ubiquitination	-	48.73	21890473
153	Acetylation	ARDLKAVKYVECSAL HHHHHHCCEEECHHH	48.73	25953088
153	Ubiquitination	ARDLKAVKYVECSAL HHHHHHCCEEECHHH	48.73	22053931
154	Phosphorylation	RDLKAVKYVECSALT HHHHHCCEEECHHHC	8.55	28152594
157	S-palmitoylation	KAVKYVECSALTQKG HHCCEEECHHHCHHH	1.74	29575903
161	Phosphorylation	YVECSALTQKGLKNV EEECHHHCHHHHHHH	28.14	25159151
163	Acetylation	ECSALTQKGLKNVFD ECHHHCHHHHHHHHC	62.06	26051181
163 (in isoform 2)	Ubiquitination	-	62.06	21890473
163	Ubiquitination	ECSALTQKGLKNVFD ECHHHCHHHHHHHHC	62.06	21890473
166	Ubiquitination	ALTQKGLKNVFDEAI HHCHHHHHHHHCHHH	60.79	21906983
166 (in isoform 2)	Ubiquitination	-	60.79	21890473
182 (in isoform 1)	Phosphorylation	-	55.97	-
183	Ubiquitination	ALEPPEPKKSRRCVL HHCCCCCCCCCCEEE	62.81	22053931
183 (in isoform 2)	Ubiquitination	-	62.81	21890473
184	Ubiquitination	LEPPEPKKSRRCVLL HCCCCCCCCCCEEEC	60.97	22053931
184 (in isoform 2)	Ubiquitination	-	60.97	21890473
188	Geranylgeranylation	EPKKSRRCVLL---- CCCCCCCEEEC----	2.16	10676816
188	Methylation	EPKKSRRCVLL---- CCCCCCCEEEC----	2.16	10676816
188	Geranylgeranylation	EPKKSRRCVLL---- CCCCCCCEEEC----	2.16	10676816

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
64	Y	Phosphorylation	Kinase	SRC	P12931	Uniprot
64	Y	Phosphorylation	Kinase	SRC	P12931	PSP
64	Y	Phosphorylation	Kinase	SRC-FAMILY	-	GPS
64	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
35	T	Glycosylation		7777059
(Microbial infection) Glycosylated (O-GlcNAcylated) at Thr-35 by C.novyi toxin TcdA.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDC42_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BORG5_HUMAN	CDC42EP1	physical	16189514
FBP1L_HUMAN	FNBP1L	physical	15260990
KAT5_HUMAN	KAT5	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
PDE6D_HUMAN	PDE6D	physical	16169070
UBR1_HUMAN	UBR1	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
P53_HUMAN	TP53	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
BNIP2_HUMAN	BNIP2	physical	10799524
ARHG8_MOUSE	Net1	physical	9535835
DIAP3_MOUSE	Diap3	physical	9535835
ROCK1_MOUSE	Rock1	physical	9535835
BORG2_HUMAN	CDC42EP3	physical	9535835
VAV_HUMAN	VAV1	physical	11287617
M3K10_HUMAN	MAP3K10	physical	9427749
RHG01_HUMAN	ARHGAP1	physical	9427749
M3K11_HUMAN	MAP3K11	physical	9427749
C42S1_HUMAN	CDC42SE1	physical	10816584
C42S2_HUMAN	CDC42SE2	physical	10816584
CDC42_HUMAN	CDC42	physical	10211824
IQGA2_HUMAN	IQGAP2	physical	8756646
M3K11_HUMAN	MAP3K11	physical	10799501
M3K4_HUMAN	MAP3K4	physical	9079650
BAIP2_HUMAN	BAIAP2	physical	11696321
ERRFI_HUMAN	ERRFI1	physical	10749885
PAK6_HUMAN	PAK6	physical	11773441
IQGA1_HUMAN	IQGAP1	physical	8798539
PAR6B_HUMAN	PARD6B	physical	10934474
WASP_HUMAN	WAS	physical	10713100
MCF2_HUMAN	MCF2	physical	10854437
DOCK9_HUMAN	DOCK9	physical	12172552
BORG3_HUMAN	CDC42EP5	physical	11035016
BORG1_HUMAN	CDC42EP2	physical	11035016
PKHG2_HUMAN	PLEKHG2	physical	11839748
PAK4_HUMAN	PAK4	physical	9822598
PAK2_HUMAN	PAK2	physical	9822598
RHG01_HUMAN	ARHGAP1	physical	10551883
BNIP2_HUMAN	BNIP2	physical	10551883
FGD1_HUMAN	FGD1	physical	8969170
ARHGP_HUMAN	ARHGEF25	physical	12547822
WASL_HUMAN	WASL	physical	9422512
PAK5_HUMAN	PAK7	physical	12032833
PLD1_HUMAN	PLD1	physical	10747870
IQGA1_HUMAN	IQGAP1	physical	8670801
IQGA1_HUMAN	IQGAP1	physical	9182573
PAK1_HUMAN	PAK1	physical	9535855
PAK2_HUMAN	PAK2	physical	9535855
IQGA1_HUMAN	IQGAP1	physical	9535855
GDIR1_HUMAN	ARHGDIA	physical	20936779
ARRB1_HUMAN	ARRB1	physical	20936779
ARRB2_HUMAN	ARRB2	physical	20936779
CASB_HUMAN	CSN2	physical	20936779
DIAP2_HUMAN	DIAPH2	physical	20936779
COX1_HUMAN	COX1	physical	20936779
MYO6_HUMAN	MYO6	physical	20936779
MYO9A_HUMAN	MYO9A	physical	20936779
PAK1_HUMAN	PAK1	physical	20936779
PAK2_HUMAN	PAK2	physical	20936779
PAK3_HUMAN	PAK3	physical	20936779
GDS1_HUMAN	RAP1GDS1	physical	20936779
RL22_HUMAN	RPL22	physical	20936779
S10A9_HUMAN	S100A9	physical	20936779
F10A1_HUMAN	ST13	physical	20936779
UBC_HUMAN	UBC	physical	20936779
VRK2_HUMAN	VRK2	physical	20936779
WASP_HUMAN	WAS	physical	20936779
ZN175_HUMAN	ZNF175	physical	20936779
MRCKA_HUMAN	CDC42BPA	physical	20936779
GANP_HUMAN	MCM3AP	physical	20936779
HERC2_HUMAN	HERC2	physical	20936779
WASL_HUMAN	WASL	physical	20936779
RL23_HUMAN	RPL23	physical	20936779
MRCKB_HUMAN	CDC42BPB	physical	20936779
RHG32_HUMAN	ARHGAP32	physical	20936779
ARHGB_HUMAN	ARHGEF11	physical	20936779
ACK1_HUMAN	TNK2	physical	20936779
PAK4_HUMAN	PAK4	physical	20936779
BORG1_HUMAN	CDC42EP2	physical	20936779
BAIP2_HUMAN	BAIAP2	physical	20936779
BORG2_HUMAN	CDC42EP3	physical	20936779
BORG5_HUMAN	CDC42EP1	physical	20936779
SYNE1_HUMAN	SYNE1	physical	20936779
BORG4_HUMAN	CDC42EP4	physical	20936779
C42S1_HUMAN	CDC42SE1	physical	20936779
PAK6_HUMAN	PAK6	physical	20936779
PAK5_HUMAN	PAK7	physical	20936779
PAR6B_HUMAN	PARD6B	physical	20936779
FMNL2_HUMAN	FMNL2	physical	20936779
SH319_HUMAN	SH3D19	physical	20936779
K2026_HUMAN	KIAA2026	physical	20936779
MUC12_HUMAN	MUC12	physical	20936779
CBL_HUMAN	CBL	physical	14505571
ARHG7_HUMAN	ARHGEF7	physical	14505571
ARHG7_MOUSE	Arhgef7	physical	14505571
PAK3_MOUSE	Pak3	physical	14505571
HAKAI_HUMAN	CBLL1	physical	18057010
CADH1_HUMAN	CDH1	physical	18057010
A2MG_HUMAN	A2M	physical	18624398
FETUA_HUMAN	AHSG	physical	18624398
APOH_HUMAN	APOH	physical	18624398
CBPN_HUMAN	CPN1	physical	18624398
ETFA_HUMAN	ETFA	physical	18624398
FHR4_HUMAN	CFHR4	physical	18624398
LEG1_HUMAN	LGALS1	physical	18624398
ZN234_HUMAN	ZNF234	physical	18624398
GDIR1_HUMAN	ARHGDIA	physical	21900206
CBL_HUMAN	CBL	physical	16356860
UBP6_HUMAN	USP6	physical	12612085
BCAR1_HUMAN	BCAR1	physical	17038317
ACK1_HUMAN	TNK2	physical	10360579
PAK1_HUMAN	PAK1	physical	10360579
WASP_HUMAN	WAS	physical	10360579
ACK1_HUMAN	TNK2	physical	15123659
ACK1_HUMAN	TNK2	physical	10684602
PAK1_HUMAN	PAK1	physical	10684602
WASP_HUMAN	WAS	physical	10684602
RHG01_HUMAN	ARHGAP1	physical	10684602
PAK1_HUMAN	PAK1	physical	10802735
LRRK2_HUMAN	LRRK2	physical	21048939
ARHG6_HUMAN	ARHGEF6	physical	15306850
FGD3_HUMAN	FGD3	physical	18363964
TGFR1_HUMAN	TGFBR1	physical	15761153
TGFR2_HUMAN	TGFBR2	physical	15761153
RAP1A_HUMAN	RAP1A	physical	22939629
PAK3_HUMAN	PAK3	physical	11157984
ZN420_HUMAN	ZNF420	physical	11157984
ACK1_HUMAN	TNK2	physical	11157984
BAIP2_HUMAN	BAIAP2	physical	11157984
WIPF1_HUMAN	WIPF1	physical	11331876
WASL_HUMAN	WASL	physical	11331876
RIOK3_HUMAN	RIOK3	physical	21988832
BORG1_HUMAN	CDC42EP2	physical	21988832
BORG5_HUMAN	CDC42EP1	physical	21988832
ADIP_HUMAN	SSX2IP	physical	21988832
SYEP_HUMAN	EPRS	physical	22863883
SYLC_HUMAN	LARS	physical	22863883
RUVB1_HUMAN	RUVBL1	physical	22863883
ELOB_HUMAN	TCEB2	physical	22863883
BIRC2_HUMAN	BIRC2	physical	24276241
PAK1_HUMAN	PAK1	physical	24276241
TRAF2_HUMAN	TRAF2	physical	24276241
GDIR1_HUMAN	ARHGDIA	physical	24276241
PAR6B_HUMAN	PARD6B	physical	23439680
PAK2_HUMAN	PAK2	physical	25416956
BORG1_HUMAN	CDC42EP2	physical	25416956
BORG5_HUMAN	CDC42EP1	physical	25416956
PAR6B_HUMAN	PARD6B	physical	25416956
ACK1_HUMAN	TNK2	physical	16052498
AHNK_HUMAN	AHNAK	physical	26344197
GDIR1_HUMAN	ARHGDIA	physical	26344197
GDIR3_HUMAN	ARHGDIG	physical	26344197
DUT_HUMAN	DUT	physical	26344197
SYFA_HUMAN	FARSA	physical	26344197
NOTC2_HUMAN	NOTCH2	physical	26344197
PAK4_HUMAN	PAK4	physical	26344197
RB11B_HUMAN	RAB11B	physical	26344197
RAB14_HUMAN	RAB14	physical	26344197
RAB1A_HUMAN	RAB1A	physical	26344197
RAB1B_HUMAN	RAB1B	physical	26344197
STMN1_HUMAN	STMN1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
VAPA_HUMAN	VAPA	physical	26344197
KTN1_MOUSE	Ktn1	physical	9535835
RHG01_HUMAN	ARHGAP1	physical	14749388
FACD2_HUMAN	FANCD2	physical	26496610
KIFC3_HUMAN	KIFC3	physical	26496610
MECP2_HUMAN	MECP2	physical	26496610
MSH3_HUMAN	MSH3	physical	26496610
MYH10_HUMAN	MYH10	physical	26496610
NDUV3_HUMAN	NDUFV3	physical	26496610
PRDX1_HUMAN	PRDX1	physical	26496610
RAD51_HUMAN	RAD51	physical	26496610
STX3_HUMAN	STX3	physical	26496610
SF01_HUMAN	SF1	physical	26496610
IQGA1_HUMAN	IQGAP1	physical	26496610
EI2BG_HUMAN	EIF2B3	physical	26496610
SC24C_HUMAN	SEC24C	physical	26496610
GOGA5_HUMAN	GOLGA5	physical	26496610
ARPC5_HUMAN	ARPC5	physical	26496610
CEPT1_HUMAN	CEPT1	physical	26496610
PRDX3_HUMAN	PRDX3	physical	26496610
FKBP9_HUMAN	FKBP9	physical	26496610
SCMH1_HUMAN	SCMH1	physical	26496610
ZC3H4_HUMAN	ZC3H4	physical	26496610
PNISR_HUMAN	PNISR	physical	26496610
GOLI4_HUMAN	GOLIM4	physical	26496610
ACAD9_HUMAN	ACAD9	physical	26496610
ASTE1_HUMAN	ASTE1	physical	26496610
5NT3A_HUMAN	NT5C3A	physical	26496610
M3K20_HUMAN	ZAK	physical	26496610
S38A2_HUMAN	SLC38A2	physical	26496610
DJC10_HUMAN	DNAJC10	physical	26496610
MID51_HUMAN	MIEF1	physical	26496610
E41LB_HUMAN	EPB41L4B	physical	26496610
RAIN_HUMAN	RASIP1	physical	26496610
RABL6_HUMAN	RABL6	physical	26496610
BBX_HUMAN	BBX	physical	26496610
C42S2_HUMAN	CDC42SE2	physical	26496610
KIF17_HUMAN	KIF17	physical	26496610
ZSWM5_HUMAN	ZSWIM5	physical	26496610
WNK1_HUMAN	WNK1	physical	26496610
IQGA3_HUMAN	IQGAP3	physical	26496610
M3K11_HUMAN	MAP3K11	physical	25241761
MK09_HUMAN	MAPK9	physical	25241761
MK08_HUMAN	MAPK8	physical	25241761
M3K4_HUMAN	MAP3K4	physical	25241761
ARHG6_HUMAN	ARHGEF6	physical	25241761
CASP3_HUMAN	CASP3	physical	25241761

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDC42_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-135 AND LYS-144, AND MASSSPECTROMETRY.	19608861 [Abstract]

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