MYO9A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO9A_HUMAN
• UniProt AC: B2RTY4
• Protein Name: Unconventional myosin-IXa
• Gene Name: MYO9A
• Organism: Homo sapiens (Human).
• Sequence Length: 2548
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in the regulation of neuronal morphology and function (By similarity)..
• Protein Sequence: MNINDGGRRRFEDNEHTLRIYPGAISEGTIYCPIPARKNSTAAEVIESLINKLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSGWEDCSFDNRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGISPSEDRRWSTELVPEGLQSPRGTPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQQDPLKTNSQLDTSIQRNKLLENEDTAGEALTLDINRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEERQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIPLVSKEALNSKNPQLHKEDEPAWKPVKLAGPGQRETSQRFSSVDEQAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMHWQNDSVQIIASVSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMGKGRIRRGNYPGPSSPVVVRLPSVSDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMESEYAISEKSERSLALSSLKTAGKSEPSSKLRKQLKKQQDSLDVVDSSVSSLCLSNTASSHGTRKLFQIYSKSPFYRAASGNEALGMEGPLGQTKFLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTVMSGRRKTVDPDCTSNQQLALFGNNEFMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	PIPARKNSTAAEVIE CCCCCCCCHHHHHHH	23.58	24114839
41	Phosphorylation	IPARKNSTAAEVIES CCCCCCCHHHHHHHH	39.00	24114839
48	Phosphorylation	TAAEVIESLINKLHL HHHHHHHHHHHHHCC	24.35	24719451
59	Ubiquitination	KLHLDKTKCYVLAEV HHCCCCCCEEEEEEE	29.34	29967540
115	Phosphorylation	REKNLDGSIHYGSLQ HHCCCCCCEEHHHHH	13.08	20873877
153	Phosphorylation	KDFDDLCSLPDLNEK CCHHHHCCCCCCCHH	50.67	27067055
160	Ubiquitination	SLPDLNEKTLLENLR CCCCCCHHHHHHHHH	43.32	29967540
181	Phosphorylation	KIYTYVGSILIVINP HHHHHHCEEEEEECC	12.27	-
198	Ubiquitination	FLPIYNPKYVKMYDN CCCCCCCCCEEEECC	60.07	-
203	Phosphorylation	NPKYVKMYDNHQLGK CCCCEEEECCCCCCC	14.10	-
216	Phosphorylation	GKLEPHIYAVADVAY CCCCCCHHHHHHHHH	7.62	-
223	Phosphorylation	YAVADVAYHAMLQRK HHHHHHHHHHHHHHH	7.03	-
294	Phosphorylation	TAHNNNSSRFGKFIQ CCCCCCCCCCEEEEE	33.48	22798277
322	Ubiquitination	VEKYLLEKSRLVYQE HHHHHHHHCCCEEEC	40.62	-
375 (in isoform 4)	Phosphorylation	-	26.49	27642862
379 (in isoform 4)	Phosphorylation	-	7.16	27642862
415	Phosphorylation	MVGFLPKTRRQIFSL HHCCCHHHHHHHHHH	29.19	25101063
475	Phosphorylation	EALVTRKTVTVGEKL HHHHCCCCEECCCEE	20.37	24702127
477	Phosphorylation	LVTRKTVTVGEKLIL HHCCCCEECCCEEEC	28.20	24702127
486	Phosphorylation	GEKLILPYKLAEAVT CCEEECCHHHHHHHH	18.39	-
602	Ubiquitination	CINLISKKPTGLLHL EEEEHHCCCCCHHHH	40.81	29967540
659	Phosphorylation	HYAGKVKYGVKDFRE HHCCCCCCCCHHHHH	30.09	-
740	Phosphorylation	APCAILKSMDSFSFL CCCHHHHCCCCCHHH	25.11	23186163
743	Phosphorylation	AILKSMDSFSFLQHP HHHHCCCCCHHHCCH	17.72	28857561
745	Phosphorylation	LKSMDSFSFLQHPVH HHCCCCCHHHCCHHH	29.06	28857561
755	Phosphorylation	QHPVHQRSLEILQRC CCHHHHHHHHHHHHH	24.63	30266825
768	Phosphorylation	RCKEEKYSITRKNPR HHHHHCCCCCCCCCC	28.66	20363803
776	Phosphorylation	ITRKNPRTPLSDLQG CCCCCCCCCHHHHCC	29.82	28555341
812	Phosphorylation	GIRQSRLSSGTSLLD CCCHHHCCCCCCCCC	26.13	21815630
813	Phosphorylation	IRQSRLSSGTSLLDK CCHHHCCCCCCCCCC	51.16	23403867
815	Phosphorylation	QSRLSSGTSLLDKDG HHHCCCCCCCCCCCC	20.39	23403867
816	Phosphorylation	SRLSSGTSLLDKDGI HHCCCCCCCCCCCCC	30.38	29978859
877	Phosphorylation	LQDRITKSLLHLHKK HHHHHHHHHHHHHHC	27.75	20873877
889	Phosphorylation	HKKKKPPSISAQFQA HHCCCCCCHHHHHHH	37.39	-
938	Phosphorylation	LVLRQLRYTGMLETV HHHHHHHHCCCEEEE	19.08	-
939	Phosphorylation	VLRQLRYTGMLETVR HHHHHHHCCCEEEEE	15.07	-
944	Phosphorylation	RYTGMLETVRIRQSG HHCCCEEEEEEECCC	15.89	-
976	Phosphorylation	LPRNIIPSKFNIQDF CCCCCCCCCCCHHHH	39.20	24719451
1147	Phosphorylation	KKIILLQSTCRGFRA HHHHHHHHHHHHHHH	29.46	28555341
1204	Ubiquitination	CSFDNRIKAIEECKS CCHHHHHHHHHHHHH	39.82	29967540
1215	Phosphorylation	ECKSVIESNRISRES HHHHHHHHCCCCCHH	21.93	30266825
1219	Phosphorylation	VIESNRISRESSVDC HHHHCCCCCHHHHHH	27.10	30266825
1222	Phosphorylation	SNRISRESSVDCLKE HCCCCCHHHHHHHHH	34.25	20873877
1223	Phosphorylation	NRISRESSVDCLKES CCCCCHHHHHHHHHC	19.74	21815630
1230	Phosphorylation	SVDCLKESPNKQQER HHHHHHHCCCHHHHH	31.99	29255136
1240	Phosphorylation	KQQERAQSQSGVDLQ HHHHHHHHHCCCCHH	25.90	25159151
1242	Phosphorylation	QERAQSQSGVDLQED HHHHHHHCCCCHHHH	46.13	27251275
1258	Phosphorylation	LVRERPRSLEDLHQK HHHCCCCCHHHHHHH	38.50	30266825
1294	Phosphorylation	LELLKVRSLGGISPS HHHHHHHHHCCCCCC	34.06	23403867
1299	Phosphorylation	VRSLGGISPSEDRRW HHHHCCCCCCCCCCC	26.16	30266825
1301	Phosphorylation	SLGGISPSEDRRWST HHCCCCCCCCCCCCC	45.39	30266825
1307	Phosphorylation	PSEDRRWSTELVPEG CCCCCCCCCCCCCCC	15.36	30266825
1308	Phosphorylation	SEDRRWSTELVPEGL CCCCCCCCCCCCCCC	26.78	30266825
1317	Phosphorylation	LVPEGLQSPRGTPDS CCCCCCCCCCCCCCC	22.93	30266825
1327	Phosphorylation	GTPDSESSQGSLELL CCCCCCCCHHHHEEE	34.21	28348404
1330	Phosphorylation	DSESSQGSLELLSYE CCCCCHHHHEEECHH	15.84	28348404
1346	Phosphorylation	SQKSKLESVISDEGD HHHHHHHHHHCCCCC	34.88	30266825
1349	Phosphorylation	SKLESVISDEGDLQF HHHHHHHCCCCCCCC	27.70	30266825
1358	Phosphorylation	EGDLQFPSPKISSSP CCCCCCCCCCCCCCC	39.86	30266825
1362	Phosphorylation	QFPSPKISSSPKFDS CCCCCCCCCCCCCCC	30.78	28450419
1363	Phosphorylation	FPSPKISSSPKFDSR CCCCCCCCCCCCCCC	54.88	28450419
1364	Phosphorylation	PSPKISSSPKFDSRD CCCCCCCCCCCCCCC	25.89	28450419
1369	Phosphorylation	SSSPKFDSRDNALSA CCCCCCCCCCCCCCC	44.67	23186163
1375	Phosphorylation	DSRDNALSASNETSS CCCCCCCCCCCCCCC	27.52	24300666
1377	Phosphorylation	RDNALSASNETSSAE CCCCCCCCCCCCCHH	31.64	30619164
1380	Phosphorylation	ALSASNETSSAEHLK CCCCCCCCCCHHHCC	32.03	22210691
1381	Phosphorylation	LSASNETSSAEHLKD CCCCCCCCCHHHCCC	22.75	28450419
1382	Phosphorylation	SASNETSSAEHLKDG CCCCCCCCHHHCCCC	45.13	28450419
1399	Phosphorylation	KEMVVCSSESITCKP CEEEEECCCCEECCC	30.18	24260401
1416	Phosphorylation	KDSFISNSLPTFFYI CCCHHHCCCCEEEEE	29.00	28348404
1437	Phosphorylation	KTNSQLDTSIQRNKL CCCHHHCHHHHHCCC	36.00	25627689
1438	Phosphorylation	TNSQLDTSIQRNKLL CCHHHCHHHHHCCCC	19.18	25159151
1525	Sumoylation	QQTDILEKERKAFKT HHHHHHHHHHHHHHC	60.41	-
1525	Sumoylation	QQTDILEKERKAFKT HHHHHHHHHHHHHHC	60.41	-
1558	Phosphorylation	KQRVERPSSLLSLNT CCCCCCCHHHCCCCC	39.58	23312004
1559	Phosphorylation	QRVERPSSLLSLNTS CCCCCCHHHCCCCCC	35.69	24961811
1562	Phosphorylation	ERPSSLLSLNTSNKG CCCHHHCCCCCCCCC	25.51	23312004
1576	Phosphorylation	GELNVLGSLSLKDAA CCEEEEEEEEHHHHH	15.60	24719451
1578	Phosphorylation	LNVLGSLSLKDAALA EEEEEEEEHHHHHHH	34.76	24719451
1589	Phosphorylation	AALAQKDSSSAHLPP HHHHCCCCCCCCCCC	32.98	-
1590	Phosphorylation	ALAQKDSSSAHLPPK HHHCCCCCCCCCCCC	41.50	23532336
1610	Phosphorylation	VFFERKGSPCQSSTV EEEEECCCCCCCHHH	26.07	27251275
1643	Ubiquitination	LSNNRISKREHFRPT HCCCCCCCCCCCCCC	60.48	-
1652	Phosphorylation	EHFRPTQSYSHNSDD CCCCCCCCCCCCCCC	30.95	28348404
1654	Phosphorylation	FRPTQSYSHNSDDLS CCCCCCCCCCCCCCC	22.80	28348404
1657	Phosphorylation	TQSYSHNSDDLSREG CCCCCCCCCCCCCCC	27.38	-
1661	Phosphorylation	SHNSDDLSREGNARP CCCCCCCCCCCCCCC	34.97	-
1672	Phosphorylation	NARPIFFTPKDNMSI CCCCCEECCCCCCCC	20.76	28555341
1683	Phosphorylation	NMSIPLVSKEALNSK CCCCCCCCHHHHHCC	32.25	22985185
1729 (in isoform 4)	Phosphorylation	-	23.88	29083192
1731	Phosphorylation	EQAKLHKTMSQGEIT HHHHHHHHCCHHHHH	16.00	28176443
1731 (in isoform 4)	Phosphorylation	-	16.00	24719451
1733	Phosphorylation	AKLHKTMSQGEITKL HHHHHHCCHHHHHHH	40.02	25159151
1738	Phosphorylation	TMSQGEITKLAVRQK HCCHHHHHHHHHHHH	18.72	28176443
1747	Phosphorylation	LAVRQKASDSDIRPQ HHHHHHCCCCCCCCH	44.69	29449344
1749	Phosphorylation	VRQKASDSDIRPQRA HHHHCCCCCCCCHHH	32.23	29449344
1779 (in isoform 4)	Phosphorylation	-	39.82	24275569
1781 (in isoform 4)	Phosphorylation	-	36.88	24275569
1783 (in isoform 4)	Phosphorylation	-	16.31	24275569
1789	Phosphorylation	VSPLFAGTDVIPAHQ CCCCCCCCCEEEHHH	24.54	28348404
1804	Phosphorylation	FPDELAAYHPTPPLS CCHHHHHCCCCCCCC	11.61	28348404
1807	Phosphorylation	ELAAYHPTPPLSPEL HHHHCCCCCCCCCCC	24.99	28348404
1811	Phosphorylation	YHPTPPLSPELPGSC CCCCCCCCCCCCCCH	23.31	28348404
1829	Phosphorylation	FKENKEPSPKAKRKR HHHCCCCCHHHHHCC	39.87	23401153
1885	Trimethylation	LDNEDSKKDTLVDVV CCCCCCCCCHHHHHH	60.95	-
1885	Methylation	LDNEDSKKDTLVDVV CCCCCCCCCHHHHHH	60.95	-
1936	Phosphorylation	FEQILEKTMRLEQRD HHHHHHHHCCHHHHH	9.73	24719451
1948	Phosphorylation	QRDSLGESPVRVWVN HHHCCCCCCCCHHHH	27.22	21815630
1991	Phosphorylation	KKRRKKETDLVEEHN HHHHHHHCCCHHHHC	43.44	28555341
2049	Phosphorylation	LKTTAKCSKKYDPEL HHHCCCCCHHCCHHH	31.32	-
2052	Phosphorylation	TAKCSKKYDPELSSR CCCCCHHCCHHHHHH	40.23	27794612
2151	Phosphorylation	PLMTFELYEEFLRAM CCCHHHHHHHHHHHC	13.25	-
2251	Phosphorylation	VVEQMNKYKARLKDI HHHHHHHHHHHHHCC	12.60	-
2260	Phosphorylation	ARLKDISSLEFAENK HHHHCCCCHHHHHHH	32.05	18669648
2270	Phosphorylation	FAENKAKTRLSLIRR HHHHHHHHHHHHHHH	41.52	23312004
2273	Phosphorylation	NKAKTRLSLIRRSMG HHHHHHHHHHHHHCC	20.61	23312004
2286	Methylation	MGKGRIRRGNYPGPS CCCCCCCCCCCCCCC	35.02	115484255
2289	Phosphorylation	GRIRRGNYPGPSSPV CCCCCCCCCCCCCCE	16.64	27080861
2293	Phosphorylation	RGNYPGPSSPVVVRL CCCCCCCCCCEEEEC	53.87	28450419
2294	Phosphorylation	GNYPGPSSPVVVRLP CCCCCCCCCEEEECC	25.50	27794612
2302	Phosphorylation	PVVVRLPSVSDVSEE CEEEECCCHHCCCHH	38.55	28348404
2304	Phosphorylation	VVRLPSVSDVSEETL EEECCCHHCCCHHHH	36.31	28348404
2362	Phosphorylation	LVLEPRASDDETLES EEECCCCCCCCCHHH	47.04	-
2366	Phosphorylation	PRASDDETLESEASI CCCCCCCCHHHHHCC	42.70	-
2397	Phosphorylation	ISEKSERSLALSSLK CCHHHHHHHHHHHHH	17.59	23403867
2401	Phosphorylation	SERSLALSSLKTAGK HHHHHHHHHHHHCCC	28.19	24719451
2402	Phosphorylation	ERSLALSSLKTAGKS HHHHHHHHHHHCCCC	34.43	23403867
2405	Phosphorylation	LALSSLKTAGKSEPS HHHHHHHHCCCCCCC	46.03	-
2425	Phosphorylation	QLKKQQDSLDVVDSS HHHHHHHCHHHHHHH	23.33	27080861
2454	Phosphorylation	TRKLFQIYSKSPFYR HHHHHHHHHCCCCCC	10.16	21945579
2455	Phosphorylation	RKLFQIYSKSPFYRA HHHHHHHHCCCCCCC	28.43	21945579
2457	Phosphorylation	LFQIYSKSPFYRAAS HHHHHHCCCCCCCCC	17.82	28796482
2460	Phosphorylation	IYSKSPFYRAASGNE HHHCCCCCCCCCCCC	11.61	28796482
2464	Phosphorylation	SPFYRAASGNEALGM CCCCCCCCCCCCCCC	40.96	25159151
2478	Phosphorylation	MEGPLGQTKFLEDKP CCCCCCCCCCCCCCC	23.20	-
2489	Phosphorylation	EDKPQFISRGTFNPE CCCCCEECCCCCCHH	26.41	-
2499	Acetylation	TFNPEKGKQKLKNVK CCCHHHHHHHHHCCC	56.16	15620591
2501	Acetylation	NPEKGKQKLKNVKNS CHHHHHHHHHCCCCC	65.98	14509947
2503	Acetylation	EKGKQKLKNVKNSPQ HHHHHHHHCCCCCCC	67.73	19823101
2508	Phosphorylation	KLKNVKNSPQKTKET HHHCCCCCCCCCCCC	24.00	24719451
2515	Phosphorylation	SPQKTKETPEGTVMS CCCCCCCCCCCCEEC	28.35	28674419
2525 (in isoform 4)	Phosphorylation	-	42.39	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO9A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO9A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO9A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO9A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.