5NT3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 5NT3A_HUMAN
• UniProt AC: Q9H0P0
• Protein Name: Cytosolic 5'-nucleotidase 3A {ECO:0000305|PubMed:15968458, ECO:0000305|PubMed:24603684}
• Gene Name: NT5C3A
• Organism: Homo sapiens (Human).
• Sequence Length: 336
• Subcellular Localization: Cytoplasm .; Isoform 2: Endoplasmic reticulum.
• Protein Description: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). [PubMed: 24603684 CMP seems to be the preferred substrate]
• Protein Sequence: MRAPSMDRAAVARVGAVASASVCALVAGVVLAQYIFTLKRKTGRKTKIIEMMPEFQKSSVRIKNPTRVEEIICGLIKGGAAKLQIITDFDMTLSRFSYKGKRCPTCHNIIDNCKLVTDECRKKLLQLKEKYYAIEVDPVLTVEEKYPYMVEWYTKSHGLLVQQALPKAKLKEIVAESDVMLKEGYENFFDKLQQHSIPVFIFSAGIGDVLEEVIRQAGVYHPNVKVVSNFMDFDETGVLKGFKGELIHVFNKHDGALRNTEYFNQLKDNSNIILLGDSQGDLRMADGVANVEHILKIGYLNDRVDELLEKYMDSYDIVLVQDESLEVANSILQKIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 1)	Phosphorylation	-		25159151
47	Ubiquitination	RKTGRKTKIIEMMPE CHHCCCEEEEEECHH		-
57	Ubiquitination	EMMPEFQKSSVRIKN EECHHHHHHCCCCCC		-
77	Ubiquitination	EIICGLIKGGAAKLQ HHHHHHHHCCCCEEE		-
77	Acetylation	EIICGLIKGGAAKLQ HHHHHHHHCCCCEEE		25953088
91 (in isoform 1)	Ubiquitination	-		-
116 (in isoform 1)	Ubiquitination	-		-
128	Ubiquitination	RKKLLQLKEKYYAIE HHHHHHHHHHEEEEE		-
128	2-Hydroxyisobutyrylation	RKKLLQLKEKYYAIE HHHHHHHHHHEEEEE		-
132 (in isoform 1)	Ubiquitination	-		-
180	Sulfoxidation	IVAESDVMLKEGYEN HHHHCHHHHHCHHHH		21406390
182	Ubiquitination	AESDVMLKEGYENFF HHCHHHHHCHHHHHH		-
192	Ubiquitination	YENFFDKLQQHSIPV HHHHHHHHHHCCCCE		21890473
192 (in isoform 3)	Ubiquitination	-		21890473
193 (in isoform 2)	Ubiquitination	-		21890473
201 (in isoform 1)	Ubiquitination	-		-
204 (in isoform 1)	Ubiquitination	-		21890473
216 (in isoform 3)	Ubiquitination	-		21890473
217 (in isoform 2)	Ubiquitination	-		21890473
225	Ubiquitination	GVYHPNVKVVSNFMD CCCCCCEEEEECCCC		-
228 (in isoform 1)	Ubiquitination	-		21890473
228	Phosphorylation	HPNVKVVSNFMDFDE CCCEEEEECCCCCCC		20068231
236	Phosphorylation	NFMDFDETGVLKGFK CCCCCCCCCCCCCCC		20068231
240	Ubiquitination	FDETGVLKGFKGELI CCCCCCCCCCCCEEE		-
243	Ubiquitination	TGVLKGFKGELIHVF CCCCCCCCCEEEEEE		21890473
243 (in isoform 4)	Ubiquitination	-		21890473
260	Phosphorylation	HDGALRNTEYFNQLK CCCCCCCHHHHHHCC		28555341
267	Ubiquitination	TEYFNQLKDNSNIIL HHHHHHCCCCCEEEE		2190698
267 (in isoform 4)	Ubiquitination	-		21890473
278	Phosphorylation	NIILLGDSQGDLRMA EEEEEECCCCCCCCC		29507054
296	Ubiquitination	ANVEHILKIGYLNDR CCHHHHHHHHCCCHH		-
303	Methylation	KIGYLNDRVDELLEK HHHCCCHHHHHHHHH		115485675
334	Ubiquitination	VANSILQKIL----- HHHHHHHHHC-----		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 5NT3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 5NT3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 5NT3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VANG1_HUMAN	VANGL1	physical	21988832
RB11B_HUMAN	RAB11B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 266120: P5N deficiency (P5ND)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.