VANG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VANG1_HUMAN
• UniProt AC: Q8TAA9
• Protein Name: Vang-like protein 1
• Gene Name: VANGL1
• Organism: Homo sapiens (Human).
• Sequence Length: 524
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Sequence: MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTESTYSGY -----CCCCCCCCCC	30.45	23090842
5	Phosphorylation	---MDTESTYSGYSY ---CCCCCCCCCCCC	34.44	23090842
6	Phosphorylation	--MDTESTYSGYSYY --CCCCCCCCCCCCC	18.57	27251275
7	Phosphorylation	-MDTESTYSGYSYYS -CCCCCCCCCCCCCC	14.91	27259358
8	Phosphorylation	MDTESTYSGYSYYSS CCCCCCCCCCCCCCC	31.20	30576142
10	Phosphorylation	TESTYSGYSYYSSHS CCCCCCCCCCCCCCC	6.38	27251275
11	Phosphorylation	ESTYSGYSYYSSHSK CCCCCCCCCCCCCCC	22.56	23090842
12	Phosphorylation	STYSGYSYYSSHSKK CCCCCCCCCCCCCCC	10.01	23090842
13	Phosphorylation	TYSGYSYYSSHSKKS CCCCCCCCCCCCCCC	9.58	23090842
14	Phosphorylation	YSGYSYYSSHSKKSH CCCCCCCCCCCCCCC	17.22	25159151
15	Phosphorylation	SGYSYYSSHSKKSHR CCCCCCCCCCCCCCC	18.69	25159151
17	Phosphorylation	YSYYSSHSKKSHRQG CCCCCCCCCCCCCCC	43.67	23090842
19	Ubiquitination	YYSSHSKKSHRQGER CCCCCCCCCCCCCCH	55.28	-
20	Phosphorylation	YSSHSKKSHRQGERT CCCCCCCCCCCCCHH	27.86	-
42	Phosphorylation	RNKDGRGSEKSVTIQ CCCCCCCCCCEEEEC	40.25	29255136
44	Ubiquitination	KDGRGSEKSVTIQPP CCCCCCCCEEEECCC	52.50	21906983
44 (in isoform 1)	Ubiquitination	-	52.50	21890473
44 (in isoform 2)	Ubiquitination	-	52.50	21890473
45	Phosphorylation	DGRGSEKSVTIQPPT CCCCCCCEEEECCCC	22.05	30266825
47	Phosphorylation	RGSEKSVTIQPPTGE CCCCCEEEECCCCCC	22.45	30266825
52	Phosphorylation	SVTIQPPTGEPLLGN EEEECCCCCCCCCCC	61.94	29255136
61	Phosphorylation	EPLLGNDSTRTEEVQ CCCCCCCCCCCEECC	24.64	21955146
62	Phosphorylation	PLLGNDSTRTEEVQD CCCCCCCCCCEECCC	44.46	21955146
74 (in isoform 2)	Phosphorylation	-	34.30	22210691
75	Phosphorylation	QDDNWGETTTAITGT CCCCCCCEEEECCCC	26.05	23663014
76	Phosphorylation	DDNWGETTTAITGTS CCCCCCEEEECCCCC	15.21	23663014
77	Phosphorylation	DNWGETTTAITGTSE CCCCCEEEECCCCCC	24.39	30266825
80	Phosphorylation	GETTTAITGTSEHSI CCEEEECCCCCCCCC	31.76	23663014
82	Phosphorylation	TTTAITGTSEHSISQ EEEECCCCCCCCCCH	23.45	30266825
83	Phosphorylation	TTAITGTSEHSISQE EEECCCCCCCCCCHH	34.36	30266825
86	Phosphorylation	ITGTSEHSISQEDIA CCCCCCCCCCHHHHH	21.63	30266825
88	Phosphorylation	GTSEHSISQEDIARI CCCCCCCCHHHHHHH	30.45	30266825
94 (in isoform 2)	Phosphorylation	-	33.76	22210691
96	Phosphorylation	QEDIARISKDMEDSV HHHHHHHCCCCHHHH	19.63	17192257
97	Ubiquitination	EDIARISKDMEDSVG HHHHHHCCCCHHHHC	59.74	-
100 (in isoform 2)	Phosphorylation	-	58.21	22210691
107	S-palmitoylation	EDSVGLDCKRYLGLT HHHHCCCHHHHHHHH	3.04	29575903
271	Phosphorylation	FYSLGHLSIQRAALV EEEEHHHHHHHHHHH	15.82	24719451
283	Phosphorylation	ALVVLENYYKDFTIY HHHHHHHHHCCCEEE	11.52	23401153
284	Phosphorylation	LVVLENYYKDFTIYN HHHHHHHHCCCEEEC	18.70	23401153
288	Phosphorylation	ENYYKDFTIYNPNLL HHHHCCCEEECCCCC	32.46	-
290	Phosphorylation	YYKDFTIYNPNLLTA HHCCCEEECCCCCHH	22.85	22817900
296	Phosphorylation	IYNPNLLTASKFRAA EECCCCCHHHHHHHH	31.86	25850435
297 (in isoform 2)	Ubiquitination	-	15.64	21890473
298	Phosphorylation	NPNLLTASKFRAAKH CCCCCHHHHHHHHHH	27.39	25627689
299	Ubiquitination	PNLLTASKFRAAKHM CCCCHHHHHHHHHHH	36.08	21890473
299 (in isoform 1)	Ubiquitination	-	36.08	21890473
304	Ubiquitination	ASKFRAAKHMAGLKV HHHHHHHHHHCCCEE	32.69	-
308 (in isoform 2)	Ubiquitination	-	20.61	21890473
310	Ubiquitination	AKHMAGLKVYNVDGP HHHHCCCEEEECCCC	41.58	21906983
310	Acetylation	AKHMAGLKVYNVDGP HHHHCCCEEEECCCC	41.58	7706083
310 (in isoform 1)	Ubiquitination	-	41.58	21890473
312	Phosphorylation	HMAGLKVYNVDGPSN HHCCCEEEECCCCCC	14.10	21945579
318	Phosphorylation	VYNVDGPSNNATGQS EEECCCCCCCCCHHH	48.52	28555341
322	Phosphorylation	DGPSNNATGQSRAMI CCCCCCCCHHHHHHH	37.57	26425664
325	Phosphorylation	SNNATGQSRAMIAAA CCCCCHHHHHHHHHH	24.29	21945579
338	Phosphorylation	AAARRRDSSHNELYY HHHHHCCCCCCCHHH	31.52	27273156
339	Phosphorylation	AARRRDSSHNELYYE HHHHCCCCCCCHHHH	34.32	21712546
344	Phosphorylation	DSSHNELYYEEAEHE CCCCCCHHHHHHHHH	11.58	30108239
345	Phosphorylation	SSHNELYYEEAEHER CCCCCHHHHHHHHHH	21.66	30108239
380 (in isoform 2)	Ubiquitination	-	41.39	21890473
382	Ubiquitination	LQAEEQQKAPGEVMD HCHHHHHCCCCCCCC	57.13	21906983
382 (in isoform 1)	Ubiquitination	-	57.13	21890473
407	Ubiquitination	SMARALQKYLRITRQ HHHHHHHHHHHHHHH	47.29	-
408	Phosphorylation	MARALQKYLRITRQQ HHHHHHHHHHHHHHC	6.56	27174698
412	Phosphorylation	LQKYLRITRQQNYHS HHHHHHHHHHCCCCC	18.91	27174698
417	Phosphorylation	RITRQQNYHSMESIL HHHHHCCCCCHHHHH	7.31	30576142
422	Phosphorylation	QNYHSMESILQHLAF CCCCCHHHHHHHHHH	21.69	30576142
436	Phosphorylation	FCITNGMTPKAFLER HHHHCCCCHHHHHHH	24.04	30576142
444	Phosphorylation	PKAFLERYLSAGPTL HHHHHHHHHHCCCCC	8.81	22817900
446	Phosphorylation	AFLERYLSAGPTLQY HHHHHHHHCCCCCCC	23.42	28331001
450	Phosphorylation	RYLSAGPTLQYDKDR HHHHCCCCCCCCCHH	26.10	22210691
453	Phosphorylation	SAGPTLQYDKDRWLS HCCCCCCCCCHHCCC	28.24	22817900
455	Ubiquitination	GPTLQYDKDRWLSTQ CCCCCCCCHHCCCCE	44.23	-
460	Phosphorylation	YDKDRWLSTQWRLVS CCCHHCCCCEEEECC	16.16	29083192
461	Phosphorylation	DKDRWLSTQWRLVSD CCHHCCCCEEEECCH	29.95	29083192
511 (in isoform 2)	Ubiquitination	-	36.98	21890473
513	Ubiquitination	FIDPKSHKFVLRLQS CCCCCCCCEEEEEEE	44.23	21890473
513 (in isoform 1)	Ubiquitination	-	44.23	21890473
520	Phosphorylation	KFVLRLQSETSV--- CEEEEEEECCCC---	47.65	27273156
522	Phosphorylation	VLRLQSETSV----- EEEEEECCCC-----	39.78	28176443
523	Phosphorylation	LRLQSETSV------ EEEEECCCC------	23.06	27273156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VANG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VANG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VANG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF41_HUMAN	RNF41	physical	27648936
RNF41_HUMAN	RNF41	physical	28481871

Drug and Disease Associations

• Kegg Disease
• H00262: Spina bifida
• H00979: Caudal regression syndrome and Sirenomelia
• OMIM Disease
• 182940: Neural tube defects (NTD)
• 600145: Sacral defect with anterior meningocele (SDAM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND MASSSPECTROMETRY.
PubMed: 18691976