dbPTM

IQGA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IQGA2_HUMAN
UniProt AC	Q13576
Protein Name	Ras GTPase-activating-like protein IQGAP2
Gene Name	IQGAP2
Organism	Homo sapiens (Human).
Sequence Length	1575
Subcellular Localization
Protein Description	Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin..
Protein Sequence	MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPHEELPSLQRPRYG CCHHHCCCCCCCCCC	50.16	26091039
14	Phosphorylation	PSLQRPRYGSIVDDE CCCCCCCCCCCCCHH	20.22	27696853
16	Phosphorylation	LQRPRYGSIVDDERL CCCCCCCCCCCHHHC	15.54	19664994
24	Phosphorylation	IVDDERLSAEEMDER CCCHHHCCHHHHHHH	39.60	20166139
38	Phosphorylation	RRRQNIAYEYLCHLE HHHHHHHHHHHHCHH	10.99	27642862
62	Phosphorylation	LVEELPPTTELEEGL EEEECCCCCCHHHHH	30.84	27732954
63	Phosphorylation	VEELPPTTELEEGLR EEECCCCCCHHHHHH	44.33	27732954
74	Phosphorylation	EGLRNGVYLAKLAKF HHHHCCHHHHHHHHH	11.44	-
77	Ubiquitination	RNGVYLAKLAKFFAP HCCHHHHHHHHHHCC	46.51	-
85	Ubiquitination	LAKFFAPKMVSEKKI HHHHHCCCCCCCCCE	48.80	-
91	Ubiquitination	PKMVSEKKIYDVEQT CCCCCCCCEEEHHHH	42.31	-
93	Phosphorylation	MVSEKKIYDVEQTRY CCCCCCEEEHHHHCC	23.86	21253578
102	Ubiquitination	VEQTRYKKSGLHFRH HHHHCCCCCCCCCCC	40.60	-
103	Phosphorylation	EQTRYKKSGLHFRHT HHHCCCCCCCCCCCC	42.30	24275569
122	Phosphorylation	QWLRAMESIGLPKIF HHHHHHHHHCCCCCC	14.63	27251275
137	Phosphorylation	YPETTDVYDRKNIPR CCCCCCCCCCCCCCH	16.91	-
171	Ubiquitination	QIQDLLGKVDFTEEE HHHHHHCCCCCCHHH	38.30	2190698
171 (in isoform 1)	Ubiquitination	-	38.30	21890473
171 (in isoform 2)	Ubiquitination	-	38.30	21890473
186 (in isoform 2)	Phosphorylation	-	8.47	26699800
186 (in isoform 3)	Phosphorylation	-	8.47	26699800
189	Phosphorylation	MRKELEKYGIQMPSF HHHHHHHHCCCCCCH	15.30	21406692
189 (in isoform 2)	Phosphorylation	-	15.30	26699800
189 (in isoform 3)	Phosphorylation	-	15.30	26699800
195	Phosphorylation	KYGIQMPSFSKIGGI HHCCCCCCHHHCCCH	36.49	21406692
197	Phosphorylation	GIQMPSFSKIGGILA CCCCCCHHHCCCHHH	27.92	21406692
200 (in isoform 2)	Phosphorylation	-	22.33	26699800
200 (in isoform 3)	Phosphorylation	-	22.33	26699800
208	Phosphorylation	GILANELSVDEAALH CHHHCCCCCCHHHHH	22.73	24275569
275	Phosphorylation	ENARLKNSCISEEER HHHHHHHCCCCHHHH	15.96	28258704
278	Phosphorylation	RLKNSCISEEERDAY HHHHCCCCHHHHHHH	43.19	28258704
285	Phosphorylation	SEEERDAYEELLTQA CHHHHHHHHHHHHHH	17.77	28258704
300	Ubiquitination	EIQGNINKVNRQAAV HHHCCHHHHHHHHHH	36.77	-
356	Phosphorylation	FNLQKQNTMNYLAHE HHHHHCCCHHHHHHH	12.33	24275569
373	O-linked_Glycosylation	LIAVEMLSAVALLNQ HHHHHHHHHHHHHHH	21.27	30379171
396	Phosphorylation	SVQNQLRSPAIGLNN HHHHHHCCCCCCCCC	27.55	27499020
406	Ubiquitination	IGLNNLDKAYVERYA CCCCCCCHHHHHHHH	44.79	21890473
406 (in isoform 2)	Ubiquitination	-	44.79	21890473
412	Phosphorylation	DKAYVERYANTLLSV CHHHHHHHHHHHHHH	7.24	21406692
415	Phosphorylation	YVERYANTLLSVKLE HHHHHHHHHHHHHHH	22.39	21406692
418	Phosphorylation	RYANTLLSVKLEVLS HHHHHHHHHHHHHHH	21.96	24719451
432	Phosphorylation	SQGQDNLSWNEIQNC HCCCCCCCHHHHHHH	33.82	24275569
494	Phosphorylation	DPAHAQHYQDVLYHA CHHHHHHHHHHHHHH	8.37	-
499	Phosphorylation	QHYQDVLYHAKSQKL HHHHHHHHHHHCCCC	10.28	-
509	Phosphorylation	KSQKLGDSESVSKVL HCCCCCCCHHHHHHH	29.94	25072903
511	Phosphorylation	QKLGDSESVSKVLWL CCCCCCHHHHHHHHH	35.33	25072903
513	Phosphorylation	LGDSESVSKVLWLDE CCCCHHHHHHHHHHH	26.73	30622161
520 (in isoform 2)	Ubiquitination	-	40.29	-
562	Ubiquitination	SDILSVLKSSTSNAN HHHHHHHHHCCCCCC	39.96	-
579	Phosphorylation	IPECADKYYDALVKA CHHHHHHHHHHHHHH	13.71	21253578
580	Phosphorylation	PECADKYYDALVKAK HHHHHHHHHHHHHHH	10.65	-
585	Ubiquitination	KYYDALVKAKELKSE HHHHHHHHHHHHCCC	55.37	-
590	Ubiquitination	LVKAKELKSERVSSD HHHHHHHCCCCCCCC	51.90	-
591	Phosphorylation	VKAKELKSERVSSDG HHHHHHCCCCCCCCC	43.17	23401153
595	Phosphorylation	ELKSERVSSDGSWLK HHCCCCCCCCCCEEE	29.00	23917254
596	Phosphorylation	LKSERVSSDGSWLKL HCCCCCCCCCCEEEE	43.04	23312004
599	Phosphorylation	ERVSSDGSWLKLNLH CCCCCCCCEEEEEEC	33.94	22115753
602	Ubiquitination	SSDGSWLKLNLHKKY CCCCCEEEEEECCCC	29.13	-
608	Ubiquitination	LKLNLHKKYDYYYNT EEEEECCCCCEEECC	32.38	-
609	Phosphorylation	KLNLHKKYDYYYNTD EEEECCCCCEEECCC	17.62	30576142
611	Phosphorylation	NLHKKYDYYYNTDSK EECCCCCEEECCCCC	12.54	17360941
612	Phosphorylation	LHKKYDYYYNTDSKE ECCCCCEEECCCCCC	6.32	25159151
613	Phosphorylation	HKKYDYYYNTDSKES CCCCCEEECCCCCCC	12.83	29978859
615	Phosphorylation	KYDYYYNTDSKESSW CCCEEECCCCCCCCC	26.06	24719451
617	Phosphorylation	DYYYNTDSKESSWVT CEEECCCCCCCCCCC	35.96	30576142
624	Phosphorylation	SKESSWVTPESCLYK CCCCCCCCCHHHCEE	18.32	27251275
630	Phosphorylation	VTPESCLYKESWLTG CCCHHHCEECCCCCC	19.62	22817900
631	Ubiquitination	TPESCLYKESWLTGK CCHHHCEECCCCCCC	32.12	-
658	Phosphorylation	YIRENIWSASEELLL HHHHHHHHCCHHHHH	20.37	25693802
660	Phosphorylation	RENIWSASEELLLRF HHHHHHCCHHHHHHH	26.53	25693802
671	Phosphorylation	LLRFQATSSGPILRE HHHHHHCCCCCCHHH	35.99	-
672	Phosphorylation	LRFQATSSGPILREE HHHHHCCCCCCHHHH	44.21	-
685	Phosphorylation	EEFEARKSFLHEQEE HHHHHHHHHHHHHHH	27.73	23401153
710	Phosphorylation	GYKQRKEYMHRRQTF HHHHHHHHHHHHHHH	10.97	-
716	Phosphorylation	EYMHRRQTFIDNTDS HHHHHHHHHCCCCHH	22.27	28857561
721	Phosphorylation	RQTFIDNTDSIVKIQ HHHHCCCCHHHHHHH	27.63	25072903
723	Phosphorylation	TFIDNTDSIVKIQSW HHCCCCHHHHHHHHH	27.52	25072903
735	Phosphorylation	QSWFRMATARKSYLS HHHHHHHHHCHHHHH	20.04	-
739	Phosphorylation	RMATARKSYLSRLQY HHHHHCHHHHHHHHH	26.25	24275569
740	Phosphorylation	MATARKSYLSRLQYF HHHHCHHHHHHHHHH	16.25	-
746	Phosphorylation	SYLSRLQYFRDHNNE HHHHHHHHHHHCCCH	12.74	-
756	Ubiquitination	DHNNEIVKIQSLLRA HCCCHHHHHHHHHHH	40.46	-
759	Phosphorylation	NEIVKIQSLLRANKA CHHHHHHHHHHHHCC	32.61	23401153
770	Phosphorylation	ANKARDDYKTLVGSE HHCCCCCHHHHCCCC	15.34	21552520
771	Acetylation	NKARDDYKTLVGSEN HCCCCCHHHHCCCCC	42.23	19823609
772	Phosphorylation	KARDDYKTLVGSENP CCCCCHHHHCCCCCC	22.05	-
782	Phosphorylation	GSENPPLTVIRKFVY CCCCCCHHHHHHHHH	21.47	24275569
786	Acetylation	PPLTVIRKFVYLLDQ CCHHHHHHHHHHHCC	28.23	19823617
814	Ubiquitination	LREEVVTKIRANQQL HHHHHHHHHHHHHHH	20.70	-
823	Ubiquitination	RANQQLEKDLNLMDI HHHHHHHHHCCHHHH	75.90	-
828	Sulfoxidation	LEKDLNLMDIKIGLL HHHHCCHHHHHHHHH	4.94	21406390
837	Ubiquitination	IKIGLLVKNRITLED HHHHHHHCCCCCHHH	40.24	-
847	Phosphorylation	ITLEDVISHSKKLNK CCHHHHHHHHHHHCC	22.89	27080861
849	Phosphorylation	LEDVISHSKKLNKKK HHHHHHHHHHHCCCC	25.37	27080861
856	Ubiquitination	SKKLNKKKGGEMEIL HHHHCCCCCCCCEEC	73.99	-
860	Sulfoxidation	NKKKGGEMEILNNTD CCCCCCCCEECCCCC	4.37	21406390
866	Phosphorylation	EMEILNNTDNQGIKS CCEECCCCCCCHHHH	34.94	20068231
872	Ubiquitination	NTDNQGIKSLSKERR CCCCCHHHHCCHHHH	52.77	-
873	Phosphorylation	TDNQGIKSLSKERRK CCCCHHHHCCHHHHH	35.63	20068231
875	Phosphorylation	NQGIKSLSKERRKTL CCHHHHCCHHHHHHH	39.29	20068231
881	Phosphorylation	LSKERRKTLETYQQL CCHHHHHHHHHHHHH	28.19	27251275
885	Phosphorylation	RRKTLETYQQLFYLL HHHHHHHHHHHHHHH	5.72	-
890	Phosphorylation	ETYQQLFYLLQTNPL HHHHHHHHHHHHCHH	18.33	-
910	Ubiquitination	IFQMPQNKSTKFMDT HHCCCCCCCCCCHHH	55.01	21890473
910	Ubiquitination	IFQMPQNKSTKFMDT HHCCCCCCCCCCHHH	55.01	-
910 (in isoform 1)	Ubiquitination	-	55.01	21890473
959	Phosphorylation	DQVQDIVTGNPTVIK HHHHHHHCCCCCEEE	31.41	29978859
963	Phosphorylation	DIVTGNPTVIKMVVS HHHCCCCCEEEEEEE	38.57	29978859
970	Phosphorylation	TVIKMVVSFNRGARG CEEEEEEECCCCCCC	12.85	20873877
1002	Phosphorylation	DKSLIINTNPVEVYK CCCEEECCCCHHHHH	30.41	24275569
1024	Ubiquitination	TQTGEASKLPYDVTT HCCCCCCCCCCCCCH	61.60	-
1027	Phosphorylation	GEASKLPYDVTTEQA CCCCCCCCCCCHHHC	33.22	29396449
1030	Phosphorylation	SKLPYDVTTEQALTY CCCCCCCCHHHCCCC	23.01	29396449
1031	Phosphorylation	KLPYDVTTEQALTYP CCCCCCCHHHCCCCH	26.42	29396449
1036	Phosphorylation	VTTEQALTYPEVKNK CCHHHCCCCHHHHHH	39.79	29396449
1037	Phosphorylation	TTEQALTYPEVKNKL CHHHCCCCHHHHHHH	9.76	29396449
1083	Phosphorylation	IAKVLKNSIHEKFPD HHHHHHHCHHHHCCC	24.60	26074081
1106	Phosphorylation	IVGNLLYYRYMNPAI HHHHHHHHHCCCCCE	8.67	21253578
1172	Phosphorylation	NNYLSETYQEFRKYF HHHHHHHHHHHHHHH	11.29	-
1178	Phosphorylation	TYQEFRKYFKEACNV HHHHHHHHHHHHHCC	18.67	-
1249	Phosphorylation	GSLGEVPTVESFLGE HHCCCCCCHHHHHCC	41.92	24275569
1269	Phosphorylation	NDPNKANTLSQLSKT CCCCCCCHHHHHCHH	32.42	24275569
1271	Phosphorylation	PNKANTLSQLSKTEI CCCCCHHHHHCHHHH	27.34	22617229
1276	Phosphorylation	TLSQLSKTEISLVLT HHHHHCHHHHEEEEE	34.86	20068231
1279	Phosphorylation	QLSKTEISLVLTSKY HHCHHHHEEEEEECC	13.24	20068231
1283	Phosphorylation	TEISLVLTSKYDIED HHHEEEEEECCCCCC	18.72	20068231
1284	Phosphorylation	EISLVLTSKYDIEDG HHEEEEEECCCCCCC	25.67	20068231
1286	Phosphorylation	SLVLTSKYDIEDGEA EEEEEECCCCCCCCE	23.17	21214269
1296	Phosphorylation	EDGEAIDSRSLMIKT CCCCEECCCCEEEEE	20.04	21214269
1298	Phosphorylation	GEAIDSRSLMIKTKK CCEECCCCEEEEECE	26.66	21214269
1349	Phosphorylation	RAMIDSRTPEEMKHS HHHHCCCCHHHHHCC	38.72	22115753
1356	Phosphorylation	TPEEMKHSQSMIEDA CHHHHHCCHHHHHHC	20.59	23401153
1358	Phosphorylation	EEMKHSQSMIEDAQL HHHHCCHHHHHHCCC	25.41	23401153
1380	Phosphorylation	KIQRNLRTLEQTGHV HHHHHHHHHHHHCCC	37.50	21406692
1384	Phosphorylation	NLRTLEQTGHVSSEN HHHHHHHHCCCCCCH	21.63	21406692
1388	Phosphorylation	LEQTGHVSSENKYQD HHHHCCCCCCHHHHH	26.68	21406692
1389	Phosphorylation	EQTGHVSSENKYQDI HHHCCCCCCHHHHHH	44.06	21406692
1392	Ubiquitination	GHVSSENKYQDILNE CCCCCCHHHHHHHHH	39.99	-
1393	Phosphorylation	HVSSENKYQDILNEI CCCCCHHHHHHHHHH	24.01	21406692
1430	Ubiquitination	QTLNALNKKAAFYEE HHHHHHHHHHHHHHH	44.64	-
1454	Acetylation	KTCLDNLKRKNTRRS HHHHHHHHHCCCCCC	68.53	25953088
1461	Phosphorylation	KRKNTRRSIKLDGKG HHCCCCCCEECCCCC	22.30	23401153
1467	Acetylation	RSIKLDGKGEPKGAK CCEECCCCCCCCCCC	60.82	20167786
1471	Acetylation	LDGKGEPKGAKRAKP CCCCCCCCCCCCCCC	68.17	20167786
1474	Acetylation	KGEPKGAKRAKPVKY CCCCCCCCCCCCCCE	62.65	19608861
1489	Ubiquitination	TAAKLHEKGVLLDID EHHHHHHCCEEEEHH	43.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
716	T	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IQGA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
14	Phosphorylation	8 (6)	V ⇒ A	rs7722711	Mean platelet volume	27863252
16	Phosphorylation	8 (8)	V ⇒ A	rs7722711	Mean platelet volume	27863252
875	Phosphorylation	883 (8)	E ⇒ Q	rs34968964	Mean platelet volume	27863252
881	Phosphorylation	883 (2)	E ⇒ Q	rs34968964	Mean platelet volume	27863252
885	Phosphorylation	883;894 (2;9)	E;T ⇒ Q;I	rs34968964;rs34950321	Mean platelet volume Reticulocyte count	27863252
890	Phosphorylation	883;894 (7;4)	E;T ⇒ Q;I	rs34968964;rs34950321	Mean platelet volume Reticulocyte count	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAC1_HUMAN	RAC1	physical	8756646
CDC42_HUMAN	CDC42	physical	8756646
TERA_HUMAN	VCP	physical	28970065

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IQGA2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1471 AND LYS-1474, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.	18318008 [Abstract]