KIF17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF17_HUMAN
• UniProt AC: Q9P2E2
• Protein Name: Kinesin-like protein KIF17
• Gene Name: KIF17
• Organism: Homo sapiens (Human).
• Sequence Length: 1029
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell projection, cilium .
• Protein Description: Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules..
• Protein Sequence: MASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEHVFESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVHSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGSERQSKTGATGERLKEATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVRLSTLEENLRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSRFAELPKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLDECLGQEAAGHLLGEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKVPVQVPAPTDLLEPSDARPEAEAADDFPPRPEVDLASEVALEVVRTAEPGVWLEAQAPVALVAQPEPLPATAGVKRESVGMEVAVLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRYADERRKQLVAALQNSDEDSGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQSEFQLEKIDYLATIRRQERDSMLLQQLLEQVQPLIRRDCNYSNLEKILRESCWDEDNGFWKIPHPVITKTSLPVAVSTGPQNKPARKTSAADNGEPNMEDDRYRLMLSRSNSENIASNYFRSKRASQILSTDARKSLTHHNSPPGLSCPLSNNSAIPPTQAPEMPQPRPFRLESLDIPFTKAKRKKSKSNFGSEPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
175	Phosphorylation	GVYVKGLSMHTVHSV CEEEECCCHHCHHHH	19.72	-
181	Phosphorylation	LSMHTVHSVAQCEHI CCHHCHHHHHHCHHH	18.14	-
291	Ubiquitination	HVPYRDSKLTRLLQD CCCCCCHHHHHHHHH	59.16	-
293	Phosphorylation	PYRDSKLTRLLQDSL CCCCHHHHHHHHHHC	24.02	20068231
328	Phosphorylation	ETLSTLRYANRAKNI HHHHHHHHHHHHHCC	16.02	-
346	Ubiquitination	PRINEDPKDALLREY CCCCCCHHHHHHHHH	68.87	-
369	Phosphorylation	AILTQQMSPSSLSAL HHHHHCCCHHHHHHH	19.79	29978859
371	Phosphorylation	LTQQMSPSSLSALLS HHHCCCHHHHHHHHC	36.28	29978859
372	Phosphorylation	TQQMSPSSLSALLSR HHCCCHHHHHHHHCC	29.72	29978859
424	Phosphorylation	LARLKADYKAEQESR HHHHHHHHHHHHHHH	19.56	24719451
450	Phosphorylation	NSYDVRLSTLEENLR HHHHHHHHHHHHHHH	22.00	24719451
451	Phosphorylation	SYDVRLSTLEENLRK HHHHHHHHHHHHHHH	42.66	24719451
460	Phosphorylation	EENLRKETEAVLQVG HHHHHHHHHHHHHHH	32.07	24719451
811	Acetylation	IQEEVRAKSKLLEKM HHHHHHHHHHHHHHH	37.24	7378723
813	Acetylation	EEVRAKSKLLEKMQR HHHHHHHHHHHHHHH	57.28	7378735
903	Phosphorylation	PHPVITKTSLPVAVS CCCEEECCCCCEEEE	27.18	-
904	Phosphorylation	HPVITKTSLPVAVST CCEEECCCCCEEEEC	32.03	-
943	Phosphorylation	YRLMLSRSNSENIAS HHHHHHHCCCCCHHH	41.13	29978859
945	Phosphorylation	LMLSRSNSENIASNY HHHHHCCCCCHHHHH	33.01	29978859
959	Phosphorylation	YFRSKRASQILSTDA HHHCHHHHHHCCCHH	23.06	28555341
1026	Phosphorylation	KSKSNFGSEPL---- CCCCCCCCCCC----	31.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KIF17_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-945, AND MASSSPECTROMETRY.
PubMed: 19413330