DIAP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DIAP3_MOUSE
• UniProt AC: Q9Z207
• Protein Name: Protein diaphanous homolog 3
• Gene Name: Diaph3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1171
• Subcellular Localization: Cytoplasm, cytosol. During mitosis, colocalizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis..
• Protein Description: Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics..
• Protein Sequence: MERHRARALGRDSKSSRRKGLQSAPPAGPYEPGEKRPKLHLNIRTLTDDMLDKFASIRIPGSKKERPPLPHLKTVSGISDSSSLSSETMENNPKALPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYINTASKTGSLRSSRQISPQEFLHELKMGYTDERLFTYLESLRVSLTSHPVSWVQSFGHEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGLERIMSDKRSLSLLAKAMDPRQPAMMADVVKLLSAVCIVGEESILEEVLEALTSAGEERKIDRFFSIVEGLRHNSVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGIKNDGLDIQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKLIDECVSQIVLHRDGTDPDFTYRKRLDLDLSQFVDVCIDQAKLDEWEEKASEHCKKFEKECTDHQETQAQLQKREAKINELQAELQAFKSQFGALPPGTKIPLQPSVEGEAGPSALPPAPPALSGGVPPPPPPPPPPPPPLPGMPMPFGGPVPPPPPLGFLGGQSSIPLNLPFGLKPKKEFKPEISMRRLNWLKIGPNEMSENCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNTNDFDEKKVIKKRMKELKFLDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKSADQKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSSFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSFMLALKENIKKREAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEGDETGVMDSLLEALQSGAAFRDRRKRTPKLKDIRQSLSPMSQRPVLKVCNHENQKMQLTEGSRPHHSINCNSTRTPVAKELNYNLDTHASTGRIKAVEKEACNAESNKKKEMELLGSVAKSESVPEVEALLARLRAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	ARALGRDSKSSRRKG HHHCCCCCHHHHHCC	32.83	29514104
15	Phosphorylation	ALGRDSKSSRRKGLQ HCCCCCHHHHHCCCC	32.79	29514104
47	Phosphorylation	HLNIRTLTDDMLDKF EEEEEECCHHHHHHH	29.37	-
56	Phosphorylation	DMLDKFASIRIPGSK HHHHHHHCCCCCCCC	18.61	-
118	Ubiquitination	DMNLNEDKKAPLREK HCCCCCCCCCCHHHC	44.66	PubMed
119	Ubiquitination	MNLNEDKKAPLREKD CCCCCCCCCCHHHCH	68.51	PubMed
154	Phosphorylation	LRSSRQISPQEFLHE CCCCCCCCHHHHHHH	16.52	26370283
454	Phosphorylation	IVLHRDGTDPDFTYR HHHCCCCCCCCCCCH	48.96	23970565
493	Ubiquitination	EKASEHCKKFEKECT HHHHHHHHHHHHHHC	63.51	PubMed
494	Ubiquitination	KASEHCKKFEKECTD HHHHHHHHHHHHHCH	65.24	PubMed
604	Phosphorylation	GFLGGQSSIPLNLPF CCCCCCCCCCCCCCC	21.97	-
675	Phosphorylation	QEKEKRNTNDFDEKK CHHHHCCCCCCCHHH	39.95	26824392
947	Phosphorylation	NEQYEKLSTLLGSMT HHHHHHHHHHHHHHH	28.25	25293948
948	Phosphorylation	EQYEKLSTLLGSMTQ HHHHHHHHHHHHHHH	36.12	25293948
952	Phosphorylation	KLSTLLGSMTQLYQS HHHHHHHHHHHHHHH	20.73	25293948
954	Phosphorylation	STLLGSMTQLYQSIM HHHHHHHHHHHHHHH	19.67	25293948
957	Phosphorylation	LGSMTQLYQSIMGYY HHHHHHHHHHHHCHH	7.15	25293948
959	Phosphorylation	SMTQLYQSIMGYYAV HHHHHHHHHHCHHHC	10.86	25293948
963	Phosphorylation	LYQSIMGYYAVDMKK HHHHHHCHHHCCCCE	3.20	25293948
964	Phosphorylation	YQSIMGYYAVDMKKV HHHHHCHHHCCCCEE	8.40	25293948
1061	Phosphorylation	FRDRRKRTPKLKDIR HHHHHHCCCCHHHHH	28.01	21699497
1070	Phosphorylation	KLKDIRQSLSPMSQR CHHHHHHHCCCCHHC	22.44	26643407
1072	Phosphorylation	KDIRQSLSPMSQRPV HHHHHHCCCCHHCCH	24.65	22942356
1075	Phosphorylation	RQSLSPMSQRPVLKV HHHCCCCHHCCHHHH	26.82	26643407
1077	Methylation	SLSPMSQRPVLKVCN HCCCCHHCCHHHHCC	18.91	-
1157	Phosphorylation	GSVAKSESVPEVEAL HHHHHCCCCHHHHHH	50.49	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1061	T	Phosphorylation	Kinase	ROCK1	Q13464	GPS
1061	T	Phosphorylation	Kinase	ROCK1	P70335	PSP
1070	S	Phosphorylation	Kinase	ROCK1	Q13464	GPS
1070	S	Phosphorylation	Kinase	ROCK1	P70335	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DIAP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DIAP3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHOA_HUMAN	RHOA	physical	9535835
CDC42_HUMAN	CDC42	physical	9535835

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.