MRCKA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRCKA_HUMAN
• UniProt AC: Q5VT25
• Protein Name: Serine/threonine-protein kinase MRCK alpha
• Gene Name: CDC42BPA {ECO:0000312|EMBL:CAH71336.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 1732
• Subcellular Localization: Cytoplasm . Cell projection, lamellipodium . Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Localizes in the lame
• Protein Description: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. [PubMed: 15723050]
• Protein Sequence: MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFERSPSCTPASKGRRTVDSTPLSVHTPTLRKKGCPGSTGFPPKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETDFYKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMPSPSEGSLSSGGMDQGSDAPARDFDGEDSDSPRHSTASNSSNLSSPPSPASPRKTKSLSLESTDRGSWDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGEVRLRQ ------CCCCCCHHH	55.77	20068231
81	Ubiquitination	REDFEILKVIGRGAF HHHHHHHHEECCCCC	37.15	22817900
167	Phosphorylation	GDLLTLLSKFEDRLP HHHHHHHHHHHHCCC	38.11	24719451
172	Methylation	LLSKFEDRLPEDMAR HHHHHHHCCCHHHHH	44.97	115483649
179	Methylation	RLPEDMARFYLAEMV CCCHHHHHHHHHHHH	17.69	115483657
211	Ubiquitination	PDNILMDMNGHIRLA CCCEEECCCCCEEEC	3.94	23503661
222	Phosphorylation	IRLADFGSCLKLMED EEECCCHHHHHHCCC	19.10	11283256
234	Phosphorylation	MEDGTVQSSVAVGTP CCCCCEEEEEECCCC	23.57	11283256
234	Ubiquitination	MEDGTVQSSVAVGTP CCCCCEEEEEECCCC	23.57	27667366
240	Phosphorylation	QSSVAVGTPDYISPE EEEEECCCCCCCCHH	13.34	11283256
245	Phosphorylation	VGTPDYISPEILQAM CCCCCCCCHHHHHHH	15.39	-
315	Ubiquitination	TDVSENAKDLIRRLI CCCCHHHHHHHHHHH	65.73	23503661
315 (in isoform 2)	Ubiquitination	-	65.73	-
338	Ubiquitination	QNGIEDFKKHPFFSG CCCHHHHHHCCCCCC	63.59	27667366
338 (in isoform 1)	Ubiquitination	-	63.59	21906983
338 (in isoform 2)	Ubiquitination	-	63.59	21906983
338 (in isoform 3)	Ubiquitination	-	63.59	21906983
338 (in isoform 4)	Ubiquitination	-	63.59	21906983
338 (in isoform 5)	Ubiquitination	-	63.59	21906983
338 (in isoform 6)	Ubiquitination	-	63.59	21906983
339	Ubiquitination	NGIEDFKKHPFFSGI CCHHHHHHCCCCCCC	57.41	29967540
363	Phosphorylation	APYIPEVSSPTDTSN CCCCCCCCCCCCCCC	29.01	29116813
364	Phosphorylation	PYIPEVSSPTDTSNF CCCCCCCCCCCCCCC	36.67	29116813
366	Phosphorylation	IPEVSSPTDTSNFDV CCCCCCCCCCCCCCC	54.58	28348404
368	Phosphorylation	EVSSPTDTSNFDVDD CCCCCCCCCCCCCCC	28.22	28348404
403	Phosphorylation	HLPFVGFTYTSSCVL CCCCCCEEEECCEEE	21.69	11283256
444	Phosphorylation	NNLATEAYERRIKRL CCHHHHHHHHHHHHH	12.07	-
461	Ubiquitination	EKLELSRKLQESTQT HHHHHHHHHHHHHHH	51.66	29967540
465	Phosphorylation	LSRKLQESTQTVQAL HHHHHHHHHHHHHHH	16.92	21945579
466	Phosphorylation	SRKLQESTQTVQALQ HHHHHHHHHHHHHHC	27.75	21945579
468	Phosphorylation	KLQESTQTVQALQYS HHHHHHHHHHHHCEE	18.05	21945579
474	Phosphorylation	QTVQALQYSTVDGPL HHHHHHCEECCCCCC	13.73	21945579
475	Phosphorylation	TVQALQYSTVDGPLT HHHHHCEECCCCCCC	14.70	21945579
476	Phosphorylation	VQALQYSTVDGPLTA HHHHCEECCCCCCCC	20.06	21945579
482	Phosphorylation	STVDGPLTASKDLEI ECCCCCCCCCCCHHC	31.83	21945579
484	Phosphorylation	VDGPLTASKDLEIKN CCCCCCCCCCHHCCC	22.82	21945579
490	Ubiquitination	ASKDLEIKNLKEEIE CCCCHHCCCHHHHHH	47.02	29967540
531	Ubiquitination	DDAFRQIKAYEKQIK HHHHHHHHHHHHHHH	36.26	29967540
588	Ubiquitination	EINERLTELHTQKQK HHHHHHHHHHHHHHH	43.05	29967540
592	Ubiquitination	RLTELHTQKQKLARH HHHHHHHHHHHHHHH	35.12	22505724
613	Ubiquitination	EVDLVMQKVESLRQE HHHHHHHHHHHHHHH	29.85	32015554
615	Ubiquitination	DLVMQKVESLRQELR HHHHHHHHHHHHHHH	51.60	22505724
635	Phosphorylation	KKELEVHTEALAAEA HHHHHHHHHHHHHHH	28.29	29255136
643	Phosphorylation	EALAAEASKDRKLRE HHHHHHHHHHHHHHH	26.96	29255136
652	Phosphorylation	DRKLREQSEHYSKQL HHHHHHHHHHHHHHH	22.91	29083192
655	Phosphorylation	LREQSEHYSKQLENE HHHHHHHHHHHHHHH	17.32	29083192
656	Phosphorylation	REQSEHYSKQLENEL HHHHHHHHHHHHHHH	18.81	29083192
669	Acetylation	ELEGLKQKQISYSPG HHHHHHHCCCCCCCC	48.27	11794929
669	Ubiquitination	ELEGLKQKQISYSPG HHHHHHHCCCCCCCC	48.27	29967540
672	Phosphorylation	GLKQKQISYSPGVCS HHHHCCCCCCCCCCC	19.64	26657352
673	Phosphorylation	LKQKQISYSPGVCSI HHHCCCCCCCCCCCH	22.10	29978859
674	Phosphorylation	KQKQISYSPGVCSIE HHCCCCCCCCCCCHH	14.37	26657352
679	Phosphorylation	SYSPGVCSIEHQQEI CCCCCCCCHHHHHHH	28.71	28985074
687	Phosphorylation	IEHQQEITKLKTDLE HHHHHHHHHHCHHHH	29.58	24719451
696	Ubiquitination	LKTDLEKKSIFYEEE HCHHHHHCCCCCHHH	39.13	22505724
696 (in isoform 6)	Ubiquitination	-	39.13	-
700	Phosphorylation	LEKKSIFYEEELSKR HHHCCCCCHHHHHHC	22.29	28258704
704	Ubiquitination	SIFYEEELSKREGIH CCCCHHHHHHCCCCC	9.17	29967540
725	Phosphorylation	LKKELHDSEGQQLAL HHHHHCCHHHHHHHH	32.64	-
750	Phosphorylation	LEKTRRESQSEREEF HHHHHHHHHHHHHHH	36.88	29255136
752	Phosphorylation	KTRRESQSEREEFES HHHHHHHHHHHHHHH	48.15	29255136
759	Phosphorylation	SEREEFESEFKQQYE HHHHHHHHHHHHHHH	54.37	23403867
763	Ubiquitination	EFESEFKQQYEREKV HHHHHHHHHHHHHHH	57.31	32015554
785	Ubiquitination	KLTSELDKLTTLYEN HHHHHHHHHHHHHHH	61.43	29967540
812	Ubiquitination	KDLADKKESVAHWEA HHHHHHHHHHHHHHH	57.07	29967540
832	Ubiquitination	IQWVSDEKDARGYLQ HHHHCCCCCHHHHHH	62.77	29967540
837	Phosphorylation	DEKDARGYLQALASK CCCCHHHHHHHHHHH	7.06	27174698
839	Ubiquitination	KDARGYLQALASKMT CCHHHHHHHHHHHHH	26.33	29967540
843	Phosphorylation	GYLQALASKMTEELE HHHHHHHHHHHHHHH	24.66	27174698
844	Ubiquitination	YLQALASKMTEELEA HHHHHHHHHHHHHHH	44.21	32015554
846	Phosphorylation	QALASKMTEELEALR HHHHHHHHHHHHHHH	30.00	19664994
855	Phosphorylation	ELEALRNSSLGTRAT HHHHHHHCCCCCCCC	22.10	22199227
856	Phosphorylation	LEALRNSSLGTRATD HHHHHHCCCCCCCCC	34.07	22199227
859	Phosphorylation	LRNSSLGTRATDMPW HHHCCCCCCCCCCCH	23.56	22199227
861	Ubiquitination	NSSLGTRATDMPWKM HCCCCCCCCCCCHHH	14.06	29967540
862	Phosphorylation	SSLGTRATDMPWKMR CCCCCCCCCCCHHHH	29.55	-
868 (in isoform 3)	Phosphorylation	-	3.08	27251275
871 (in isoform 3)	Phosphorylation	-	5.05	27251275
880 (in isoform 3)	Phosphorylation	-	8.45	28122231
884	Phosphorylation	SARLELQSALDAEIR HHHHHHHHHHHHHHH	43.34	20068231
888 (in isoform 3)	Phosphorylation	-	18.24	28122231
891 (in isoform 3)	Phosphorylation	-	27.51	28122231
892 (in isoform 3)	Phosphorylation	-	17.61	28122231
893	Ubiquitination	LDAEIRAKQAIQEEL HHHHHHHHHHHHHHH	30.34	29967540
895 (in isoform 3)	Phosphorylation	-	12.53	23836654
898	Phosphorylation	RAKQAIQEELNKVKA HHHHHHHHHHHHCHH	59.34	32142685
898 (in isoform 3)	Phosphorylation	-	59.34	23836654
900 (in isoform 3)	Phosphorylation	-	8.06	28122231
913	Ubiquitination	SNIITECKLKDSEKK HHHHHHEECCHHHHH	52.95	29967540
920	Ubiquitination	KLKDSEKKNLELLSE ECCHHHHHHHHHHHH	63.81	29967540
940	Phosphorylation	KDTEELRSEKGIEHQ HCHHHHHHHCCCCCC	57.17	29255136
942	Ubiquitination	TEELRSEKGIEHQDS HHHHHHHCCCCCCCC	67.45	29967540
949 (in isoform 5)	Phosphorylation	-	24.19	27251275
949 (in isoform 6)	Phosphorylation	-	24.19	27251275
952 (in isoform 5)	Phosphorylation	-	17.83	27251275
952 (in isoform 6)	Phosphorylation	-	17.83	27251275
959	Phosphorylation	SFLAFLNTPTDALDQ CEEHHHCCCCHHHHH	29.70	32142685
961 (in isoform 5)	Phosphorylation	-	31.68	28122231
961 (in isoform 6)	Phosphorylation	-	31.68	28122231
969 (in isoform 5)	Phosphorylation	-	55.97	28122231
969 (in isoform 6)	Phosphorylation	-	55.97	28122231
972 (in isoform 5)	Phosphorylation	-	31.69	28122231
972 (in isoform 6)	Phosphorylation	-	31.69	28122231
973 (in isoform 5)	Phosphorylation	-	6.32	28122231
973 (in isoform 6)	Phosphorylation	-	6.32	28122231
976 (in isoform 5)	Phosphorylation	-	13.01	23836654
976 (in isoform 6)	Phosphorylation	-	13.01	23836654
979	Phosphorylation	SCTPASKGRRTVDST CCCCCCCCCCCCCCC	23.08	32142685
979 (in isoform 5)	Phosphorylation	-	23.08	23836654
979 (in isoform 6)	Phosphorylation	-	23.08	23836654
981 (in isoform 5)	Phosphorylation	-	48.01	28122231
981 (in isoform 6)	Phosphorylation	-	48.01	28122231
982	Phosphorylation	PASKGRRTVDSTPLS CCCCCCCCCCCCCCE	27.57	26437602
985	Phosphorylation	KGRRTVDSTPLSVHT CCCCCCCCCCCEEEC	27.82	23403867
985	Ubiquitination	KGRRTVDSTPLSVHT CCCCCCCCCCCEEEC	27.82	29967540
986	Phosphorylation	GRRTVDSTPLSVHTP CCCCCCCCCCEEECC	24.64	23403867
989	Phosphorylation	TVDSTPLSVHTPTLR CCCCCCCEEECCCHH	17.04	23403867
990 (in isoform 2)	Phosphorylation	-	8.42	28450419
991 (in isoform 2)	Phosphorylation	-	23.82	28450419
992	Phosphorylation	STPLSVHTPTLRKKG CCCCEEECCCHHHCC	18.80	25627689
992 (in isoform 2)	Phosphorylation	-	18.80	25159151
994	Phosphorylation	PLSVHTPTLRKKGCP CCEEECCCHHHCCCC	40.11	23403867
994 (in isoform 2)	Phosphorylation	-	40.11	28450419
995 (in isoform 2)	Phosphorylation	-	8.77	30624053
996 (in isoform 2)	Phosphorylation	-	40.91	28450419
997 (in isoform 2)	Phosphorylation	-	57.54	28270605
1003	Phosphorylation	RKKGCPGSTGFPPKR HHCCCCCCCCCCCCC	15.53	28674419
1014 (in isoform 2)	Phosphorylation	-	38.41	25159151
1028	Ubiquitination	TTPTKCHQCTSLMVG CCCCCHHHCHHHHHH	41.47	23503661
1028 (in isoform 3)	Ubiquitination	-	41.47	21906983
1040	Ubiquitination	MVGLIRQGCSCEVCG HHHHHHCCCCCEECC	8.75	23503661
1066	Ubiquitination	PTTCPVPPEQTKGPL CCCCCCCHHHCCCCC	46.70	29967540
1069	Ubiquitination	CPVPPEQTKGPLGID CCCCHHHCCCCCCCC	35.99	23503661
1081 (in isoform 4)	Ubiquitination	-	5.96	21906983
1092	Ubiquitination	YEGHVRIPKPAGVKK EECCCCCCCCCCCCC	26.47	23503661
1109	Ubiquitination	QRALAIVCDFKLFLY HHHHHHHHCCEEEEH	4.09	23503661
1109 (in isoform 5)	Ubiquitination	-	4.09	21906983
1109 (in isoform 6)	Ubiquitination	-	4.09	21906983
1116	Phosphorylation	CDFKLFLYDIAEGKA HCCEEEEHHHHCCCC	9.66	22210691
1122	Ubiquitination	LYDIAEGKASQPSVV EHHHHCCCCCCCCEE	36.05	21906983
1122 (in isoform 1)	Ubiquitination	-	36.05	21906983
1123	Ubiquitination	YDIAEGKASQPSVVI HHHHCCCCCCCCEEE	25.02	29967540
1124	Phosphorylation	DIAEGKASQPSVVIS HHHCCCCCCCCEEEE	46.22	22210691
1125	Ubiquitination	IAEGKASQPSVVISQ HHCCCCCCCCEEEEE	38.86	23503661
1127	Phosphorylation	EGKASQPSVVISQVI CCCCCCCCEEEEEEE	22.75	22210691
1134	Ubiquitination	SVVISQVIDMRDEEF CEEEEEEECCCCCCC	2.39	29967540
1138	Ubiquitination	SQVIDMRDEEFSVSS EEEECCCCCCCCHHH	53.81	23503661
1144	Ubiquitination	RDEEFSVSSVLASDV CCCCCCHHHHHHHHH	17.33	23503661
1144 (in isoform 2)	Ubiquitination	-	17.33	21906983
1157	Ubiquitination	DVIHASRKDIPCIFR HHHHHHCCCCCEEEE	58.47	23503661
1160	Ubiquitination	HASRKDIPCIFRVTA HHHCCCCCEEEEECH	18.45	23503661
1171	Phosphorylation	RVTASQLSASNNKCS EECHHHHHCCCCEEE	23.24	-
1173	Phosphorylation	TASQLSASNNKCSIL CHHHHHCCCCEEEEE	37.24	-
1173	Ubiquitination	TASQLSASNNKCSIL CHHHHHCCCCEEEEE	37.24	23503661
1178	Phosphorylation	SASNNKCSILMLADT HCCCCEEEEEEEECC	21.99	26270265
1185	Phosphorylation	SILMLADTENEKNKW EEEEEECCCCCCCCH	34.79	-
1204	Ubiquitination	SELHKILKKNKFRDR HHHHHHHHCCCCCCC	58.74	29967540
1213	Ubiquitination	NKFRDRSVYVPKEAY CCCCCCCEECCHHHH	6.10	29967540
1215	Ubiquitination	FRDRSVYVPKEAYDS CCCCCEECCHHHHCC	5.24	29967540
1218	Ubiquitination	RSVYVPKEAYDSTLP CCEECCHHHHCCCCC	46.52	29967540
1294	Ubiquitination	NRHVRLFPMSALDGR CCEEEEEEHHHCCCC	22.02	29967540
1299	Ubiquitination	LFPMSALDGRETDFY EEEHHHCCCCCCCEE	54.54	29967540
1378	Phosphorylation	QLCVGFQSGFLRYPL CEEHEECCEECCEEC	29.29	-
1492	Phosphorylation	PLKKVRPLNNEGSLN CCCCCCCCCCCCCCE	8.23	20068231
1497	Phosphorylation	RPLNNEGSLNLLGLE CCCCCCCCCEECCCC	14.12	20068231
1505	Phosphorylation	LNLLGLETIRLIYFK CEECCCCCEEEEEEC	19.21	20068231
1510	Phosphorylation	LETIRLIYFKNKMAE CCCEEEEEECCCCCC	17.06	20068231
1527	Phosphorylation	ELVVPETSDNSRKQM CCCCCCCCCCHHHHH	32.88	28851738
1532	Phosphorylation	ETSDNSRKQMVRNIN CCCCCHHHHHHHHHC	42.43	18669648
1544	Phosphorylation	NINNKRRYSFRVPEE HHCCCCCEECCCCHH	19.05	23927012
1545	Phosphorylation	INNKRRYSFRVPEEE HCCCCCEECCCCHHH	12.55	23401153
1562	Phosphorylation	QQRREMLRDPEMRNK HHHHHHHHCHHHHHH	57.01	32142685
1604	Phosphorylation	MNPRPQESRTVFSGS CCCCCCCCCEEEECE	28.18	21712546
1606	Phosphorylation	PRPQESRTVFSGSVS CCCCCCCEEEECEEE	34.87	27251275
1609	O-linked_Glycosylation	QESRTVFSGSVSIPS CCCCEEEECEEECCC	26.31	28657654
1609	Phosphorylation	QESRTVFSGSVSIPS CCCCEEEECEEECCC	26.31	29978859
1611	Phosphorylation	SRTVFSGSVSIPSIT CCEEEECEEECCCCC	16.11	20044836
1613	Phosphorylation	TVFSGSVSIPSITKS EEEECEEECCCCCCC	30.40	26657352
1615	Phosphorylation	FSGSVSIPSITKSRP EECEEECCCCCCCCC	16.51	32142685
1616	Phosphorylation	SGSVSIPSITKSRPE ECEEECCCCCCCCCC	41.02	20044836
1618	Phosphorylation	SVSIPSITKSRPEPG EEECCCCCCCCCCCC	27.57	25159151
1620	Phosphorylation	SIPSITKSRPEPGRS ECCCCCCCCCCCCCC	44.40	29449344
1623	Phosphorylation	SITKSRPEPGRSMSA CCCCCCCCCCCCCCC	60.31	32142685
1627	Phosphorylation	SRPEPGRSMSASSGL CCCCCCCCCCCCCCC	24.01	26657352
1629	Phosphorylation	PEPGRSMSASSGLSA CCCCCCCCCCCCCCC	26.67	25159151
1629 (in isoform 6)	Phosphorylation	-	26.67	25850435
1630	Phosphorylation	EPGRSMSASSGLSAR CCCCCCCCCCCCCCC	10.08	33259812
1630 (in isoform 6)	Phosphorylation	-	10.08	25850435
1631	Phosphorylation	PGRSMSASSGLSARS CCCCCCCCCCCCCCH	20.03	22199227
1632	Phosphorylation	GRSMSASSGLSARSS CCCCCCCCCCCCCHH	43.39	25159151
1632 (in isoform 6)	Phosphorylation	-	43.39	25850435
1635	Phosphorylation	MSASSGLSARSSAQN CCCCCCCCCCHHCCC	25.76	25159151
1635 (in isoform 6)	Phosphorylation	-	25.76	27174698
1638	Phosphorylation	SSGLSARSSAQNGSA CCCCCCCHHCCCCCC	29.73	19651622
1639	Phosphorylation	SGLSARSSAQNGSAL CCCCCCHHCCCCCCC	28.46	27251275
1641	Phosphorylation	LSARSSAQNGSALKR CCCCHHCCCCCCCCE	57.68	19651622
1643	Phosphorylation	ARSSAQNGSALKREF CCHHCCCCCCCCEEC	11.38	32142685
1644	Phosphorylation	RSSAQNGSALKREFS CHHCCCCCCCCEECC	37.67	27251275
1651	Phosphorylation	SALKREFSGGSYSAK CCCCEECCCCCCCCC	37.18	20164059
1654	Phosphorylation	KREFSGGSYSAKRQP CEECCCCCCCCCCCC	21.31	23401153
1655	Phosphorylation	REFSGGSYSAKRQPM EECCCCCCCCCCCCC	18.87	23898821
1656	Phosphorylation	EFSGGSYSAKRQPMP ECCCCCCCCCCCCCC	29.07	29255136
1658	Acetylation	SGGSYSAKRQPMPSP CCCCCCCCCCCCCCC	45.70	25953088
1664	Phosphorylation	AKRQPMPSPSEGSLS CCCCCCCCCCCCCCC	34.50	23663014
1666	Phosphorylation	RQPMPSPSEGSLSSG CCCCCCCCCCCCCCC	59.95	23663014
1669	Phosphorylation	MPSPSEGSLSSGGMD CCCCCCCCCCCCCCC	22.49	28348404
1671	Phosphorylation	SPSEGSLSSGGMDQG CCCCCCCCCCCCCCC	28.74	23663014
1672	Phosphorylation	PSEGSLSSGGMDQGS CCCCCCCCCCCCCCC	44.66	23663014
1679	Phosphorylation	SGGMDQGSDAPARDF CCCCCCCCCCCCCCC	25.60	20363803
1683	Phosphorylation	DQGSDAPARDFDGED CCCCCCCCCCCCCCC	25.95	33259812
1691	Phosphorylation	RDFDGEDSDSPRHST CCCCCCCCCCCCCCC	35.37	33259812
1693	Phosphorylation	FDGEDSDSPRHSTAS CCCCCCCCCCCCCCC	27.99	20873877
1697	Phosphorylation	DSDSPRHSTASNSSN CCCCCCCCCCCCCCC	27.27	27732954
1698	Phosphorylation	SDSPRHSTASNSSNL CCCCCCCCCCCCCCC	28.16	27732954
1700	Phosphorylation	SPRHSTASNSSNLSS CCCCCCCCCCCCCCC	37.02	20044836
1702	Phosphorylation	RHSTASNSSNLSSPP CCCCCCCCCCCCCCC	20.36	27732954
1703	Phosphorylation	HSTASNSSNLSSPPS CCCCCCCCCCCCCCC	46.14	20044836
1706	Phosphorylation	ASNSSNLSSPPSPAS CCCCCCCCCCCCCCC	45.08	18669648
1707	Phosphorylation	SNSSNLSSPPSPASP CCCCCCCCCCCCCCC	43.95	27732954
1708	Phosphorylation	NSSNLSSPPSPASPR CCCCCCCCCCCCCCC	29.97	18669648
1710	Phosphorylation	SNLSSPPSPASPRKT CCCCCCCCCCCCCCC	36.16	20044836
1711	Phosphorylation	NLSSPPSPASPRKTK CCCCCCCCCCCCCCC	42.40	33259812
1713	Phosphorylation	SSPPSPASPRKTKSL CCCCCCCCCCCCCCC	28.73	27732954
1719	Phosphorylation	ASPRKTKSLSLESTD CCCCCCCCCCCCCCC	28.55	23401153
1721	Phosphorylation	PRKTKSLSLESTDRG CCCCCCCCCCCCCCC	36.86	29255136
1724	Phosphorylation	TKSLSLESTDRGSWD CCCCCCCCCCCCCCC	40.68	30266825
1725	Phosphorylation	KSLSLESTDRGSWDP CCCCCCCCCCCCCCC	21.97	30266825
1729	Phosphorylation	LESTDRGSWDP---- CCCCCCCCCCC----	29.24	22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
234	S	Phosphorylation	Kinase	CDC42BPA	Q5VT25	GPS
240	T	Phosphorylation	Kinase	CDC42BPA	Q5VT25	GPS
403	T	Phosphorylation	Kinase	CDC42BPA	Q5VT25	GPS
1003	S	Phosphorylation	Kinase	CDC42BPA	Q5VT25	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRCKA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRCKA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MRCKA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1719, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1545; SER-1719 ANDSER-1721, AND MASS SPECTROMETRY.
PubMed: 18669648

"Intermolecular and intramolecular interactions regulate catalyticactivity of myotonic dystrophy kinase-related Cdc42-binding kinasealpha.";
Tan I., Seow K.T., Lim L., Leung T.;
Mol. Cell. Biol. 21:2767-2778(2001).
Cited for: ENZYME REGULATION, OLIGOMERIZATION, PHOSPHORYLATION AT SER-222;SER-234 AND THR-240, AND MUTAGENESIS OF LYS-106; SER-222; SER-234;THR-240 AND THR-403.
PubMed: 11283256