UniProt ID | WIPF1_HUMAN | |
---|---|---|
UniProt AC | O43516 | |
Protein Name | WAS/WASL-interacting protein family member 1 | |
Gene Name | WIPF1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 503 | |
Subcellular Localization | Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle . Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear | |
Protein Description | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.. | |
Protein Sequence | MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
33 | Methylation | NKTEQAGRNALLSDI CHHHHHHHHHHHHHH | 28.41 | 80702493 | |
33 | Asymmetric dimethylarginine | NKTEQAGRNALLSDI CHHHHHHHHHHHHHH | 28.41 | - | |
49 | Phosphorylation | KGKKLKKTVTNDRSA HCCCCCCCCCCCCCC | 30.86 | 26437602 | |
91 | Phosphorylation | GGGGGGGSFGGGGPP CCCCCCCCCCCCCCC | 24.80 | 27251275 | |
125 | Methylation | DNDSGGSRPPLLPPG CCCCCCCCCCCCCCC | 39.88 | 58860295 | |
125 | Dimethylation | DNDSGGSRPPLLPPG CCCCCCCCCCCCCCC | 39.88 | - | |
134 | Methylation | PLLPPGGRSTSAKPF CCCCCCCCCCCCCCC | 42.55 | 16287957 | |
134 | Dimethylation | PLLPPGGRSTSAKPF CCCCCCCCCCCCCCC | 42.55 | - | |
135 | Phosphorylation | LLPPGGRSTSAKPFS CCCCCCCCCCCCCCC | 29.95 | 29978859 | |
136 | Phosphorylation | LPPGGRSTSAKPFSP CCCCCCCCCCCCCCC | 31.20 | 29978859 | |
137 | Phosphorylation | PPGGRSTSAKPFSPP CCCCCCCCCCCCCCC | 35.23 | 29978859 | |
142 | Phosphorylation | STSAKPFSPPSGPGR CCCCCCCCCCCCCCC | 44.41 | 29978859 | |
145 | Phosphorylation | AKPFSPPSGPGRFPV CCCCCCCCCCCCCCC | 62.09 | 29978859 | |
149 | Dimethylation | SPPSGPGRFPVPSPG CCCCCCCCCCCCCCC | 35.51 | - | |
149 | Methylation | SPPSGPGRFPVPSPG CCCCCCCCCCCCCCC | 35.51 | 115391861 | |
154 | Phosphorylation | PGRFPVPSPGHRSGP CCCCCCCCCCCCCCC | 43.69 | 29978859 | |
203 | Phosphorylation | SSPHNRGSPPVPGGP CCCCCCCCCCCCCCC | 23.85 | 23401153 | |
211 | Dimethylation | PPVPGGPRQPSPGPT CCCCCCCCCCCCCCC | 65.40 | - | |
211 | Methylation | PPVPGGPRQPSPGPT CCCCCCCCCCCCCCC | 65.40 | 80702477 | |
214 | Phosphorylation | PGGPRQPSPGPTPPP CCCCCCCCCCCCCCC | 33.86 | 23401153 | |
218 | Phosphorylation | RQPSPGPTPPPFPGN CCCCCCCCCCCCCCC | 55.10 | 28450419 | |
226 | Methylation | PPPFPGNRGTALGGG CCCCCCCCCCCCCCC | 50.16 | 52723719 | |
228 | Phosphorylation | PFPGNRGTALGGGSI CCCCCCCCCCCCCCC | 18.57 | 23403867 | |
234 | Phosphorylation | GTALGGGSIRQSPLS CCCCCCCCCCCCCCC | 20.20 | 23401153 | |
236 | Methylation | ALGGGSIRQSPLSSS CCCCCCCCCCCCCCC | 32.40 | 80702485 | |
238 | Phosphorylation | GGGSIRQSPLSSSSP CCCCCCCCCCCCCCC | 20.26 | 26055452 | |
241 | Phosphorylation | SIRQSPLSSSSPFSN CCCCCCCCCCCCCCC | 31.40 | 21712546 | |
242 | Phosphorylation | IRQSPLSSSSPFSNR CCCCCCCCCCCCCCC | 42.38 | 26425664 | |
243 | Phosphorylation | RQSPLSSSSPFSNRP CCCCCCCCCCCCCCC | 38.36 | 21712546 | |
244 | Phosphorylation | QSPLSSSSPFSNRPP CCCCCCCCCCCCCCC | 31.73 | 21712546 | |
247 | Phosphorylation | LSSSSPFSNRPPLPP CCCCCCCCCCCCCCC | 35.00 | 21712546 | |
249 | Methylation | SSSPFSNRPPLPPTP CCCCCCCCCCCCCCC | 32.77 | 80702501 | |
255 | Phosphorylation | NRPPLPPTPSRALDD CCCCCCCCCCCCCCC | 31.77 | 26055452 | |
257 | Phosphorylation | PPLPPTPSRALDDKP CCCCCCCCCCCCCCC | 32.44 | 21712546 | |
258 | Methylation | PLPPTPSRALDDKPP CCCCCCCCCCCCCCC | 40.13 | 115383587 | |
276 | Phosphorylation | PPVGNRPSIHREAVP CCCCCCCCCCCCCCC | 27.99 | 23401153 | |
296 | Phosphorylation | NNKPPVPSTPRPSAS CCCCCCCCCCCCCCC | 51.80 | 22210691 | |
301 | Phosphorylation | VPSTPRPSASSQAPP CCCCCCCCCCCCCCC | 41.90 | 22210691 | |
331 | Phosphorylation | SSSGNDETPRLPQRN CCCCCCCCCCCCCCC | 19.30 | 26074081 | |
340 | Phosphorylation | RLPQRNLSLSSSTPP CCCCCCCCCCCCCCC | 29.74 | 28674151 | |
342 | Phosphorylation | PQRNLSLSSSTPPLP CCCCCCCCCCCCCCC | 20.90 | 22115753 | |
343 | Phosphorylation | QRNLSLSSSTPPLPS CCCCCCCCCCCCCCC | 43.45 | 29255136 | |
344 | Phosphorylation | RNLSLSSSTPPLPSP CCCCCCCCCCCCCCC | 41.37 | 29255136 | |
345 | Phosphorylation | NLSLSSSTPPLPSPG CCCCCCCCCCCCCCC | 30.76 | 23401153 | |
350 | Phosphorylation | SSTPPLPSPGRSGPL CCCCCCCCCCCCCCC | 47.90 | 29255136 | |
354 | Phosphorylation | PLPSPGRSGPLPPPP CCCCCCCCCCCCCCC | 51.15 | 26074081 | |
362 | Phosphorylation | GPLPPPPSERPPPPV CCCCCCCCCCCCCCC | 52.60 | 26074081 | |
376 | Phosphorylation | VRDPPGRSGPLPPPP CCCCCCCCCCCCCCC | 51.15 | 28555341 | |
386 | O-linked_Glycosylation | LPPPPPVSRNGSTSR CCCCCCCCCCCCCCC | 26.29 | 29485866 | |
386 | Phosphorylation | LPPPPPVSRNGSTSR CCCCCCCCCCCCCCC | 26.29 | 29978859 | |
390 | Phosphorylation | PPVSRNGSTSRALPA CCCCCCCCCCCCCCC | 27.10 | 29978859 | |
391 | Phosphorylation | PVSRNGSTSRALPAT CCCCCCCCCCCCCCC | 24.51 | 29978859 | |
392 | Phosphorylation | VSRNGSTSRALPATP CCCCCCCCCCCCCCC | 19.77 | 29978859 | |
398 | Phosphorylation | TSRALPATPQLPSRS CCCCCCCCCCCCCCC | 15.04 | 23401153 | |
403 | Phosphorylation | PATPQLPSRSGVDSP CCCCCCCCCCCCCCC | 47.90 | 22199227 | |
404 | Methylation | ATPQLPSRSGVDSPR CCCCCCCCCCCCCCC | 35.17 | 115383595 | |
405 | Phosphorylation | TPQLPSRSGVDSPRS CCCCCCCCCCCCCCC | 47.72 | 22199227 | |
409 | Phosphorylation | PSRSGVDSPRSGPRP CCCCCCCCCCCCCCC | 21.58 | 22199227 | |
412 | Phosphorylation | SGVDSPRSGPRPPLP CCCCCCCCCCCCCCC | 57.44 | 22210691 | |
415 | Methylation | DSPRSGPRPPLPPDR CCCCCCCCCCCCCCC | 49.33 | 115383603 | |
422 | Methylation | RPPLPPDRPSAGAPP CCCCCCCCCCCCCCC | 32.61 | 115383611 | |
424 | Phosphorylation | PLPPDRPSAGAPPPP CCCCCCCCCCCCCCC | 39.98 | 27080861 | |
434 | Phosphorylation | APPPPPPSTSIRNGF CCCCCCCCCCCCCCC | 40.33 | 29052541 | |
435 | Phosphorylation | PPPPPPSTSIRNGFQ CCCCCCCCCCCCCCC | 33.67 | 29052541 | |
436 | Phosphorylation | PPPPPSTSIRNGFQD CCCCCCCCCCCCCCC | 24.72 | 29052541 | |
444 | Phosphorylation | IRNGFQDSPCEDEWE CCCCCCCCCCCCHHH | 22.22 | 23401153 | |
452 | Phosphorylation | PCEDEWESRFYFHPI CCCCHHHHCCEEEEH | 28.85 | 29449344 | |
455 | Phosphorylation | DEWESRFYFHPISDL CHHHHCCEEEEHHHC | 10.40 | 28674419 | |
468 | Phosphorylation | DLPPPEPYVQTTKSY HCCCCCCCCCCCCCC | 11.97 | 28555341 | |
488 | Phosphorylation | RNESRSGSNRRERGA CCCCCCCCCCCCCCC | 28.54 | 12504004 | |
493 | Methylation | SGSNRRERGAPPLPP CCCCCCCCCCCCCCC | 44.77 | 115383619 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WIPF1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WIPF1_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
NCK1_HUMAN | NCK1 | physical | 9694849 | |
WASP_HUMAN | WAS | physical | 9694849 | |
WASL_HUMAN | WASL | physical | 11331876 | |
ACTG_HUMAN | ACTG1 | physical | 11331876 | |
WASL_HUMAN | WASL | physical | 25416956 | |
HOME3_HUMAN | HOMER3 | physical | 25416956 | |
SC24C_HUMAN | SEC24C | physical | 25416956 | |
ABI2_HUMAN | ABI2 | physical | 25416956 | |
FASTK_HUMAN | FASTK | physical | 25416956 | |
WWP2_HUMAN | WWP2 | physical | 25416956 | |
HOME3_HUMAN | HOMER3 | physical | 21516116 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
614493 | Wiskott-Aldrich syndrome 2 (WAS2) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340 AND SER-350, ANDMASS SPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-345 AND SER-350, ANDMASS SPECTROMETRY. | |
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340, AND MASSSPECTROMETRY. | |
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350, AND MASSSPECTROMETRY. |