| UniProt ID | WWP2_HUMAN | |
|---|---|---|
| UniProt AC | O00308 | |
| Protein Name | NEDD4-like E3 ubiquitin-protein ligase WWP2 | |
| Gene Name | WWP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 870 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.. | |
| Protein Sequence | MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASASSSRAG -----CCCCCCCCCC | 27.64 | 20068231 | |
| 5 | Phosphorylation | ---MASASSSRAGVA ---CCCCCCCCCCCC | 26.76 | 23532336 | |
| 6 | Phosphorylation | --MASASSSRAGVAL --CCCCCCCCCCCCC | 24.45 | 23532336 | |
| 7 | Phosphorylation | -MASASSSRAGVALP -CCCCCCCCCCCCCC | 24.53 | 20068231 | |
| 17 | Ubiquitination | GVALPFEKSQLTLKV CCCCCCCHHCEEEEE | 43.83 | - | |
| 18 | Phosphorylation | VALPFEKSQLTLKVV CCCCCCHHCEEEEEE | 24.19 | - | |
| 21 | Phosphorylation | PFEKSQLTLKVVSAK CCCHHCEEEEEEECC | 19.52 | - | |
| 40 | Phosphorylation | NRQPRINSYVEVAVD CCCCCCCCEEEEEEC | 28.34 | 28857561 | |
| 41 | Phosphorylation | RQPRINSYVEVAVDG CCCCCCCEEEEEECC | 8.99 | 30622161 | |
| 87 | Phosphorylation | HLDLKVWSCHTLRNE CCCCEEEEHHHHCHH | 10.06 | - | |
| 90 | Phosphorylation | LKVWSCHTLRNELLG CEEEEHHHHCHHHHC | 31.57 | - | |
| 169 | Phosphorylation | QLPSRDSSGTAVAPE CCCCCCCCCCCCCCC | 44.44 | 21815630 | |
| 171 | Phosphorylation | PSRDSSGTAVAPENR CCCCCCCCCCCCCCC | 21.65 | 22210691 | |
| 186 | S-nitrosylation | HQPPSTNCFGGRSRT CCCCCCCCCCCCCCC | 3.21 | 24105792 | |
| 193 | Ubiquitination | CFGGRSRTHRHSGAS CCCCCCCCCCCCCCC | 25.22 | 21890473 | |
| 193 | Phosphorylation | CFGGRSRTHRHSGAS CCCCCCCCCCCCCCC | 25.22 | - | |
| 197 | Phosphorylation | RSRTHRHSGASARTT CCCCCCCCCCCCCCC | 35.69 | - | |
| 203 | Phosphorylation | HSGASARTTPATGEQ CCCCCCCCCCCCCCC | 36.53 | 23403867 | |
| 204 | Phosphorylation | SGASARTTPATGEQS CCCCCCCCCCCCCCC | 12.84 | 23403867 | |
| 207 | Phosphorylation | SARTTPATGEQSPGA CCCCCCCCCCCCCCC | 42.32 | 23927012 | |
| 211 | Phosphorylation | TPATGEQSPGARSRH CCCCCCCCCCCCCCC | 22.46 | 29255136 | |
| 216 | Phosphorylation | EQSPGARSRHRQPVK CCCCCCCCCCCCCCC | 31.72 | 28111955 | |
| 324 | Ubiquitination | YYVDHNTKTTTWERP EEEECCCCEEEEECC | 49.55 | - | |
| 338 | Ubiquitination | PLPPGWEKRTDPRGR CCCCCCCCCCCCCCC | 54.83 | - | |
| 369 | Phosphorylation | TAEYVRNYEQWQSQR CHHHHHCHHHHHHHH | 10.03 | 25884760 | |
| 392 | Phosphorylation | HFSQRFLYQSSSAST HHHHHHHHCCCCCCC | 12.02 | - | |
| 413 | Ubiquitination | PLPPGWEKRQDNGRV CCCCCCEEECCCCCE | 49.18 | - | |
| 454 | Phosphorylation | PPGWEMKYTSEGVRY CCCEEEEEECCCEEE | 17.75 | 20068231 | |
| 455 | Phosphorylation | PGWEMKYTSEGVRYF CCEEEEEECCCEEEE | 18.13 | 20068231 | |
| 456 | Phosphorylation | GWEMKYTSEGVRYFV CEEEEEECCCEEEEE | 29.30 | 20068231 | |
| 461 | Phosphorylation | YTSEGVRYFVDHNTR EECCCEEEEEECCCC | 12.92 | 20068231 | |
| 467 | Phosphorylation | RYFVDHNTRTTTFKD EEEEECCCCEEEECC | 26.44 | 20068231 | |
| 469 | Phosphorylation | FVDHNTRTTTFKDPR EEECCCCEEEECCCC | 28.31 | 26657352 | |
| 471 | Phosphorylation | DHNTRTTTFKDPRPG ECCCCEEEECCCCCC | 28.24 | 26657352 | |
| 473 | Ubiquitination | NTRTTTFKDPRPGFE CCCEEEECCCCCCCC | 65.81 | - | |
| 473 | Sumoylation | NTRTTTFKDPRPGFE CCCEEEECCCCCCCC | 65.81 | - | |
| 484 | Ubiquitination | PGFESGTKQGSPGAY CCCCCCCCCCCCCCC | 57.07 | - | |
| 487 | Phosphorylation | ESGTKQGSPGAYDRS CCCCCCCCCCCCCCC | 20.05 | 23312004 | |
| 491 | Phosphorylation | KQGSPGAYDRSFRWK CCCCCCCCCCCCCEE | 20.15 | 29759185 | |
| 498 | Ubiquitination | YDRSFRWKYHQFRFL CCCCCCEEEEEEEHH | 28.71 | PubMed | |
| 518 | Phosphorylation | LPSHVKISVSRQTLF CCCCEEEEECCCHHH | 14.34 | 24719451 | |
| 528 | Phosphorylation | RQTLFEDSFQQIMNM CCHHHHHHHHHHHCC | 20.11 | 22817900 | |
| 545 | Phosphorylation | YDLRRRLYIIMRGEE HHHHHEEEEEEECCC | 6.13 | 20049867 | |
| 556 | Phosphorylation | RGEEGLDYGGIAREW ECCCCCCCCHHHHHH | 23.46 | - | |
| 587 | Phosphorylation | EYAGKNNYCLQINPA EECCCCCEEEEECCH | 12.16 | - | |
| 631 | Phosphorylation | TGFTLPFYKRMLNKR CCCCHHHHHHHHHCC | 8.85 | - | |
| 632 | Ubiquitination | GFTLPFYKRMLNKRP CCCHHHHHHHHHCCC | 31.54 | 21890473 | |
| 632 | Ubiquitination | GFTLPFYKRMLNKRP CCCHHHHHHHHHCCC | 31.54 | 21890473 | |
| 688 | Ubiquitination | KVTTHELKEGGESIR EEEEEHHHCCCEEEE | 51.86 | - | |
| 758 | Phosphorylation | GMQEIDMSDWQKSTI CCEECCCCHHHHHHH | 31.76 | 23532336 | |
| 766 | Phosphorylation | DWQKSTIYRHYTKNS HHHHHHHHHHHCCCC | 7.45 | 23532336 | |
| 773 | Phosphorylation | YRHYTKNSKQIQWFW HHHHCCCCHHHHHHH | 27.74 | 30576142 | |
| 820 | Ubiquitination | IGSNGPQKFCIDKVG HCCCCCCCEEEECCC | 45.39 | - | |
| 825 | Ubiquitination | PQKFCIDKVGKETWL CCCEEEECCCCCCCC | 32.73 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WWP2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WWP2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASSSPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASSSPECTROMETRY. | |
| "A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND MASSSPECTROMETRY. | |
