BAG4_HUMAN - dbPTM
BAG4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BAG4_HUMAN
UniProt AC O95429
Protein Name BAG family molecular chaperone regulator 4
Gene Name BAG4
Organism Homo sapiens (Human).
Sequence Length 457
Subcellular Localization Cytoplasm.
Protein Description Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria..
Protein Sequence MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Methylation---MSALRRSGYGPS
---CCCCHHCCCCCC		30.36-
6Methylation--MSALRRSGYGPSD
--CCCCHHCCCCCCC		34.97-
7Phosphorylation-MSALRRSGYGPSDG
-CCCCHHCCCCCCCC		29.9025159151
9PhosphorylationSALRRSGYGPSDGPS
CCCHHCCCCCCCCCC		27.4021815630
12PhosphorylationRRSGYGPSDGPSYGR
HHCCCCCCCCCCCCC		51.3323186163
17PhosphorylationGPSDGPSYGRYYGPG
CCCCCCCCCCCCCCC		14.5723186163
19MethylationSDGPSYGRYYGPGGG
CCCCCCCCCCCCCCC		17.17-
40MethylationPPPLYPLRPEPPQPP
CCCCCCCCCCCCCCC		29.0924129315
49PhosphorylationEPPQPPISWRVRGGG
CCCCCCCCEEEECCC		18.0124719451
51MethylationPQPPISWRVRGGGPA
CCCCCCEEEECCCCC		11.06-
53MethylationPPISWRVRGGGPAET
CCCCEEEECCCCCCC		29.4824129315
72PhosphorylationEGGGGDGYYPSGGAW
CCCCCCCCCCCCCCC		19.5522817900
73PhosphorylationGGGGDGYYPSGGAWP
CCCCCCCCCCCCCCC		9.10-
102PhosphorylationYPSYNSNYWNSTARS
CCCCCCCCCCCCCCC		13.0420090780
108MethylationNYWNSTARSRAPYPS
CCCCCCCCCCCCCCC		27.1124129315
108DimethylationNYWNSTARSRAPYPS
CCCCCCCCCCCCCCC		27.11-
110DimethylationWNSTARSRAPYPSTY
CCCCCCCCCCCCCCC		33.75-
110MethylationWNSTARSRAPYPSTY
CCCCCCCCCCCCCCC		33.75-
143PhosphorylationYGPTYPPGPGANTAS
CCCCCCCCCCCCCCC		28.8632645325
175PhosphorylationEVPSTYRSSGNSPTP
CCCCCCCCCCCCCCC		31.9830266825
176PhosphorylationVPSTYRSSGNSPTPV
CCCCCCCCCCCCCCC		32.7530266825
179PhosphorylationTYRSSGNSPTPVSRW
CCCCCCCCCCCCCCC		33.4129255136
181PhosphorylationRSSGNSPTPVSRWIY
CCCCCCCCCCCCCEE		35.8230266825
184PhosphorylationGNSPTPVSRWIYPQQ
CCCCCCCCCCEECCC		24.0923927012
185MethylationNSPTPVSRWIYPQQD
CCCCCCCCCEECCCC		24.8524129315
201MethylationQTEAPPLRGQVPGYP
CCCCCCCCCCCCCCC		38.99-
207PhosphorylationLRGQVPGYPPSQNPG
CCCCCCCCCCCCCCC		13.10-
210PhosphorylationQVPGYPPSQNPGMTL
CCCCCCCCCCCCCCC		37.78-
216PhosphorylationPSQNPGMTLPHYPYG
CCCCCCCCCCCCCCC		42.95-
228PhosphorylationPYGDGNRSVPQSGPT
CCCCCCCCCCCCCCC		41.9927251275
232PhosphorylationGNRSVPQSGPTVRPQ
CCCCCCCCCCCCCCC		40.4427251275
235PhosphorylationSVPQSGPTVRPQEDA
CCCCCCCCCCCCCCC		32.4527251275
237MethylationPQSGPTVRPQEDAWA
CCCCCCCCCCCCCCC		29.66-
245PhosphorylationPQEDAWASPGAYGMG
CCCCCCCCCCCCCCC		17.1128450419
249PhosphorylationAWASPGAYGMGGRYP
CCCCCCCCCCCCCCC		17.3528450419
263PhosphorylationPWPSSAPSAPPGNLY
CCCCCCCCCCCCCEE		53.8030177828
270PhosphorylationSAPPGNLYMTESTSP
CCCCCCEEECCCCCC		13.1427251275
272PhosphorylationPPGNLYMTESTSPWP
CCCCEEECCCCCCCC		17.1520873877
274PhosphorylationGNLYMTESTSPWPSS
CCEEECCCCCCCCCC		25.6425137130
275PhosphorylationNLYMTESTSPWPSSG
CEEECCCCCCCCCCC		32.3530206219
276PhosphorylationLYMTESTSPWPSSGS
EEECCCCCCCCCCCC		33.9620873877
280PhosphorylationESTSPWPSSGSPQSP
CCCCCCCCCCCCCCC		43.3820873877
281PhosphorylationSTSPWPSSGSPQSPP
CCCCCCCCCCCCCCC		38.9320873877
283PhosphorylationSPWPSSGSPQSPPSP
CCCCCCCCCCCCCCC		23.0120873877
286PhosphorylationPSSGSPQSPPSPPVQ
CCCCCCCCCCCCCCC		42.0120873877
289PhosphorylationGSPQSPPSPPVQQPK
CCCCCCCCCCCCCCC		45.2630206219
298PhosphorylationPVQQPKDSSYPYSQS
CCCCCCCCCCCCCCC		37.5927134283
299PhosphorylationVQQPKDSSYPYSQSD
CCCCCCCCCCCCCCC		40.0227134283
300PhosphorylationQQPKDSSYPYSQSDQ
CCCCCCCCCCCCCCC		15.3321945579
302PhosphorylationPKDSSYPYSQSDQSM
CCCCCCCCCCCCCCC		15.8821945579
303PhosphorylationKDSSYPYSQSDQSMN
CCCCCCCCCCCCCCC		20.7821945579
305PhosphorylationSSYPYSQSDQSMNRH
CCCCCCCCCCCCCCC		31.5121945579
308PhosphorylationPYSQSDQSMNRHNFP
CCCCCCCCCCCCCCC		24.0227134283
367UbiquitinationDQSSSLPEECVPSDE
CCCCCCCHHHCCCCC		70.1329967540
375PhosphorylationECVPSDESTPPSIKK
HHCCCCCCCCHHHHH		51.72-
403UbiquitinationEVEEFVGKKTDKAYW
HHHHHHCCHHHHHHH		47.3929967540
409PhosphorylationGKKTDKAYWLLEEML
CCHHHHHHHHHHHHH		11.4328509920
417PhosphorylationWLLEEMLTKELLELD
HHHHHHHHHHHHHHC		22.5925219547
444AcetylationARKEAVCKIQAILEK
HHHHHHHHHHHHHHH		31.1125953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BAG4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BAG4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BAG4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABEC1_HUMANAPOBEC1physical
14559896
HS90A_HUMANHSP90AA1physical
14559896
HSP74_HUMANHSPA4physical
14559896
HSP7C_HUMANHSPA8physical
11909948
TNR1A_HUMANTNFRSF1Aphysical
11909948
HSP72_HUMANHSPA2physical
25036637
CHIP_HUMANSTUB1physical
25036637
MLF2_HUMANMLF2physical
25036637
DCP1A_HUMANDCP1Aphysical
25036637
DNJB6_HUMANDNAJB6physical
25036637
DNJB1_HUMANDNAJB1physical
25036637
EDC3_HUMANEDC3physical
25036637
HS71L_HUMANHSPA1Lphysical
25036637
DNJC9_HUMANDNAJC9physical
25036637
DJB12_HUMANDNAJB12physical
25036637
DDX6_HUMANDDX6physical
25036637
C1QR1_HUMANCD93physical
25036637
DNJC7_HUMANDNAJC7physical
25036637
BEX1_HUMANBEX1physical
25640309
IL24_HUMANIL24physical
25640309
LYPD3_HUMANLYPD3physical
25640309
BCAS3_HUMANBCAS3physical
25640309
ARY2_HUMANNAT2physical
25640309
ATAD2_HUMANATAD2physical
25640309
BAP1_HUMANBAP1physical
25640309
KLK5_HUMANKLK5physical
25640309
BRE1A_HUMANRNF20physical
25640309
SG3A1_HUMANSCGB3A1physical
25640309
THRSP_HUMANTHRSPphysical
25640309
CASZ1_HUMANCASZ1physical
25640309
CCL5_HUMANCCL5physical
25640309
DIRA3_HUMANDIRAS3physical
25640309
ESIP1_HUMANEPSTI1physical
25640309
FA84B_HUMANFAM84Bphysical
25640309
GLCE_HUMANGLCEphysical
25640309
I13R2_HUMANIL13RA2physical
25640309
KLK9_HUMANKLK9physical
25640309
PDLI2_HUMANPDLIM2physical
25640309
ERRFI_HUMANERRFI1physical
25640309
KLK7_HUMANKLK7physical
25640309
MTA3_HUMANMTA3physical
25640309
PRD14_HUMANPRDM14physical
25640309
RSLAB_HUMANRASL10Bphysical
25640309
ITIH5_HUMANITIH5physical
25640309
MRC2_HUMANMRC2physical
25640309
RHBT2_HUMANRHOBTB2physical
25640309
DCP1B_HUMANDCP1Bphysical
28514442
CC038_HUMANC3orf38physical
28514442
HSF1_HUMANHSF1physical
28514442
DJC13_HUMANDNAJC13physical
28514442
BCORL_HUMANBCORL1physical
28514442
HSF2_HUMANHSF2physical
28514442
ZN318_HUMANZNF318physical
28514442
DCP1A_HUMANDCP1Aphysical
28514442
NUCG_HUMANENDOGphysical
28514442
WNK1_HUMANWNK1physical
28514442
ZN703_HUMANZNF703physical
28514442
BRCA2_HUMANBRCA2physical
28514442
QRIC1_HUMANQRICH1physical
28514442
EDC4_HUMANEDC4physical
28514442
YAP1_HUMANYAP1physical
28514442
SF3A3_HUMANSF3A3physical
28514442
DNJB5_HUMANDNAJB5physical
28514442
NMT1_HUMANNMT1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BAG4_HUMAN

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Related Literatures of Post-Translational Modification

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