RHBT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHBT2_HUMAN
• UniProt AC: Q9BYZ6
• Protein Name: Rho-related BTB domain-containing protein 2
• Gene Name: RHOBTB2
• Organism: Homo sapiens (Human).
• Sequence Length: 727
• Protein Sequence: MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQLLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVGCQLDLRYADLEAVNRARRPLARPIKPNEILPPEKGREVAKELGIPYYETSVVAQFGIKDVFDNAIRAALISRRHLQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEECPAHLLEDPLCADVILVLQERVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQHHHHHHHHHGRDFLLRAASFDVCESVDEAGGSGPAGLRASTSDGILRGNGTGYLPGRGRVLSSWSRAFVSIQEEMAEDPLTYKSRLMVVVKMDSSIQPGPFRAVLKYLYTGELDENERDLMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRRTNRVKECLAKGTFSDVTFILDDGTISAHKPLLISSCDWMAAMFGGPFVESSTREVVFPYTSKSCMRAVLEYLYTGMFTSSPDLDDMKLIILANRLCLPHLVALTEQYTVTGLMEATQMMVDIDGDVLVFLELAQFHCAYQLADWCLHHICTNYNNVCRKFPRDMKAMSPENQEYFEKHRWPPVWYLKEEDHYQRARKEREKEDYLHLKRQPKRRWLFWNSPSSPSSSAASSSSPSSSSAVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14 (in isoform 2)	Phosphorylation	-	22.81	22210691
15 (in isoform 2)	Phosphorylation	-	1.74	22210691
16 (in isoform 2)	Phosphorylation	-	28.53	22210691
18 (in isoform 2)	Phosphorylation	-	3.12	22210691
20 (in isoform 2)	Phosphorylation	-	3.88	22210691
25 (in isoform 2)	Phosphorylation	-	11.51	22210691
36 (in isoform 2)	Phosphorylation	-	2.72	22210691
77	Phosphorylation	RDVVDDVSVSLRLWD CCCCCCCEEEEEEHH	17.00	24719451
79	Phosphorylation	VVDDVSVSLRLWDTF CCCCCEEEEEEHHHC	10.56	24719451
97	Phosphorylation	HKDRRFAYGRSDVVV CCCCCCCCCCCCEEE	15.45	21712546
120	Phosphorylation	NSLHHVKTMWYPEIK CCCHHHHHCCCHHHH	16.31	24719451
186	Phosphorylation	KELGIPYYETSVVAQ HHHCCCCEECCHHHH	13.84	28258704
189	Phosphorylation	GIPYYETSVVAQFGI CCCCEECCHHHHHCH	11.58	28258704
344	Phosphorylation	DFLLRAASFDVCESV HHHHHHHCCEECCCC	22.46	28348404
376	Phosphorylation	GILRGNGTGYLPGRG CCCCCCCCCCCCCCC	27.01	-
388	Phosphorylation	GRGRVLSSWSRAFVS CCCCCCCHHHHEEHH	25.55	-
390	Phosphorylation	GRVLSSWSRAFVSIQ CCCCCHHHHEEHHHH	18.71	-
432	Phosphorylation	PFRAVLKYLYTGELD CHHHHHHHHHHCCCC	10.77	-
434	Phosphorylation	RAVLKYLYTGELDEN HHHHHHHHHCCCCCC	15.03	-
435	Phosphorylation	AVLKYLYTGELDENE HHHHHHHHCCCCCCH	22.91	-
560	Phosphorylation	AVLEYLYTGMFTSSP HHHHHHHHCCCCCCC	21.41	22210691
564	Phosphorylation	YLYTGMFTSSPDLDD HHHHCCCCCCCCHHH	21.28	24719451
654	Phosphorylation	PRDMKAMSPENQEYF CCCHHHCCHHHHHHH	33.64	28258704
660	Phosphorylation	MSPENQEYFEKHRWP CCHHHHHHHHHHCCC	13.79	28258704
687	Ubiquitination	RARKEREKEDYLHLK HHHHHHHHHCHHHHC	63.21	29967540
694	Ubiquitination	KEDYLHLKRQPKRRW HHCHHHHCCCCCCCE	37.93	29967540
709	Ubiquitination	LFWNSPSSPSSSAAS EEECCCCCCCCCCCC	31.99	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHBT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHBT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHBT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	15107402
CUL3_HUMAN	CUL3	physical	18835386
CUL5_HUMAN	CUL5	physical	18835386
RHBT2_HUMAN	RHOBTB2	physical	18835386
RHBT3_HUMAN	RHOBTB3	physical	18835386
HS90A_HUMAN	HSP90AA1	physical	24608665
LRC41_MOUSE	Lrrc41	physical	22709582
MSI2H_HUMAN	MSI2	physical	27941885
ARI1_HUMAN	ARIH1	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.