LRC41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC41_MOUSE
• UniProt AC: Q8K1C9
• Protein Name: Leucine-rich repeat-containing protein 41
• Gene Name: Lrrc41
• Organism: Mus musculus (Mouse).
• Sequence Length: 807
• Protein Description: Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPSAPPALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDKRLCDQRFSPLLHSSRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGSLPCRLCGEASRGRAPSRDEGSLLLGSRRPRRDAAERCAAALMATRRKSEVKQMPRAVPPTRVTRRSTQESLAIGGTDSKLYLPATSYEASGTKQPSAPAAASASSSTSSKRAPASSASQPKPLKRFKRAAGKKGPRTRQGSGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNPAVPENAGPPGHIVGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEHNLSLKRLSFHDMNLADCQSEVLFLLKNLTLQEITFSFCRLFEKRPVQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDSWDSTQAFADYVSTM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	LPGPILQSILPLLNI CCHHHHHHHHHHHCH	23.73	-
147	Ubiquitination	TIDVSSDKRLCDQRF CCCCCCCCCCCCCCC	49.58	27667366
155	Phosphorylation	RLCDQRFSPLLHSSR CCCCCCCCHHHCCCH	19.48	-
276	Phosphorylation	ASRGRAPSRDEGSLL HCCCCCCCCCCCCCC	51.91	26824392
281	Phosphorylation	APSRDEGSLLLGSRR CCCCCCCCCCCCCCC	17.50	29176673
286	Phosphorylation	EGSLLLGSRRPRRDA CCCCCCCCCCCCHHH	25.70	20469934
305	Phosphorylation	AAALMATRRKSEVKQ HHHHHHHHCHHHHHC	34.20	24719451
323	Phosphorylation	AVPPTRVTRRSTQES CCCCCCCCCCCCCCH	19.64	29514104
326	Phosphorylation	PTRVTRRSTQESLAI CCCCCCCCCCCHHCC	31.02	25521595
327	Phosphorylation	TRVTRRSTQESLAIG CCCCCCCCCCHHCCC	34.25	25521595
330	Phosphorylation	TRRSTQESLAIGGTD CCCCCCCHHCCCCCC	17.18	25619855
345	Phosphorylation	SKLYLPATSYEASGT CEEEEECCEEECCCC	29.87	28576409
350	Phosphorylation	PATSYEASGTKQPSA ECCEEECCCCCCCCC	34.75	22871156
352	Phosphorylation	TSYEASGTKQPSAPA CEEECCCCCCCCCCC	24.82	22871156
368	Phosphorylation	ASASSSTSSKRAPAS HHCCCCCCCCCCCCC	35.49	-
370	Ubiquitination	ASSSTSSKRAPASSA CCCCCCCCCCCCCCC	52.96	27667366
397	Phosphorylation	AGKKGPRTRQGSGAE HCCCCCCCCCCCCCC	30.40	25338131
401	Phosphorylation	GPRTRQGSGAESEDL CCCCCCCCCCCCHHH	26.88	29514104
725	Phosphorylation	ADVFSEDSSSSLCQL HHHCCCCCCCCCEEE	28.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC41_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC41_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBX1_MOUSE	Rbx1	physical	11384984
ELOB_HUMAN	TCEB2	physical	11384984
ELOC_HUMAN	TCEB1	physical	11384984
CUL5_HUMAN	CUL5	physical	11384984
RHBT1_HUMAN	RHOBTB1	physical	22709582
RHBT2_HUMAN	RHOBTB2	physical	22709582
RHBT3_HUMAN	RHOBTB3	physical	22709582
CUL5_HUMAN	CUL5	physical	15601820
RBX2_HUMAN	RNF7	physical	15601820
ELOB_HUMAN	TCEB2	physical	15601820
ELOC_HUMAN	TCEB1	physical	15601820
LRC41_MOUSE	Lrrc41	physical	22709582

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.