RHBT3_HUMAN - dbPTM
RHBT3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHBT3_HUMAN
UniProt AC O94955
Protein Name Rho-related BTB domain-containing protein 3
Gene Name RHOBTB3
Organism Homo sapiens (Human).
Sequence Length 611
Subcellular Localization Golgi apparatus .
Protein Description Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9..
Protein Sequence MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12UbiquitinationIVALGNEGDTFHQDN
EEEECCCCCCCCCCC		43.1723000965
14UbiquitinationALGNEGDTFHQDNRP
EECCCCCCCCCCCCC		33.6023000965
15UbiquitinationLGNEGDTFHQDNRPS
ECCCCCCCCCCCCCC		6.0723000965
17UbiquitinationNEGDTFHQDNRPSGL
CCCCCCCCCCCCCCH		45.5423000965
32PhosphorylationIRTYLGRSPLVSGDE
HHHHCCCCCCCCCCH		22.3125850435
36PhosphorylationLGRSPLVSGDESSLL
CCCCCCCCCCHHHHH		48.4827732954
40PhosphorylationPLVSGDESSLLLNAA
CCCCCCHHHHHHHHH		30.9027732954
41PhosphorylationLVSGDESSLLLNAAS
CCCCCHHHHHHHHHH		22.4627732954
105UbiquitinationIKYNVNDKFSFHEVK
EEEECCCCEEEEECC		37.3921890473
107PhosphorylationYNVNDKFSFHEVKDN
EECCCCEEEEECCCC		31.2829083192
112UbiquitinationKFSFHEVKDNYIPVI
CEEEEECCCCCHHHH		36.9529967540
120UbiquitinationDNYIPVIKRALNSVP
CCCHHHHHHHHCCCC		31.6723000965
125PhosphorylationVIKRALNSVPVIIAA
HHHHHHCCCCEEEEE		28.75-
135PhosphorylationVIIAAVGTRQNEELP
EEEEEECCCCCCCCC		23.60-
137UbiquitinationIAAVGTRQNEELPCT
EEEECCCCCCCCCCC		62.6221890473
138UbiquitinationAAVGTRQNEELPCTC
EEECCCCCCCCCCCC		41.2321987572
144PhosphorylationQNEELPCTCPLCTSD
CCCCCCCCCCEECCC		18.41-
149PhosphorylationPCTCPLCTSDRGSCV
CCCCCEECCCCCCCE		41.15-
150PhosphorylationCTCPLCTSDRGSCVS
CCCCEECCCCCCCEE		25.06-
152UbiquitinationCPLCTSDRGSCVSTT
CCEECCCCCCCEEHH		38.4021890473
169UbiquitinationIQLAKELGATYLELH
HHHHHHHCCCEEEEC		19.5723503661
170UbiquitinationQLAKELGATYLELHS
HHHHHHCCCEEEECC		13.0023503661
172UbiquitinationAKELGATYLELHSLD
HHHHCCCEEEECCCC		9.5421987572
183UbiquitinationHSLDDFYIGKYFGGV
CCCCCEEHHHHHHHH		3.7623503661
185UbiquitinationLDDFYIGKYFGGVLE
CCCEEHHHHHHHHHH		28.0423503661
189UbiquitinationYIGKYFGGVLEYFMI
EHHHHHHHHHHHHHH		15.7823503661
201UbiquitinationFMIQALNQKTSEKMK
HHHHHHCHHCCHHHH		51.7823000965
206UbiquitinationLNQKTSEKMKKRKMS
HCHHCCHHHHHHHCC		56.6523000965
207UbiquitinationNQKTSEKMKKRKMSN
CHHCCHHHHHHHCCC		5.6223000965
208UbiquitinationQKTSEKMKKRKMSNS
HHCCHHHHHHHCCCC		61.5723000965
209UbiquitinationKTSEKMKKRKMSNSF
HCCHHHHHHHCCCCC		54.4723000965
209AcetylationKTSEKMKKRKMSNSF
HCCHHHHHHHCCCCC		54.477711215
211AcetylationSEKMKKRKMSNSFHG
CHHHHHHHCCCCCCC		56.407711225
211UbiquitinationSEKMKKRKMSNSFHG
CHHHHHHHCCCCCCC		56.4023000965
213PhosphorylationKMKKRKMSNSFHGIR
HHHHHHCCCCCCCCC		32.1523663014
215PhosphorylationKKRKMSNSFHGIRPP
HHHHCCCCCCCCCCC		16.0023663014
241UbiquitinationKAEASHYNSDLNNLL
EEHHHCCCCCCHHHH		24.5123503661
242UbiquitinationAEASHYNSDLNNLLF
EHHHCCCCCCHHHHH		35.9923503661
244UbiquitinationASHYNSDLNNLLFCC
HHCCCCCCHHHHHHH		4.6121987572
255UbiquitinationLFCCQCVDVVFYNPN
HHHHHHEEEEEECCC		38.1923503661
257UbiquitinationCCQCVDVVFYNPNLK
HHHHEEEEEECCCHH		3.4923503661
261UbiquitinationVDVVFYNPNLKKVVE
EEEEEECCCHHHHHH		35.8323503661
273UbiquitinationVVEAHKIVLCAVSHV
HHHHHHHHHHHHHHH		4.2423000965
279UbiquitinationIVLCAVSHVFMLLFN
HHHHHHHHHHHHHHC		15.3823000965
332UbiquitinationPPLRVIVKDALFCSC
CCCEEHHCHHHHHHH		26.5921987572
344UbiquitinationCSCLSDILRFIYSGA
HHHHHHHHHHHHHCC		4.3721890473
345UbiquitinationSCLSDILRFIYSGAF
HHHHHHHHHHHHCCC		19.0922817900
347UbiquitinationLSDILRFIYSGAFQW
HHHHHHHHHHCCCCH		1.8522817900
363UbiquitinationELEEDIRKKLKDSGD
HHHHHHHHHHHHCCC		63.8923503661
364UbiquitinationLEEDIRKKLKDSGDV
HHHHHHHHHHHCCCH		51.4223503661
366UbiquitinationEDIRKKLKDSGDVSN
HHHHHHHHHCCCHHH		59.7421906983
377UbiquitinationDVSNVIEKVKCILKT
CHHHHHHHHHHHHCC		35.5521906983
379UbiquitinationSNVIEKVKCILKTPG
HHHHHHHHHHHCCCC		26.9923503661
379AcetylationSNVIEKVKCILKTPG
HHHHHHHHHHHCCCC		26.997718305
383UbiquitinationEKVKCILKTPGKINC
HHHHHHHCCCCCCEE		32.5323503661
387UbiquitinationCILKTPGKINCLRNC
HHHCCCCCCEEECCC		31.7629967540
395UbiquitinationINCLRNCKTYQARKP
CEEECCCCCEECCCC		54.5423000965
398UbiquitinationLRNCKTYQARKPLWF
ECCCCCEECCCCEEE		39.6621890473
401UbiquitinationCKTYQARKPLWFYNT
CCCEECCCCEEEEEC		47.6923000965
409UbiquitinationPLWFYNTSLKFFLNK
CEEEEECCHHHHHCC		26.3921890473
416UbiquitinationSLKFFLNKPMLADVV
CHHHHHCCCCCCCEE		33.6721890473
417UbiquitinationLKFFLNKPMLADVVF
HHHHHCCCCCCCEEE		23.1922817900
419UbiquitinationFFLNKPMLADVVFEI
HHHCCCCCCCEEEEE		5.0922817900
464PhosphorylationKSVLIPVYGVSKETF
EEEEEEECCCCHHHH		13.3726074081
467PhosphorylationLIPVYGVSKETFLSF
EEEECCCCHHHHHHH		22.0226074081
470UbiquitinationVYGVSKETFLSFLEY
ECCCCHHHHHHHHHH		33.3421890473
528PhosphorylationMPSRELASMNLDIVD
CCHHHHHHCCCCHHH		22.34-
538UbiquitinationLDIVDLLKKAKFHHS
CCHHHHHHHHCCCCH		58.9621906983
539UbiquitinationDIVDLLKKAKFHHSD
CHHHHHHHHCCCCHH		57.7022817900
541UbiquitinationVDLLKKAKFHHSDCL
HHHHHHHCCCCHHHH		54.8622817900
570UbiquitinationFSQKPEFQDLSVEER
HCCCCCCCCCCHHHH		49.4221890473
582UbiquitinationEERSFVEKHRWPSNM
HHHHHHHHHCCCCHH		32.92-
587PhosphorylationVEKHRWPSNMYLKQL
HHHHCCCCHHHHHHH		27.5427732954
590PhosphorylationHRWPSNMYLKQLAEY
HCCCCHHHHHHHHHH		18.2627732954
592UbiquitinationWPSNMYLKQLAEYRK
CCCHHHHHHHHHHHH		26.2723000965
624Ubiquitination--------------------
--------------------		21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHBT3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHBT3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHBT3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
5HT7R_HUMANHTR7physical
22245496
CUL3_HUMANCUL3physical
18835386
RHBT3_HUMANRHOBTB3physical
18835386
RHBT2_HUMANRHOBTB2physical
18835386
RAB9A_HUMANRAB9Aphysical
19490898
PLIN3_HUMANPLIN3physical
19490898
CCNE1_HUMANCCNE1physical
24145166
CUL3_HUMANCUL3physical
24145166
RBX1_HUMANRBX1physical
24145166
LRC41_MOUSELrrc41physical
22709582
UBX11_HUMANUBXN11physical
25416956
EGLN1_HUMANEGLN1physical
26215701
VHL_HUMANVHLphysical
26215701
RHBT3_HUMANRHOBTB3physical
26215701
LIMD1_HUMANLIMD1physical
26215701
HS90A_HUMANHSP90AA1physical
26215701
HIF1A_HUMANHIF1Aphysical
26215701
PCYOX_HUMANPCYOX1physical
28514442
TOPK_HUMANPBKphysical
28514442
ARF5_HUMANARF5physical
28514442
PO210_HUMANNUP210physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHBT3_HUMAN

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Related Literatures of Post-Translational Modification

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