ARF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARF5_HUMAN
• UniProt AC: P84085
• Protein Name: ADP-ribosylation factor 5
• Gene Name: ARF5
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Golgi apparatus . Cytoplasm, perinuclear region . Membrane ; Lipid-anchor .
• Protein Description: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus..
• Protein Sequence: MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQESADELQKMLQEDELRDAVLLVFANKQDMPNAMPVSELTDKLGLQHLRSRTWYVQATCATQGTGLYDGLDWLSHELSKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGLTVSALF ------CCCCHHHHH	30.01	25255805
4	Phosphorylation	----MGLTVSALFSR ----CCCCHHHHHHH	13.49	24719451
6	Phosphorylation	--MGLTVSALFSRIF --CCCCHHHHHHHHH	17.64	24719451
10	Phosphorylation	LTVSALFSRIFGKKQ CCHHHHHHHHHCCCC	25.89	24719451
22	Sulfoxidation	KKQMRILMVGLDAAG CCCEEEEEEEECCCC	1.77	28183972
35	Phosphorylation	AGKTTILYKLKLGEI CCCEEEEEEEECCCE	15.49	-
36	Acetylation	GKTTILYKLKLGEIV CCEEEEEEEECCCEE	35.38	22647643
36	Ubiquitination	GKTTILYKLKLGEIV CCEEEEEEEECCCEE	35.38	-
38	Ubiquitination	TTILYKLKLGEIVTT EEEEEEEECCCEEEE	50.74	21890473
58	Phosphorylation	FNVETVEYKNICFTV CCCEEEEEEEEEEEE	12.66	-
73	Sumoylation	WDVGGQDKIRPLWRH EECCCCCCCHHHHHH	32.50	-
81	Phosphorylation	IRPLWRHYFQNTQGL CHHHHHHHHCCCCEE	9.78	29759185
85	Phosphorylation	WRHYFQNTQGLIFVV HHHHHCCCCEEEEEE	17.15	28152594
94	Phosphorylation	GLIFVVDSNDRERVQ EEEEEECCCCHHHHH	29.08	29759185
103	Phosphorylation	DRERVQESADELQKM CHHHHHHHHHHHHHH	24.75	21712546
117	Methylation	MLQEDELRDAVLLVF HHCHHHHHHHEEHHE	28.00	-
127	Ubiquitination	VLLVFANKQDMPNAM EEHHEECCCCCCCCC	44.22	21890473
130	Sulfoxidation	VFANKQDMPNAMPVS HEECCCCCCCCCCHH	2.27	21406390
137	Phosphorylation	MPNAMPVSELTDKLG CCCCCCHHHHHHHHC	22.48	24719451
140	Phosphorylation	AMPVSELTDKLGLQH CCCHHHHHHHHCHHH	27.34	-
142	Ubiquitination	PVSELTDKLGLQHLR CHHHHHHHHCHHHHH	38.94	21890473
150	Phosphorylation	LGLQHLRSRTWYVQA HCHHHHHHCCEEEEE	40.18	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARFP2_HUMAN	ARFIP2	physical	9038142
ARFP1_HUMAN	ARFIP1	physical	9038142
RFIP3_HUMAN	RAB11FIP3	physical	16148947
ACADM_HUMAN	ACADM	physical	26344197
PCBP2_HUMAN	PCBP2	physical	26344197
SERC_HUMAN	PSAT1	physical	26344197
RAB5B_HUMAN	RAB5B	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.