ARFP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARFP2_HUMAN
• UniProt AC: P53365
• Protein Name: Arfaptin-2
• Gene Name: ARFIP2
• Organism: Homo sapiens (Human).
• Sequence Length: 341
• Protein Description: Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling..
• Protein Sequence: MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GILGKAATMEIPIHG CCCCCEEEEEEECCC	21.87	24719451
72	Phosphorylation	TGSGRHPSHSTTPSG CCCCCCCCCCCCCCC	24.76	25159151
74	Phosphorylation	SGRHPSHSTTPSGPG CCCCCCCCCCCCCCC	38.01	25159151
75	Phosphorylation	GRHPSHSTTPSGPGD CCCCCCCCCCCCCCH	36.98	25159151
76	Phosphorylation	RHPSHSTTPSGPGDE CCCCCCCCCCCCCHH	20.62	28731282
78	Phosphorylation	PSHSTTPSGPGDEVA CCCCCCCCCCCHHHH	56.37	28450419
86	Methylation	GPGDEVARGIAGEKF CCCHHHHHCCCCCCH	42.07	-
92	Ubiquitination	ARGIAGEKFDIVKKW HHCCCCCCHHHHHHH	47.63	-
103	Phosphorylation	VKKWGINTYKCTKQL HHHHCCCHHHHHHHH	23.57	29978859
104	Phosphorylation	KKWGINTYKCTKQLL HHHCCCHHHHHHHHH	10.28	29978859
107	Phosphorylation	GINTYKCTKQLLSER CCCHHHHHHHHHHHH	20.06	30108239
112	Phosphorylation	KCTKQLLSERFGRGS HHHHHHHHHHHCCCC	35.01	30108239
139	Acetylation	LLRETKRKYESVLQL HHHHHHHHHHHHHHH	55.73	27452117
190	Ubiquitination	GYNAETQKLLCKNGE CCCHHHHEEEECCCC	51.34	-
226	Ubiquitination	EDTLMTVKQYEAARL HHHCHHHHHHHHHHC	37.69	-
235	Phosphorylation	YEAARLEYDAYRTDL HHHHHCHHHHCCCCH	15.51	-
240	Phosphorylation	LEYDAYRTDLEELSL CHHHHCCCCHHHHCC	32.06	22817900
246	Phosphorylation	RTDLEELSLGPRDAG CCCHHHHCCCCCCCC	34.26	27251275
260	Phosphorylation	GTRGRLESAQATFQA CCCHHHHHHHHHHHH	30.21	28555341
264	Phosphorylation	RLESAQATFQAHRDK HHHHHHHHHHHHHHH	12.28	23312004
284	Ubiquitination	GDVAIKLKFLEENKI CCHHHHHHHHHHCCC	42.79	-
290	Ubiquitination	LKFLEENKIKVMHKQ HHHHHHCCCCCHHHH	47.38	-
334	Ubiquitination	LRPPGAEKPSWLEEQ CCCCCCCCCCHHHCC	43.76	-
336	Phosphorylation	PPGAEKPSWLEEQ-- CCCCCCCCHHHCC--	56.19	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
260	S	Phosphorylation	Kinase	AKT1	P31749	PSP
260	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARFP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARFP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARF6_HUMAN	ARF6	physical	9312003
DTBP1_HUMAN	DTNBP1	physical	16189514
ARF5_HUMAN	ARF5	physical	11478794
ARF6_HUMAN	ARF6	physical	11478794
RAC1_HUMAN	RAC1	physical	11346801
ARFP2_HUMAN	ARFIP2	physical	11346801
A4_HUMAN	APP	physical	21832049
RAC1_HUMAN	RAC1	physical	21988832
SNX1_HUMAN	SNX1	physical	21988832
STAT3_HUMAN	STAT3	physical	21988832
LY6D_HUMAN	LY6D	physical	21988832
SOCS2_HUMAN	SOCS2	physical	21988832
ARFP2_HUMAN	ARFIP2	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
CEP63_HUMAN	CEP63	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
ING5_HUMAN	ING5	physical	25416956
MAL2_HUMAN	MAL2	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
ARFP1_HUMAN	ARFIP1	physical	26186194
PDLI5_HUMAN	PDLIM5	physical	26344197
PFKAM_HUMAN	PFKM	physical	26344197
ATRAP_HUMAN	AGTRAP	physical	21516116
ARFP1_HUMAN	ARFIP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.