| UniProt ID | CEP63_HUMAN | |
|---|---|---|
| UniProt AC | Q96MT8 | |
| Protein Name | Centrosomal protein of 63 kDa | |
| Gene Name | CEP63 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 703 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Colocalize | |
| Protein Description | Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. [PubMed: 21983783] | |
| Protein Sequence | MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEALLEGI -------CHHHHHHH | 6.49 | 22814378 | |
| 11 | Ubiquitination | LLEGIQNRGHGGGFL HHHHHHHCCCCCCHH | 23.31 | 30230243 | |
| 24 | Ubiquitination | FLTSCEAELQELMKQ HHHHHHHHHHHHHHH | 28.79 | 30230243 | |
| 27 | Ubiquitination | SCEAELQELMKQIDI HHHHHHHHHHHHHCH | 64.55 | 30230243 | |
| 39 | Ubiquitination | IDIMVAHKKSEWEGR HCHHHHCCCCCCCCC | 48.54 | 30230243 | |
| 48 | Ubiquitination | SEWEGRTHALETCLK CCCCCCCHHHHHHHH | 27.27 | 30230243 | |
| 55 | Ubiquitination | HALETCLKIREQELK HHHHHHHHHHHHHHH | 41.69 | 30230243 | |
| 55 (in isoform 3) | Ubiquitination | - | 41.69 | - | |
| 62 (in isoform 3) | Ubiquitination | - | 46.84 | - | |
| 62 | Ubiquitination | KIREQELKSLRSQLD HHHHHHHHHHHHHCC | 46.84 | 29967540 | |
| 64 | Ubiquitination | REQELKSLRSQLDVT HHHHHHHHHHHCCCH | 6.12 | 30230243 | |
| 73 | Ubiquitination | SQLDVTHKEVGMLHQ HHCCCHHHHHHHHHH | 44.74 | - | |
| 73 (in isoform 3) | Ubiquitination | - | 44.74 | - | |
| 117 | Ubiquitination | LKRSYEKLQKKQMRE HHHHHHHHHHHHHHH | 6.36 | 30230243 | |
| 145 (in isoform 3) | Ubiquitination | - | 45.47 | - | |
| 145 | Ubiquitination | EIERLTAKIEEFRQK HHHHHHHHHHHHHHH | 45.47 | 30230243 | |
| 148 | Ubiquitination | RLTAKIEEFRQKSLD HHHHHHHHHHHHCCC | 49.99 | 30230243 | |
| 152 | Ubiquitination | KIEEFRQKSLDWEKQ HHHHHHHHCCCHHHH | 49.05 | 29967540 | |
| 154 | Ubiquitination | EEFRQKSLDWEKQRL HHHHHHCCCHHHHHH | 13.14 | 30230243 | |
| 158 (in isoform 3) | Ubiquitination | - | 36.14 | - | |
| 158 | Ubiquitination | QKSLDWEKQRLIYQQ HHCCCHHHHHHHHHH | 36.14 | 29967540 | |
| 163 | Phosphorylation | WEKQRLIYQQQVSSL HHHHHHHHHHHHHHH | 12.59 | 25072903 | |
| 168 | Phosphorylation | LIYQQQVSSLEAQRK HHHHHHHHHHHHHHH | 25.52 | 25072903 | |
| 169 | Phosphorylation | IYQQQVSSLEAQRKA HHHHHHHHHHHHHHH | 31.22 | 25072903 | |
| 175 | Ubiquitination | SSLEAQRKALAEQSE HHHHHHHHHHHHHHH | 35.35 | - | |
| 175 (in isoform 3) | Ubiquitination | - | 35.35 | - | |
| 212 | Ubiquitination | EIQHLSSKLERANDT HHHHHHHHHHHHCCC | 51.49 | 29967540 | |
| 231 | Phosphorylation | ELEIERLTMRVNDLV HHHHHHHHHHHHHHH | 14.78 | 29888752 | |
| 240 | Phosphorylation | RVNDLVGTSMTVLQE HHHHHHHHHHHHHHH | 14.08 | 29888752 | |
| 241 | Ubiquitination | VNDLVGTSMTVLQEQ HHHHHHHHHHHHHHH | 13.41 | 30230243 | |
| 241 | Phosphorylation | VNDLVGTSMTVLQEQ HHHHHHHHHHHHHHH | 13.41 | 29888752 | |
| 243 | Phosphorylation | DLVGTSMTVLQEQQQ HHHHHHHHHHHHHHH | 20.17 | 29888752 | |
| 251 | Ubiquitination | VLQEQQQKEEKLRES HHHHHHHHHHHHHHH | 64.60 | 29967540 | |
| 260 | Ubiquitination | EKLRESEKLLEALQE HHHHHHHHHHHHHHH | 68.59 | 29967540 | |
| 260 (in isoform 3) | Ubiquitination | - | 68.59 | - | |
| 269 | Ubiquitination | LEALQEEKRELKAAL HHHHHHHHHHHHHHH | 50.88 | 30230243 | |
| 269 (in isoform 3) | Ubiquitination | - | 50.88 | - | |
| 273 | Ubiquitination | QEEKRELKAALQSQE HHHHHHHHHHHHHHH | 27.19 | 29967540 | |
| 273 (in isoform 3) | Ubiquitination | - | 27.19 | - | |
| 278 | Phosphorylation | ELKAALQSQENLIHE HHHHHHHHHHHHHHH | 40.07 | 14702039 | |
| 278 | Ubiquitination | ELKAALQSQENLIHE HHHHHHHHHHHHHHH | 40.07 | 30230243 | |
| 290 | Ubiquitination | IHEARIQKEKLQEKV HHHHHHHHHHHHHHH | 55.21 | 29967540 | |
| 298 (in isoform 3) | Ubiquitination | - | 61.64 | - | |
| 302 | Phosphorylation | EKVKATNTQHAVEAI HHHHHCCHHHHHHHH | 19.85 | 28787133 | |
| 303 | Ubiquitination | KVKATNTQHAVEAIR HHHHCCHHHHHHHHC | 25.31 | 30230243 | |
| 310 (in isoform 3) | Phosphorylation | - | 31.13 | - | |
| 310 (in isoform 4) | Phosphorylation | - | 31.13 | - | |
| 319 | Ubiquitination | REESLAEKKYTSQGQ CHHHHHCCCCCCCCC | 45.53 | 29967540 | |
| 343 | Ubiquitination | LNFTHTSEDLLQAEV CCCCCCCHHHHHHHH | 54.56 | 29967540 | |
| 350 | Ubiquitination | EDLLQAEVTCLEGSL HHHHHHHHHHHHHCH | 5.26 | 29967540 | |
| 350 (in isoform 3) | Ubiquitination | - | 5.26 | - | |
| 368 | Ubiquitination | SATCKQLSQELMEKY HHHHHHHHHHHHHHH | 21.08 | 29967540 | |
| 389 (in isoform 3) | Ubiquitination | - | 33.11 | - | |
| 389 | Ubiquitination | EAHNNEYKAEIKKLK HHCCHHHHHHHHHHH | 33.11 | 29967540 | |
| 396 | Ubiquitination | KAEIKKLKEQILQGE HHHHHHHHHHHHCCC | 57.35 | 30230243 | |
| 405 | Phosphorylation | QILQGEQSYSSALEG HHHCCCCCHHHHHHH | 23.76 | - | |
| 414 | Ubiquitination | SSALEGMKMEISHLT HHHHHHHHHHHHHHH | 44.21 | 29967540 | |
| 424 (in isoform 3) | Ubiquitination | - | 2.76 | - | |
| 424 | Ubiquitination | ISHLTQELHQRDITI HHHHHHHHHHCCCEE | 2.76 | 30230243 | |
| 433 | Ubiquitination | QRDITIASTKGSSSD HCCCEEEECCCCCHH | 27.14 | 30230243 | |
| 433 | Phosphorylation | QRDITIASTKGSSSD HCCCEEEECCCCCHH | 27.14 | 27251275 | |
| 434 | Phosphorylation | RDITIASTKGSSSDM CCCEEEECCCCCHHH | 30.33 | 27251275 | |
| 435 | Ubiquitination | DITIASTKGSSSDME CCEEEECCCCCHHHH | 55.06 | 29967540 | |
| 437 | Phosphorylation | TIASTKGSSSDMEKR EEEECCCCCHHHHHH | 28.38 | 23401153 | |
| 438 | Phosphorylation | IASTKGSSSDMEKRL EEECCCCCHHHHHHH | 38.74 | 27251275 | |
| 439 | Phosphorylation | ASTKGSSSDMEKRLR EECCCCCHHHHHHHH | 42.55 | 27251275 | |
| 445 (in isoform 3) | Phosphorylation | - | 10.10 | 28450419 | |
| 449 (in isoform 3) | Phosphorylation | - | 4.90 | 25159151 | |
| 453 (in isoform 3) | Phosphorylation | - | 68.06 | 30108239 | |
| 456 (in isoform 3) | Phosphorylation | - | 25.01 | 30108239 | |
| 460 | Ubiquitination | EDKAVEHKEILDQLE HHHHHHHHHHHHHHH | 32.70 | 29967540 | |
| 468 | Phosphorylation | EILDQLESLKLENRH HHHHHHHHHHCCCHH | 39.12 | 23898821 | |
| 470 | Ubiquitination | LDQLESLKLENRHLS HHHHHHHHCCCHHHH | 64.13 | 30230243 | |
| 481 | Ubiquitination | RHLSEMVMKLELGLH HHHHHHHHHHHHCHH | 3.86 | 29967540 | |
| 491 (in isoform 2) | Phosphorylation | - | 53.23 | 28450419 | |
| 495 (in isoform 2) | Phosphorylation | - | 5.44 | 25159151 | |
| 499 (in isoform 2) | Phosphorylation | - | 37.12 | 30108239 | |
| 502 (in isoform 2) | Phosphorylation | - | 10.21 | 30108239 | |
| 508 | Ubiquitination | NYIEALNKLVSENQQ HHHHHHHHHHHHHHH | 51.63 | 29967540 | |
| 523 | Phosphorylation | LQKDLMNTKSQLEIS HHHHHHHHHHHHHHH | 20.36 | 20860994 | |
| 527 | Ubiquitination | LMNTKSQLEISTQMC HHHHHHHHHHHHHHH | 9.01 | 29967540 | |
| 530 | Phosphorylation | TKSQLEISTQMCKKQ HHHHHHHHHHHHHHC | 11.83 | 20860994 | |
| 576 | Phosphorylation | IKTEHYKTDLHSPRG CCCCEEECCCCCCCC | 36.31 | - | |
| 586 | Phosphorylation | HSPRGQASDSINPMS CCCCCCCCCCCCHHH | 24.81 | - | |
| 650 | Phosphorylation | NDQEEFISSCSLPVS CCHHHHHHHCCCCCC | 30.52 | - | |
| 653 | Phosphorylation | EEFISSCSLPVSPLG HHHHHHCCCCCCCCC | 37.34 | - | |
| 657 | Phosphorylation | SSCSLPVSPLGSIAT HHCCCCCCCCCHHHH | 16.68 | - | |
| 689 | Ubiquitination | DAHIEELKRESEKTV HHHHHHHHHHHHHHH | 58.35 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CEP63_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CEP63_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CEP63_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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