| UniProt ID | INT6L_HUMAN | |
|---|---|---|
| UniProt AC | Q5JSJ4 | |
| Protein Name | Integrator complex subunit 6-like | |
| Gene Name | INTS6L | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 861 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MPILLFLIDTSASMNQRTDLGTSYLDIAKGAVELFLKLRARDPASRGDRYMLVTYDEPPYCIKAGWKENHATFMSELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQGRNPFFLEPSILITITDGNKLTSTAGVQEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGVASTEPEQLGSVPTDESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQKVQSGVVINFEKTGPDPLPIGEDGLMDSSRPSNSFAAQPWHSCHKLIYVRPNSKTGVPVGHWPIPESFWPDQNLPSLPPRTSHPVVRFSCVDCEPMVIDKLPFDKYELEPSPLTQYILERKSPHTCWQVFVTSSGKYNELGYPFGYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLLTKLESERILASVGKKPPQEIGIKVKNHSGGGMSLTHNKNFRKLLKEITGETALRLTELNTKEFAGFQIGLLNKDLKPQTYRNAYDIPRRGLLDQLTRMRSNLLKTHKFIVGQDEDSLHSVPVAQMGNYQEYLKTLASPLREIDPDQPKRLHTFGNPFKQDKKGMMIDEADEFVAGPQNKVKRPGEPNSPMSSKRRRSMSLLLRKPQTPPTVTNHVGGKGPPSASWFPSYPNLIKPTLVHTDATIIHDGHEEKMENGQITPDGFLSKSAPSELINMTGDLMPPNQVDSLSDDFTSLSKDGLIQKPGSNAFVGGAKNCSLSVDDQKDPVASTLGAMPNTLQITPAMAQGINADIKHQLMKEVRKFGRKYERIFILLEEVQGPLEMKKQFVEFTIKEAARFKRRVLIQYLEKVLEKINSHHLHNNISHINSRSSC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 (in isoform 4) | Phosphorylation | - | 29507054 | ||
| 24 | Phosphorylation | RTDLGTSYLDIAKGA CCCCCCCHHHHHHHH | 18452278 | ||
| 50 | Phosphorylation | PASRGDRYMLVTYDE CCCCCCCEEEEECCC | 22817900 | ||
| 60 | Phosphorylation | VTYDEPPYCIKAGWK EECCCCCCEEEECCC | 22817900 | ||
| 150 | Phosphorylation | ELHLPLNSPLPGSEL EECCCCCCCCCCCHH | 26074081 | ||
| 159 | Ubiquitination | LPGSELTKEPFRWDQ CCCCHHCCCCCCHHH | 22817900 | ||
| 229 | Phosphorylation | SLVQKVQSGVVINFE HHHHHHHCCCEEEEE | 21406692 | ||
| 238 | Phosphorylation | VVINFEKTGPDPLPI CEEEEEECCCCCCCC | 21406692 | ||
| 253 | Phosphorylation | GEDGLMDSSRPSNSF CCCCCCCCCCCCCCC | 21406692 | ||
| 254 | Phosphorylation | EDGLMDSSRPSNSFA CCCCCCCCCCCCCCC | 21406692 | ||
| 257 | Phosphorylation | LMDSSRPSNSFAAQP CCCCCCCCCCCCCCC | 21406692 | ||
| 259 | Phosphorylation | DSSRPSNSFAAQPWH CCCCCCCCCCCCCCC | 21406692 | ||
| 267 | Phosphorylation | FAAQPWHSCHKLIYV CCCCCCCCCCEEEEE | 21406692 | ||
| 285 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 301 | Phosphorylation | WPDQNLPSLPPRTSH CCCCCCCCCCCCCCC | 24719451 | ||
| 422 | Phosphorylation | AFDSYLKTLPPYYLL HHHHHHHHCCCCHHH | 24043423 | ||
| 426 | Phosphorylation | YLKTLPPYYLLTKLE HHHHCCCCHHHHHHH | 24043423 | ||
| 427 | Phosphorylation | LKTLPPYYLLTKLES HHHCCCCHHHHHHHH | 24043423 | ||
| 430 | Phosphorylation | LPPYYLLTKLESERI CCCCHHHHHHHHHHH | 24043423 | ||
| 440 | Phosphorylation | ESERILASVGKKPPQ HHHHHHHHCCCCCCH | - | ||
| 467 | Ubiquitination | GMSLTHNKNFRKLLK CCCCCCCHHHHHHHH | 29967540 | ||
| 508 | Phosphorylation | NKDLKPQTYRNAYDI CCCCCCCCCCCHHHC | 29083192 | ||
| 509 | Phosphorylation | KDLKPQTYRNAYDIP CCCCCCCCCCHHHCC | 29083192 | ||
| 513 | Phosphorylation | PQTYRNAYDIPRRGL CCCCCCHHHCCCCHH | 22817900 | ||
| 525 | Phosphorylation | RGLLDQLTRMRSNLL CHHHHHHHHHHHHHH | - | ||
| 566 | Phosphorylation | EYLKTLASPLREIDP HHHHHHHHHHHHCCC | - | ||
| 581 | Phosphorylation | DQPKRLHTFGNPFKQ CCCCCCCCCCCCCCC | 20068231 | ||
| 596 | Ubiquitination | DKKGMMIDEADEFVA CCCCCCCCCHHHHCC | 21890473 | ||
| 600 | Ubiquitination | MMIDEADEFVAGPQN CCCCCHHHHCCCCCC | 22817900 | ||
| 617 | Phosphorylation | KRPGEPNSPMSSKRR CCCCCCCCCCCHHHH | 14702039 | ||
| 620 | Phosphorylation | GEPNSPMSSKRRRSM CCCCCCCCHHHHHCH | 21406692 | ||
| 621 | Phosphorylation | EPNSPMSSKRRRSMS CCCCCCCHHHHHCHH | 21406692 | ||
| 626 | Phosphorylation | MSSKRRRSMSLLLRK CCHHHHHCHHHHHCC | 23403867 | ||
| 628 | Phosphorylation | SKRRRSMSLLLRKPQ HHHHHCHHHHHCCCC | 23403867 | ||
| 688 | Phosphorylation | KMENGQITPDGFLSK HHCCCEECCCCCCCC | - | ||
| 794 | Ubiquitination | KEVRKFGRKYERIFI HHHHHHHHHHHHHHH | 21890473 | ||
| 798 | Ubiquitination | KFGRKYERIFILLEE HHHHHHHHHHHHHHH | 22817900 | ||
| 831 | Ubiquitination | AARFKRRVLIQYLEK HHHHHHHHHHHHHHH | 21890473 | ||
| 835 | Ubiquitination | KRRVLIQYLEKVLEK HHHHHHHHHHHHHHH | 22817900 | ||
| 835 | Phosphorylation | KRRVLIQYLEKVLEK HHHHHHHHHHHHHHH | 19664994 | ||
| 838 | Ubiquitination | VLIQYLEKVLEKINS HHHHHHHHHHHHHHH | 22817900 | ||
| 838 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 842 | Ubiquitination | YLEKVLEKINSHHLH HHHHHHHHHHHCCCC | 22817900 | ||
| 875 | Ubiquitination | --------------------- --------------------- | 21890473 | ||
| 879 | Ubiquitination | ------------------------- ------------------------- | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of INT6L_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of INT6L_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of INT6L_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of INT6L_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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