dbPTM

CCD18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CCD18_HUMAN
UniProt AC	Q5T9S5
Protein Name	Coiled-coil domain-containing protein 18
Gene Name	CCDC18
Organism	Homo sapiens (Human).
Sequence Length	1454
Subcellular Localization
Protein Description
Protein Sequence	MESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKESELTRLQAKISGHEKAEDIKFLPAPFTSPTEIMPDVQDPKFAKCFHTSFSKCTKLRRSISASDLTFKIHGDEDLSEELLQDLKKMQLEQPSTLEESHKNLTYTQPDSFKPLTYNLEADSSENNDFNTLSGMLRYINKEVRLLKKSSMQTGAGLNQGENV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESSSSDYYN -----CCCCCCCCCC	47.59	23401153
4	Phosphorylation	----MESSSSDYYNK ----CCCCCCCCCCC	36.83	23401153
5	Phosphorylation	---MESSSSDYYNKD ---CCCCCCCCCCCC	36.19	23401153
6	Phosphorylation	--MESSSSDYYNKDN --CCCCCCCCCCCCC	31.42	23401153
8	Phosphorylation	MESSSSDYYNKDNEE CCCCCCCCCCCCCHH	15.75	23401153
9	Phosphorylation	ESSSSDYYNKDNEEE CCCCCCCCCCCCHHH	22.26	23401153
17	Phosphorylation	NKDNEEESLLANVAS CCCCHHHHHHHHHHH	31.78	20860994
38	Phosphorylation	ITEWSLQSLGEELSS HCHHHHHHHHHHHHC	43.57	20068231
45	Phosphorylation	SLGEELSSVSPSENS HHHHHHHCCCCCCCC	38.96	-
47	Phosphorylation	GEELSSVSPSENSDY HHHHHCCCCCCCCCC	25.34	22468782
63	Ubiquitination	PNPSRSEKLILDVQP CCCCCCCCEEEECCC	41.91	-
71	Phosphorylation	LILDVQPSHPGLLNY EEEECCCCCCCCCCC	25.81	28152594
78	Phosphorylation	SHPGLLNYSPYENVC CCCCCCCCCCCCCCE	15.82	28152594
79	Phosphorylation	HPGLLNYSPYENVCK CCCCCCCCCCCCCEE	21.67	28152594
81	Phosphorylation	GLLNYSPYENVCKIS CCCCCCCCCCCEECC	17.75	28152594
86	Ubiquitination	SPYENVCKISGSSTD CCCCCCEECCCCCCC	35.31	-
88	Phosphorylation	YENVCKISGSSTDFQ CCCCEECCCCCCCCC	20.37	26471730
90	Phosphorylation	NVCKISGSSTDFQKK CCEECCCCCCCCCCC	24.23	20860994
91	Phosphorylation	VCKISGSSTDFQKKP CEECCCCCCCCCCCC	35.21	26471730
92	Phosphorylation	CKISGSSTDFQKKPR EECCCCCCCCCCCCC	42.40	26471730
96	Ubiquitination	GSSTDFQKKPRDKMF CCCCCCCCCCCCCCC	65.81	-
101	Ubiquitination	FQKKPRDKMFSSSAP CCCCCCCCCCCCCCC	43.03	-
104	Phosphorylation	KPRDKMFSSSAPVDQ CCCCCCCCCCCCHHH	21.64	28555341
294	Phosphorylation	LQERCGLYKSELEIL HHHHHCCCHHHHHHH	9.58	26699800
296	Phosphorylation	ERCGLYKSELEILKE HHHCCCHHHHHHHHH	33.58	26699800
334	Phosphorylation	SEVMAQLTESRQSIL HHHHHHHHHHHHHHH	21.60	17081983
339	Phosphorylation	QLTESRQSILKLESE HHHHHHHHHHHHHHH	28.86	24719451
342	Ubiquitination	ESRQSILKLESELEN HHHHHHHHHHHHHCC	48.84	-
350	Ubiquitination	LESELENKDEILRDK HHHHHCCHHHHHHHH	47.57	-
357	Ubiquitination	KDEILRDKFSLMNEN HHHHHHHHHHHHCCC	30.34	-
359	Phosphorylation	EILRDKFSLMNENRE HHHHHHHHHHCCCCH	32.23	20068231
397	Ubiquitination	VELRSLEKIISQLPL HHHHHHHHHHHCCCC	51.11	-
405	Ubiquitination	IISQLPLKRELFGFK HHHCCCCCHHHHCHH	41.72	-
412	Ubiquitination	KRELFGFKSYLSKYQ CHHHHCHHHHHHHHC	38.27	-
426	Ubiquitination	QMSSFSNKEDRCIGC CHHCCCCCCCCEECH	60.85	-
442	Phosphorylation	EANKLVISELRIKLA HHHHHHHHHHHHHHH	24.09	24719451
457	Ubiquitination	IKEAEIQKLHANLTA HHHHHHHHHHCCCCH	48.15	-
477	Phosphorylation	SLITCNDSQESSKLS HHHHCCCCCCHHHCC	23.12	20068231
482	Ubiquitination	NDSQESSKLSSLETE CCCCCHHHCCCCCCC	62.76	-
485	Phosphorylation	QESSKLSSLETEPVK CCHHHCCCCCCCCCC	40.43	20860994
508	Phosphorylation	VKDQNQHTMNKQYEK HHHCCHHHHHHHHHH	16.81	25072903
513	Phosphorylation	QHTMNKQYEKERQRL HHHHHHHHHHHHHHH	30.49	25072903
530	Ubiquitination	GIEELRTKLIQIEAE HHHHHHHHHHHHHHC	36.84	-
539	Phosphorylation	IQIEAENSDLKVNMA HHHHHCCCCCCEECC	35.51	30622161
562	Ubiquitination	IQEELLEKASNSSKL HHHHHHHHHCCCHHH	58.02	-
564	Phosphorylation	EELLEKASNSSKLES HHHHHHHCCCHHHHH	48.60	30622161
566	Phosphorylation	LLEKASNSSKLESEM HHHHHCCCHHHHHHH	26.76	30622161
567	Phosphorylation	LEKASNSSKLESEMT HHHHCCCHHHHHHHH	45.57	30622161
571	Phosphorylation	SNSSKLESEMTKKCS CCCHHHHHHHHHHHH	43.00	30622161
574	Phosphorylation	SKLESEMTKKCSQLL HHHHHHHHHHHHHHH	24.25	30622161
578	Phosphorylation	SEMTKKCSQLLTLEK HHHHHHHHHHHHHHH	32.51	30622161
582	Phosphorylation	KKCSQLLTLEKQLEE HHHHHHHHHHHHHHH	41.27	30622161
594	Phosphorylation	LEEKIVAYSSIAAKN HHHHHHHHHHHHHHC	7.64	-
637	Ubiquitination	CLAFEKAKKIHLEQH HHHHHHHHHHCHHHH	64.43	-
660	Ubiquitination	RLEAQLEKKDQQFKE HHHHHHHHHHHHHHH	70.96	-
697	Ubiquitination	DRLLTESKGEMKKEN HHHHHCCHHHHCHHH	53.29	-
719	Phosphorylation	KALQNQVSEETIKVR HHHHHHCCHHHHHHH	21.68	25159151
722	Phosphorylation	QNQVSEETIKVRQLD HHHCCHHHHHHHHHH	23.26	29978859
724	Ubiquitination	QVSEETIKVRQLDSA HCCHHHHHHHHHHHH	38.49	-
765	Phosphorylation	KKKSEEVYCLQKELK HHHHHHHHHHHHHHH	7.24	23917254
881	Phosphorylation	DQYKEELSKMEKEIM HHHHHHHHHHHHHHH	32.98	-
911	Phosphorylation	LDMILDQTKTELEKK HHHHHHHHHHHHHHH	39.33	28270605
973	Ubiquitination	ELRDVLQKAQLSLEE HHHHHHHHHCCCHHH	33.66	-
1003	Acetylation	KMEIEDKKQELLEMD HCCHHHHHHHHHHHH	62.42	28732967
1068	Phosphorylation	ECNKQIESLNDKLQN HHHHHHHHHHHHHHH	33.82	17081983
1095	Phosphorylation	LQNEQEISQLKKEIE HHCHHHHHHHHHHHH	28.80	20860994
1116	Methylation	KEMESVMKEQEQYIA HHHHHHHHHHHHHHH	54.83	23644510
1121	Phosphorylation	VMKEQEQYIATQYKE HHHHHHHHHHHHHHH	7.56	29083192
1124	Phosphorylation	EQEQYIATQYKEAID HHHHHHHHHHHHHHH	23.91	29083192
1126	Phosphorylation	EQYIATQYKEAIDLG HHHHHHHHHHHHHHH	13.36	29083192
1168	Phosphorylation	QREIERLSSELEDMK HHHHHHHHHHHHHHH	28.17	30206219
1169	Phosphorylation	REIERLSSELEDMKQ HHHHHHHHHHHHHHH	51.28	30206219
1214	Phosphorylation	QAEIKKLSAEVESLK HHHHHHHHHHHHHHH	31.12	28509920
1219	Phosphorylation	KLSAEVESLKEAYHM HHHHHHHHHHHHHHH	50.33	28509920
1241	Phosphorylation	NHAKWKISADSQKSS HHCCCCCCHHHHHHH	23.46	-
1244	Phosphorylation	KWKISADSQKSSVQQ CCCCCHHHHHHHHHH	38.94	-
1322	Phosphorylation	KFLPAPFTSPTEIMP CEECCCCCCCCCCCC	32.51	26074081
1323	Phosphorylation	FLPAPFTSPTEIMPD EECCCCCCCCCCCCC	30.15	26074081
1325	Phosphorylation	PAPFTSPTEIMPDVQ CCCCCCCCCCCCCCC	37.60	26074081
1343	Phosphorylation	FAKCFHTSFSKCTKL HHHHHCCCHHHCHHH	20.96	24719451
1353	Phosphorylation	KCTKLRRSISASDLT HCHHHHHCCCHHHCE	17.92	30266825
1355	Phosphorylation	TKLRRSISASDLTFK HHHHHCCCHHHCEEE	23.98	23401153
1357	Phosphorylation	LRRSISASDLTFKIH HHHCCCHHHCEEEEC	26.77	30266825
1360	Phosphorylation	SISASDLTFKIHGDE CCCHHHCEEEECCCC	28.07	23403867
1440	Phosphorylation	EVRLLKKSSMQTGAG HHHHHHHHCCCCCCC	29.47	20068231
1441	Phosphorylation	VRLLKKSSMQTGAGL HHHHHHHCCCCCCCC	24.64	20068231
1444	Phosphorylation	LKKSSMQTGAGLNQG HHHHCCCCCCCCCCC	21.98	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CCD18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CCD18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CCD18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CCD18_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CCD18_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-334 AND SER-1068, ANDMASS SPECTROMETRY.	17081983 [Abstract]