CCD77_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD77_HUMAN
• UniProt AC: Q9BR77
• Protein Name: Coiled-coil domain-containing protein 77
• Gene Name: CCDC77
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Protein Sequence: MNFTPTHTPVCRKRTVVSKRGVAVSGPTKRRGMADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MNFTPTHTPVC ----CCCCCCCCCCC	23.44	20873877
4 (in isoform 2)	Phosphorylation	-	23.44	25159151
6	Phosphorylation	--MNFTPTHTPVCRK --CCCCCCCCCCCCC	35.01	20873877
7 (in isoform 2)	Phosphorylation	-	29.40	25159151
8 (in isoform 2)	Phosphorylation	-	21.64	25159151
8	Phosphorylation	MNFTPTHTPVCRKRT CCCCCCCCCCCCCCE	21.64	25159151
12 (in isoform 2)	Phosphorylation	-	31.55	25159151
19	Ubiquitination	RKRTVVSKRGVAVSG CCCEEEECCCEECCC	41.37	29967540
24	Ubiquitination	VSKRGVAVSGPTKRR EECCCEECCCCCCCC	6.72	29967540
25	Phosphorylation	SKRGVAVSGPTKRRG ECCCEECCCCCCCCC	29.35	25159151
28	Phosphorylation	GVAVSGPTKRRGMAD CEECCCCCCCCCCCC	40.48	20860994
29	Ubiquitination	VAVSGPTKRRGMADS EECCCCCCCCCCCCC	43.14	29967540
32	Ubiquitination	SGPTKRRGMADSLES CCCCCCCCCCCCCCC	21.47	29967540
36	Phosphorylation	KRRGMADSLESTPLP CCCCCCCCCCCCCCC	25.21	30108239
39	Phosphorylation	GMADSLESTPLPSPE CCCCCCCCCCCCCHH	40.39	30108239
40	Phosphorylation	MADSLESTPLPSPED CCCCCCCCCCCCHHH	21.33	30108239
44	Phosphorylation	LESTPLPSPEDRLAK CCCCCCCCHHHHHHH	48.91	30108239
46	Ubiquitination	STPLPSPEDRLAKLH CCCCCCHHHHHHHHC	61.16	29967540
51	Sumoylation	SPEDRLAKLHPSKEL CHHHHHHHHCCCHHH	52.50	28112733
51	Ubiquitination	SPEDRLAKLHPSKEL CHHHHHHHHCCCHHH	52.50	29967540
52	Ubiquitination	PEDRLAKLHPSKELL HHHHHHHHCCCHHHH	6.29	29967540
56	Ubiquitination	LAKLHPSKELLEYYQ HHHHCCCHHHHHHHH	57.75	29967540
60	Ubiquitination	HPSKELLEYYQKKMA CCCHHHHHHHHHHHH	55.61	29967540
64	Ubiquitination	ELLEYYQKKMAECEA HHHHHHHHHHHHHHH	28.53	29967540
65	Ubiquitination	LLEYYQKKMAECEAE HHHHHHHHHHHHHHH	28.02	-
77	Ubiquitination	EAENEDLLKKLELYK HHHCHHHHHHHHHHH	7.71	29967540
78	Ubiquitination	AENEDLLKKLELYKE HHCHHHHHHHHHHHH	63.71	29967540
84	Ubiquitination	LKKLELYKEACEGQH HHHHHHHHHHHCCCH	52.00	29967540
92	Ubiquitination	EACEGQHKLECDLQQ HHHCCCHHHHCCHHH	37.79	29967540
109	Ubiquitination	EEIAELQKALSDMQV HHHHHHHHHHHHHCH	65.01	29967540
133	Ubiquitination	LRLYSENDRLRIREL HHHHCCCCCHHHHHH	47.11	32015554
138	Ubiquitination	ENDRLRIRELEDKKK CCCCHHHHHHHCHHH	35.69	29967540
144	Ubiquitination	IRELEDKKKIQNLLA HHHHHCHHHHHHHHH	68.39	29967540
161	Ubiquitination	GTDAGEVTYFCKEPP CCCCCCEEEEECCCC	13.43	32015554
165	Ubiquitination	GEVTYFCKEPPHKVT CCEEEEECCCCCEEE	64.46	32015554
170	Ubiquitination	FCKEPPHKVTILQKT EECCCCCEEEEEHHH	47.01	29967540
176	Ubiquitination	HKVTILQKTIQAVGE CEEEEEHHHHHHHHH	44.12	29967540
187	Phosphorylation	AVGECEQSESSAFKA HHHHHCCCCCCCCCC	19.70	28555341
189	Phosphorylation	GECEQSESSAFKADP HHHCCCCCCCCCCCC	32.01	25627689
190	Phosphorylation	ECEQSESSAFKADPK HHCCCCCCCCCCCCC	33.40	25627689
193	Ubiquitination	QSESSAFKADPKISK CCCCCCCCCCCCHHC	52.15	32015554
204	Phosphorylation	KISKRRPSRERKESS CHHCCCCCCCCHHHH	44.99	-
205	Ubiquitination	ISKRRPSRERKESSE HHCCCCCCCCHHHHH	50.88	29967540
210	Phosphorylation	PSRERKESSEHYQRD CCCCCHHHHHHHHHH	44.02	22817900
211	Phosphorylation	SRERKESSEHYQRDI CCCCHHHHHHHHHHH	29.50	27273156
220	Phosphorylation	HYQRDIQTLILQVEA HHHHHHHHHHHHHHH	18.99	-
237	Ubiquitination	AQLGEQTKLSREQIE HHHCCCCCCCHHHHH	44.13	29967540
241	Ubiquitination	EQTKLSREQIEGLIE CCCCCCHHHHHHHHH	53.16	29967540
255	Ubiquitination	EDRRIHLEEIQVQHQ HHCCHHHHHHHHHHH	38.60	21963094
269	Ubiquitination	QRNQNKIKELTKNLH HHHHHHHHHHHHHHH	48.56	29967540
273	Ubiquitination	NKIKELTKNLHHTQE HHHHHHHHHHHHHHH	70.86	29967540
283	Phosphorylation	HHTQELLYESTKDFL HHHHHHHHHHHHHHH	22.06	25159151
287	Ubiquitination	ELLYESTKDFLQLRS HHHHHHHHHHHHHHH	56.62	21963094
301	Ubiquitination	SENQNKEKSWMLEKD HCCCCCHHHHHHHHH	51.53	29967540
330	Ubiquitination	KKEDKIGKVLPVMHE CCHHCCCCHHHCCCC	44.03	-
352	Ubiquitination	YIKSLKDKLVQEKKL HHHHHHHHHHHHHHH	49.31	-
393	Ubiquitination	EIFKDRTNKMGKRLQ HHHHHCCCHHHHHHH	32.96	29967540
404	Acetylation	KRLQIMTKRYEALER HHHHHHHHHHHHHHH	35.29	27452117
408	Ubiquitination	IMTKRYEALERRRIL HHHHHHHHHHHCCCC	13.04	32015554
425	Ubiquitination	EGFKTDIKVLRQKLK CCCHHHHHHHHHHHH	37.72	29967540
434	Ubiquitination	LRQKLKDLEQMLYKA HHHHHHHHHHHHHHH	4.75	29967540
439	Phosphorylation	KDLEQMLYKATVNAR HHHHHHHHHHHHHHH	8.01	23186163
440	Ubiquitination	DLEQMLYKATVNARA HHHHHHHHHHHHHHC	33.35	32015554
442	Phosphorylation	EQMLYKATVNARANQ HHHHHHHHHHHHCCC	15.33	20860994
445	Ubiquitination	LYKATVNARANQDLA HHHHHHHHHCCCCHH	13.97	29967540
460	Phosphorylation	LLCEVRDSNRRAHKI HHEEECCCCHHHHHH	22.98	28555341
466	Ubiquitination	DSNRRAHKIQGELKN CCCHHHHHHHHHHHH	35.42	29967540
472	Ubiquitination	HKIQGELKNLKSKVF HHHHHHHHHHHHHHH	56.80	29967540
477	Sumoylation	ELKNLKSKVFGLENE HHHHHHHHHHCCHHH	39.74	-
477	Sumoylation	ELKNLKSKVFGLENE HHHHHHHHHHCCHHH	39.74	-
477	Ubiquitination	ELKNLKSKVFGLENE HHHHHHHHHHCCHHH	39.74	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD77_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD77_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD77_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CCD77_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.