C2CD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2CD3_HUMAN
• UniProt AC: Q4AC94
• Protein Name: C2 domain-containing protein 3
• Gene Name: C2CD3
• Organism: Homo sapiens (Human).
• Sequence Length: 2353
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is
• Protein Description: Component of the centrioles that acts as a positive regulator of centriole elongation. [PubMed: 24997988 Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation]
• Protein Sequence: MKQRKGQGSGGSRGRKKRGLSDISPSTSLPPLVEGQLRCFLKLTVNRVIWKIAKPPTCVLVRVRWWGETSDGTLFCPRDALQTEPKAVRTTTRYAIRCGPKQFTSYLTDMAVLVLEVITKLDGLPIGRVQINGLAQLSPTHQINGFFTIVSSTSKKLGELQVSLALEPLSETYDSYHPLPTTDMTENVLLSKQGFRENTEPSSTQFQVPSRPRDIHTIKIDGKELAANSSRSTTPRGKDHVCFAENPDTIKDSSFGLQHSLNSGQSLESVTLKGRAPRKQMSLLNSSEFQPQIRTVAKSHSDSCILSSNNLPTKDLLSALLEQGNKLRNAMVISAMKSSPETSMLLDQVHPPINEDSLRASTQIRAFSRNRFKDHIEDHLLPSTENTFWRHDTKADTRAIQLLLGSAELSQGNFWDGLGSPPDSPSPGSDVYCISELNDPQYDQSLLENLFYTAPKSDTSISDFLSEEDDIVPSKKISQSTALARSSKVLESSDHKLKKRSAGKRNRNLVEQQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQMTPGKKSYAGPPPKVTTAKKRTFFVEYHFPVGFSESGLGKTALITEVVRLASSKITDGKVKFQQRFVFPVQFGGPMIEHWWNSNLTFQIYVKKTPQKKPEVIGSVSLSLRAVIQSELLSFSDQLPVQQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHYTPLCAPTSPNKALPELNQDMTCTKNPQNLNQIHEETAKKAQNLVLPNRKSPSPVAPHPSTFVATPASHNLVNQTNGTTKESALLLHVLLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRSVIAWGTTQPVFNFSQVIPVSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDAKISRLLLDAQYPVVAVDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMALQRLKNEEGTLPPFSPRPAHFLDQPTAASVAMAEDRGNGLMEHCFEIHIEMVKGLAPLQATVWGEADCYVQYYFPVQHSQSSVLKGPEFLENGITLKPFRTATTLCVPDPIFNSEHHHSLLLPAEVPVQRLLLSAFSAQGLVPGGGVQFEIWCRYYYPNVRDQKVAKGTLPLSRICAMVTTQHREDVGIQTFNLPLTPRIENRKELRNQSSGLLDVGLRYRRSPRTAEGVLAARTVSISVQIIRACGLQAAAKALAEREPALQFSATVGVNASVTTHLSFLPQGEQRRTHPVACSFCPEFSHHVEFTCNLVTQHCSGEACFLAELLEFAEVIFAVYHENTKSASDIISIESCKEYLLGVVKVPTKELLIKRSGITGWYPIILPEDGGLPHGLELMQKIVGGLELSISFTHRGDRERVLEAAEHLGWSFENSLKDFVRMDEGEPATVTISTPRLWLPIHCVLLAGHNHIHKNTYCYLRYKFYDHEAFWTPLKKPKESVNKKQIMVTFKASKRAEVTRGPSLLWYFREERLEIQVWRAYGNDSVERPHQTDSWIGSAYVDLARLGERSARTLTVSGVYPLFGRNASNLSGAALRVHVVLSSLSSHLEPTHELDSMDCSSHSESEQLPRRNDEVQLSPPEVISCHQKSPASTQVPCSSTTAEVRLTQEGPADLDGTFAVSILVERAMHLSLKGSPLTERKVSIPSCCVSFATADESSPVYTQVVENTDSPIWNFQQQSRLSKELLLDPQQTLVFKVWHKGDEERVIGFASVDLSPLLSGFQFVCGWYNITDFSGECQGQIKVAVSPLESLIHFKEERQARRGVETSKSLIPIYSPFSFPASDTYAAFSSHMARQTLDQLAHASSKELDFSSPGRSDTTRSQASRHEEHVQNIRRFHESLHLQGEAPLPCDDKLTTSPLSSQTSILTSLRKNLSELDQIQRYFRQKLTKPFLPLSPQTQTAISQHQESCRDHLGPGASSLDPGSQCILEKSSNLVLQVSSLITDLQTITRDSQAALSSHRARSRSNKATTLPDAQDTEALQERCTMPDEPLVRAPDKGTDSPSPPPLEETSNGGRMLHESLRHAVPITRMQSSEDTEAGPAYSDEDYEEDIIEPRTLNEITTVTDKTSPWSSVISDTSEVISPQPDEVQREGPSCPSPGPFCREELMVKSSFLSSPERAVNPHLPRQGSPSQSLVACECEASKARVGGESASANPQPIPCPTLSGAQQSSTFVGWSSPQTDQNKEPKSEAPAENEAATSELGDSADSFKKLPLNLASQSRRENHKGPPIDSSDIRQRQVTTGSETSTKQSLLLPGPIVVPNFFLPPQQLEASLRMLSLSATLPPAATTDQDKSEATRGALSQRPCRPRPNSLPLNLPEEETLRIARIFSSQYSQKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MKQRKGQGSGGS ---CCCCCCCCCCCC	53.76	-
9	Phosphorylation	KQRKGQGSGGSRGRK CCCCCCCCCCCCCCC	31.90	23312004
12	Phosphorylation	KGQGSGGSRGRKKRG CCCCCCCCCCCCCCC	34.78	23312004
57	O-linked_Glycosylation	WKIAKPPTCVLVRVR HHHCCCCEEEEEEEE	24.63	30379171
86	Ubiquitination	DALQTEPKAVRTTTR HHHCCCCCCCCCCCH	53.97	-
175	Phosphorylation	PLSETYDSYHPLPTT CCCCCCCCCCCCCCC	18.22	22468782
185	Phosphorylation	PLPTTDMTENVLLSK CCCCCCCCCCEEECC	27.50	22468782
191	Phosphorylation	MTENVLLSKQGFREN CCCCEEECCCCCCCC	20.83	22468782
217	Phosphorylation	SRPRDIHTIKIDGKE CCCCCEEEEEECCEE	25.05	24719451
219	Ubiquitination	PRDIHTIKIDGKELA CCCEEEEEECCEEHH	35.58	29967540
223	Ubiquitination	HTIKIDGKELAANSS EEEEECCEEHHCCCC	45.89	29967540
229	Phosphorylation	GKELAANSSRSTTPR CEEHHCCCCCCCCCC	23.54	24719451
230	Phosphorylation	KELAANSSRSTTPRG EEHHCCCCCCCCCCC	30.02	21060948
232	Phosphorylation	LAANSSRSTTPRGKD HHCCCCCCCCCCCCC	38.28	21964256
233	Phosphorylation	AANSSRSTTPRGKDH HCCCCCCCCCCCCCC	39.44	30576142
234	Phosphorylation	ANSSRSTTPRGKDHV CCCCCCCCCCCCCCE	16.54	30576142
238	Ubiquitination	RSTTPRGKDHVCFAE CCCCCCCCCCEEECC	46.04	29967540
249	Phosphorylation	CFAENPDTIKDSSFG EECCCCCCCCCCCCC	31.05	-
251	Ubiquitination	AENPDTIKDSSFGLQ CCCCCCCCCCCCCCC	54.36	29967540
254	Phosphorylation	PDTIKDSSFGLQHSL CCCCCCCCCCCCCCC	33.20	28555341
260	Phosphorylation	SSFGLQHSLNSGQSL CCCCCCCCCCCCCCC	19.11	25159151
263	Phosphorylation	GLQHSLNSGQSLESV CCCCCCCCCCCCEEE	43.43	28348404
266	Phosphorylation	HSLNSGQSLESVTLK CCCCCCCCCEEEEEC	37.31	28348404
273	Ubiquitination	SLESVTLKGRAPRKQ CCEEEEECCCCCHHH	36.66	29967540
279	Ubiquitination	LKGRAPRKQMSLLNS ECCCCCHHHHHHCCC	49.66	29967540
282	Phosphorylation	RAPRKQMSLLNSSEF CCCHHHHHHCCCCCC	27.49	30624053
295	Phosphorylation	EFQPQIRTVAKSHSD CCCHHHHHHHHHCCC	26.83	-
298	Ubiquitination	PQIRTVAKSHSDSCI HHHHHHHHHCCCCCE	44.35	29967540
299	Phosphorylation	QIRTVAKSHSDSCIL HHHHHHHHCCCCCEE	20.63	28450419
301	Phosphorylation	RTVAKSHSDSCILSS HHHHHHCCCCCEECC	38.01	28450419
303	Phosphorylation	VAKSHSDSCILSSNN HHHHCCCCCEECCCC	13.18	28450419
314	Ubiquitination	SSNNLPTKDLLSALL CCCCCCHHHHHHHHH	44.43	29967540
326	Ubiquitination	ALLEQGNKLRNAMVI HHHHHHHHHHHHHHH	56.50	21906983
326 (in isoform 1)	Ubiquitination	-	56.50	21906983
326 (in isoform 2)	Ubiquitination	-	56.50	21906983
326 (in isoform 3)	Ubiquitination	-	56.50	21906983
326 (in isoform 4)	Ubiquitination	-	56.50	21906983
326 (in isoform 5)	Ubiquitination	-	56.50	21906983
337	Ubiquitination	AMVISAMKSSPETSM HHHHHHCCCCHHHHH	47.72	-
338	Phosphorylation	MVISAMKSSPETSML HHHHHCCCCHHHHHH	37.73	27732954
339	Phosphorylation	VISAMKSSPETSMLL HHHHCCCCHHHHHHH	22.64	27732954
342	Phosphorylation	AMKSSPETSMLLDQV HCCCCHHHHHHHHCC	23.87	27251275
343	Phosphorylation	MKSSPETSMLLDQVH CCCCHHHHHHHHCCC	13.03	27732954
373	Methylation	AFSRNRFKDHIEDHL HHHCHHHHHHHHHCC	45.20	-
373	Ubiquitination	AFSRNRFKDHIEDHL HHHCHHHHHHHHHCC	45.20	29967540
457	Phosphorylation	LFYTAPKSDTSISDF HHCCCCCCCCCHHHH	45.09	29978859
459	Phosphorylation	YTAPKSDTSISDFLS CCCCCCCCCHHHHCC	34.74	29978859
460	Phosphorylation	TAPKSDTSISDFLSE CCCCCCCCHHHHCCC	25.70	29978859
462	Phosphorylation	PKSDTSISDFLSEED CCCCCCHHHHCCCCC	23.29	29978859
466	Phosphorylation	TSISDFLSEEDDIVP CCHHHHCCCCCCCCC	38.64	25159151
474	Phosphorylation	EEDDIVPSKKISQST CCCCCCCCCCCCHHH	35.37	23186163
476	Ubiquitination	DDIVPSKKISQSTAL CCCCCCCCCCHHHHH	52.51	29967540
493	Phosphorylation	SSKVLESSDHKLKKR HCHHHHCCCHHHHHC	34.07	-
496	Ubiquitination	VLESSDHKLKKRSAG HHHCCCHHHHHCHHC	67.97	29967540
547	Phosphorylation	SVRIIIETMGVPPDS EEEEEEEECCCCCCC	14.60	26471730
554	Phosphorylation	TMGVPPDSPQMTPGK ECCCCCCCCCCCCCC	23.86	30576142
558	Phosphorylation	PPDSPQMTPGKKSYA CCCCCCCCCCCCCCC	24.52	26471730
564	Phosphorylation	MTPGKKSYAGPPPKV CCCCCCCCCCCCCCC	25.18	23822953
615	Ubiquitination	SSKITDGKVKFQQRF HCCCCCCCCEEEEEE	45.09	-
660	Phosphorylation	KKPEVIGSVSLSLRA CCCEEEEEEEHHHHH	9.45	26091039
662	Phosphorylation	PEVIGSVSLSLRAVI CEEEEEEEHHHHHHH	17.59	26091039
664	Phosphorylation	VIGSVSLSLRAVIQS EEEEEEHHHHHHHHH	14.33	26091039
697	Phosphorylation	PFGPLKVTMELITDN CCCCEEEEEEEECCC	11.89	30177828
702	Phosphorylation	KVTMELITDNKDFTG EEEEEEECCCCCCCC	46.26	30177828
708	Phosphorylation	ITDNKDFTGINTKLS ECCCCCCCCEEEECC	47.49	26074081
712	Phosphorylation	KDFTGINTKLSGNTH CCCCCEEEECCCCCC	31.29	26074081
715	Phosphorylation	TGINTKLSGNTHYTP CCEEEECCCCCCCCC	31.39	26552605
718	Phosphorylation	NTKLSGNTHYTPLCA EEECCCCCCCCCCCC	21.56	29396449
720	Phosphorylation	KLSGNTHYTPLCAPT ECCCCCCCCCCCCCC	14.17	29396449
721	Phosphorylation	LSGNTHYTPLCAPTS CCCCCCCCCCCCCCC	11.37	28450419
727	Phosphorylation	YTPLCAPTSPNKALP CCCCCCCCCCCCCCH	37.99	22167270
728	Phosphorylation	TPLCAPTSPNKALPE CCCCCCCCCCCCCHH	25.97	22167270
744	Ubiquitination	NQDMTCTKNPQNLNQ CCCCCCCCCCCHHHH	69.63	29967540
758	Ubiquitination	QIHEETAKKAQNLVL HHCHHHHHHHHHCCC	56.94	29967540
770	Phosphorylation	LVLPNRKSPSPVAPH CCCCCCCCCCCCCCC	27.63	26074081
772	Phosphorylation	LPNRKSPSPVAPHPS CCCCCCCCCCCCCCC	38.81	25159151
779	Phosphorylation	SPVAPHPSTFVATPA CCCCCCCCCEEECCC	31.29	26074081
780	Phosphorylation	PVAPHPSTFVATPAS CCCCCCCCEEECCCC	26.95	26074081
784	Phosphorylation	HPSTFVATPASHNLV CCCCEEECCCCCCCC	17.68	26074081
787	Phosphorylation	TFVATPASHNLVNQT CEEECCCCCCCCCCC	17.70	26074081
824	Ubiquitination	FISGESEKQSPCNVY CCCCCCCCCCCCEEE	66.41	29967540
894	Ubiquitination	VRSPGQDKLLGLVKL CCCCCCCHHHHEEEC	37.41	29967540
976	Phosphorylation	EGTLPPFSPRPAHFL CCCCCCCCCCCHHHC	26.27	29255136
1130	Phosphorylation	DQKVAKGTLPLSRIC CCCCCCCCCCHHHHH	25.21	17924679
1134	Phosphorylation	AKGTLPLSRICAMVT CCCCCCHHHHHHHHH	20.05	-
1152	Phosphorylation	REDVGIQTFNLPLTP HHHCCCEECCCCCCC	16.75	26074081
1158	Phosphorylation	QTFNLPLTPRIENRK EECCCCCCCCCCCHH	14.47	26074081
1181	Phosphorylation	LLDVGLRYRRSPRTA CHHHCCCCCCCCCCC	18.54	-
1184	Phosphorylation	VGLRYRRSPRTAEGV HCCCCCCCCCCCCCC	15.10	17081983
1187	Phosphorylation	RYRRSPRTAEGVLAA CCCCCCCCCCCCEEE	32.23	-
1200	Phosphorylation	AARTVSISVQIIRAC EEEEEEHHHHHHHHC	10.64	-
1314	Ubiquitination	IISIESCKEYLLGVV EEEHHHHHHHHHCCE	59.69	29967540
1466	Phosphorylation	NKKQIMVTFKASKRA CCCEEEEEEEHHCCC	11.31	29759185
1532	Phosphorylation	ERSARTLTVSGVYPL CCCCCEEEEEEEHHC	16.41	-
1534	Phosphorylation	SARTLTVSGVYPLFG CCCEEEEEEEHHCCC	19.80	-
1537	Phosphorylation	TLTVSGVYPLFGRNA EEEEEEEHHCCCCCC	9.57	-
1595	Phosphorylation	RNDEVQLSPPEVISC CCCCCCCCCCCEEEE	22.71	20873877
1601	Phosphorylation	LSPPEVISCHQKSPA CCCCCEEEEECCCCC	15.66	27251275
1606	Phosphorylation	VISCHQKSPASTQVP EEEEECCCCCCCCCC	21.09	22199227
1609	Phosphorylation	CHQKSPASTQVPCSS EECCCCCCCCCCCCC	23.82	22199227
1648	Phosphorylation	VERAMHLSLKGSPLT HHHHHHHHCCCCCCC	17.23	21712546
1652	Phosphorylation	MHLSLKGSPLTERKV HHHHCCCCCCCCCCC	18.36	21712546
1700	Ubiquitination	QQQSRLSKELLLDPQ HHHHCCCHHHCCCHH	57.90	29967540
1753 (in isoform 2)	Ubiquitination	-	23.59	21906983
1763	Phosphorylation	GQIKVAVSPLESLIH CEEEEEEECHHHHHC	17.65	-
1772	Ubiquitination	LESLIHFKEERQARR HHHHHCHHHHHHHHC	44.49	21906983
1772 (in isoform 1)	Ubiquitination	-	44.49	21906983
1772 (in isoform 3)	Ubiquitination	-	44.49	21906983
1772 (in isoform 4)	Ubiquitination	-	44.49	21906983
1772 (in isoform 5)	Ubiquitination	-	44.49	21906983
1785	Ubiquitination	RRGVETSKSLIPIYS HCCCCCCHHHCCCCC	57.62	-
1791	Phosphorylation	SKSLIPIYSPFSFPA CHHHCCCCCCCCCCC	12.63	-
1821	Phosphorylation	LDQLAHASSKELDFS HHHHHHHHCCCCCCC	31.88	28985074
1822	Phosphorylation	DQLAHASSKELDFSS HHHHHHHCCCCCCCC	30.82	28985074
1823	Ubiquitination	QLAHASSKELDFSSP HHHHHHCCCCCCCCC	60.85	-
1828	Phosphorylation	SSKELDFSSPGRSDT HCCCCCCCCCCCCCC	34.98	30266825
1829	Phosphorylation	SKELDFSSPGRSDTT CCCCCCCCCCCCCCC	31.22	30266825
1872	Phosphorylation	LPCDDKLTTSPLSSQ CCCCCCCCCCCCCHH	30.85	25850435
1873	Phosphorylation	PCDDKLTTSPLSSQT CCCCCCCCCCCCHHH	38.49	25850435
1874	Phosphorylation	CDDKLTTSPLSSQTS CCCCCCCCCCCHHHH	20.71	22199227
1877	Phosphorylation	KLTTSPLSSQTSILT CCCCCCCCHHHHHHH	24.63	22199227
1878	Phosphorylation	LTTSPLSSQTSILTS CCCCCCCHHHHHHHH	45.20	22199227
1880	Phosphorylation	TSPLSSQTSILTSLR CCCCCHHHHHHHHHH	21.49	26074081
1881	Phosphorylation	SPLSSQTSILTSLRK CCCCHHHHHHHHHHH	14.15	22199227
1888	Ubiquitination	SILTSLRKNLSELDQ HHHHHHHHCHHHHHH	68.48	29967540
1891	Phosphorylation	TSLRKNLSELDQIQR HHHHHCHHHHHHHHH	45.57	28450419
1891 (in isoform 4)	Phosphorylation	-	45.57	22985185
1906	Ubiquitination	YFRQKLTKPFLPLSP HHHHHCCCCCCCCCH	44.18	29967540
1912	Phosphorylation	TKPFLPLSPQTQTAI CCCCCCCCHHHHHHH	17.02	25159151
1915	Phosphorylation	FLPLSPQTQTAISQH CCCCCHHHHHHHHHC	31.13	-
1969	Phosphorylation	LQTITRDSQAALSSH HHHHCHHHHHHHHHH	20.59	29083192
1974	Phosphorylation	RDSQAALSSHRARSR HHHHHHHHHHHHHHC	21.26	29083192
1975	Phosphorylation	DSQAALSSHRARSRS HHHHHHHHHHHHHCC	20.17	29083192
1980	Phosphorylation	LSSHRARSRSNKATT HHHHHHHHCCCCCCC	38.79	29083192
1984	Ubiquitination	RARSRSNKATTLPDA HHHHCCCCCCCCCCH	48.64	2190698
1984 (in isoform 5)	Ubiquitination	-	48.64	21906983
2002	Phosphorylation	EALQERCTMPDEPLV HHHHHHCCCCCCCCC	37.65	26074081
2016	Phosphorylation	VRAPDKGTDSPSPPP CCCCCCCCCCCCCCC	38.76	25219547
2018	Phosphorylation	APDKGTDSPSPPPLE CCCCCCCCCCCCCCH	27.41	22617229
2020	Phosphorylation	DKGTDSPSPPPLEET CCCCCCCCCCCCHHC	54.73	22617229
2027	Phosphorylation	SPPPLEETSNGGRML CCCCCHHCCCCCCCC	20.37	26471730
2037	Phosphorylation	GGRMLHESLRHAVPI CCCCCCHHHHHCCCC	21.69	-
2049	Phosphorylation	VPITRMQSSEDTEAG CCCEECCCCCCCCCC	26.76	30576142
2050	Phosphorylation	PITRMQSSEDTEAGP CCEECCCCCCCCCCC	23.70	28985074
2053	Phosphorylation	RMQSSEDTEAGPAYS ECCCCCCCCCCCCCC	24.55	28634120
2059	Phosphorylation	DTEAGPAYSDEDYEE CCCCCCCCCCCCCHH	21.56	26657352
2060	Phosphorylation	TEAGPAYSDEDYEED CCCCCCCCCCCCHHC	36.31	33259812
2064	Phosphorylation	PAYSDEDYEEDIIEP CCCCCCCCHHCCCCC	21.12	30576142
2092	Phosphorylation	SPWSSVISDTSEVIS CCCHHHCCCCCCCCC	32.45	28102081
2094	Phosphorylation	WSSVISDTSEVISPQ CHHHCCCCCCCCCCC	21.72	28102081
2095	Phosphorylation	SSVISDTSEVISPQP HHHCCCCCCCCCCCC	34.55	28102081
2099	Phosphorylation	SDTSEVISPQPDEVQ CCCCCCCCCCCHHHH	23.74	28102081
2111	Phosphorylation	EVQREGPSCPSPGPF HHHCCCCCCCCCCCC	49.90	23401153
2114	Phosphorylation	REGPSCPSPGPFCRE CCCCCCCCCCCCCCH	46.98	23401153
2126	Acetylation	CREELMVKSSFLSSP CCHHHHHCHHHCCCH	26.81	19813309
2127	Phosphorylation	REELMVKSSFLSSPE CHHHHHCHHHCCCHH	18.21	23403867
2128	Phosphorylation	EELMVKSSFLSSPER HHHHHCHHHCCCHHH	25.21	23403867
2131	Phosphorylation	MVKSSFLSSPERAVN HHCHHHCCCHHHHCC	41.66	30266825
2132	Phosphorylation	VKSSFLSSPERAVNP HCHHHCCCHHHHCCC	32.69	19664994
2146	Phosphorylation	PHLPRQGSPSQSLVA CCCCCCCCCCCCEEE	17.03	23401153
2148	Phosphorylation	LPRQGSPSQSLVACE CCCCCCCCCCEEEEE	33.81	25850435
2150	Phosphorylation	RQGSPSQSLVACECE CCCCCCCCEEEEEEE	29.20	22199227
2159	Phosphorylation	VACECEASKARVGGE EEEEEECCCCCCCCC	12.45	23927012
2226	Ubiquitination	GDSADSFKKLPLNLA CCCHHHHHCCCCCHH	58.30	29967540
2227	Ubiquitination	DSADSFKKLPLNLAS CCHHHHHCCCCCHHC	54.01	29967540
2260	Phosphorylation	QRQVTTGSETSTKQS HCCCCCCCCCCCCCE	35.29	19562805
2328	Phosphorylation	PCRPRPNSLPLNLPE CCCCCCCCCCCCCCH	33.76	25850435
2346	Phosphorylation	LRIARIFSSQYSQKD HHHHHHHHHHHCCCC	17.73	29978859
2347	Phosphorylation	RIARIFSSQYSQKD- HHHHHHHHHHCCCC-	23.53	29978859
2349	Phosphorylation	ARIFSSQYSQKD--- HHHHHHHHCCCC---	18.28	23186163
2350	Phosphorylation	RIFSSQYSQKD---- HHHHHHHCCCC----	24.10	29978859
2352	Ubiquitination	FSSQYSQKD------ HHHHHCCCC------	60.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C2CD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2CD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2CD3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of C2CD3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615948: Orofaciodigital syndrome 14 (OFD14)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2132, AND MASSSPECTROMETRY.
PubMed: 19413330

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2114, AND MASSSPECTROMETRY.
PubMed: 18220336

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1130, AND MASSSPECTROMETRY.
PubMed: 17924679