| UniProt ID | MOONR_HUMAN | |
|---|---|---|
| UniProt AC | Q2KHM9 | |
| Protein Name | Protein moonraker {ECO:0000303|PubMed:26297806} | |
| Gene Name | KIAA0753 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 967 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizati | |
| Protein Description | Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2. [PubMed: 24613305] | |
| Protein Sequence | MGPGQPASTCVHLAPRTQLDGRSDPKVLQTQNQLQFNRNVPTHSSNLAIRYSCPHAIRIEKLKHSYNESYHCKDADCRVGPDLGSSVSFSVISQERLSYAVHLARRDVKRRQFEKHIKEHHLRSQPQSSQKCGHTKYKIPDHRVERKESKSQAACQCSHQPSKVEISSSGAKVYLYSSHPGQSDLTVPNSPPTHDPGLQPHPRIGDHKNISEQKSLLEVQRLQKELSSCIHKIEEVTKKDRLEEALDPDEERRIRIRRQEQAARSARMLYVLQQQVKEIQEELDKLSPHKIKHTKKSWAMSKLAAAHRGAIRALQMFVTQFTDRGEHPLPARCKELGSLIRQLSLCSVKLDADPSVPDVVIDILQQIEALESLLEKKLSPKKVKKCFSEIRSRFPIGSQKALERWPSTSPKGERRPLTAKDTFPQETSRPSVAKQLLADKYQPDTELPETQRLQSELDVLDADIVLEEGPFILDQSASFKDEVLAVAKTKAGKKKPVTENVPFRKKDTLAPARQQGLRKAERGRQSQPHSKSRVQQTTVSSRLKMNRQPVKDRKAPWIPPNPTSPPASPKCAAWLKVKTSPRDATKEPLQQEDPQEESHLTGAVEHEAARLAWLDAETSKRLKELEELKAKEIDSMQKQRLDWLDAETSRRTKELNELKAEEMYRLQQLSVSATHLADKVEEAVLDRLKPLLVKAQRVNSTTEANIHLKDGSSVNTAKAQPAQEVAAVDFESNNIRQLDDFLEDCASELWAVTHAKILGSETLATVEDSKDSPDLEIMMRRMEEMEKYQESVRQRYNKIAYADPRLWMQEENNDQKISAISEKPLSPHPIRITKTVDRKDPAVNIMLERPCNGNSLDESVGTEEGSEKREAPLLSLAEDSQQKEGRAPLFVPPGMQHSIGDYCSRFEQYLRIISHEAVGSFNPWLIAESFSEELVDEALGAVAAELQDMCEDYAEAVFTSEFLEAAT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MGPGQPASTCVHLAP CCCCCCCCCCEEECC | 27732954 | ||
| 9 | Phosphorylation | GPGQPASTCVHLAPR CCCCCCCCCEEECCC | 27732954 | ||
| 26 | Ubiquitination | LDGRSDPKVLQTQNQ CCCCCCHHHHHHHHH | 22817900 | ||
| 26 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 42 | Phosphorylation | QFNRNVPTHSSNLAI HCCCCCCCCCCCEEE | 27732954 | ||
| 42 | Ubiquitination | QFNRNVPTHSSNLAI HCCCCCCCCCCCEEE | 22817900 | ||
| 44 | Phosphorylation | NRNVPTHSSNLAIRY CCCCCCCCCCEEEEE | 27732954 | ||
| 45 | Phosphorylation | RNVPTHSSNLAIRYS CCCCCCCCCEEEEEC | 27732954 | ||
| 63 | Acetylation | AIRIEKLKHSYNESY CHHHHHHCCCCCCCC | 20167786 | ||
| 63 | Ubiquitination | AIRIEKLKHSYNESY CHHHHHHCCCCCCCC | 29967540 | ||
| 65 | Phosphorylation | RIEKLKHSYNESYHC HHHHHCCCCCCCCCC | - | ||
| 73 | Ubiquitination | YNESYHCKDADCRVG CCCCCCCCCCCCCCC | - | ||
| 90 | Phosphorylation | LGSSVSFSVISQERL CCCCEEEEEECHHHH | - | ||
| 93 | Phosphorylation | SVSFSVISQERLSYA CEEEEEECHHHHHHH | 27251275 | ||
| 115 | Ubiquitination | VKRRQFEKHIKEHHL HHHHHHHHHHHHHHH | 22817900 | ||
| 124 | Phosphorylation | IKEHHLRSQPQSSQK HHHHHHHCCCCCCCC | - | ||
| 128 | Phosphorylation | HLRSQPQSSQKCGHT HHHCCCCCCCCCCCC | - | ||
| 129 | Phosphorylation | LRSQPQSSQKCGHTK HHCCCCCCCCCCCCC | - | ||
| 131 | Ubiquitination | SQPQSSQKCGHTKYK CCCCCCCCCCCCCCC | 29967540 | ||
| 135 | Phosphorylation | SSQKCGHTKYKIPDH CCCCCCCCCCCCCCH | - | ||
| 138 | Ubiquitination | KCGHTKYKIPDHRVE CCCCCCCCCCCHHHC | 29967540 | ||
| 141 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 145 | Ubiquitination | KIPDHRVERKESKSQ CCCCHHHCCCCCHHH | 22817900 | ||
| 149 | Phosphorylation | HRVERKESKSQAACQ HHHCCCCCHHHHHHH | 28258704 | ||
| 150 | Ubiquitination | RVERKESKSQAACQC HHCCCCCHHHHHHHC | 21963094 | ||
| 169 | Phosphorylation | SKVEISSSGAKVYLY CEEEECCCCCEEEEE | 24114839 | ||
| 172 | Ubiquitination | EISSSGAKVYLYSSH EECCCCCEEEEEECC | 29967540 | ||
| 174 | Phosphorylation | SSSGAKVYLYSSHPG CCCCCEEEEEECCCC | 23312004 | ||
| 174 | Ubiquitination | SSSGAKVYLYSSHPG CCCCCEEEEEECCCC | 21963094 | ||
| 176 | Phosphorylation | SGAKVYLYSSHPGQS CCCEEEEEECCCCCC | 28450419 | ||
| 177 | Phosphorylation | GAKVYLYSSHPGQSD CCEEEEEECCCCCCC | 28450419 | ||
| 178 | Phosphorylation | AKVYLYSSHPGQSDL CEEEEEECCCCCCCC | 28450419 | ||
| 183 | Phosphorylation | YSSHPGQSDLTVPNS EECCCCCCCCCCCCC | 28450419 | ||
| 186 | Phosphorylation | HPGQSDLTVPNSPPT CCCCCCCCCCCCCCC | 28450419 | ||
| 190 | Phosphorylation | SDLTVPNSPPTHDPG CCCCCCCCCCCCCCC | 25159151 | ||
| 193 | Phosphorylation | TVPNSPPTHDPGLQP CCCCCCCCCCCCCCC | 28450419 | ||
| 208 | Ubiquitination | HPRIGDHKNISEQKS CCCCCCCCCHHHHHH | 21906983 | ||
| 208 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 211 | Phosphorylation | IGDHKNISEQKSLLE CCCCCCHHHHHHHHH | 20860994 | ||
| 214 | Ubiquitination | HKNISEQKSLLEVQR CCCHHHHHHHHHHHH | 21906983 | ||
| 214 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 215 | Phosphorylation | KNISEQKSLLEVQRL CCHHHHHHHHHHHHH | 27251275 | ||
| 224 | Ubiquitination | LEVQRLQKELSSCIH HHHHHHHHHHHHHHH | 29967540 | ||
| 232 | Ubiquitination | ELSSCIHKIEEVTKK HHHHHHHHHHHHHHH | 29967540 | ||
| 254 | Ubiquitination | DPDEERRIRIRRQEQ CCCHHHHHHHHHHHH | 21963094 | ||
| 265 | Phosphorylation | RQEQAARSARMLYVL HHHHHHHHHHHHHHH | 30622161 | ||
| 270 | Phosphorylation | ARSARMLYVLQQQVK HHHHHHHHHHHHHHH | 30622161 | ||
| 285 | Ubiquitination | EIQEELDKLSPHKIK HHHHHHHHHCHHHCH | 29967540 | ||
| 287 | Phosphorylation | QEELDKLSPHKIKHT HHHHHHHCHHHCHHC | 23401153 | ||
| 287 | Ubiquitination | QEELDKLSPHKIKHT HHHHHHHCHHHCHHC | 22817900 | ||
| 287 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 319 | Phosphorylation | RALQMFVTQFTDRGE HHHHHHHHHCCCCCC | 23312004 | ||
| 322 | Phosphorylation | QMFVTQFTDRGEHPL HHHHHHCCCCCCCCC | 23312004 | ||
| 334 | Ubiquitination | HPLPARCKELGSLIR CCCCHHHHHHHHHHH | - | ||
| 338 | Phosphorylation | ARCKELGSLIRQLSL HHHHHHHHHHHHHHC | 27251275 | ||
| 344 | Phosphorylation | GSLIRQLSLCSVKLD HHHHHHHHCCCEECC | 22985185 | ||
| 360 | Ubiquitination | DPSVPDVVIDILQQI CCCCCHHHHHHHHHH | 22817900 | ||
| 360 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 372 | Phosphorylation | QQIEALESLLEKKLS HHHHHHHHHHHHCCC | 24719451 | ||
| 385 | Ubiquitination | LSPKKVKKCFSEIRS CCHHHHHHHHHHHHH | 29967540 | ||
| 390 | Ubiquitination | VKKCFSEIRSRFPIG HHHHHHHHHHHCCCC | 22817900 | ||
| 395 | Ubiquitination | SEIRSRFPIGSQKAL HHHHHHCCCCCHHHH | 21963094 | ||
| 398 | Phosphorylation | RSRFPIGSQKALERW HHHCCCCCHHHHHCC | 24961811 | ||
| 400 | Ubiquitination | RFPIGSQKALERWPS HCCCCCHHHHHCCCC | 29967540 | ||
| 407 | Phosphorylation | KALERWPSTSPKGER HHHHCCCCCCCCCCC | 25159151 | ||
| 408 | Phosphorylation | ALERWPSTSPKGERR HHHCCCCCCCCCCCC | 27282143 | ||
| 409 | Phosphorylation | LERWPSTSPKGERRP HHCCCCCCCCCCCCC | 25159151 | ||
| 419 | Ubiquitination | GERRPLTAKDTFPQE CCCCCCCCCCCCCCC | 21963094 | ||
| 419 (in isoform 2) | Ubiquitination | - | 21906983 | ||
| 420 | Ubiquitination | ERRPLTAKDTFPQET CCCCCCCCCCCCCCC | 29967540 | ||
| 434 | Ubiquitination | TSRPSVAKQLLADKY CCCHHHHHHHHHHHC | 29967540 | ||
| 440 | Ubiquitination | AKQLLADKYQPDTEL HHHHHHHHCCCCCCC | 21906983 | ||
| 440 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 478 | Phosphorylation | FILDQSASFKDEVLA EEECCCCCCCHHHHH | 24719451 | ||
| 488 | Ubiquitination | DEVLAVAKTKAGKKK HHHHHHHCCCCCCCC | 29967540 | ||
| 490 | Acetylation | VLAVAKTKAGKKKPV HHHHHCCCCCCCCCC | 30589691 | ||
| 494 | Ubiquitination | AKTKAGKKKPVTENV HCCCCCCCCCCCCCC | 29967540 | ||
| 495 | Ubiquitination | KTKAGKKKPVTENVP CCCCCCCCCCCCCCC | 29967540 | ||
| 499 | Ubiquitination | GKKKPVTENVPFRKK CCCCCCCCCCCCCCC | 21963094 | ||
| 505 | Acetylation | TENVPFRKKDTLAPA CCCCCCCCCCCCHHH | 30589695 | ||
| 521 | Ubiquitination | QQGLRKAERGRQSQP HHHHHHHHHHCCCCC | 21963094 | ||
| 537 | Phosphorylation | SKSRVQQTTVSSRLK CCCCCCHHHHHHHHH | 27732954 | ||
| 538 | Phosphorylation | KSRVQQTTVSSRLKM CCCCCHHHHHHHHHC | 27732954 | ||
| 540 | Phosphorylation | RVQQTTVSSRLKMNR CCCHHHHHHHHHCCC | 27732954 | ||
| 541 | Phosphorylation | VQQTTVSSRLKMNRQ CCHHHHHHHHHCCCC | 27732954 | ||
| 563 | Phosphorylation | PWIPPNPTSPPASPK CCCCCCCCCCCCCHH | 25159151 | ||
| 564 | Phosphorylation | WIPPNPTSPPASPKC CCCCCCCCCCCCHHH | 25159151 | ||
| 568 | Phosphorylation | NPTSPPASPKCAAWL CCCCCCCCHHHHHEE | 25159151 | ||
| 576 | Ubiquitination | PKCAAWLKVKTSPRD HHHHHEEEECCCCCC | - | ||
| 586 | Ubiquitination | TSPRDATKEPLQQED CCCCCCCCCCCCCCC | 21906983 | ||
| 586 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 620 | Ubiquitination | WLDAETSKRLKELEE HHCHHHHHHHHHHHH | 29967540 | ||
| 623 | Ubiquitination | AETSKRLKELEELKA HHHHHHHHHHHHHHH | 29967540 | ||
| 629 | Ubiquitination | LKELEELKAKEIDSM HHHHHHHHHHHHHHH | - | ||
| 631 | Ubiquitination | ELEELKAKEIDSMQK HHHHHHHHHHHHHHH | - | ||
| 635 | Phosphorylation | LKAKEIDSMQKQRLD HHHHHHHHHHHHHHH | 23403867 | ||
| 638 | Ubiquitination | KEIDSMQKQRLDWLD HHHHHHHHHHHHHHH | 29967540 | ||
| 653 | Ubiquitination | AETSRRTKELNELKA HHHHHHHHHHHHHCH | 29967540 | ||
| 659 | Ubiquitination | TKELNELKAEEMYRL HHHHHHHCHHHHHHH | 21906983 | ||
| 659 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 670 | Phosphorylation | MYRLQQLSVSATHLA HHHHHHHHHHHHHHH | 28450419 | ||
| 672 | Phosphorylation | RLQQLSVSATHLADK HHHHHHHHHHHHHHH | 22617229 | ||
| 674 | Phosphorylation | QQLSVSATHLADKVE HHHHHHHHHHHHHHH | 28450419 | ||
| 679 | Ubiquitination | SATHLADKVEEAVLD HHHHHHHHHHHHHHH | 29967540 | ||
| 689 | Ubiquitination | EAVLDRLKPLLVKAQ HHHHHHHHHHHHEEE | 22817900 | ||
| 694 | Ubiquitination | RLKPLLVKAQRVNST HHHHHHHEEEECCCC | 21963094 | ||
| 700 | Phosphorylation | VKAQRVNSTTEANIH HEEEECCCCCEEEEE | 27273156 | ||
| 701 | Phosphorylation | KAQRVNSTTEANIHL EEEECCCCCEEEEEE | 25159151 | ||
| 702 | Phosphorylation | AQRVNSTTEANIHLK EEECCCCCEEEEEEC | 30108239 | ||
| 709 | Ubiquitination | TEANIHLKDGSSVNT CEEEEEECCCCCCCC | 29967540 | ||
| 712 | Phosphorylation | NIHLKDGSSVNTAKA EEEECCCCCCCCCCC | 20860994 | ||
| 713 | Phosphorylation | IHLKDGSSVNTAKAQ EEECCCCCCCCCCCC | 29759185 | ||
| 718 | Ubiquitination | GSSVNTAKAQPAQEV CCCCCCCCCCCCCHH | 21963094 | ||
| 718 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 769 | Phosphorylation | TLATVEDSKDSPDLE CEEEHHCCCCCCCHH | 26471730 | ||
| 770 | Ubiquitination | LATVEDSKDSPDLEI EEEHHCCCCCCCHHH | 29967540 | ||
| 772 | Phosphorylation | TVEDSKDSPDLEIMM EHHCCCCCCCHHHHH | 26471730 | ||
| 787 | Ubiquitination | RRMEEMEKYQESVRQ HHHHHHHHHHHHHHH | - | ||
| 798 | Ubiquitination | SVRQRYNKIAYADPR HHHHHHHHHHHCCHH | 21963094 | ||
| 816 | Ubiquitination | QEENNDQKISAISEK CCCCCCCCEEEECCC | 29967540 | ||
| 818 | Phosphorylation | ENNDQKISAISEKPL CCCCCCEEEECCCCC | 23403867 | ||
| 820 | Ubiquitination | NDQKISAISEKPLSP CCCCEEEECCCCCCC | 21963094 | ||
| 821 | Phosphorylation | DQKISAISEKPLSPH CCCEEEECCCCCCCC | 22617229 | ||
| 823 | Ubiquitination | KISAISEKPLSPHPI CEEEECCCCCCCCCE | 29967540 | ||
| 826 | Phosphorylation | AISEKPLSPHPIRIT EECCCCCCCCCEEEE | 30266825 | ||
| 834 | Ubiquitination | PHPIRITKTVDRKDP CCCEEEEEECCCCCC | 29967540 | ||
| 875 | Phosphorylation | KREAPLLSLAEDSQQ CCCCCCHHHHHHHCC | 27251275 | ||
| 880 | Phosphorylation | LLSLAEDSQQKEGRA CHHHHHHHCCCCCCC | 20860994 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MOONR_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOONR_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOONR_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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