MA7D3_HUMAN - dbPTM
MA7D3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MA7D3_HUMAN
UniProt AC Q8IWC1
Protein Name MAP7 domain-containing protein 3
Gene Name MAP7D3
Organism Homo sapiens (Human).
Sequence Length 876
Subcellular Localization Cytoplasm, cytoskeleton, spindle . Localizes to the microtubules throughout mitosis.
Protein Description Promotes the assembly and stability of microtubules..
Protein Sequence MMADGAAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSSNIRSTFKPVIDGSMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKRKTDKERSSSLNRRDSNLHSSTDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPMSTMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDSEMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPEAMVKASPKTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLPSPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVNASKVTETSSHDIYEEAEADNEESDKDSLNEMFPSAILNGTGSPTKFKMPFNNAKKMTHKLVFLEDGTSQVRKEPKTYFNGDLKNFRQKSMKDTSIQEVVSRPSSKRMTSHTTKTRKADETNTTSRSSAQTKSEGFHDILPKSSDTFRQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MMADGAAA
-------CCCCCCCC		4.5122814378
13PhosphorylationAAAGAGGSPSLRELR
CCCCCCCCHHHHHHH		15.4819691289
15PhosphorylationAGAGGSPSLRELRAR
CCCCCCHHHHHHHHH		41.5819691289
46UbiquitinationVVNRVATHSSNIRST
HHHHHHHCCHHHHHH		21.3532015554
52PhosphorylationTHSSNIRSTFKPVID
HCCHHHHHHCCCCCC		34.1025954137
53PhosphorylationHSSNIRSTFKPVIDG
CCHHHHHHCCCCCCH		26.3225954137
55AcetylationSNIRSTFKPVIDGSM
HHHHHHCCCCCCHHH		38.1626051181
61PhosphorylationFKPVIDGSMLKNDIK
CCCCCCHHHCHHHHH		19.7328857561
64UbiquitinationVIDGSMLKNDIKQRL
CCCHHHCHHHHHHHH		43.8832015554
98PhosphorylationLLEKERKTKLQYEKQ
HHHHHHHHHHHHHHH		43.1129449344
102PhosphorylationERKTKLQYEKQMEER
HHHHHHHHHHHHHHH		35.2129496907
143PhosphorylationEAQKEKFTAILYRTL
HHHHHHHHHHHHHHH		24.6923312004
147PhosphorylationEKFTAILYRTLERRR
HHHHHHHHHHHHHHH		8.7429978859
149PhosphorylationFTAILYRTLERRRLA
HHHHHHHHHHHHHCC		21.2925003641
159PhosphorylationRRRLADDYQQKRWSW
HHHCCHHHHHCHHCC		17.2529496907
162UbiquitinationLADDYQQKRWSWGGS
CCHHHHHCHHCCCCH		40.07-
165PhosphorylationDYQQKRWSWGGSAMA
HHHHCHHCCCCHHHC		21.6325159151
169PhosphorylationKRWSWGGSAMANSES
CHHCCCCHHHCCCCC		15.7823927012
169 (in isoform 3)Phosphorylation-15.78-
174PhosphorylationGGSAMANSESKTANK
CCHHHCCCCCCCCCC		33.4423403867
176PhosphorylationSAMANSESKTANKRS
HHHCCCCCCCCCCCC		34.8223403867
183PhosphorylationSKTANKRSASTEKLE
CCCCCCCCCCHHHHH		28.3423401153
185PhosphorylationTANKRSASTEKLEQG
CCCCCCCCHHHHHHH		38.0423927012
186PhosphorylationANKRSASTEKLEQGT
CCCCCCCHHHHHHHH		36.5330266825
193PhosphorylationTEKLEQGTSALIRQM
HHHHHHHHHHHHHHC		15.5523403867
194PhosphorylationEKLEQGTSALIRQMP
HHHHHHHHHHHHHCC		28.0923403867
203PhosphorylationLIRQMPLSSAGLQNS
HHHHCCCCHHHHHHH		16.5729083192
204PhosphorylationIRQMPLSSAGLQNSV
HHHCCCCHHHHHHHH		33.7629083192
210PhosphorylationSSAGLQNSVAKRKTD
CHHHHHHHHHCHHCH		15.5326462736
223PhosphorylationTDKERSSSLNRRDSN
CHHHHHHHCHHHHHC		30.8017287340
229PhosphorylationSSLNRRDSNLHSSTD
HHCHHHHHCCCCCCC		39.2127273156
233PhosphorylationRRDSNLHSSTDKEQA
HHHHCCCCCCCHHHH		37.7929255136
234PhosphorylationRDSNLHSSTDKEQAE
HHHCCCCCCCHHHHH		29.8529255136
235PhosphorylationDSNLHSSTDKEQAER
HHCCCCCCCHHHHHH		54.8529255136
252PhosphorylationRVTGVTNYVMQYVTV
CHHCHHHHHHHHEEE		6.4718083107
256PhosphorylationVTNYVMQYVTVPLRK
HHHHHHHHEEEEHHH		4.6818083107
277PhosphorylationRAVMFPMSTMKIPPQ
HHHEECHHCCCCCCC		26.1128555341
278PhosphorylationAVMFPMSTMKIPPQT
HHEECHHCCCCCCCC		19.0728555341
290PhosphorylationPQTKVEESPLEKVET
CCCCCCCCCCCCCCC		22.6821815630
297PhosphorylationSPLEKVETPPKASVD
CCCCCCCCCCCCCCC		48.1321815630
302PhosphorylationVETPPKASVDAPPQV
CCCCCCCCCCCCCCE		27.0218669648
317PhosphorylationNVEVFCNTSMEASPK
EEEEEECCCCCCCCC		30.5422777824
318PhosphorylationVEVFCNTSMEASPKA
EEEEECCCCCCCCCC		10.7127080861
322PhosphorylationCNTSMEASPKAGVGM
ECCCCCCCCCCCCCC		17.3930576142
381PhosphorylationLETVPKVSIVASPEA
CCCCCCEEEEECCCC		19.9227251275
385PhosphorylationPKVSIVASPEASLEA
CCEEEEECCCCCCCC		16.6328102081
389PhosphorylationIVASPEASLEAPPEV
EEECCCCCCCCCCCC		25.6927251275
405PhosphorylationLEALPEVSVEAAPEG
HHHCCCCEEEECCCC		16.7527251275
429PhosphorylationAEVAPKESVKGSPKE
CCCCCHHHCCCCCHH		34.9427422710
433PhosphorylationPKESVKGSPKESMEA
CHHHCCCCCHHHCCC		27.3823401153
437PhosphorylationVKGSPKESMEASPEA
CCCCCHHHCCCCHHH		28.2228176443
441PhosphorylationPKESMEASPEAMVKA
CHHHCCCCHHHHHHC		15.2323401153
449PhosphorylationPEAMVKASPKTSLEA
HHHHHHCCCCCCHHH		22.6322199227
452PhosphorylationMVKASPKTSLEASME
HHHCCCCCCHHHHHH		41.7623403867
453PhosphorylationVKASPKTSLEASMEA
HHCCCCCCHHHHHHC		30.2725159151
457PhosphorylationPKTSLEASMEASPKA
CCCCHHHHHHCCHHH		14.0529255136
461PhosphorylationLEASMEASPKAKARD
HHHHHHCCHHHHHCC		17.3929255136
489PhosphorylationPIAKKRLSSYTECYK
HHHHHHHHHCHHHHC		25.9025159151
490PhosphorylationIAKKRLSSYTECYKW
HHHHHHHHCHHHHCC		40.4423401153
491PhosphorylationAKKRLSSYTECYKWS
HHHHHHHCHHHHCCC		11.8123090842
492PhosphorylationKKRLSSYTECYKWSS
HHHHHHCHHHHCCCC		22.8728450419
495PhosphorylationLSSYTECYKWSSSPE
HHHCHHHHCCCCCCC		14.8421712546
498PhosphorylationYTECYKWSSSPENAC
CHHHHCCCCCCCCCC		19.4525850435
499PhosphorylationTECYKWSSSPENACG
HHHHCCCCCCCCCCC		49.1225850435
500PhosphorylationECYKWSSSPENACGL
HHHCCCCCCCCCCCC		30.6225850435
500 (in isoform 2)Ubiquitination-30.6221890473
506UbiquitinationSSPENACGLPSPIST
CCCCCCCCCCCCCCC		37.9121890473
506 (in isoform 3)Ubiquitination-37.9121890473
509PhosphorylationENACGLPSPISTNRQ
CCCCCCCCCCCCCCH		39.6527050516
512PhosphorylationCGLPSPISTNRQIQK
CCCCCCCCCCCHHHH		24.0229978859
513PhosphorylationGLPSPISTNRQIQKN
CCCCCCCCCCHHHHH		34.8329396449
518 (in isoform 2)Ubiquitination-23.6721890473
520 (in isoform 2)Ubiquitination-27.4421890473
521 (in isoform 2)Ubiquitination-7.2621890473
523UbiquitinationQIQKNCPPSPLPLIS
HHHHHCCCCCCCCCC		51.2621890473
524PhosphorylationIQKNCPPSPLPLISK
HHHHCCCCCCCCCCC		24.9825159151
524UbiquitinationIQKNCPPSPLPLISK
HHHHCCCCCCCCCCC		24.9821890473
524 (in isoform 3)Ubiquitination-24.9821890473
526 (in isoform 3)Ubiquitination-6.7321890473
527UbiquitinationNCPPSPLPLISKQSP
HCCCCCCCCCCCCCC		30.9121890473
527 (in isoform 3)Ubiquitination-30.9121890473
530PhosphorylationPSPLPLISKQSPQTS
CCCCCCCCCCCCCCC		32.1225159151
533PhosphorylationLPLISKQSPQTSFPY
CCCCCCCCCCCCCCC		23.7825159151
536PhosphorylationISKQSPQTSFPYKIM
CCCCCCCCCCCCEEE		35.4022199227
537PhosphorylationSKQSPQTSFPYKIMP
CCCCCCCCCCCEEEC		20.9830576142
540PhosphorylationSPQTSFPYKIMPIQH
CCCCCCCCEEECCEE		15.9023186163
540UbiquitinationSPQTSFPYKIMPIQH
CCCCCCCCEEECCEE		15.9021890473
541UbiquitinationPQTSFPYKIMPIQHT
CCCCCCCEEECCEEE		32.5421890473
541UbiquitinationPQTSFPYKIMPIQHT
CCCCCCCEEECCEEE		32.5421890473
541 (in isoform 1)Ubiquitination-32.5421890473
545UbiquitinationFPYKIMPIQHTLSVQ
CCCEEECCEEEEECC		2.3121890473
548PhosphorylationKIMPIQHTLSVQSAS
EEECCEEEEECCCCC		12.3520860994
550PhosphorylationMPIQHTLSVQSASST
ECCEEEEECCCCCHH		21.1829978859
553PhosphorylationQHTLSVQSASSTVKK
EEEEECCCCCHHCHH		28.1429978859
555PhosphorylationTLSVQSASSTVKKKK
EEECCCCCHHCHHHH		31.6129978859
556PhosphorylationLSVQSASSTVKKKKE
EECCCCCHHCHHHHH		36.6229978859
557PhosphorylationSVQSASSTVKKKKET
ECCCCCHHCHHHHHH		33.5729978859
558UbiquitinationVQSASSTVKKKKETV
CCCCCHHCHHHHHHH		10.3921890473
559UbiquitinationQSASSTVKKKKETVS
CCCCHHCHHHHHHHC		59.9921890473
559UbiquitinationQSASSTVKKKKETVS
CCCCHHCHHHHHHHC		59.9921890473
559 (in isoform 1)Ubiquitination-59.9921890473
561UbiquitinationASSTVKKKKETVSKT
CCHHCHHHHHHHCHH		50.5621906983
561 (in isoform 1)Ubiquitination-50.5621890473
562UbiquitinationSSTVKKKKETVSKTT
CHHCHHHHHHHCHHH		68.452190698
562 (in isoform 1)Ubiquitination-68.4521890473
566UbiquitinationKKKKETVSKTTNRCE
HHHHHHHCHHHHHHH		31.5332015554
576PhosphorylationTNRCEALSQRHMIYE
HHHHHHHHHHHCEEE		32.0123663014
582PhosphorylationLSQRHMIYEESGNKS
HHHHHCEEECCCCCC		13.1823663014
583UbiquitinationSQRHMIYEESGNKST
HHHHCEEECCCCCCH		34.4632015554
585PhosphorylationRHMIYEESGNKSTAG
HHCEEECCCCCCHHH		35.4123663014
590PhosphorylationEESGNKSTAGIMNAE
ECCCCCCHHHCCCHH		30.4328555341
601AcetylationMNAEAATKILTELRR
CCHHHHHHHHHHHHH		30.8726051181
601UbiquitinationMNAEAATKILTELRR
CCHHHHHHHHHHHHH		30.8732015554
608MethylationKILTELRRLAREQRE
HHHHHHHHHHHHHHH		45.37115387575
630UbiquitinationREEMQQRVIKKSKDM
HHHHHHHHHHHHHHH		6.9929967540
644UbiquitinationMAKEAVGGQAEDHLK
HHHHHHCCCHHHHHC		19.5429967540
647UbiquitinationEAVGGQAEDHLKLKD
HHHCCCHHHHHCCCC		37.7729967540
661UbiquitinationDGQQQNETKKKKGWL
CCCCCCHHHCCCCCC		56.5729967540
665UbiquitinationQNETKKKKGWLDQED
CCHHHCCCCCCCHHH		65.2929967540
679UbiquitinationDQEAPLQKGDAKIKA
HCCCCCCCCCHHHHH		67.4529967540
722PhosphorylationIEEIMKRTRKTDVNA
HHHHHHHHHCCCCCH		30.8822468782
730PhosphorylationRKTDVNASKVTETSS
HCCCCCHHHCCCCCC		23.58-
733PhosphorylationDVNASKVTETSSHDI
CCCHHHCCCCCCCHH		36.9622468782
751PhosphorylationAEADNEESDKDSLNE
HHHCCCCCCHHHHHH		43.7225159151
762PhosphorylationSLNEMFPSAILNGTG
HHHHHCCHHHHCCCC		19.3728102081
768PhosphorylationPSAILNGTGSPTKFK
CHHHHCCCCCCCCCC		33.1525850435
770PhosphorylationAILNGTGSPTKFKMP
HHHCCCCCCCCCCCC		29.2725159151
772PhosphorylationLNGTGSPTKFKMPFN
HCCCCCCCCCCCCCC		51.3022496350
795PhosphorylationLVFLEDGTSQVRKEP
EEEECCCCHHCCCCC		28.4522210691
796PhosphorylationVFLEDGTSQVRKEPK
EEECCCCHHCCCCCC		32.0122210691
805PhosphorylationVRKEPKTYFNGDLKN
CCCCCCCCCCCCHHH		10.9427642862
817PhosphorylationLKNFRQKSMKDTSIQ
HHHHHHHHCCCCCHH		23.7928450419
821PhosphorylationRQKSMKDTSIQEVVS
HHHHCCCCCHHHHHC		23.3923663014
822PhosphorylationQKSMKDTSIQEVVSR
HHHCCCCCHHHHHCC		32.2023663014
828PhosphorylationTSIQEVVSRPSSKRM
CCHHHHHCCCCCCCC		43.5823401153
831PhosphorylationQEVVSRPSSKRMTSH
HHHHCCCCCCCCCCC		47.5925159151
832PhosphorylationEVVSRPSSKRMTSHT
HHHCCCCCCCCCCCC		27.2814702039
833AcetylationVVSRPSSKRMTSHTT
HHCCCCCCCCCCCCC		50.9926051181
839PhosphorylationSKRMTSHTTKTRKAD
CCCCCCCCCCCCCCC		29.7426657352
840PhosphorylationKRMTSHTTKTRKADE
CCCCCCCCCCCCCCC		25.6226657352
850PhosphorylationRKADETNTTSRSSAQ
CCCCCCCCCCCHHCC		33.30-
854PhosphorylationETNTTSRSSAQTKSE
CCCCCCCHHCCCCCC		29.77-
860PhosphorylationRSSAQTKSEGFHDIL
CHHCCCCCCCCHHCC		46.4728555341
870PhosphorylationFHDILPKSSDTFRQ-
CHHCCCCCCCCCCC-		31.3520860994
871PhosphorylationHDILPKSSDTFRQ--
HHCCCCCCCCCCC--		46.9620860994
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MA7D3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MA7D3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MA7D3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TBA1A_HUMANTUBA1Aphysical
24614595
TBB3_HUMANTUBB3physical
24614595
HDAC6_HUMANHDAC6physical
24614595
CBY1_HUMANCBY1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MA7D3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437; SER-441 ANDSER-461, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-302; THR-317; SER-322;SER-457; SER-461 AND SER-524, AND MASS SPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND SER-461, ANDMASS SPECTROMETRY.
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185; SER-223 ANDSER-229, AND MASS SPECTROMETRY.
"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533, AND MASSSPECTROMETRY.

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